{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:17:13Z","timestamp":1793215033817,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["2019\\u221223822"],"award-info":[{"award-number":["2019\\u221223822"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ejso.2024.109557","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T18:02:20Z","timestamp":1734372140000},"page":"109557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["CT-radiomics and pathological tumor response to systemic therapy: A predictive analysis for colorectal liver metastases. Development and internal validation of a clinical-radiomic model"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-053X","authenticated-orcid":false,"given":"Angela","family":"Ammirabile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-0205","authenticated-orcid":false,"given":"Lara","family":"Cavinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6352-9556","authenticated-orcid":false,"given":"Carola Anna Paolina","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-1330","authenticated-orcid":false,"given":"Francesco","family":"Fiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Stefano","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Russolillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Balbo Mussetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-8690","authenticated-orcid":false,"given":"Elisa Maria","family":"Ragaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-8798","authenticated-orcid":false,"given":"Ezio","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-0932","authenticated-orcid":false,"given":"Reha","family":"Akpinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Procopio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Francone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Maria","family":"Terracciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-5810","authenticated-orcid":false,"given":"Alessandro","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Di Tommaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-1983","authenticated-orcid":false,"given":"Francesca","family":"Ieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Torzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-4832","authenticated-orcid":false,"given":"Luca","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2024.109557_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","article-title":"Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Cervantes","year":"2023","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3748\/wjg.v28.i6.608","article-title":"Is precision medicine for colorectal liver metastases still a utopia? New perspectives by modern biomarkers, radiomics, and artificial intelligence","volume":"28","author":"Vigan\u00f2","year":"2022","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejso.2024.109557_bib3","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/01.sla.0000145964.08365.01","article-title":"Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?","volume":"240","author":"Adam","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2024.109557_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejso.2024.109557_bib5","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1001\/jama.2009.1755","article-title":"Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases","volume":"302","author":"Chun","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.ejso.2024.109557_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/annonc\/mdl386","article-title":"Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery","volume":"18","author":"Rubbia-Brandt","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib7","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1245\/s10434-020-08284-1","article-title":"What is the prognostic value of a discordant radiologic and pathologic response in patients undergoing resection of colorectal liver metastases after preoperative chemotherapy?","volume":"27","author":"Brouquet","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4251\/wjgo.v11.i4.295","article-title":"Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy","volume":"11","author":"Serayssol","year":"2019","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s40880-017-0244-1","article-title":"Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases","volume":"36","author":"Wang","year":"2017","journal-title":"Chin J Cancer"},{"key":"10.1016\/j.ejso.2024.109557_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2023.111015","article-title":"Radiomics models for preoperative prediction of the histopathological grade of hepatocellular carcinoma: a systematic review and radiomics quality score assessment","volume":"166","author":"Wang","year":"2023","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.ejso.2024.109557_bib11","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.3390\/cancers12102881","article-title":"Radiomics of liver metastases: a systematic review","volume":"12","author":"Fiz","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejso.2024.109557_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/2050640615601603","article-title":"CT texture analysis in colorectal liver metastases: a better way than size and volume measurements to assess response to chemotherapy?","volume":"4","author":"Rao","year":"2016","journal-title":"United Eur Gastroenterol J"},{"key":"10.1016\/j.ejso.2024.109557_bib13","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s10278-023-00799-9","article-title":"Mapping tumor heterogeneity via local entropy assessment: making biomarkers visible","volume":"36","author":"Costa","year":"2023","journal-title":"J Digit Imag"},{"key":"10.1016\/j.ejso.2024.109557_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/cjp2.178","article-title":"Prognostic assessment of resected colorectal liver metastases integrating pathological features, RAS mutation and Immunoscore","volume":"7","author":"Baldin","year":"2021","journal-title":"J Pathol Clin Res"},{"key":"10.1016\/j.ejso.2024.109557_bib15","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41416-022-01859-7","article-title":"Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights","volume":"127","author":"Latacz","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejso.2024.109557_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/bjs.6436","article-title":"Dangerous halo after neoadjuvant chemotherapy and two-step hepatectomy for colorectal liver metastases","volume":"96","author":"Mentha","year":"2009","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2024.109557_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/bjs.9736","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement","volume":"102","author":"Collins","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2024.109557_bib18","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1158\/0008-5472.CAN-18-0125","article-title":"LIFEx: a freeware for radiomic feature calculation in multimodality imaging to accelerate advances in the characterization of tumor heterogeneity","volume":"78","author":"Nioche","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejso.2024.109557_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15174204","article-title":"Radiomic analysis of intrahepatic cholangiocarcinoma: non-invasive prediction of pathology data: a multicenter study to develop a clinical\u2013radiomic model","volume":"15","author":"Fiz","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.ejso.2024.109557_bib20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1148\/radiol.2020191145","article-title":"The image biomarker standardization initiative: standardized quantitative radiomics for high-throughput image-based phenotyping","volume":"295","author":"Zwanenburg","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.ejso.2024.109557_bib21","doi-asserted-by":"crossref","first-page":"W1060","DOI":"10.2214\/AJR.11.6459","article-title":"CT findings of response and recurrence, independent of change in tumor size, in colorectal liver metastasis treated with bevacizumab","volume":"197","author":"Boonsirikamchai","year":"2011","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.ejso.2024.109557_bib22","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.hpb.2019.03.368","article-title":"KRAS mutational status impacts pathologic response to pre-hepatectomy chemotherapy: a study from the International Genetic Consortium for Liver Metastases","volume":"21","author":"Margonis","year":"2019","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.ejso.2024.109557_bib23","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1245\/s10434-019-07910-x","article-title":"Prediction of histopathologic growth patterns of colorectal liver metastases with a noninvasive imaging method","volume":"26","author":"Cheng","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib24","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1245\/s10434-022-11717-8","article-title":"The histopathological growth pattern of colorectal liver metastases impacts local recurrence risk and the adequate width of the surgical margin","volume":"29","author":"Vigan\u00f2","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics11071162","article-title":"Contrast administration impacts CT-based radiomics of colorectal liver metastases and non-tumoral liver parenchyma revealing the \"radiological\" Tumour microenvironment","volume":"11","author":"Fiz","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.ejso.2024.109557_bib26","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s00259-022-05765-1","article-title":"PET\/CT-based radiomics of mass-forming intrahepatic cholangiocarcinoma improves prediction of pathology data and survival","volume":"49","author":"Fiz","year":"2022","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.ejso.2024.109557_bib27","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.7150\/jca.31493","article-title":"Histological tumor response assessment in colorectal liver metastases after neoadjuvant chemotherapy: impact of the variation in tumor regression grading and peritumoral lymphocytic infiltration","volume":"10","author":"Cai","year":"2019","journal-title":"J Cancer"},{"key":"10.1016\/j.ejso.2024.109557_bib28","first-page":"48","article-title":"Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases","volume":"8","author":"Nierop","year":"2022","journal-title":"J Pathol: Clin Res"},{"key":"10.1016\/j.ejso.2024.109557_bib29","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1245\/s10434-018-6387-8","article-title":"Progression of colorectal liver metastases from the end of chemotherapy to resection: a new contraindication to surgery?","volume":"25","author":"Vigano","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib30","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1007\/s00432-023-04852-6","article-title":"A CT-based radiomics nomogram for predicting histopathologic growth patterns of colorectal liver metastases","volume":"149","author":"Sun","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ejso.2024.109557_bib31","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s13304-023-01620-6","article-title":"Radiomics in liver surgery: defining the path toward clinical application","volume":"75","author":"Vigan\u00f2","year":"2023","journal-title":"Updates in Surgery"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798324016251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798324016251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:46:22Z","timestamp":1741927582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798324016251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0748798324016251"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2024.109557","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CT-radiomics and pathological tumor response to systemic therapy: A predictive analysis for colorectal liver metastases. Development and internal validation of a clinical-radiomic model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2024.109557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109557"}}