{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:24:56Z","timestamp":1789874696212,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ejso.2026.111750","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:46:24Z","timestamp":1773938784000},"page":"111750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biologic stratification with tumor burden score and CA19-9 to inform vascular resection in intrahepatic cholangiocarcinoma"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2899-4030","authenticated-orcid":false,"given":"Kizuki","family":"Yuza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8377-0263","authenticated-orcid":false,"given":"Odysseas P.","family":"Chatzipanagiotou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hobeika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Aucejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo P.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir K.","family":"Maithel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas Groot","family":"Koerkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinel","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-1199","authenticated-orcid":false,"given":"Minoru","family":"Kitago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-5050","authenticated-orcid":false,"given":"Matthew J.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Martel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pulitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Poultsides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-563X","authenticated-orcid":false,"given":"Andrea","family":"Ruzzenente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-1848","authenticated-orcid":false,"given":"Todd W.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-4105","authenticated-orcid":false,"given":"Ana","family":"Gleisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-8114","authenticated-orcid":false,"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-9870","authenticated-orcid":false,"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejso.2026.111750_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"10.1016\/j.ejso.2026.111750_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00432-010-0971-z","article-title":"Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson cancer center","volume":"137","author":"Singal","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2026.111750_bib3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jamasurg.2013.5137","article-title":"Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: systematic review and meta-analysis","volume":"149","author":"Mavros","year":"2014","journal-title":"JAMA Surg"},{"issue":"4","key":"10.1016\/j.ejso.2026.111750_bib4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S1072-7515(01)01016-X","article-title":"Intrahepatic cholangiocarcinoma: resectability, recurrence pattern, and outcomes","volume":"193","author":"Weber","year":"2001","journal-title":"J Am Coll Surg"},{"issue":"6","key":"10.1016\/j.ejso.2026.111750_bib5","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1245\/s10434-012-2808-2","article-title":"Role of major vascular resection in patients with intrahepatic cholangiocarcinoma","volume":"20","author":"Ali","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2026.111750_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jso.24633","article-title":"Impact of major vascular resection on outcomes and survival in patients with intrahepatic cholangiocarcinoma: a multi\u2010institutional analysis","volume":"116","author":"Reames","year":"2017","journal-title":"J Surg Oncol"},{"issue":"9","key":"10.1016\/j.ejso.2026.111750_bib7","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.ejso.2020.04.007","article-title":"Outcomes of vascular resection associated with curative intent hepatectomy for intrahepatic cholangiocarcinoma","volume":"46","author":"Conci","year":"2020","journal-title":"Eur J Surg Oncol"},{"issue":"9","key":"10.1016\/j.ejso.2026.111750_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2025.110193","article-title":"Vascular resection and reconstruction in surgery for advanced intrahepatic cholangiocarcinoma \u2013 single center experience with 59 vascular resections","volume":"51","author":"Lang","year":"2025","journal-title":"Eur J Surg Oncol"},{"issue":"15","key":"10.1016\/j.ejso.2026.111750_bib9","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.3390\/cancers13153735","article-title":"Vascular involvements in cholangiocarcinoma: tips and tricks","volume":"13","author":"Angelico","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.ejso.2026.111750_bib10","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s00268-009-9970-0","article-title":"Intrahepatic cholangiocarcinoma: prognostic factors after surgical resection","volume":"33","author":"Guglielmi","year":"2009","journal-title":"World J Surg"},{"issue":"0","key":"10.1016\/j.ejso.2026.111750_bib11","article-title":"Surgical management of intrahepatic cholangiocarcinoma. hr","volume":"9","author":"Ruff","year":"2023"},{"issue":"3","key":"10.1016\/j.ejso.2026.111750_bib12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11605-023-05578-z","article-title":"Albumin-bilirubin grade and tumor burden score predict outcomes among patients with intrahepatic cholangiocarcinoma after hepatic resection: a multi-institutional analysis","volume":"27","author":"Munir","year":"2023","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"10.1016\/j.ejso.2026.111750_bib13","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1245\/s10434-025-17013-5","article-title":"The influence of tumor burden score and lymph node metastasis on the survival benefit of adjuvant chemotherapy in intrahepatic cholangiocarcinoma","volume":"32","author":"Kawashima","year":"2025","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2026.111750_bib14","article-title":"Tumor burden score stratifies prognosis of patients with intrahepatic cholangiocarcinoma after hepatic resection: a retrospective, multi-institutional study","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.ejso.2026.111750_bib15","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/XCS.0000000000000557","article-title":"Combined tumor burden score and carbohydrate antigen 19-9 grading system to predict outcomes among patients with intrahepatic cholangiocarcinoma","volume":"236","author":"Moazzam","year":"2023","journal-title":"J Am Coll Surg"},{"issue":"4","key":"10.1016\/j.ejso.2026.111750_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/bjs\/znaf050","article-title":"Tumour burden predicts outcomes after curative resection of multifocal intrahepatic cholangiocarcinoma","volume":"112","author":"Kawashima","year":"2025","journal-title":"Br J Surg"},{"issue":"9","key":"10.1016\/j.ejso.2026.111750_bib17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1001\/jamasurg.2020.1973","article-title":"Very early recurrence after liver resection for intrahepatic cholangiocarcinoma: considering alternative treatment approaches","volume":"155","author":"Tsilimigras","year":"2020","journal-title":"JAMA Surg"},{"issue":"6","key":"10.1016\/j.ejso.2026.111750_bib18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jso.24720","article-title":"Evaluation of the 8th edition American joint commission on cancer (AJCC) staging system for patients with intrahepatic cholangiocarcinoma: a surveillance, epidemiology, and end results (SEER) analysis","volume":"116","author":"Kim","year":"2017","journal-title":"J Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2026.111750_bib19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/SLA.0000000000002064","article-title":"The tumor burden score: a new \u201cMetro-ticket\u201d prognostic tool for colorectal liver metastases based on tumor size and number of tumors","volume":"267","author":"Sasaki","year":"2018","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.ejso.2026.111750_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/AS9.0000000000000557","article-title":"International validation and refinement of oncological borderline resectability criteria for hepatocellular carcinoma using tumor burden score to predict survival","volume":"6","author":"Akabane","year":"2025","journal-title":"Ann Surg Open"},{"issue":"5","key":"10.1016\/j.ejso.2026.111750_bib21","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/jso.70071","article-title":"Characteristics of \u201cVery Early\u201d intrahepatic cholangiocarcinoma undergoing liver resection and its relationship with carbohydrate antigen 19-9","volume":"132","author":"Endo","year":"2025","journal-title":"J Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2026.111750_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jhep.2023.03.010","article-title":"EASL-ILCA clinical practice guidelines on the management of intrahepatic cholangiocarcinoma","volume":"79","author":"Alvaro","year":"2023","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.ejso.2026.111750_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000522403","article-title":"Liver cancer study group of Japan clinical practice guidelines for intrahepatic cholangiocarcinoma","volume":"11","author":"Kubo","year":"2022","journal-title":"Liver Cancer"},{"issue":"2","key":"10.1016\/j.ejso.2026.111750_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"11","key":"10.1016\/j.ejso.2026.111750_bib25","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1245\/s10434-023-13809-5","article-title":"NEO-GAP: a single-arm, phase II feasibility trial of neoadjuvant gemcitabine, Cisplatin, and nab-paclitaxel for resectable, high-risk intrahepatic cholangiocarcinoma","volume":"30","author":"Maithel","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2026.111750_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v045.i03","article-title":"Mice: multivariate imputation by chained equations in R","volume":"45","author":"Buuren","year":"2011","journal-title":"J Stat Software"},{"key":"10.1016\/j.ejso.2026.111750_bib27","author":"Hothorn"},{"issue":"1","key":"10.1016\/j.ejso.2026.111750_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.21037\/atm.2018.12.10","article-title":"Balance diagnostics after propensity score matching","volume":"7","author":"Zhang","year":"2019","journal-title":"Ann Transl Med"},{"issue":"17","key":"10.1016\/j.ejso.2026.111750_bib31","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.3390\/cancers13174403","article-title":"Risk score model for microvascular invasion in hepatocellular carcinoma: the role of tumor burden and alpha-fetoprotein","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.ejso.2026.111750_bib32","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/wjs.12376","article-title":"Preoperative identification of early extrahepatic recurrence after hepatectomy for colorectal liver metastases: a machine learning approach","volume":"48","author":"Kawashima","year":"2024","journal-title":"World J Surg"},{"key":"10.1016\/j.ejso.2026.111750_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.surg.2025.109527","article-title":"Development and validation of a preoperative risk prediction model for severe complications and very early recurrence after liver resection for hepatocellular carcinoma","volume":"185","author":"Kawashima","year":"2025","journal-title":"Surgery"},{"issue":"12","key":"10.1016\/j.ejso.2026.111750_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2025.110527","article-title":"Time-varying hazards of recurrence patterns among patients with colorectal liver metastases undergoing liver resection and the role of the modified tumor burden score","volume":"51","author":"Chatzipanagiotou","year":"2025","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"10.1016\/j.ejso.2026.111750_bib35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jso.28007","article-title":"Recurrence timing and risk following curative resection of colorectal liver metastases: insights from a hazard function analysis","volume":"131","author":"Kawashima","year":"2025","journal-title":"J Surg Oncol"},{"issue":"7","key":"10.1016\/j.ejso.2026.111750_bib36","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/bjs.11464","article-title":"Hepatocellular carcinoma tumour burden score to stratify prognosis after resection","volume":"107","author":"Tsilimigras","year":"2020","journal-title":"Br J Surg"},{"issue":"2","key":"10.1016\/j.ejso.2026.111750_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.hpb.2022.10.011","article-title":"Predictive risk-score model to select patients with intrahepatic cholangiocarcinoma for adjuvant chemotherapy","volume":"25","author":"Endo","year":"2023","journal-title":"HPB"},{"issue":"1","key":"10.1016\/j.ejso.2026.111750_bib38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.hpb.2020.07.007","article-title":"Quality and performance of validated prognostic models for survival after resection of intrahepatic cholangiocarcinoma: a systematic review and meta-analysis","volume":"23","author":"B\u00fcttner","year":"2021","journal-title":"HPB"},{"issue":"4","key":"10.1016\/j.ejso.2026.111750_bib39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jso.24381","article-title":"Implications of CA19-9 elevation for survival, staging, and treatment sequencing in intrahepatic cholangiocarcinoma: a national cohort analysis","volume":"114","author":"Bergquist","year":"2016","journal-title":"J Surg Oncol"},{"issue":"15","key":"10.1016\/j.ejso.2026.111750_bib40","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v31.i15.104901","article-title":"Conversion treatment for advanced intrahepatic cholangiocarcinoma: opportunities and challenges","volume":"31","author":"Liu","year":"2025","journal-title":"World J Gastroenterol"},{"issue":"5","key":"10.1016\/j.ejso.2026.111750_bib41","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/jso.70068","article-title":"Conversion therapy for locally advanced intrahepatic cholangiocarcinoma: a retrospective cohort study","volume":"132","author":"Lu","year":"2025","journal-title":"J Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2026.111750_bib42","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S2468-1253(22)00043-7","article-title":"Gemcitabine and cisplatin plus durvalumab with or without tremelimumab in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, single-centre, phase 2 study","volume":"7","author":"Oh","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"10391","key":"10.1016\/j.ejso.2026.111750_bib43","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0140-6736(23)00727-4","article-title":"Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"401","author":"Kelley","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ejso.2026.111750_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41575-023-00856-2","article-title":"Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer","volume":"21","author":"Stoop","year":"2025","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"10.1016\/j.ejso.2026.111750_bib45","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.4251\/wjgo.v15.i11.2017","article-title":"Role of routine lymph node dissection alongside resection of intrahepatic cholangiocarcinoma: systematic review and meta-analysis","volume":"15","author":"Atif","year":"2023","journal-title":"World J Gastrointest Oncol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798326003690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798326003690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:03:15Z","timestamp":1789182195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798326003690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0748798326003690"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2026.111750","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biologic stratification with tumor burden score and CA19-9 to inform vascular resection in intrahepatic cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2026.111750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111750"}}