{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:22:45Z","timestamp":1789053765214,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["LHGJ20250278"],"award-info":[{"award-number":["LHGJ20250278"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019331","name":"Henan Medical Science and Technique Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502625"],"award-info":[{"award-number":["82502625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejso.2025.111167","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T01:35:37Z","timestamp":1762565737000},"page":"111167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of a circulating tumor DNA methylation biomarker panel for hepatocellular carcinoma detection"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-5648","authenticated-orcid":false,"given":"Yanzhao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejso.2025.111167_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ejso.2025.111167_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejrad.2018.01.025","article-title":"Diagnosis and staging of hepatocellular carcinoma (HCC): current guidelines","volume":"101","author":"Ayuso","year":"2018","journal-title":"Eur J Radiol"},{"issue":"1","key":"10.1016\/j.ejso.2025.111167_bib3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: Management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.ejso.2025.111167_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13148-023-01508-7","article-title":"HepaClear, a blood-based panel combining novel methylated CpG sites and protein markers, for the detection of early-stage hepatocellular carcinoma","volume":"15","author":"Bai","year":"2023","journal-title":"Clin Epigenet"},{"issue":"6","key":"10.1016\/j.ejso.2025.111167_bib5","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1053\/j.gastro.2018.01.064","article-title":"Surveillance imaging and alpha fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis","volume":"154","author":"Tzartzeva","year":"2018","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.ejso.2025.111167_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.trecan.2023.08.010","article-title":"Circulating cell-free DNA-based multi-cancer early detection","volume":"10","author":"Zhang","year":"2024","journal-title":"Trends Cancer"},{"issue":"2","key":"10.1016\/j.ejso.2025.111167_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41576-018-0071-5","article-title":"Current and future perspectives of liquid biopsies in genomics-driven oncology","volume":"20","author":"Heitzer","year":"2019","journal-title":"Nat Rev Genet"},{"issue":"5","key":"10.1016\/j.ejso.2025.111167_bib8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrclinonc.2018.30","article-title":"Epigenome-based cancer risk prediction: rationale, opportunities and challenges","volume":"15","author":"Widschwendter","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"issue":"9","key":"10.1016\/j.ejso.2025.111167_bib9","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/life11090890","article-title":"Liquid biopsy, ctDNA diagnosis through NGS","volume":"11","author":"Lin","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.ejso.2025.111167_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcancer.2017.12.004","article-title":"Epigenetic biomarkers in gastrointestinal cancers: the current 405 state and clinical perspectives","volume":"51","author":"Vedeld","year":"2018","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"10.1016\/j.ejso.2025.111167_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188722","article-title":"DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer","volume":"1877","author":"M\u00fcller","year":"2022","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"4","key":"10.1016\/j.ejso.2025.111167_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/path.1654","article-title":"The pathobiology of the septin gene family","volume":"204","author":"Hall","year":"2004","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.ejso.2025.111167_bib13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4251\/wjgo.v12.i6.619","article-title":"Structure and function of Septin 9 and its role in human malignant tumors","volume":"12","author":"Sun","year":"2020","journal-title":"World J Gastrointest Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2025.111167_bib14","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/hep.27732","article-title":"DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma","volume":"61","author":"Villanueva","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ejso.2025.111167_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6289063","article-title":"SEPT9 gene methylation as a noninvasive marker for hepatocellular carcinoma","volume":"2020","author":"Li","year":"2020","journal-title":"Dis Markers"},{"key":"10.1016\/j.ejso.2025.111167_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cyto.2016.01.005","article-title":"SOCS1 in cancer: an oncogene and a tumor suppressor","volume":"82","author":"Beaurivage","year":"2016","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.ejso.2025.111167_bib17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/CEJ.0000000000000121","article-title":"Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis","volume":"24","author":"Liu","year":"2015","journal-title":"Eur J Cancer Prev"},{"issue":"31","key":"10.1016\/j.ejso.2025.111167_bib18","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1038\/onc.2017.73","article-title":"Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.ejso.2025.111167_bib19","article-title":"Simultaneous detection of eight cancer types using a multiplex droplet digital PCR assay","volume":"6","author":"Neefs","year":"2024","journal-title":"Mol Oncol"},{"issue":"8","key":"10.1016\/j.ejso.2025.111167_bib20","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000386","article-title":"Detection of circulating tumor DNA methylation in diagnosis of colorectal cancer","volume":"12","author":"Xu","year":"2021","journal-title":"Clin Transl Gastroenterol"},{"issue":"3","key":"10.1016\/j.ejso.2025.111167_bib21","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristic curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"key":"10.1016\/j.ejso.2025.111167_bib22","article-title":"Opportunistic screening and 412 survival prediction of digestive cancers by the combination of blood mSEPT9 with protein 413 markers","volume":"12","author":"cSong","year":"2020","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.ejso.2025.111167_bib23","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3389\/fgene.2019.01150","article-title":"DNA methylation cancer biomarkers: translation to the clinic","volume":"10","author":"Locke","year":"2019","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.ejso.2025.111167_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2023.2299044","article-title":"Plasma methylated GNB4 and riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma","volume":"19","author":"Zhao","year":"2024","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.ejso.2025.111167_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12916-021-02201-3","article-title":"Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma","volume":"20","author":"Luo","year":"2022","journal-title":"BMC Med"},{"issue":"11","key":"10.1016\/j.ejso.2025.111167_bib26","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nmat4997","article-title":"Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma","volume":"16","author":"Xu","year":"2017","journal-title":"Nat Mater"},{"key":"10.1016\/j.ejso.2025.111167_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-4598-3-9","article-title":"Genetic alteration and gene expression modulation during cancer progression","volume":"3","author":"Garnis","year":"2004","journal-title":"Mol Cancer"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325015951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798325015951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:33:02Z","timestamp":1777573982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798325015951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0748798325015951"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2025.111167","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a circulating tumor DNA methylation biomarker panel for hepatocellular carcinoma detection","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2025.111167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111167"}}