{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:55:41Z","timestamp":1783695341215,"version":"3.55.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["ippan-041"],"award-info":[{"award-number":["ippan-041"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15K09691"],"award-info":[{"award-number":["15K09691"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17H04189"],"award-info":[{"award-number":["17H04189"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K16086"],"award-info":[{"award-number":["17K16086"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ekir.2018.09.015","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T14:52:38Z","timestamp":1538146358000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Clinical and Genetic Characteristics in Patients With Gitelman Syndrome"],"prefix":"10.1016","volume":"4","author":[{"given":"Junya","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandai","family":"Nozu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Minamikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Horinouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"China","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Miyako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Nozu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Morisada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ninchoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumoto","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2018.09.015_bib1","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1046\/j.1523-1755.1998.00124.x","article-title":"Molecular pathogenesis of Bartter's and Gitelman's syndromes","volume":"54","author":"Kurtz","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2018.09.015_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng0196-24","article-title":"Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter","volume":"12","author":"Simon","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2018.09.015_bib3","first-page":"1019","article-title":"Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman syndrome","volume":"59","author":"Mastroianni","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ekir.2018.09.015_bib4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1530\/EJE-11-0224","article-title":"Phenotype-genotype correlation and follow-up in adult patients with hypokalaemia of renal origin suggesting Gitelman syndrome","volume":"165","author":"Balavoine","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ekir.2018.09.015_bib5","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1046\/j.1523-1755.2001.059002710.x","article-title":"Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life","volume":"59","author":"Cruz","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2018.09.015_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.6065\/apem.2013.18.1.36","article-title":"Gitelman syndrome combined with complete growth hormone deficiency","volume":"18","author":"Min","year":"2013","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"10.1016\/j.ekir.2018.09.015_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12020-007-0024-9","article-title":"Two novel genotypes of the thiazide-sensitive Na-Cl cotransporter (SLC12A3) gene in patients with Gitelman's syndrome","volume":"31","author":"Aoi","year":"2007","journal-title":"Endocrine"},{"key":"10.1016\/j.ekir.2018.09.015_bib8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00467-006-0321-1","article-title":"Gitelman's syndrome: towards genotype-phenotype correlations?","volume":"22","author":"Riveira-Munoz","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ekir.2018.09.015_bib9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.ajkd.2003.10.018","article-title":"Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium\/chloride cotransporter","volume":"43","author":"Lin","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2018.09.015_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/gim.2015.56","article-title":"Differential diagnosis of Bartter syndrome, Gitelman syndrome, and pseudo-Bartter\/Gitelman syndrome based on clinical characteristics","volume":"18","author":"Matsunoshita","year":"2016","journal-title":"Genet Med"},{"key":"10.1016\/j.ekir.2018.09.015_bib11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1046\/j.1523-1755.2002.00467.x","article-title":"Electrocardiogram with prolonged QT interval in Gitelman disease","volume":"62","author":"Bettinelli","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2018.09.015_bib12","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1097\/01.ASN.0000138234.18569.63","article-title":"Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome","volume":"15","author":"Loffing","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2018.09.015_bib13","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00467-016-3416-3","article-title":"Genetic causes of hypomagnesemia, a clinical overview","volume":"32","author":"Viering","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ekir.2018.09.015_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000168701","article-title":"Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome","volume":"14","author":"Colussi","year":"1994","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.ekir.2018.09.015_bib15","first-page":"253","article-title":"The relationship between disorders of K+ and Mg+ homeostasis","volume":"7","author":"Solomon","year":"1987","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ekir.2018.09.015_bib16","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1365-2265.2009.03649.x","article-title":"Problems in diagnosing atypical Gitelman's syndrome presenting with normomagnesaemia","volume":"72","author":"Nakamura","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ekir.2018.09.015_bib17","doi-asserted-by":"crossref","first-page":"E1478","DOI":"10.1210\/jc.2012-1707","article-title":"Genotype, phenotype, and follow-up in Taiwanese patients with salt-losing tubulopathy associated with SLC12A3 mutation","volume":"97","author":"Tseng","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ekir.2018.09.015_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ndt\/gfq352","article-title":"Gitelman syndrome in Gypsy paediatric patients carrying the same intron 9\u00a0+ 1 G>T mutation. Clinical features and impact on quality of life","volume":"26","author":"Herrero-Morin","year":"2011","journal-title":"Nephrol Dial Transplant"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024918302158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024918302158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:22:46Z","timestamp":1762831366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024918302158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S2468024918302158"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2018.09.015","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Genetic Characteristics in Patients With Gitelman Syndrome","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2018.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}