{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:32:12Z","timestamp":1793367132910,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejso.2026.112056","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:50:57Z","timestamp":1786690257000},"page":"112056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival after breast conserving surgery in patients with multiple ipsilateral breast cancers"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-7448","authenticated-orcid":false,"given":"Rebecca E.","family":"Swan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arran","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lucocq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-3900","authenticated-orcid":false,"given":"Alexander","family":"Leeper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Michael","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2026.112056_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.semcancer.2014.07.002","article-title":"Evolving paradigms in multifocal breast cancer","volume":"31","author":"Salgado","year":"2015","journal-title":"Semin Cancer Biol"},{"issue":"16","key":"10.1016\/j.ejso.2026.112056_bib2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer","volume":"347","author":"Fisher","year":"2002","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ejso.2026.112056_bib3","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1200\/JCO.1992.10.6.976","article-title":"Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute","volume":"10","author":"Lichter","year":"1992","journal-title":"J Clin Oncol : off J Am Soc Clin Oncol"},{"issue":"14","key":"10.1016\/j.ejso.2026.112056_bib4","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/92.14.1143","article-title":"Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial","volume":"92","author":"van Dongen","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"10.1016\/j.ejso.2026.112056_bib5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/02841860801971439","article-title":"Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol","volume":"47","author":"Blichert-Toft","year":"2008","journal-title":"Acta oncologica (Stockholm, Sweden)"},{"issue":"16","key":"10.1016\/j.ejso.2026.112056_bib6","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa020989","article-title":"Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer","volume":"347","author":"Veronesi","year":"2002","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ejso.2026.112056_bib7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/bjs5.53","article-title":"Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers","volume":"2","author":"Winters","year":"2018","journal-title":"BJS Open"},{"issue":"1","key":"10.1016\/j.ejso.2026.112056_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00000658-199007000-00006","article-title":"Breast-conserving therapy for macroscopically multiple cancers","volume":"212","author":"Kurtz","year":"1990","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.ejso.2026.112056_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0360-3016(89)90004-7","article-title":"Results of conservative surgery and radiation therapy for multiple synchronous cancers of one breast","volume":"16","author":"Leopold","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejso.2026.112056_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/1097-0142(19930701)72:1<137::AID-CNCR2820720126>3.0.CO;2-E","article-title":"Conservative surgery and radiation in the treatment of synchronous ipsilateral breast cancers","volume":"72","author":"Wilson","year":"1993","journal-title":"Cancer"},{"issue":"17","key":"10.1016\/j.ejso.2026.112056_bib11","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/jnci\/djr240","article-title":"Role of science in the treatment of breast cancer when tumor multicentricity is present","volume":"103","author":"Fisher","year":"2011","journal-title":"JNCI: J Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.ejso.2026.112056_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.amjsurg.2013.08.008","article-title":"Feasibility of breast conserving surgery in multifocal breast cancers","volume":"208","author":"Kadio\u011flu","year":"2014","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.ejso.2026.112056_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2482-15-1","article-title":"Clinical significance of multifocal and multicentric breast cancers and choice of surgical treatment: a retrospective study on a series of 1158 cases","volume":"15","author":"Neri","year":"2015","journal-title":"BMC Surg"},{"issue":"4","key":"10.1016\/j.ejso.2026.112056_bib14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/annonc\/mdr326","article-title":"Is breast-conserving therapy a safe option for patients with tumor multicentricity and multifocality?","volume":"23","author":"Yerushalmi","year":"2012","journal-title":"Ann Oncol : off J Euro Soc Med Oncol"},{"issue":"17","key":"10.1016\/j.ejso.2026.112056_bib15","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1200\/JCO.22.02553","article-title":"Local recurrence after breast-conserving therapy in patients with multiple ipsilateral breast cancer: results from ACOSOG Z11102 (Alliance)","volume":"41","author":"Boughey","year":"2023","journal-title":"J Clin Oncol : off J Am Soc Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2026.112056_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10549-007-9801-7","article-title":"Oncological and aesthetic considerations of skin-sparing mastectomy","volume":"111","author":"Patani","year":"2008","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1016\/j.ejso.2026.112056_bib17","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1016\/j.clbc.2024.10.009","article-title":"Local recurrence and survival outcomes of multifocal\/multicentric breast cancer after breast conserving therapy: a systematic review and meta-analysis","volume":"25","author":"Sun","year":"2025","journal-title":"Clin Breast Cancer"},{"issue":"12","key":"10.1016\/j.ejso.2026.112056_bib18","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1093\/annonc\/mds136","article-title":"Multifocality and multicentricity in breast cancer and survival outcomes","volume":"23","author":"Lynch","year":"2012","journal-title":"Ann Oncol"},{"issue":"31","key":"10.1016\/j.ejso.2026.112056_bib19","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1200\/JCO.2006.07.6067","article-title":"Locoregional control of clinically diagnosed multifocal or multicentric breast cancer after neoadjuvant chemotherapy and locoregional therapy","volume":"24","author":"Oh","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejso.2026.112056_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejca.2017.03.034","article-title":"Characterisation of multifocal breast cancer using the 70-gene signature in clinical low-risk patients enrolled in the EORTC 10041\/BIG 03-04 MINDACT trial","volume":"79","author":"Aalders","year":"2017","journal-title":"Euro J Cancer (Oxford, England : 1990)"},{"issue":"3","key":"10.1016\/j.ejso.2026.112056_bib21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10549-013-2772-y","article-title":"Comparing the outcome between multicentric and multifocal breast cancer: what is the impact on survival, and is there a role for guideline-adherent adjuvant therapy? A retrospective multicenter cohort study of 8,935 patients","volume":"142","author":"Wolters","year":"2013","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.1016\/j.ejso.2026.112056_bib22","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1245\/s10434-014-4122-7","article-title":"Impact of multifocal or multicentric disease on surgery and locoregional, distant and overall survival of 6,134 breast cancer patients treated with neoadjuvant chemotherapy","volume":"22","author":"Ataseven","year":"2015","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2026.112056_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.108266","article-title":"Oncologic safety of breast conserving surgery after neoadjuvant chemotherapy in patients with multiple ipsilateral breast cancer: a retrospective multi-institutional cohort study","volume":"50","author":"Di Lena","year":"2024","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2026.112056_bib24","doi-asserted-by":"crossref","DOI":"10.21037\/gs.2018.07.01","article-title":"Evaluating the current evidence to support therapeutic mammoplasty or breast-conserving surgery as an alternative to mastectomy in the treatment of multifocal and multicentric breast cancers","volume":"7","author":"Winters","year":"2018","journal-title":"Gland Surg"},{"issue":"1","key":"10.1016\/j.ejso.2026.112056_bib25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40814-022-01007-1","article-title":"The challenge of equipoise: qualitative interviews exploring the views of health professionals and women with multiple ipsilateral breast cancer on recruitment to a surgical randomised controlled feasibility trial","volume":"8","author":"Ingram","year":"2022","journal-title":"Pilot Feasibility Stud"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879832600675X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879832600675X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:44:16Z","timestamp":1793364256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074879832600675X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S074879832600675X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2026.112056","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Survival after breast conserving surgery in patients with multiple ipsilateral breast cancers","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2026.112056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112056"}}