{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:42:42Z","timestamp":1762310562348,"version":"build-2065373602"},"reference-count":57,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44 AG045011-02"],"award-info":[{"award-number":["R44 AG045011-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R44 AG045011-02"],"award-info":[{"award-number":["R44 AG045011-02"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007231","name":"Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejso.2025.110458","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T22:58:02Z","timestamp":1758581882000},"page":"110458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term impact of preoperative radiotherapy for rectal cancer on testicular function"],"prefix":"10.1016","volume":"51","author":[{"given":"Louise","family":"de la Motte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tapper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-355X","authenticated-orcid":false,"given":"Stefan","family":"Arver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f6rn","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-9806","authenticated-orcid":false,"given":"Josefin","family":"Segelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Jasuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5998-4735","authenticated-orcid":false,"given":"Anna","family":"Martling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-5395","authenticated-orcid":false,"given":"Christian","family":"Buchli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejso.2025.110458_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol"},{"issue":"9","key":"10.1016\/j.ejso.2025.110458_bib2","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/1097-0142(19950501)75:9<2269::AID-CNCR2820750913>3.0.CO;2-I","article-title":"The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. A prospective randomized trial. Stockholm colorectal cancer study group","volume":"75","author":"Cedermark","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2025.110458_bib3","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/1097-0142(20010815)92:4<896::AID-CNCR1398>3.0.CO;2-R","article-title":"The Stockholm II trial on preoperative radiotherapy in rectal carcinoma: long-term follow-up of a population-based study","volume":"92","author":"Martling","year":"2001","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.ejso.2025.110458_bib4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJMoa010580","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer","volume":"345","author":"Kapiteijn","year":"2001","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.ejso.2025.110458_bib5","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1056\/NEJM199704033361402","article-title":"Improved survival with preoperative radiotherapy in resectable rectal cancer","volume":"336","author":"Cedermark","year":"1997","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ejso.2025.110458_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.ejso.2025.110458_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jamasurg.2014.1756","article-title":"Increasing disparities in the age-related incidences of Colon and rectal cancers in the United States, 1975-2010","volume":"150","author":"Bailey","year":"2015","journal-title":"JAMA Surg"},{"issue":"8","key":"10.1016\/j.ejso.2025.110458_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw322","article-title":"Colorectal cancer incidence patterns in the United States, 1974-2013","volume":"109","author":"Siegel","year":"2017","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"10.1016\/j.ejso.2025.110458_bib9","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1111\/j.1743-6109.2011.02455.x","article-title":"Testicular function after radiotherapy for rectal cancer--a review","volume":"8","author":"Buchli","year":"2011","journal-title":"J Sex Med"},{"issue":"2","key":"10.1016\/j.ejso.2025.110458_bib10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/SLA.0000000000002081","article-title":"Risk of acute testicular failure after preoperative radiotherapy for rectal cancer: a prospective cohort study","volume":"267","author":"Buchli","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2025.110458_bib11","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/bjs\/znab019","article-title":"Effect of preoperative radiotherapy for rectal cancer on spermatogenesis","volume":"107","author":"de la Motte","year":"2021","journal-title":"Br J Surg"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ijrobp.2007.10.043","article-title":"Radiotherapy for rectal cancer is associated with reduced serum testosterone and increased FSH and LH","volume":"70","author":"Bruheim","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-8140(03)00120-8","article-title":"Radiation therapy induced changes in male sex hormone levels in rectal cancer patients","volume":"68","author":"Dueland","year":"2003","journal-title":"Radiother Oncol : J Eur Soc Ther Radiol Oncol"},{"issue":"4","key":"10.1016\/j.ejso.2025.110458_bib14","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.ijrobp.2008.09.027","article-title":"Alterations in hormone levels after adjuvant chemoradiation in male rectal cancer patients","volume":"74","author":"Yoon","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ejso.2025.110458_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.ijrobp.2009.03.010","article-title":"Late side effects and quality of life after radiotherapy for rectal cancer","volume":"76","author":"Bruheim","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.ejso.2025.110458_bib16","doi-asserted-by":"crossref","first-page":"768","DOI":"10.7326\/M23-2781","article-title":"Associations of testosterone and related hormones with all-cause and cardiovascular mortality and incident cardiovascular disease in men","volume":"177","author":"Yeap","year":"2024","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib17","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/cen.13534","article-title":"High risk of hypogonadism in young male cancer survivors","volume":"88","author":"Isaksson","year":"2018","journal-title":"Clin Endocrinol"},{"issue":"7","key":"10.1016\/j.ejso.2025.110458_bib18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S1470-2045(10)70021-8","article-title":"Male hypogonadism associated with advanced cancer: a systematic review","volume":"11","author":"Vigano","year":"2010","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib19","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.sxmr.2019.04.001","article-title":"A review of Male and female sexual function following colorectal surgery","volume":"7","author":"Towe","year":"2019","journal-title":"Sex Med Rev"},{"issue":"7","key":"10.1016\/j.ejso.2025.110458_bib20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00384-016-2605-7","article-title":"Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report","volume":"31","author":"Huang","year":"2016","journal-title":"Int J Colorectal Dis"},{"issue":"4","key":"10.1016\/j.ejso.2025.110458_bib21","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.ijrobp.2009.03.075","article-title":"Sexual function in males after radiotherapy for rectal cancer","volume":"76","author":"Bruheim","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"10.1016\/j.ejso.2025.110458_bib22","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s00066-012-0139-7","article-title":"Testicular radiation dose after multimodal curative therapy for locally advanced rectal cancer. Influence on hormone levels, quality of life, and sexual functioning","volume":"188","author":"Hennies","year":"2012","journal-title":"Strahlenther Onkol"},{"issue":"9","key":"10.1016\/j.ejso.2025.110458_bib23","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2005.05.256","article-title":"Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial","volume":"23","author":"Marijnen","year":"2005","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2025.110458_bib24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.sla.0000171299.43954.ce","article-title":"Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer","volume":"242","author":"Hendren","year":"2005","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.ejso.2025.110458_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0911101","article-title":"Identification of late-onset hypogonadism in middle-aged and elderly men","volume":"363","author":"Wu","year":"2010","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ejso.2025.110458_bib26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40618-015-0425-1","article-title":"How to define hypogonadism? Results from a population of men consulting for sexual dysfunction","volume":"39","author":"Rastrelli","year":"2016","journal-title":"J Endocrinol Investig"},{"issue":"7","key":"10.1016\/j.ejso.2025.110458_bib27","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/jc.2015-4106","article-title":"Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone","volume":"101","author":"Antonio","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ejso.2025.110458_bib28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/13685538.2015.1004049","article-title":"Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men","volume":"18","author":"Lunenfeld","year":"2015","journal-title":"Aging Male"},{"issue":"12","key":"10.1016\/j.ejso.2025.110458_bib29","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.jsxm.2017.10.067","article-title":"British society for sexual medicine guidelines on adult testosterone deficiency, with statements for UK practice","volume":"14","author":"Hackett","year":"2017","journal-title":"J Sex Med"},{"issue":"8","key":"10.1016\/j.ejso.2025.110458_bib30","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1111\/jsm.12952","article-title":"The international society for sexual medicine's process of care for the assessment and management of testosterone deficiency in adult men","volume":"12","author":"Dean","year":"2015","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejso.2025.110458_bib31","unstructured":"Dohle G.R., Bettocchi C., Jones T.H., Kliesch S., Punab M. EAU guidelines on Male hypogonadism. European Association of Urology 2016. Accessed via: https:\/\/uroweb.org\/eau-guidelines\/discontinued-topics\/male-hypogonadism."},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3803\/EnM.2020.760","article-title":"Current national and international guidelines for the management of Male hypogonadism: helping clinicians to navigate variation in diagnostic criteria and treatment recommendations","volume":"35","author":"Al-Sharefi","year":"2020","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"5","key":"10.1016\/j.ejso.2025.110458_bib33","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/andr.12770","article-title":"European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: endorsing organization: European Society of Endocrinology","volume":"8","author":"Corona","year":"2020","journal-title":"Andrology"},{"issue":"12","key":"10.1016\/j.ejso.2025.110458_bib34","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.jsxm.2016.10.009","article-title":"Diagnosis and treatment of testosterone deficiency: recommendations from the fourth international consultation for sexual medicine (ICSM 2015)","volume":"13","author":"Khera","year":"2016","journal-title":"J Sex Med"},{"issue":"5","key":"10.1016\/j.ejso.2025.110458_bib35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10654-021-00738-4","article-title":"Sildenafil and suicide in Sweden","volume":"36","author":"Catalano","year":"2021","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib36","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/jsm.12751","article-title":"Testosterone and body composition in men after treatment for rectal cancer","volume":"12","author":"Buchli","year":"2015","journal-title":"J Sex Med"},{"issue":"4","key":"10.1016\/j.ejso.2025.110458_bib37","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3109\/0284186X.2015.1073349","article-title":"Assessment of testicular dose during preoperative radiotherapy for rectal cancer","volume":"55","author":"Buchli","year":"2016","journal-title":"Acta Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2025.110458_bib38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejso.2019.07.023","article-title":"Acute primary testicular failure due to radiotherapy increases risk of severe postoperative adverse events in rectal cancer patients","volume":"46","author":"Tapper","year":"2019","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110458_bib39","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline","volume":"95","author":"Bhasin","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejso.2025.110458_bib40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.mce.2014.09.001","article-title":"A multi-step, dynamic allosteric model of testosterone's binding to sex hormone binding globulin","volume":"399","author":"Zakharov","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.ejso.2025.110458_bib41","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1532-5415.2011.03398.x","article-title":"Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men: results from the European male aging study","volume":"59","author":"Tajar","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ejso.2025.110458_bib42","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.ejso.2025.110458_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0090-4295(99)00099-0","article-title":"Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function","volume":"54","author":"Cappelleri","year":"1999","journal-title":"Urology"},{"issue":"5","key":"10.1016\/j.ejso.2025.110458_bib44","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.eururo.2011.07.053","article-title":"Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale","volume":"60","author":"Rosen","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.ejso.2025.110458_bib45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/13685539909003173","article-title":"A new \u2018aging males\u2019 symptoms' rating scale","volume":"2","author":"Heinemann","year":"1999","journal-title":"Aging Male"},{"issue":"13","key":"10.1016\/j.ejso.2025.110458_bib46","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/jnci\/djm024","article-title":"Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials","volume":"99","author":"Punt","year":"2007","journal-title":"J Natl Cancer Inst"},{"issue":"23","key":"10.1016\/j.ejso.2025.110458_bib47","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.3390\/cancers16234005","article-title":"Long-Term effects on gonadal function after treatment of colorectal cancer: a systematic review and meta-analysis","volume":"16","author":"Anthon","year":"2024","journal-title":"Cancers"},{"issue":"12","key":"10.1016\/j.ejso.2025.110458_bib48","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/molehr\/gav055","article-title":"The impact of oxaliplatin on the gonads: from bedside to the bench","volume":"21","author":"Levi","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ejso.2025.110458_bib49","article-title":"Sex hormones and sperm parameters after adjuvant oxaliplatin-based treatment for colorectal cancer","volume":"31","author":"Falk","year":"2022","journal-title":"Cancer Treat Res Commun"},{"issue":"12","key":"10.1016\/j.ejso.2025.110458_bib50","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1210\/jc.2015-2460","article-title":"The association of reproductive hormone levels and all-cause, cancer, and cardiovascular disease mortality in men","volume":"100","author":"Holmboe","year":"2015","journal-title":"J Clin Endocrinol Metabol"},{"issue":"6","key":"10.1016\/j.ejso.2025.110458_bib51","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/cen.13152","article-title":"Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal data from the European Male Ageing Study","volume":"85","author":"Ahern","year":"2016","journal-title":"Clin Endocrinol"},{"issue":"1","key":"10.1016\/j.ejso.2025.110458_bib52","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.euf.2019.08.001","article-title":"Sperm count and hypogonadism as markers of general Male health","volume":"7","author":"Ferlin","year":"2021","journal-title":"Eur Urology Focus"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib53","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/cen.13524","article-title":"Elevated luteinizing hormone despite normal testosterone levels in older men-natural history, risk factors and clinical features","volume":"88","author":"Eendebak","year":"2018","journal-title":"Clin Endocrinol"},{"issue":"7","key":"10.1016\/j.ejso.2025.110458_bib54","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019559","article-title":"Association of serum testosterone and luteinizing hormone with blood pressure and risk of cardiovascular disease in middle-aged and elderly men","volume":"10","author":"Qu","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.ejso.2025.110458_bib55","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/andr.13365","article-title":"Testicular function is associated with cardiometabolic health markers: a cross-sectional study of 2289 young men","volume":"11","author":"Hansen","year":"2023","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.ejso.2025.110458_bib56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.eururo.2013.08.048","article-title":"A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review","volume":"65","author":"Isidori","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.ejso.2025.110458_bib57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fendo.2019.00225","article-title":"Androgen deficiency and phosphodiesterase type 5 expression changes in aging Male: therapeutic implications","volume":"10","author":"Aversa","year":"2019","journal-title":"Front Endocrinol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325008868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325008868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:39:24Z","timestamp":1762310364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798325008868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0748798325008868"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110458","relation":{},"ISSN":["0748-7983"],"issn-type":[{"type":"print","value":"0748-7983"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term impact of preoperative radiotherapy for rectal cancer on testicular function","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2025.110458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110458"}}