{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:48:41Z","timestamp":1769824121715,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejso.2024.108320","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T23:02:49Z","timestamp":1712185369000},"page":"108320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraoperative frozen section of subareolar tissue in nipple-sparing mastectomy: Towards a less is more approach"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-3452","authenticated-orcid":false,"given":"Jonathan","family":"Spoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Heeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romy C.","family":"Collewijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris M.C.","family":"van der Ploeg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije J.","family":"Hoornweg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose G.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Jeanne F.T.D.","family":"Vrancken Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederieke H.","family":"van Duijnhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10549-020-05725-z","article-title":"Breast-contour preserving procedures for early-stage breast cancer: a population-based study of the trends, variation in practice and predictive characteristics in Denmark and The Netherlands","volume":"182","author":"Heeg","year":"2020","journal-title":"Breast Cancer Res Treat"},{"issue":"10 Pt A","key":"10.1016\/j.ejso.2024.108320_bib3","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.ejso.2020.06.009","article-title":"The added value of immediate breast reconstruction to health-related quality of life of breast cancer patients","volume":"46","author":"van Bommel","year":"2020","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2024.108320_bib4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0002-9610(71)90441-7","article-title":"Breast reconstruction: a plea for saving the uninvolved nipple","volume":"122","author":"Millard","year":"1971","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/bjs.1800740118","article-title":"Nipple preservation during mastectomy","volume":"74","author":"Kissin","year":"1987","journal-title":"Br J Surg"},{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/bjs.6970","article-title":"Nipple-sparing mastectomy","volume":"97","author":"Rusby","year":"2010","journal-title":"Br J Surg"},{"issue":"10","key":"10.1016\/j.ejso.2024.108320_bib7","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1245\/s10434-015-4737-3","article-title":"Expanded indications and improved outcomes for nipple-sparing mastectomy over time","volume":"22","author":"Krajewski","year":"2015","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12032-013-0481-3","article-title":"Long-term follow-up of nipple-sparing mastectomy without radiotherapy: a single center study at a Japanese institution","volume":"30","author":"Sakurai","year":"2013","journal-title":"Med Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/SLA.0b013e31819a044f","article-title":"The oncological safety of skin sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction: an extended follow-up study","volume":"249","author":"Gerber","year":"2009","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.ejso.2024.108320_bib10","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1245\/s10434-022-13006-w","article-title":"Oncologic safety of nipple-sparing mastectomy for breast cancer in BRCA gene mutation carriers: outcomes at 70 Months median follow-up","volume":"30","author":"Webster","year":"2023","journal-title":"Ann Surg Oncol"},{"issue":"10","key":"10.1016\/j.ejso.2024.108320_bib11","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1245\/s10434-018-6585-4","article-title":"A Comparison of patient-reported outcomes after nipple-sparing mastectomy and conventional mastectomy with reconstruction","volume":"25","author":"Romanoff","year":"2018","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2024.108320_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/PRS.0000000000003505","article-title":"Cooney D.S., et al. Quality-of-Life outcomes improve with nipple-sparing mastectomy and breast reconstruction","volume":"140","author":"Bailey","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10549-008-0238-4","article-title":"Does nipple preservation in mastectomy improve satisfaction with cosmetic results, psychological adjustment, body image and sexuality?","volume":"118","author":"Didier","year":"2009","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib14","article-title":"Quality of life and complications after nipple- versus skin-sparing mastectomy followed by immediate breast reconstruction: a systematic review and meta-analysis","volume":"152","author":"Clarijs","year":"2023","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"10.1016\/j.ejso.2024.108320_bib15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/107327481201900405","article-title":"The changing face of mastectomy: an oncologic and cosmetic perspective","volume":"19","author":"Laronga","year":"2012","journal-title":"Cancer Control"},{"issue":"5","key":"10.1016\/j.ejso.2024.108320_bib16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF00390043","article-title":"Nipple involvement and multicentricity in breast cancer. A study on whole organ sections","volume":"113","author":"L\u00fcttges","year":"1987","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"30","key":"10.1016\/j.ejso.2024.108320_bib17","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1200\/JCO.2008.20.8785","article-title":"Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens","volume":"27","author":"Brachtel","year":"2009","journal-title":"J Clin Oncol"},{"issue":"15","key":"10.1016\/j.ejso.2024.108320_bib18","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.ejca.2012.04.017","article-title":"Clinical and radiological predictors of nipple-areola complex involvement in breast cancer patients","volume":"48","author":"D\u2019Alonzo","year":"2012","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.amjsurg.2007.12.020","article-title":"Mammographic distance as a predictor of nipple-areola complex involvement in breast cancer","volume":"195","author":"Loewen","year":"2008","journal-title":"Am J Surg"},{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/01.sap.0000171680.49971.85","article-title":"Nipple-areola complex preservation: predictive factors of neoplastic nipple-areola complex invasion","volume":"55","author":"Vlajcic","year":"2005","journal-title":"Ann Plast Surg"},{"issue":"2","key":"10.1016\/j.ejso.2024.108320_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1245\/s10434-012-2641-7","article-title":"Predicting nipple-areolar involvement using preoperative breast MRI and primary tumor characteristics","volume":"20","author":"Steen","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"10.1016\/j.ejso.2024.108320_bib22","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/bjs.6349","article-title":"Development and validation of a model predictive of occult nipple involvement in women undergoing mastectomy","volume":"95","author":"Rusby","year":"2008","journal-title":"Br J Surg"},{"issue":"4","key":"10.1016\/j.ejso.2024.108320_bib23","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s12282-018-0845-9","article-title":"Preoperative breast MRI: reproducibility and significance of findings relevant to nipple-areolar complex involvement","volume":"25","author":"Machida","year":"2018","journal-title":"Breast Cancer"},{"issue":"14","key":"10.1016\/j.ejso.2024.108320_bib24","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.ejca.2015.07.001","article-title":"MRI and intraoperative pathology to predict nipple-areola complex (NAC) involvement in patients undergoing NAC-sparing mastectomy","volume":"51","author":"Ponzone","year":"2015","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0748-7983(98)80117-0","article-title":"Prediction of nipple and areola involvement in breast cancer","volume":"24","author":"Vyas","year":"1998","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10549-008-9968-6","article-title":"Nipple-sparing mastectomy: risk of nipple-areolar recurrences in a series of 579 cases","volume":"114","author":"Petit","year":"2009","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.1016\/j.ejso.2024.108320_bib27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jamcollsurg.2010.12.039","article-title":"Oncologic safety of nipple skin-sparing or total skin-sparing mastectomies with immediate reconstruction","volume":"212","author":"Boneti","year":"2011","journal-title":"J Am Coll Surg"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib28","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie","year":"2007","journal-title":"Cell Oncol"},{"key":"10.1016\/j.ejso.2024.108320_bib29","first-page":"1739","article-title":"Ernstige complicaties van subcutane injecties met vloeibare paraffine of siliconen voor het verbeteren van de lichaamscontour bij 15 man-naar-vrouw transseksuelen","volume":"145","author":"Verduijn","year":"2001","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"4","key":"10.1016\/j.ejso.2024.108320_bib30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1524-4741.2009.00758.x","article-title":"Nipple-sparing mastectomy: initial experience at the Memorial Sloan-Kettering Cancer Center and a comprehensive review of literature","volume":"15","author":"Garcia-Etienne","year":"2009","journal-title":"Breast J"},{"issue":"10","key":"10.1016\/j.ejso.2024.108320_bib31","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1245\/s10434-013-3174-4","article-title":"Nipple skin-sparing mastectomy is feasible for advanced disease","volume":"20","author":"Burdge","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2024.108320_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/tbj.12517","article-title":"Nipple-sparing mastectomy and sub-areolar biopsy: to freeze or not to freeze? Evaluating the role of sub-areolar intraoperative frozen section","volume":"22","author":"Alperovich","year":"2016","journal-title":"Breast J"},{"issue":"3","key":"10.1016\/j.ejso.2024.108320_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10549-015-3568-z","article-title":"Accuracy of frozen section, imprint cytology, and permanent histology of sub-nipple tissue for predicting occult nipple involvement in patients with breast carcinoma","volume":"153","author":"Duarte","year":"2015","journal-title":"Breast Cancer Res Treat"},{"issue":"11","key":"10.1016\/j.ejso.2024.108320_bib34","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.ejso.2018.07.059","article-title":"Nipple-Sparing Mastectomy: reliability of sub-areolar sampling and frozen section in predicting occult nipple involvement in breast cancer patients","volume":"44","author":"D\u2019Alonzo","year":"2018","journal-title":"Eur J Surg Oncol"},{"issue":"12","key":"10.1016\/j.ejso.2024.108320_bib35","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1245\/s10434-015-4648-3","article-title":"The nipple is just another margin","volume":"22","author":"Coopey","year":"2015","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"10.1016\/j.ejso.2024.108320_bib36","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1245\/s10434-012-2362-y","article-title":"Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts","volume":"19","author":"Warren Peled","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"10.1016\/j.ejso.2024.108320_bib37","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1245\/s10434-015-4646-5","article-title":"Tumor involvement of the nipple in total skin-sparing mastectomy: strategies for management","volume":"22","author":"Amara","year":"2015","journal-title":"Ann Surg Oncol"},{"issue":"30","key":"10.1016\/j.ejso.2024.108320_bib38","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1200\/JCO.2008.21.5764","article-title":"Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial","volume":"27","author":"Jones","year":"2009","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2024.108320_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.radonc.2012.06.009","article-title":"Impact of negative margin width on local recurrence in breast conserving therapy","volume":"104","author":"Chen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejso.2024.108320_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2020.151697","article-title":"The utility of intraoperative retroareolar margin frozen section assessment and the management of atypical epithelial proliferative lesions at the retroareolar margin in nipple-sparing mastectomies","volume":"51","author":"Hogan","year":"2021","journal-title":"Ann Diagn Pathol"},{"issue":"6","key":"10.1016\/j.ejso.2024.108320_bib41","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jamcollsurg.2016.02.016","article-title":"Positive nipple margins in nipple-sparing mastectomies: rates, management, and oncologic safety","volume":"222","author":"Tang","year":"2016","journal-title":"J Am Coll Surg"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879832400372X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879832400372X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T20:48:22Z","timestamp":1737665302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074879832400372X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S074879832400372X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2024.108320","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraoperative frozen section of subareolar tissue in nipple-sparing mastectomy: Towards a less is more approach","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2024.108320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108320"}}