{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:36:23Z","timestamp":1786988183316,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["202240145"],"award-info":[{"award-number":["202240145"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["20224Y0170"],"award-info":[{"award-number":["20224Y0170"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["20Y11909600"],"award-info":[{"award-number":["20Y11909600"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["21Y11909500"],"award-info":[{"award-number":["21Y11909500"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["21S31904300"],"award-info":[{"award-number":["21S31904300"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017677","name":"Chuzhou Science and Technology Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370494"],"award-info":[{"award-number":["82370494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300540"],"award-info":[{"award-number":["82300540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170509"],"award-info":[{"award-number":["82170509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170411"],"award-info":[{"award-number":["82170411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JYLJ202204"],"award-info":[{"award-number":["JYLJ202204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JYLJ202010"],"award-info":[{"award-number":["JYLJ202010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejves.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Vascular and Endovascular Surgery"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejvs.2025.08.001","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T02:08:57Z","timestamp":1754446137000},"page":"125-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Air Pollution, Genetic Susceptibility, and Risk of Symptomatic Peripheral Arterial Disease: A Cohort Study of the UK Biobank"],"prefix":"10.1016","volume":"71","author":[{"given":"Chenshu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2094-0345","authenticated-orcid":false,"given":"Pin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejvs.2025.08.001_bib1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ejvs.2025.08.001_bib2","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1161\/CIRCRESAHA.121.318535","article-title":"Epidemiology of peripheral artery disease and polyvascular disease","volume":"128","author":"Aday","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.ejvs.2025.08.001_bib3","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1161\/CIR.0000000000001005","article-title":"Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions: a scientific statement from the American Heart Association","volume":"144","author":"Criqui","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ejvs.2025.08.001_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.hlc.2017.10.014","article-title":"Peripheral arterial disease","volume":"27","author":"Conte","year":"2018","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.ejvs.2025.08.001_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12940-023-01038-y","article-title":"Association of air pollution exposure and increased coronary artery disease risk: the modifying effect of genetic susceptibility","volume":"22","author":"Fu","year":"2023","journal-title":"Environ Health"},{"key":"10.1016\/j.ejvs.2025.08.001_bib6","first-page":"1253","article-title":"Air pollution and arrhythmias","volume":"39","author":"Bennett","year":"2023","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib7","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/eurheartj\/ehad886","article-title":"Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study","volume":"45","author":"Ma","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejvs.2025.08.001_bib8","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2147\/RMHP.S307150","article-title":"Environmental pollution and peripheral artery disease","volume":"14","author":"Serra","year":"2021","journal-title":"Risk Manag Healthc Policy"},{"key":"10.1016\/j.ejvs.2025.08.001_bib9","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.jacc.2023.09.830","article-title":"Disparities in diagnosis, treatment, and outcomes of peripheral artery disease: JACC scientific statement","volume":"82","author":"McDermott","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib10","first-page":"157","article-title":"The association between major adverse cardiovascular events and peripheral artery disease burden","volume":"11","author":"Niiranen","year":"2024","journal-title":"J Cardiovasc Dev Dis"},{"key":"10.1016\/j.ejvs.2025.08.001_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.796423","article-title":"Long-term exposures to air pollutants and risk of peripheral arterial occlusive disease: a nationwide cohort study in Taiwan","volume":"9","author":"Liao","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ejvs.2025.08.001_bib12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/00033197221121010","article-title":"Exposure to long-term air pollution and incidence of peripheral arterial disease in the general population: a Korean national population-based retrospective cohort study","volume":"74","author":"Gwon","year":"2023","journal-title":"Angiology"},{"key":"10.1016\/j.ejvs.2025.08.001_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/d41586-018-06950-9","article-title":"people paves way to precision medicine","volume":"562","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ejvs.2025.08.001_bib14","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/s41467-020-15948-9","article-title":"The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions","volume":"11","author":"Littlejohns","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.ejvs.2025.08.001_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41416-022-02053-5","article-title":"UK Biobank: a globally important resource for cancer research","volume":"128","author":"Conroy","year":"2023","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejvs.2025.08.001_bib16","first-page":"1","article-title":"Personal, indoor, and outdoor exposures to PM2.5 and its components for groups of cardiovascular patients in Amsterdam and Helsinki","volume":"127","author":"Brunekreef","year":"2005","journal-title":"Res Rep Health Eff Inst"},{"key":"10.1016\/j.ejvs.2025.08.001_bib17","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/es301948k","article-title":"Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project","volume":"46","author":"Eeftens","year":"2012","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib18","doi-asserted-by":"crossref","first-page":"13555","DOI":"10.1021\/es403089q","article-title":"Western European land use regression incorporating satellite- and ground-based measurements of NO2 and PM10","volume":"47","author":"Vienneau","year":"2013","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ejvs.2025.08.001_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s43856-024-00596-7","article-title":"Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores","volume":"4","author":"Naito","year":"2024","journal-title":"Commun Med (Lond)"},{"key":"10.1016\/j.ejvs.2025.08.001_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0307270","article-title":"A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release","volume":"19","author":"Thompson","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ejvs.2025.08.001_bib22","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s41591-019-0492-5","article-title":"Genome-wide association study of peripheral artery disease in the Million Veteran Program","volume":"25","author":"Klarin","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.ejvs.2025.08.001_bib23","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/eurheartj\/ehz849","article-title":"Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385\u2009292 UK Biobank participants","volume":"41","author":"Fan","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ejvs.2025.08.001_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40249-023-01056-5","article-title":"Associations of socioeconomic status with infectious diseases mediated by lifestyle, environmental pollution and chronic comorbidities: a comprehensive evaluation based on UK Biobank","volume":"12","author":"Ye","year":"2023","journal-title":"Infect Dis Poverty"},{"key":"10.1016\/j.ejvs.2025.08.001_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/CIRCULATIONAHA.115.018585","article-title":"Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ejvs.2025.08.001_bib26","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.recesp.2022.05.022","article-title":"Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment","volume":"75","author":"Ba\u00f1eras","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.ejvs.2025.08.001_bib27","doi-asserted-by":"crossref","first-page":"H1417","DOI":"10.1152\/ajpheart.00706.2020","article-title":"Cardiovascular effects of air pollution: current evidence from animal and human studies","volume":"320","author":"Lederer","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10741-017-9606-7","article-title":"The mechanisms of air pollution and particulate matter in cardiovascular diseases","volume":"22","author":"Fiordelisi","year":"2017","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.ejvs.2025.08.001_bib29","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2020.01.004","article-title":"Oxidative stress and the cardiovascular effects of air pollution","volume":"151","author":"Miller","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ejvs.2025.08.001_bib31","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/ATVBAHA.120.315151","article-title":"Internalization of HMGB1 (high mobility group box 1) promotes angiogenesis in endothelial cells","volume":"40","author":"Lan","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib32","doi-asserted-by":"crossref","first-page":"23960","DOI":"10.18632\/aging.104073","article-title":"The long noncoding RNA HCG18 participates in PM2.5-mediated vascular endothelial barrier dysfunction","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ejvs.2025.08.001_bib33","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1161\/ATVBAHA.120.315857","article-title":"Gene expression signature in patients with symptomatic peripheral artery disease","volume":"41","author":"Newman","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ejvs.2025.08.001_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/1471-2164-9-369","article-title":"Peripheral arterial occlusive disease: global gene expression analyses suggest a major role for immune and inflammatory responses","volume":"9","author":"Fu","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ejvs.2025.08.001_bib35","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/CIRCRESAHA.124.324411","article-title":"Exposure to fine particulate matter air pollution disrupts erythrocyte turnover","volume":"134","author":"Asplund","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.ejvs.2025.08.001_bib36","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.abn8455","article-title":"Analysis of genetic dominance in the UK Biobank","volume":"379","author":"Palmer","year":"2023","journal-title":"Science"}],"container-title":["European Journal of Vascular and Endovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078588425007208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1078588425007208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:22:51Z","timestamp":1778588571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1078588425007208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1078588425007208"],"URL":"https:\/\/doi.org\/10.1016\/j.ejvs.2025.08.001","relation":{},"ISSN":["1078-5884"],"issn-type":[{"value":"1078-5884","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Air Pollution, Genetic Susceptibility, and Risk of Symptomatic Peripheral Arterial Disease: A Cohort Study of the UK Biobank","name":"articletitle","label":"Article Title"},{"value":"European Journal of Vascular and Endovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejvs.2025.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society for Vascular Surgery. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}