{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:39:34Z","timestamp":1789205974252,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ejso.2025.110006","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T11:23:03Z","timestamp":1743679383000},"page":"110006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nodal status in major salivary gland cancer: External validation of a novel N- classification"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-4789","authenticated-orcid":false,"given":"Davide","family":"Lombardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-1654","authenticated-orcid":false,"given":"Michele","family":"Tomasoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Missale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig E.","family":"Smeele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Van Lierde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3672-7859","authenticated-orcid":false,"given":"Matthieu","family":"Van Eecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Pellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-8832","authenticated-orcid":false,"given":"Francesco","family":"Mazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ravanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-736X","authenticated-orcid":false,"given":"Tsui-Hui (Hubert)","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-1224","authenticated-orcid":false,"given":"Jason C.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Ghazal-Asswad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-2580","authenticated-orcid":false,"given":"Laura","family":"Locati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-3006","authenticated-orcid":false,"given":"Marta","family":"Filauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2362-8936","authenticated-orcid":false,"given":"Giorgio","family":"Peretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gagliardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-829X","authenticated-orcid":false,"given":"Vincent Vander","family":"Poorten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.ejso.2025.110006_bib1","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1002\/cncr.31535","article-title":"Development of a novel salivary gland cancer lymph node staging system: lymph Node Staging for Salivary Cancer","volume":"124","author":"Aro","year":"2018","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.ejso.2025.110006_bib2","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/hed.26135","article-title":"Positive lymph node number and extranodal extension for predicting recurrence and survival in patients with salivary gland cancer","volume":"42","author":"Lee","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.ejso.2025.110006_bib3","doi-asserted-by":"crossref","first-page":"105076","DOI":"10.1016\/j.oraloncology.2020.105076","article-title":"The impact of nodal status in major salivary gland carcinoma: a multicenter experience and proposal of a novel N-classification","volume":"112","author":"Lombardi","year":"2021","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ejso.2025.110006_bib4","series-title":"TNM classification of malignant tumours","year":"2017"},{"issue":"3","key":"10.1016\/j.ejso.2025.110006_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/hed.21614","article-title":"Proposal for a rational classification of neck dissections","volume":"33","author":"Ferlito","year":"2011","journal-title":"Head Neck"},{"issue":"3","key":"10.1016\/j.ejso.2025.110006_bib6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/hed.26541","article-title":"Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: systematic review","volume":"43","author":"Guntinas-Lichius","year":"2021","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.ejso.2025.110006_bib7","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.3390\/cancers14122822","article-title":"Role of intraparotid and neck lymph node metastasis in primary parotid cancer surgery: a population-based analysis","volume":"14","author":"Kouka","year":"2022","journal-title":"Cancers"},{"issue":"8","key":"10.1016\/j.ejso.2025.110006_bib8","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ejso.2023.04.002","article-title":"Association between factor of parotid lymph node and prognosis in parotid cancer","volume":"49","author":"Fang","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2025.110006_bib9","article-title":"Metastatic lymph node burden impacts overall survival in submandibular gland cancer","volume":"13","author":"Wang","year":"2023","journal-title":"Front Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110006_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.ejso.2018.11.008","article-title":"The number and ratio of positive lymph nodes are independent prognostic factors for patients with major salivary gland cancer: results from the surveillance, epidemiology, and End Results dataset","volume":"45","author":"Qian","year":"2019","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2025.110006_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hed.21433","article-title":"Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignancies","volume":"33","author":"Walvekar","year":"2011","journal-title":"Head Neck"},{"issue":"9","key":"10.1016\/j.ejso.2025.110006_bib12","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/lary.25342","article-title":"Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland","volume":"125","author":"Nisa","year":"2015","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.ejso.2025.110006_bib13","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.oooo.2020.01.010","article-title":"Intraparotid and cervical lymph nodes metastasis in primary parotid gland carcinoma\u2014impact on clinical outcome","volume":"129","author":"Schneider","year":"2020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"8","key":"10.1016\/j.ejso.2025.110006_bib14","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ejso.2008.02.004","article-title":"Patterns of lymph node spread and its influence on outcome in resectable parotid cancer","volume":"34","author":"Klussmann","year":"2008","journal-title":"Eur J Surg Oncol EJSO"},{"issue":"1","key":"10.1016\/j.ejso.2025.110006_bib15","doi-asserted-by":"crossref","first-page":"103194","DOI":"10.1016\/j.amjoto.2021.103194","article-title":"The role of total parotidectomy in high-grade parotid malignancy: a multisurgeon retrospective review","volume":"43","author":"Karp","year":"2022","journal-title":"Am J Otolaryngol"},{"issue":"11","key":"10.1016\/j.ejso.2025.110006_bib16","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/hed.23507","article-title":"Clinical significance of intraparotid lymph node metastasis in primary parotid cancer","volume":"36","author":"Lim","year":"2014","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.ejso.2025.110006_bib17","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.3390\/life12122053","article-title":"Role of intra-parotid lymph node metastasis in primary parotid carcinoma","volume":"12","author":"Terada","year":"2022","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.ejso.2025.110006_bib18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/coa.12672","article-title":"Prediction of outcome by lymph node ratio in patients with parotid gland cancer","volume":"42","author":"Meyer","year":"2017","journal-title":"Clin Otolaryngol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110006_bib19","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/hed.25603","article-title":"High metastatic node number, not extranodal extension, as a node\u2010related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma","volume":"41","author":"Hsieh","year":"2019","journal-title":"Head Neck"},{"issue":"8","key":"10.1016\/j.ejso.2025.110006_bib20","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/jso.23914","article-title":"Patterns and treatment of neck metastases in patients with salivary gland cancers","volume":"111","author":"Yoo","year":"2015","journal-title":"J Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110006_bib21","doi-asserted-by":"crossref","first-page":"515","DOI":"10.7326\/0003-4819-130-6-199903160-00016","article-title":"Assessing the generalizability of prognostic information","volume":"130","author":"Justice","year":"1999","journal-title":"Ann Intern Med"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325004342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325004342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:40:22Z","timestamp":1762310422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798325004342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0748798325004342"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110006","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nodal status in major salivary gland cancer: External validation of a novel N- classification","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110006"}}