{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:03:49Z","timestamp":1789848229391,"version":"4.0.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejso.2026.112126","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:40:44Z","timestamp":1789688444000},"page":"112126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Axillary nodal burden and preoperative predictors in biopsy-proven node-positive breast cancer undergoing upfront surgery"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-0362","authenticated-orcid":false,"given":"Chi Hoon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-8375","authenticated-orcid":false,"given":"Kibeom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-4440","authenticated-orcid":false,"given":"Dahn","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1072-8954","authenticated-orcid":false,"given":"Seok Jin","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-7570","authenticated-orcid":false,"given":"Seok Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-2456","authenticated-orcid":false,"given":"Jeong Eon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-100X","authenticated-orcid":false,"given":"Jonghan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-0978","authenticated-orcid":false,"given":"Byung Joo","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-1783","authenticated-orcid":false,"given":"Se Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-3364","authenticated-orcid":false,"given":"Woong Ki","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-1075","authenticated-orcid":false,"given":"Ji-Jung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5405-7385","authenticated-orcid":false,"given":"Jai Min","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2026.112126_bib1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1001\/jama.2011.90","article-title":"Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial","volume":"305","author":"Giuliano","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.ejso.2026.112126_bib2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jama.2017.11470","article-title":"Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial","volume":"318","author":"Giuliano","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ejso.2026.112126_bib3","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S1470-2045(14)70460-7","article-title":"Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial","volume":"15","author":"Donker","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib4","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1200\/JCO.22.01565","article-title":"Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer: 10-year results of the randomized controlled EORTC 10981-22023 AMAROS trial","volume":"41","author":"Bartels","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib5","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S1470-2045(18)30380-2","article-title":"Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial","volume":"19","author":"Galimberti","year":"2018","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.ejso.2016.12.011","article-title":"Eight-year follow up result of the OTOASOR trial","volume":"43","author":"S\u00e1volt","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib7","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJMoa2313487","article-title":"Omitting axillary dissection in breast cancer with sentinel-node metastases","volume":"390","author":"de Boniface","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejso.2026.112126_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10549-022-06699-w","article-title":"The role of pre-operative axillary ultrasound in assessment of axillary tumor burden in breast cancer patients: a systematic review and meta-analysis","volume":"196","author":"Man","year":"2022","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejso.2026.112126_bib9","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.2214\/AJR.05.0936","article-title":"Role of sonography in the diagnosis of axillary lymph node metastases in breast cancer: a systematic review","volume":"186","author":"Alvarez","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ejso.2026.112126_bib10","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1245\/s10434-014-3813-4","article-title":"Predicting the extent of nodal disease in early-stage breast cancer","volume":"21","author":"Caudle","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib11","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1245\/s10434-014-3674-x","article-title":"Axillary ultrasonography in breast cancer patients helps in identifying patients preoperatively with limited disease of the axilla","volume":"21","author":"Moorman","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib12","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s00268-016-3557-3","article-title":"A positive node on ultrasound-guided fine needle aspiration predicts higher nodal burden than a positive sentinel lymph node biopsy in breast carcinoma","volume":"40","author":"Boland","year":"2016","journal-title":"World J Surg"},{"key":"10.1016\/j.ejso.2026.112126_bib13","doi-asserted-by":"crossref","first-page":"520","DOI":"10.14366\/usg.20143","article-title":"Ultrasonography and ultrasound-guided fine-needle aspiration biopsy can predict a heavy nodal metastatic burden in early-stage breast cancer","volume":"40","author":"Ahn","year":"2021","journal-title":"Ultrasonography"},{"key":"10.1016\/j.ejso.2026.112126_bib14","series-title":"SENOMAC-ULTRA: a prospective randomised trial on the omission of axillary lymph node dissection in ultrasound-detectable axillary metastases in primary breast cancer treated by upfront surgery. ClinicalTrials.gov identifier: NCT06869629","author":"de Boniface","year":"2025"},{"key":"10.1016\/j.ejso.2026.112126_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10549-020-05636-z","article-title":"Axillary lymph node dissection is not obligatory in breast cancer patients with biopsy-proven axillary lymph node metastasis","volume":"181","author":"Yoo","year":"2020","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejso.2026.112126_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2025.111304","article-title":"Patients with positive axillary nodes undergoing upfront surgery: can axillary dissection be safely omitted?","volume":"52","author":"Addie","year":"2026","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40644-019-0191-y","article-title":"Prediction of high nodal burden with ultrasound and magnetic resonance imaging in clinically node-negative breast cancer patients","volume":"19","author":"Kim","year":"2019","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.ejso.2026.112126_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.suronc.2020.08.020","article-title":"Ultrasound staging in breast cancer: a decision-making oriented approach to axillary metastatic burden prediction","volume":"35","author":"G\u00e1lvez","year":"2020","journal-title":"Surg Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib19","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.ultrasmedbio.2020.04.003","article-title":"Combining the ultrasound features of primary tumor and axillary lymph nodes can reduce false-negative rate during the prediction of high axillary node burden in BI-RADS category 4 or 5 breast cancer lesions","volume":"46","author":"Yi","year":"2020","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.ejso.2026.112126_bib20","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1245\/ASO.2003.03.015","article-title":"A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy","volume":"10","author":"Van Zee","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/SLA.0b013e318238f461","article-title":"Incorporation of sentinel lymph node metastasis size into a nomogram predicting nonsentinel lymph node involvement in breast cancer patients with a positive sentinel lymph node","volume":"255","author":"Mittendorf","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2026.112126_bib22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1200\/JCO.2015.64.0094","article-title":"Improved axillary evaluation following neoadjuvant therapy for patients with node-positive breast cancer using selective evaluation of clipped nodes: implementation of targeted axillary dissection","volume":"34","author":"Caudle","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejso.2026.112126_bib23","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jama.2013.278932","article-title":"Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 clinical trial","volume":"310","author":"Boughey","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ejso.2026.112126_bib24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1470-2045(13)70166-9","article-title":"Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study","volume":"14","author":"Kuehn","year":"2013","journal-title":"Lancet Oncol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798326007456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798326007456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:28:31Z","timestamp":1789846111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798326007456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0748798326007456"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2026.112126","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Axillary nodal burden and preoperative predictors in biopsy-proven node-positive breast cancer undergoing upfront surgery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2026.112126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112126"}}