{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:21:14Z","timestamp":1790414474793,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejves.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Vascular and Endovascular Surgery"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ejvs.2022.11.010","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T22:58:21Z","timestamp":1667602701000},"page":"398-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Major Bleeding During Thrombolytic Therapy for Acute Lower Limb Ischaemia: Value of Laboratory Tests for Clinical Decision Making, 17 Years of Experience"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3254-5331","authenticated-orcid":false,"given":"Sabrina A.N.","family":"Doelare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-7441","authenticated-orcid":false,"given":"Safae","family":"Oukrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra","family":"Ergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-1607","authenticated-orcid":false,"given":"Vincent","family":"Jongkind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno M.","family":"Wiersema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-9126","authenticated-orcid":false,"given":"Rutger J.","family":"Lely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm P.","family":"Ebben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kak K.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan W.J.","family":"Hoksbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejvs.2022.11.010_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejvs.2019.09.006","article-title":"Editor's Choice \u2013 European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia","volume":"59","author":"Bj\u00f6rck","year":"2020","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejvs.2021.08.028","article-title":"Editor's Choice \u2013 Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature","volume":"63","author":"Jongkind","year":"2022","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib3","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ejvs.2018.11.018","article-title":"Catheter Directed Thrombolysis Protocols for Peripheral Arterial Occlusions: a Systematic Review","volume":"57","author":"Ebben","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00000658-199409000-00003","article-title":"Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. The STILE trial","volume":"220","year":"1994","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajh.20230","article-title":"Thrombosis associated with L-asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia","volume":"77","author":"Beinart","year":"2004","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S1051-0443(99)70196-X","article-title":"Prourokinase versus urokinase for recanalization of peripheral occlusions, safety and efficacy: the PURPOSE trial","volume":"10","author":"Ouriel","year":"1999","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib7","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1182\/blood-2002-08-2546","article-title":"Distinct dose-dependent effects of plasmin and TPA on coagulation and hemorrhage","volume":"101","author":"Stewart","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ejvs.2022.11.010_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/1538574413497107","article-title":"Fibrinogen level as a surrogate for the outcome of thrombolytic therapy using tissue plasminogen activator for acute lower extremity intravascular thrombosis","volume":"47","author":"Skeik","year":"2013","journal-title":"Vasc Endovascular Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1051-0443(07)60008-6","article-title":"Weight-based rt-PA thrombolysis protocol for acute native arterial and bypass graft occlusions","volume":"13","author":"Arepally","year":"2002","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.RVI.0000202751.74625.79","article-title":"Tenecteplase in acute lower-leg ischemia: efficacy, dose, and adverse events","volume":"17","author":"Hull","year":"2006","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib11","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1538-7836.2012.04728.x","article-title":"Safety of catheter-delivered plasmin in patients with acute lower extremity arterial or bypass graft occlusion: phase I results","volume":"10","author":"Marder","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.ejvs.2022.11.010_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ejvs.2014.06.042","article-title":"Low-dose thrombolysis for thromboembolic lower extremity arterial occlusions is effective without major hemorrhagic complications","volume":"48","author":"Ebben","year":"2014","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199804163381603","article-title":"A\u00a0comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators","volume":"338","author":"Ouriel","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ejvs.2022.11.010_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0002-9343(87)90882-5","article-title":"Relevance of changes in blood fibrinolytic and coagulation parameters during thrombolytic therapy","volume":"83","author":"Marder","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.ejvs.2022.11.010_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-2005-871867","article-title":"Differentiating pharmacologic agents used in catheter-directed thrombolysis","volume":"22","author":"Swischuk","year":"2005","journal-title":"Semin Intervent Radiol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.hoc.2004.09.008","article-title":"Thrombolytic therapy: current clinical practice","volume":"19","author":"Baker","year":"2005","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.ejvs.2022.11.010_bib17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.ejvs.2020.12.010","article-title":"Fibrinogen degradation speed as a predictor of major bleeding complications during catheter directed thrombolysis in patients with acute lower limb ischaemia","volume":"61","author":"Leenstra","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib18","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.jvs.2016.11.025","article-title":"Plasma fibrinogen level as a potential predictor of hemorrhagic complications after catheter-directed thrombolysis for peripheral arterial occlusions","volume":"65","author":"Poorthuis","year":"2017","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.ejvs.2022.11.010_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0033-0620(92)90022-R","article-title":"Monitoring thrombolytic therapy","volume":"34","author":"Bovill","year":"1992","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.ejvs.2022.11.010_bib20","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2214\/ajr.144.4.769","article-title":"Thrombolysis of peripheral arterial and graft occlusions: improved results using high-dose urokinase","volume":"144","author":"McNamara","year":"1985","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/eurheartj\/14.3.297","article-title":"A\u00a0simplified procedure for intra-arterial thrombolysis with tissue-type plasminogen activator in peripheral arterial occlusive disease: primary and long-term results","volume":"14","author":"Decrinis","year":"1993","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejvs.2022.11.010_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1051-0443(07)61418-3","article-title":"Alteplase as an alternative to urokinase","volume":"11","author":"Semba","year":"2000","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jvir.2012.09.026","article-title":"Quality improvement guidelines for percutaneous management of acute lower-extremity ischemia","volume":"24","author":"Patel","year":"2013","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.ejvs.2022.11.010_bib24","first-page":"CD007871","article-title":"Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding","volume":"8","author":"Wikkels\u00f8","year":"2016","journal-title":"Cochrane Database Syst Rev"}],"container-title":["European Journal of Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078588422007389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078588422007389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:59:30Z","timestamp":1761047970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078588422007389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1078588422007389"],"URL":"https:\/\/doi.org\/10.1016\/j.ejvs.2022.11.010","relation":{},"ISSN":["1078-5884"],"issn-type":[{"value":"1078-5884","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Major Bleeding During Thrombolytic Therapy for Acute Lower Limb Ischaemia: Value of Laboratory Tests for Clinical Decision Making, 17 Years of Experience","name":"articletitle","label":"Article Title"},{"value":"European Journal of Vascular and Endovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejvs.2022.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of European Society for Vascular Surgery.","name":"copyright","label":"Copyright"}]}}