{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:11:40Z","timestamp":1775279500001,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ejso.2025.110099","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T05:13:56Z","timestamp":1745558036000},"page":"110099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrochemotherapy for cutaneous Kaposi Sarcoma: A European register-based cohort study from the International Network for Sharing Practices of electrochemotherapy (InspECT)"],"prefix":"10.1016","volume":"51","author":[{"given":"Pietro","family":"Quaglino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Brizio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-5184","authenticated-orcid":false,"given":"Giulia","family":"Bertino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-7656","authenticated-orcid":false,"given":"Erika","family":"Kis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-8721","authenticated-orcid":false,"given":"Matteo","family":"Mascherini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Battista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kunte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mowatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4616-7753","authenticated-orcid":false,"given":"Francesco","family":"Russano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Giorgione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. James P.","family":"Clover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Minuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadrian","family":"Schepler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Fabrizio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-1879","authenticated-orcid":false,"given":"Francesca","family":"Tauceri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Bonadies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-5670","authenticated-orcid":false,"given":"Gregor","family":"Sersa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Odili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2025.110099_bib1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s13555-016-0152-3","article-title":"An update on Kaposi's sarcoma: Epidemiology, pathogenesis and treatment","volume":"6","author":"Curtiss","year":"2016","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.ejso.2025.110099_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaad.2008.05.001","article-title":"Kaposi sarcoma: a continuing conundrum","volume":"59","author":"Schwartz","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ejso.2025.110099_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5858\/arpa.2012-0101-RS","article-title":"Kaposi sarcoma","volume":"137","author":"Radu","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ejso.2025.110099_bib4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1586\/era.10.43","article-title":"Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases","volume":"10","author":"Jarm","year":"2010","journal-title":"Expet Rev Anticancer Ther"},{"key":"10.1016\/j.ejso.2025.110099_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.seminoncol.2019.04.002","article-title":"Electrochemotherapy of superficial tumors \u2013 current status","volume":"46","author":"Campana","year":"2019","journal-title":"Semin Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejcsup.2006.08.002","article-title":"Electrochemotherapy \u2013 an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study","volume":"4","author":"Marty","year":"2006","journal-title":"European Journal of Cancer Supplements"},{"key":"10.1016\/j.ejso.2025.110099_bib7","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/jdv.14708","article-title":"Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: analysis of 57 patients from the International Network for Sharing Practices of Electrochemotherapy registry","volume":"32","author":"Rotunno","year":"2018","journal-title":"Acad Dermatol Venereol"},{"key":"10.1016\/j.ejso.2025.110099_bib8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1080\/0284186X.2022.2110385","article-title":"Electrochemotherapy with intravenous bleomycin for patients with cutaneous malignancies, across tumour histology: a systematic review","volume":"61","author":"Bastrup","year":"2022","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.ejso.2025.110099_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2478\/raon-2020-0009","article-title":"Long term response of electrochemotherapy with reduced dose of bleomycin in elderly patients with head and neck non-melanoma skin cancer","volume":"54","author":"Jamsek","year":"2020","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3390\/pharmaceutics13091324","article-title":"Bleomycin concentration in patients' plasma and tumors after electrochemotherapy. A study from InspECT group","volume":"13","author":"Groselj","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejso.2025.110099_bib11","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1080\/0284186X.2018.1454602","article-title":"Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases","volume":"57","author":"Gehl","year":"2018","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1245\/s10434-011-1860-7","article-title":"Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: a two-center prospective phase II trial","volume":"19","author":"Curatolo","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1529-8019.2012.01437.x","article-title":"Effective treatment of Kaposi's sarcoma by electrochemotherapy and intravenous bleomycin administration: ECT in cKS","volume":"25","author":"Latini","year":"2012","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.ejso.2025.110099_bib14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1529-8019.2010.01370.x","article-title":"Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach","volume":"23","author":"Testori","year":"2010","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.ejso.2025.110099_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejso.2013.09.002","article-title":"Electrochemotherapy as \u201cnew standard of care\u201d treatment for cutaneous Kaposi's sarcoma","volume":"40","author":"Di","year":"2014","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13027-017-0147-4","article-title":"Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma","volume":"12","author":"Starita","year":"2017","journal-title":"Infect Agents Cancer"},{"key":"10.1016\/j.ejso.2025.110099_bib17","article-title":"Cutaneous and subcutaneous Kaposi's sarcoma lesions treated with electrochemotherapy","volume":"ijd","author":"Lalanda","year":"2022","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ejso.2025.110099_bib18","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3390\/cancers16071295","article-title":"Electrochemotherapy in kaposi's sarcoma patients: from the gold standard strategy to locally advanced cutaneous and subcutaneous lesions","volume":"16","author":"Rullo","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.ejso.2025.110099_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2020.06.020","volume":"138","author":"Clover","year":"2020","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejso.2025.110099_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3892\/mco.2021.2226","article-title":"Electrochemotherapy in Kaposi sarcoma: a systematic review","volume":"14","author":"Ferioli","year":"2021","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib21","series-title":"Handbook of electroporation","first-page":"1799","article-title":"International Network for sharing Practices on electrochemotherapy (InspECT): an integrative patients treatment consortium [internet]","author":"Brizio","year":"2017"},{"key":"10.1016\/j.ejso.2025.110099_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejso.2025.110099_bib23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3109\/0284186X.2011.573626","article-title":"Management of cutaneous metastases using electrochemotherapy","volume":"50","author":"Matthiessen","year":"2011","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.ejso.2025.110099_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejca.2018.12.036","article-title":"Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF\/EADO\/EORTC)","volume":"114","author":"Lebbe","year":"2019","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejso.2025.110099_bib25","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1097\/01.aids.0000131385.60974.b9","article-title":"Pegylated liposomal doxorubicin plus highly active antiretroviral therapy versus highly active antiretroviral therapy alone in HIV patients with Kaposi's sarcoma","volume":"18","author":"Mart\u00edn-Carbonero","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.ejso.2025.110099_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/cncr.10634","article-title":"Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma","volume":"95","author":"Tulpule","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2025.110099_bib27","first-page":"1136","article-title":"Radiotherapy in the management of Kaposi's sarcoma: comparison of 8 Gy versus 6 Gy","volume":"98","author":"Yildiz","year":"2006","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.ejso.2025.110099_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.radonc.2008.03.009","article-title":"Hypofractionated radiation therapy in the treatment of epidemic Kaposi sarcoma \u2013 a prospective randomized trial","volume":"88","author":"Singh","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib29","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/jdv.18456","article-title":"Health\u2010related quality of life trajectories in melanoma patients after electrochemotherapy: real\u2010world insights from the InspECT register","volume":"36","author":"Campana","year":"2022","journal-title":"Acad Dermatol Venereol"},{"key":"10.1016\/j.ejso.2025.110099_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/bcpt.13012","article-title":"Vascularization of the tumours affects the pharmacokinetics of bleomycin and the effectiveness of electrochemotherapy","volume":"123","author":"Groselj","year":"2018","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.ejso.2025.110099_bib31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jso.24287","article-title":"Local treatment with electrochemotherapy of superficial angiosarcomas: efficacy and safety results from a multi-institutional retrospective study: electrochemotherapy for Angiosarcomas","volume":"114","author":"Guida","year":"2016","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijsu.2019.10.013","article-title":"Electrochemotherapy for advanced cutaneous angiosarcoma: a European register-based cohort study from the International Network for Sharing Practices of electrochemotherapy (InspECT)","volume":"72","author":"Campana","year":"2019","journal-title":"Int J Surg"},{"key":"10.1016\/j.ejso.2025.110099_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejcsup.2006.07.007","article-title":"Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy","volume":"4","author":"Gehl","year":"2006","journal-title":"European Journal of Cancer Supplements"},{"key":"10.1016\/j.ejso.2025.110099_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2478\/raon-2023-0029","article-title":"Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report","volume":"57","author":"Muir","year":"2023","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.ejso.2025.110099_bib35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2478\/raon-2024-0061","article-title":"Current operating procedure (COP) for bleomycin ElectroScleroTherapy (BEST) of low-flow vascular malformations","volume":"58","author":"Muir","year":"2024","journal-title":"Radiol Oncol"}],"updated-by":[{"DOI":"10.1016\/j.ejso.2025.110187","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000}}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879832500527X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879832500527X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:41:33Z","timestamp":1755495693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074879832500527X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S074879832500527X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110099","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ejso.2025.110187","asserted-by":"object"}]},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrochemotherapy for cutaneous Kaposi Sarcoma: A European register-based cohort study from the International Network for Sharing Practices of electrochemotherapy (InspECT)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110099"}}