{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:07:47Z","timestamp":1793718467109,"version":"4.6.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejso.2025.110454","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:04:25Z","timestamp":1758132265000},"page":"110454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of lymphadenectomy extent on the efficacy of immunotherapy in recurrent gastric cancer patients"],"prefix":"10.1016","volume":"51","author":[{"given":"Danni","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejso.2025.110454_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.ejso.2025.110454_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10120-022-01331-8","volume":"26","year":"2023","journal-title":"Gastric Cancer"},{"issue":"9","key":"10.1016\/j.ejso.2025.110454_bib3","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/cncr.22229","article-title":"Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer","volume":"107","author":"Coburn","year":"2006","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.ejso.2025.110454_bib4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1046\/j.0007-1323.2001.01875.x","article-title":"Influence of the number of lymph nodes examined on staging of gastric cancer","volume":"88","author":"Lee","year":"2001","journal-title":"Br J Surg"},{"issue":"4","key":"10.1016\/j.ejso.2025.110454_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ejso.2011.01.013","article-title":"Impact on survival of the number of lymph nodes removed in patients with node-negative gastric cancer submitted to extended lymph node dissection","volume":"37","author":"Biffi","year":"2011","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110454_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ejso.2011.01.012","article-title":"Effect of negative lymph node count on survival for gastric cancer after curative distal gastrectomy","volume":"37","author":"Huang","year":"2011","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2025.110454_bib7","article-title":"Retrieval of 30 lymph nodes is mandatory for selected stage II gastric cancer patients","volume":"11","author":"Chen","year":"2021","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2025.110454_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12885-017-3872-6","article-title":"Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center","volume":"18","author":"Macalindong","year":"2018","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.ejso.2025.110454_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/cac2.12516","article-title":"The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer","volume":"44","author":"Wang","year":"2023","journal-title":"Cancer Commun (Lond)"},{"issue":"3","key":"10.1016\/j.ejso.2025.110454_bib10","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.21037\/tcr-24-1477","article-title":"Revisiting lymph node guidelines: limited lymph node examination might be sufficient for elderly gastric cancer patients","volume":"14","author":"Zhang","year":"2025","journal-title":"Transl Cancer Res"},{"issue":"5","key":"10.1016\/j.ejso.2025.110454_bib11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJMoa0707035","article-title":"D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer","volume":"359","author":"Sasako","year":"2008","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.ejso.2025.110454_bib12","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.cell.2022.04.019","article-title":"Lymph node colonization induces tumor-immune tolerance to promote distant metastasis","volume":"185","author":"Reticker-Flynn","year":"2022","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ejso.2025.110454_bib13","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","article-title":"Dynamic CD8(+) T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes","volume":"186","author":"Rahim","year":"2023","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.ejso.2025.110454_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124507","article-title":"Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy","volume":"3","author":"Fransen","year":"2018","journal-title":"JCI Insight"},{"issue":"33","key":"10.1016\/j.ejso.2025.110454_bib15","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1200\/JCO.2011.36.5908","article-title":"Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer","volume":"29","author":"Sasako","year":"2011","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2025.110454_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S2468-1253(18)30383-2","article-title":"Four courses versus eight courses of adjuvant S-1 for patients with stage II gastric cancer (JCOG1104 [OPAS-1]): an open-label, phase 3, non-inferiority, randomised trial","volume":"4","author":"Yoshikawa","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"15","key":"10.1016\/j.ejso.2025.110454_bib17","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1200\/JCO.18.01138","article-title":"Addition of docetaxel to oral fluoropyrimidine improves efficacy in patients with stage III gastric cancer: interim analysis of JACCRO GC-07, a randomized controlled trial","volume":"37","author":"Yoshida","year":"2019","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.ejso.2025.110454_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.6004\/jnccn.2025.0022","article-title":"Gastric cancer, version 2.2025, NCCN clinical Practice guidelines in oncology","volume":"23","author":"Ajani","year":"2025","journal-title":"J Natl Compr Cancer Netw"},{"issue":"10","key":"10.1016\/j.ejso.2025.110454_bib19","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.annonc.2022.07.004","article-title":"Gastric cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"33","author":"Lordick","year":"2022","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejso.2025.110454_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2021.106165","article-title":"Strocss 2021: strengthening the reporting of cohort, cross-sectional and case-control studies in surgery","volume":"96","author":"Mathew","year":"2021","journal-title":"Int J Surg"},{"issue":"2","key":"10.1016\/j.ejso.2025.110454_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.6004\/jnccn.2022.0008","article-title":"Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Ajani","year":"2022","journal-title":"J Natl Compr Cancer Netw"},{"issue":"2","key":"10.1016\/j.ejso.2025.110454_bib22","first-page":"93","article-title":"The Eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10.1016\/j.ejso.2025.110454_bib23","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.surg.2021.04.026","article-title":"Benchmarks for nodal yield and ratio for node-positive gastric cancer","volume":"170","author":"Erstad","year":"2021","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.ejso.2025.110454_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1634\/theoncologist.2016-0239","article-title":"Does a higher cutoff value of lymph node retrieval substantially improve survival in patients with advanced gastric cancer?-time to embrace a new digit","volume":"22","author":"Liu","year":"2017","journal-title":"Oncologist"},{"issue":"9","key":"10.1016\/j.ejso.2025.110454_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137365","article-title":"Importance of lymph node immune responses in MSI-H\/dMMR colorectal cancer","volume":"6","author":"Inamori","year":"2021","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.ejso.2025.110454_bib26","doi-asserted-by":"crossref","first-page":"78.e13","DOI":"10.1016\/j.urolonc.2017.10.021","article-title":"Impact of adequate pelvic lymph node dissection on overall survival after radical cystectomy: a stratified analysis by clinical stage and receipt of neoadjuvant chemotherapy","volume":"36","author":"von Landenberg","year":"2018","journal-title":"Urol Oncol"},{"issue":"17_suppl","key":"10.1016\/j.ejso.2025.110454_bib27","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2025.43.17_suppl.LBA5501","article-title":"Sentinel lymph node biopsy versus pelvic lymphadenectomy in cervical cancer: the PHENIX trial","volume":"43","author":"Tu","year":"2025","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2025.110454_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.109545","article-title":"Prime suspect or collective responsibility: impact of specific lymph node station dissection on short- and long-term outcomes among locally advanced gastric cancer patients after neoadjuvant chemotherapy","volume":"51","author":"S\u0119d\u0142ak","year":"2025","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2025.110454_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/gutjnl-2024-333617","article-title":"CAF-Macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases","volume":"74","author":"Li","year":"2025","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.ejso.2025.110454_bib30","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nri1222","article-title":"Homing and cellular traffic in lymph nodes","volume":"3","author":"von Andrian","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110454_bib31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.ccell.2024.05.015","article-title":"Let it be: preserving tumor-draining lymph nodes in the era of immuno-oncology","volume":"42","author":"Saddawi-Konefka","year":"2024","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.ejso.2025.110454_bib32","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41585-024-00912-9","article-title":"From foes to friends: rethinking the role of lymph nodes in prostate cancer","volume":"21","author":"Gupta","year":"2024","journal-title":"Nat Rev Urol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110454_bib33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ejso.2015.03.227","article-title":"Does a minimum number of 16 retrieved nodes affect survival in curatively resected gastric cancer?","volume":"41","author":"Biondi","year":"2015","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2025.110454_bib34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2016.12.022","article-title":"Systemic immunity is required for effective cancer immunotherapy","volume":"168","author":"Spitzer","year":"2017","journal-title":"Cell"},{"issue":"7823","key":"10.1016\/j.ejso.2025.110454_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2623-z","article-title":"Lymph protects metastasizing melanoma cells from ferroptosis","volume":"585","author":"Ubellacker","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejso.2025.110454_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.addr.2020.07.023","article-title":"Cell and tissue engineering in lymph nodes for cancer immunotherapy","volume":"161\u2013162","author":"Najibi","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"10.1016\/j.ejso.2025.110454_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.it.2012.02.007","article-title":"Lymph node homing of T cells and dendritic cells via afferent lymphatics","volume":"33","author":"F\u00f6rster","year":"2012","journal-title":"Trends Immunol"},{"issue":"7335","key":"10.1016\/j.ejso.2025.110454_bib38","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09737","article-title":"Programming the magnitude and persistence of antibody responses with innate immunity","volume":"470","author":"Kasturi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejso.2025.110454_bib39","article-title":"Safety and efficacy of tislelizumab plus chemotherapy versus chemotherapy alone as neoadjuvant treatment for patients with locally advanced gastric cancer: real-world experience with a consecutive patient cohort","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.ejso.2025.110454_bib40","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1097\/JS9.0000000000001468","article-title":"The safety and efficacy of neoadjuvant immunochemotherapy following laparoscopic gastrectomy for gastric cancer: a multicentre real-world clinical study","volume":"110","author":"Sun","year":"2024","journal-title":"Int J Surg"},{"issue":"7","key":"10.1016\/j.ejso.2025.110454_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.108428","article-title":"Histopathologic response in patients with curative resection with D2 dissection following neoadjuvant treatment for locally advanced gastric and esophagogastric junction adenocarcinoma","volume":"50","author":"Alemdar","year":"2024","journal-title":"Eur J Surg Oncol"},{"issue":"13","key":"10.1016\/j.ejso.2025.110454_bib42","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1200\/JCO.2010.33.0597","article-title":"Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial","volume":"29","author":"Ychou","year":"2011","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2025.110454_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11605-015-2948-3","article-title":"Ex vivo lymphadenectomy during gastrectomy for adenocarcinoma optimizes lymph node yield","volume":"20","author":"Afaneh","year":"2016","journal-title":"J Gastrointest Surg"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325008820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325008820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:21:30Z","timestamp":1761963690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798325008820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0748798325008820"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110454","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of lymphadenectomy extent on the efficacy of immunotherapy in recurrent gastric cancer patients","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110454","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110454"}}