{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:06:12Z","timestamp":1789185972889,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002918","name":"Gentofte Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002714","name":"Albert-Ludwigs-Universit\u00e4t Freiburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ejso.2026.111769","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:11:13Z","timestamp":1774462273000},"page":"111769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous angiosarcoma: Long-term outcomes and risk factors of local recurrence, metastasis and disease-specific mortality in a Danish nationwide cohort"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0921-9328","authenticated-orcid":false,"given":"Kiya","family":"Abebe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3956-296X","authenticated-orcid":false,"given":"Katrine Voss","family":"Thorsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Hebbelstrup","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2518-2108","authenticated-orcid":false,"given":"Anne Lene","family":"Wagenblast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1633-4003","authenticated-orcid":false,"given":"Grethe","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-6420","authenticated-orcid":false,"given":"Michael M.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-1255","authenticated-orcid":false,"given":"Anand C.","family":"Loya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mentzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Herly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vester-Glowinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-8392","authenticated-orcid":false,"given":"Mathias","family":"\u00d8rholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2026.111769_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2025.109680","article-title":"Clinicopathological characteristics, long-term prognosis and Follow-up recommendations of primary and secondary cutaneous angiosarcoma: a Danish nationwide population-based cohort study","author":"Abebe","year":"2025","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2026.111769_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jaad.2024.01.084","article-title":"Ambient UV radiation is associated with cutaneous angiosarcoma incidence in the United States, 1992 to 2020","volume":"91","author":"Ike","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ejso.2026.111769_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41591-019-0749-z","article-title":"The angiosarcoma project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research","volume":"26","author":"Painter","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.ejso.2026.111769_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hed.24554","article-title":"Predisposing factors for poor prognosis of angiosarcoma of the scalp and face: systematic review and meta\u2010analysis","volume":"39","author":"Shin","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.ejso.2026.111769_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2559.2005.02288.x","article-title":"Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world","volume":"48","author":"Deyrup","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.ejso.2026.111769_bib6","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3390\/cancers16101834","article-title":"A population-based long-term Follow-Up of soft tissue angiosarcomas: characteristics, treatment outcomes, and prognostic factors","volume":"16","author":"Holm","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.ejso.2026.111769_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9960085","article-title":"Localized angiosarcoma, not one disease: a retrospective single\u2010center study on prognosis depending on the primary site and etiology","volume":"2021","author":"Schott","year":"2021","journal-title":"Sarcoma"},{"key":"10.1016\/j.ejso.2026.111769_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3292-7","article-title":"Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study","volume":"17","author":"Yin","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejso.2026.111769_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.anndiagpath.2010.07.012","article-title":"Cutaneous angiosarcoma. Analysis of 434 cases from the surveillance, epidemiology, and end results program, 1973-2007","volume":"15","author":"Albores-Saavedra","year":"2011","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.ejso.2026.111769_bib10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.jcms.2014.05.002","article-title":"Prognostic features in angiosarcoma of the head and neck: a retrospective monocenter study","volume":"42","author":"Dettenborn","year":"2014","journal-title":"J Cranio-Maxillofacial Surg"},{"key":"10.1016\/j.ejso.2026.111769_bib11","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2400::AID-CNCR32>3.0.CO;2-Z","article-title":"Angiosarcoma: a report of 67 patients and a review of the literature","volume":"77","author":"Mark","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2026.111769_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jamaoto.2014.3584","article-title":"Angiosarcoma of the scalp and face: the Mayo clinic experience","volume":"141","author":"Patel","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ejso.2026.111769_bib13","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/cncr.11667","article-title":"Cutaneous angiosarcoma of the scalp: a multidisciplinary approach","volume":"98","author":"Pawlik","year":"2003","journal-title":"Cancer: Interdiscip Int J Am Cancer Soc"},{"key":"10.1016\/j.ejso.2026.111769_bib14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hed.21513","article-title":"Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp","volume":"33","author":"Guadagnolo","year":"2011","journal-title":"Head Neck"},{"key":"10.1016\/j.ejso.2026.111769_bib15","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/1097-0142(19870301)59:5<1046::AID-CNCR2820590533>3.0.CO;2-6","article-title":"Angiosarcoma of the face and scalp, prognosis and treatment","volume":"59","author":"Holden","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2026.111769_bib16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0002-9610(05)80097-2","article-title":"Angiosarcoma of the head and neck","volume":"168","author":"Lydiatt","year":"1994","journal-title":"Am J Surg"},{"key":"10.1016\/j.ejso.2026.111769_bib17","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1245\/s10434-013-3083-6","article-title":"Cutaneous angiosarcoma: a single-institution experience","volume":"20","author":"Perez","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2026.111769_bib18","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0360-3016(01)02753-5","article-title":"Angiosarcoma treated with radiotherapy: impact of tumor type and size on outcome","volume":"52","author":"Sasaki","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejso.2026.111769_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1547520","article-title":"Angiosarcoma of the head and neck","volume":"19","author":"Mullins","year":"2015","journal-title":"Int Arch Otorhinolaryngol"},{"key":"10.1016\/j.ejso.2026.111769_bib20","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/ijd.14828","article-title":"Clinicopathological and survival analyses of primary cutaneous angiosarcoma in an Asian population: prognostic value of the clinical features of skin lesions","volume":"59","author":"Moon","year":"2020","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ejso.2026.111769_bib21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.otohns.2008.07.022","article-title":"Cutaneous angiosarcoma of the head and neck: report of 23 cases from a single institution","volume":"139","author":"K\u00f6hler","year":"2008","journal-title":"Otolaryngology-Head Neck Surg (Tokyo)"},{"key":"10.1016\/j.ejso.2026.111769_bib22","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/hed.10276","article-title":"Radiation therapy for angiosarcoma","volume":"25","author":"Ward","year":"2003","journal-title":"Head Neck: J Sci Specialties Head Neck"},{"key":"10.1016\/j.ejso.2026.111769_bib23","first-page":"373","article-title":"World medical association declaration of Helsinki. Ethical principles for medical research involving human subjects","volume":"79","author":"Association","year":"2001","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.ejso.2026.111769_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies conducted using observational Routinely-collected health data (RECORD) statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.ejso.2026.111769_bib25","article-title":"No difference in prognosis between atypical intradermal smooth muscle neoplasms and dermal leiomyosarcoma: local recurrence, metastasis, and overall survival in a nationwide cohort of 423 patients","author":"Abebe","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ejso.2026.111769_bib26","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.jaad.2023.08.050","article-title":"Atypical fibroxanthoma and pleomorphic dermal sarcoma: local recurrence and metastasis in a nationwide population-based cohort of 1118 patients","volume":"89","author":"\u00d8rholt","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ejso.2026.111769_bib27","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1001\/jama.1980.03300340032015","article-title":"Progress in medical information management: Systematized nomenclature of medicine (SNOMED)","volume":"243","author":"Cote","year":"1980","journal-title":"JAMA"},{"key":"10.1016\/j.ejso.2026.111769_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002409","article-title":"Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma","volume":"3","author":"Tanas","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ejso.2026.111769_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<8::AID-CNCR3>3.0.CO;2-W","article-title":"Sarcoma arising in irradiated bone: report of eleven cases","volume":"82","author":"Cahan","year":"1998","journal-title":"Cancer: Interdiscip Int J Am Cancer Soc"},{"key":"10.1016\/j.ejso.2026.111769_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/gcc.20827","article-title":"Consistent MYC and FLT4 gene amplification in radiation\u2010induced angiosarcoma but not in other radiation\u2010associated atypical vascular lesions","volume":"50","author":"Guo","year":"2011","journal-title":"Gene Chromosome Cancer"},{"key":"10.1016\/j.ejso.2026.111769_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2022.152096","article-title":"MYC amplification in angiosarcoma depends on etiological\/clinical subgroups\u2013diagnostic and prognostic value","volume":"63","author":"Hogeboom-Gimeno","year":"2023","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.ejso.2026.111769_bib32","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/his.14433","article-title":"The impact of MYC gene amplification on the clinicopathological features and prognosis of radiation\u2010associated angiosarcomas of the breast","volume":"79","author":"Kuba","year":"2021","journal-title":"Histopathology"},{"key":"10.1016\/j.ejso.2026.111769_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2353\/ajpath.2010.090637","article-title":"MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema","volume":"176","author":"Manner","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ejso.2026.111769_bib34","article-title":"Behandling af sarkomer i bev\u00e6geapparatet hos voksne","volume":"187","author":"Abood","year":"2025","journal-title":"Ugeskr L\u00e6ger"},{"key":"10.1016\/j.ejso.2026.111769_bib35","article-title":"The Danish sarcoma database","volume":"685\u2013690","author":"J\u00f8rgensen","year":"2016","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.ejso.2026.111769_bib36","article-title":"Population-based aarhus sarcoma registry: validity, completeness of registration, and incidence of bone and soft tissue sarcomas in western Denmark","volume":"45\u201356","author":"Maretty-Nielsen","year":"2013","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.ejso.2026.111769_bib37","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/his.14265","article-title":"Updates from the 2020 world health organization classification of soft tissue and bone tumours","volume":"78","author":"Anderson","year":"2021","journal-title":"Histopathology"},{"key":"10.1016\/j.ejso.2026.111769_bib38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/1403494810393563","article-title":"The Danish pathology register","volume":"39","author":"Bjerregaard","year":"2011","journal-title":"Scand J Publ Health"},{"key":"10.1016\/j.ejso.2026.111769_bib39","article-title":"Existing data sources for clinical epidemiology: the Danish national pathology registry and data bank","volume":"51\u201356","author":"Erichsen","year":"2010","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.ejso.2026.111769_bib40","volume":"1024","author":"Amin","year":"2017"},{"key":"10.1016\/j.ejso.2026.111769_bib41","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"10.1016\/j.ejso.2026.111769_bib42","series-title":"Title product-limit estimation for censored event history analysis","author":"Gerds","year":"2015"},{"key":"10.1016\/j.ejso.2026.111769_bib43","series-title":"Risk regression for survival analysis","author":"Gerds","year":"2015"},{"key":"10.1016\/j.ejso.2026.111769_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2020.151597","article-title":"Primary and secondary cutaneous angiosarcoma: distinctive clinical, pathological and molecular features","volume":"48","author":"Ronchi","year":"2020","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.ejso.2026.111769_bib45","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1200\/JCO.1996.14.5.1679","article-title":"Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities","volume":"14","author":"Pisters","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejso.2026.111769_bib46","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/00000658-200203000-00015","article-title":"Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas","volume":"235","author":"Stojadinovic","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2026.111769_bib47","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/cncr.11365","article-title":"Prognostic factors for patients with localized soft\u2010tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients","volume":"97","author":"Zagars","year":"2003","journal-title":"Cancer: Interdiscip Int J Am Cancer Soc"},{"key":"10.1016\/j.ejso.2026.111769_bib48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/PAS.0000000000001998","article-title":"Histopathologic grading is of prognostic significance in primary angiosarcoma of breast: proposal of a simplified 2-tier grading system","volume":"47","author":"Kuba","year":"2023","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejso.2026.111769_bib49","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1097\/PAS.0b013e318176dbc7","article-title":"Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic","volume":"32","author":"Nascimento","year":"2008","journal-title":"Am J Surg Pathol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798326003884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798326003884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:10:13Z","timestamp":1789182613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798326003884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0748798326003884"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2026.111769","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cutaneous angiosarcoma: Long-term outcomes and risk factors of local recurrence, metastasis and disease-specific mortality in a Danish nationwide cohort","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2026.111769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111769"}}