{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:36:25Z","timestamp":1786988185519,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012141","name":"University Hospitals Bristol NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejves.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Vascular and Endovascular Surgery"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ejvs.2019.12.006","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T08:23:26Z","timestamp":1577348606000},"page":"606-613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Prognostic Risk Modelling for Patients Undergoing Major Lower Limb Amputation: An Analysis of the UK National Vascular Registry"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-6365","authenticated-orcid":false,"given":"Graeme K.","family":"Ambler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Thomas-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian G.K.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-5760","authenticated-orcid":false,"given":"Christopher P.","family":"Twine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejvs.2019.12.006_bib1","series-title":"National vascular registry annual report","author":"Waton","year":"2016"},{"key":"10.1016\/j.ejvs.2019.12.006_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejvs.2008.09.019","article-title":"The development of a VBHOM-based outcome model for lower limb amputation performed for critical ischaemia","volume":"37","author":"Tang","year":"2009","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1538574412445600","article-title":"Efficacy of VBHOM to predict outcome following major lower limb amputation","volume":"46","author":"Patterson","year":"2012","journal-title":"Vasc Endovascular Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/ejvs.1998.0754","article-title":"Association between age and survival following major amputation. The Scottish Vascular Audit Group","volume":"17","author":"Pell","year":"1999","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.avsg.2012.06.030","article-title":"A\u00a0practical index to predict 30-day mortality after major amputation","volume":"27","author":"Easterlin","year":"2013","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib6","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.amjsurg.2015.08.039","article-title":"Postoperative outcomes of major lower extremity amputations in patients with diabetes and peripheral artery disease: analysis using the Diagnosis Procedure Combination database in Japan","volume":"212","author":"Yamada","year":"2016","journal-title":"Am J Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1067\/msy.2001.115359","article-title":"Postoperative and late survival outcomes after major amputation: findings from the department of Veterans Affairs national surgical quality improvement program","volume":"130","author":"Feinglass","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.ejvs.2019.12.006_bib8","series-title":"Lower limb amputation: working together","author":"National Confidential Enquiry Into Patient Outcome and Death","year":"2014"},{"key":"10.1016\/j.ejvs.2019.12.006_bib9","doi-asserted-by":"crossref","first-page":"h2217","DOI":"10.1136\/bmj.h2217","article-title":"Clarifying the montgomery judgment","volume":"350","author":"Fryar","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.ejvs.2019.12.006_bib10","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/S0140-6736(13)61491-9","article-title":"Public reporting of surgeon outcomes: low numbers of procedures lead to false complacency","volume":"382","author":"Walker","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ejvs.2019.12.006_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1010-7940(99)00134-7","article-title":"European system for cardiac operative risk evaluation (EuroSCORE)","volume":"16","author":"Nashef","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib12","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.ejvs.2019.12.006_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.7326\/M14-0697","article-title":"Transparent reporting of a multivariable prediction model for individual Prognosis or diagnosis (TRIPOD): the TRIPOD statement","volume":"162","author":"Collins","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejvs.2019.12.006_bib15","series-title":"R: a language and environment for statistical computing","year":"2018"},{"key":"10.1016\/j.ejvs.2019.12.006_bib16","first-page":"1","article-title":"Mice: multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2011","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.ejvs.2019.12.006_bib17","series-title":"Statistical analysis with missing data","author":"Little","year":"2002"},{"key":"10.1016\/j.ejvs.2019.12.006_bib18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1214\/aos\/1176344136","article-title":"Estimating the dimension of a model","volume":"6","author":"Schwarz","year":"1978","journal-title":"Ann Stat"},{"key":"10.1016\/j.ejvs.2019.12.006_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ejvs.2019.12.006_bib20","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ejvs.2019.12.006_bib21","series-title":"Applied logistic regression","author":"Hosmer","year":"2013"},{"key":"10.1016\/j.ejvs.2019.12.006_bib22","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.jvs.2019.01.087","article-title":"Benefit of multidisciplinary wound care center on the volume and outcomes of a vascular surgery practice","volume":"70","author":"Flores","year":"2019","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000452746","article-title":"Development of a limb-preservation program","volume":"43","author":"Neville","year":"2017","journal-title":"Blood Purif"},{"key":"10.1016\/j.ejvs.2019.12.006_bib24","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s11606-012-2077-6","article-title":"Shared decision making: a model for clinical practice","volume":"27","author":"Elwyn","year":"2012","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.ejvs.2019.12.006_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0001-6918(96)00026-1","article-title":"How do surgeons' probability estimates of operative mortality compare with a decision analytic model?","volume":"93","author":"Timmermans","year":"1996","journal-title":"Acta Psychol"},{"key":"10.1016\/j.ejvs.2019.12.006_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jamcollsurg.2013.10.027","article-title":"Comparison of prospective risk estimates for postoperative complications: human vs computer model","volume":"218","author":"Glasgow","year":"2014","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib27","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib28","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/bjs.11214","article-title":"Observational study of the medical management of patients with peripheral artery disease","volume":"106","author":"Saratzis","year":"2019","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib29","series-title":"National vascular registry annual report","author":"Waton","year":"2018"},{"key":"10.1016\/j.ejvs.2019.12.006_bib30","series-title":"National vascular database report 2009","author":"Lees","year":"2009"},{"key":"10.1016\/j.ejvs.2019.12.006_bib31","series-title":"National vascular registry annual report","author":"Waton","year":"2017"},{"key":"10.1016\/j.ejvs.2019.12.006_bib32","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The prevention and treatment of missing data in clinical trials","volume":"367","author":"Little","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ejvs.2019.12.006_bib33","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ejvs.2015.07.021","article-title":"International vascunet validation of the Swedvasc registry","volume":"50","author":"Venermo","year":"2015","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1024\/0301-1526\/a000340","article-title":"Validation of the VASCUNET registry \u2013 pilot study","volume":"43","author":"Bergqvist","year":"2014","journal-title":"Vasa"},{"key":"10.1016\/j.ejvs.2019.12.006_bib35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/bjs.9785","article-title":"Effect of frailty on short- and mid-term outcomes in vascular surgical patients","volume":"102","author":"Ambler","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejvs.2019.12.006_bib36","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s13063-017-2358-9","article-title":"Development of a core outcome set for studies involving patients undergoing major lower limb amputation for peripheral arterial disease: study protocol for a systematic review and identification of a core outcome set using a Delphi survey","volume":"18","author":"Ambler","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.ejvs.2019.12.006_bib37","doi-asserted-by":"crossref","first-page":"j1744","DOI":"10.1136\/bmj.j1744","article-title":"Implementing shared decision making in the\u00a0NHS: lessons from the MAGIC programme","volume":"357","author":"Joseph-Williams","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.ejvs.2019.12.006_bib38","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022057","article-title":"PREHAB study: a protocol for a prospective randomised clinical trial of exercise therapy for people living with frailty having cancer surgery","volume":"8","author":"McIsaac","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.ejvs.2019.12.006_bib39","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/aas.13239","article-title":"The role of prehabilitation in frail surgical patients: a systematic review","volume":"62","author":"Milder","year":"2018","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["European Journal of Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078588419326395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078588419326395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:53:35Z","timestamp":1761047615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078588419326395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1078588419326395"],"URL":"https:\/\/doi.org\/10.1016\/j.ejvs.2019.12.006","relation":{},"ISSN":["1078-5884"],"issn-type":[{"value":"1078-5884","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Risk Modelling for Patients Undergoing Major Lower Limb Amputation: An Analysis of the UK National Vascular Registry","name":"articletitle","label":"Article Title"},{"value":"European Journal of Vascular and Endovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejvs.2019.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Society for Vascular Surgery. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}