{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:02:29Z","timestamp":1768870949862,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":1708,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejves.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Vascular and Endovascular Surgery"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.ejvs.2009.05.012","type":"journal-article","created":{"date-parts":[[2009,6,28]],"date-time":"2009-06-28T04:22:58Z","timestamp":1246162978000},"page":"518-529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Regulation of Matrix Contraction in Chronic Venous Disease"],"prefix":"10.1016","volume":"38","author":[{"given":"P.J.","family":"Pappas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.K.","family":"Lal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zapiach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.N.","family":"Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejvs.2009.05.012_bib1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0741-5214(97)70091-0","article-title":"Morphometric assessment of the dermal microcirculation in patients with\u00a0chronic venous insufficiency","volume":"26","author":"Pappas","year":"1997","journal-title":"J Vasc Surg"},{"issue":"6","key":"10.1016\/j.ejvs.2009.05.012_bib2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0741-5214(02)75295-6","article-title":"Altered proliferative responses of dermal fibroblasts to TGF-\u03b21 may contribute to chronic venous stasis ulcers","volume":"37","author":"Lal","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ejvs.2009.05.012_bib3","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0741-5214(99)70054-6","article-title":"Dermal tissue fibrosis in patients with chronic venous insufficiency is associated with increased transforming growth factor-\u03b21gene expression and protein production","volume":"30","author":"Pappas","year":"1999","journal-title":"J Vasc Surg"},{"issue":"5","key":"10.1016\/j.ejvs.2009.05.012_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1067\/mva.2001.119503","article-title":"Role of matrix metalloproteinases 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency","volume":"34","author":"Saito","year":"2001","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ejvs.2009.05.012_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/35043051","article-title":"How cells read TGF-\u03b2 signals","volume":"1","author":"Massague","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ejvs.2009.05.012_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s004030050282","article-title":"Reduced expression of mRNA for transforming growth factor \u03b2 (TGF-\u03b2) and TGF-\u03b2 receptors I and II and decreased TGF-\u03b2 binding to the receptors in in vitro-aged fibroblasts","volume":"290","author":"Mori","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.ejvs.2009.05.012_bib7","doi-asserted-by":"crossref","first-page":"21397","DOI":"10.1074\/jbc.M010783200","article-title":"Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor","volume":"276","author":"Ulloa","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejvs.2009.05.012_bib8","doi-asserted-by":"crossref","first-page":"33986","DOI":"10.1074\/jbc.M100093200","article-title":"Cross-talk between the p42\/44 MAP kinase and Smad pathway in transforming growth factor-beta 1 induced furin gene transaction","volume":"276","author":"Blanchette","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejvs.2009.05.012_bib9","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jvs.2004.09.027","article-title":"Revision of the CEAP classification for chronic venous disorders: consensus statement","volume":"40","author":"Eklof","year":"2004","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ejvs.2009.05.012_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/jsre.1998.5310","article-title":"Retinoblastoma protein: a molecular regulator of chronic venous insufficiency","volume":"76","author":"Pappas","year":"1998","journal-title":"J Surg Res"},{"key":"10.1016\/j.ejvs.2009.05.012_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/excr.2000.4869","article-title":"Transforming growth factor \u03b21 promotes the morphological and functional differentiation of the myofibroblast","volume":"257","author":"Vaugham","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ejvs.2009.05.012_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/excr.2000.4866","article-title":"Activation of ERK and p38 MAP kinases in human fibroblasts during collagen matrix contraction","volume":"257","author":"Lee","year":"2000","journal-title":"Exp Cell Res"},{"issue":"5","key":"10.1016\/j.ejvs.2009.05.012_bib13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ejvs.2009.05.012_bib14","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0741-5214(97)70012-0","article-title":"Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors","volume":"26","author":"Stanley","year":"1997","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ejvs.2009.05.012_bib15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ejvs.2009.05.012_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1432-1327.1999.00468.x","article-title":"Effect of gel re-organization and tensional forces on \u03b12\u03b21 integrin levels in dermal fibroblasts","volume":"263","author":"Jenkins","year":"1999","journal-title":"Eur J Biochem"},{"issue":"13","key":"10.1016\/j.ejvs.2009.05.012_bib17","doi-asserted-by":"crossref","first-page":"12001","DOI":"10.1074\/jbc.R300038200","article-title":"Integrins in mechanotransduction","volume":"279","author":"Katsumi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejvs.2009.05.012_bib18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.bbrc.2004.12.087","article-title":"Molecular regulation of mechanotransduction","volume":"328","author":"Iqbal","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ejvs.2009.05.012_bib19","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1681\/ASN.V104779","article-title":"\u03b11\u03b21 Integrin-mediated collagen matrix remodeling by rat mesangial cells is differentially regulated by transforming growth factor-\u03b2 and platelet-derived growth factor-BB","volume":"10","author":"Kagami","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.ejvs.2009.05.012_bib20","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1074\/jbc.274.2.918","article-title":"Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices","volume":"274","author":"Grinnell","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejvs.2009.05.012_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1357-4310(97)80541-2","article-title":"The molecular basis of keloid and hypertrophic scar formation","author":"Tuan","year":"1998","journal-title":"Mol Med Today"},{"key":"10.1016\/j.ejvs.2009.05.012_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["European Journal of Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107858840900272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107858840900272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:45:48Z","timestamp":1761043548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107858840900272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S107858840900272X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejvs.2009.05.012","relation":{},"ISSN":["1078-5884"],"issn-type":[{"value":"1078-5884","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of Matrix Contraction in Chronic Venous Disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Vascular and Endovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejvs.2009.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}