{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:18:01Z","timestamp":1790014681681,"version":"4.0.1"},"reference-count":80,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ekir.2021.02.008","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T12:27:11Z","timestamp":1612873631000},"page":"1336-1345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the Link Between Hepatic Perfusion and Endotoxemia in Hemodialysis"],"prefix":"10.1016","volume":"6","author":[{"given":"Raanan","family":"Marants","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Qirjazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Bik","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk-Chun","family":"Szeto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip K.T.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2021.02.008_bib1","first-page":"520","article-title":"Gastric intramucosal acidosis in patients with chronic kidney failure","volume":"113","author":"Diebel","year":"1993","journal-title":"Surgery"},{"key":"10.1016\/j.ekir.2021.02.008_bib2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/jsre.2001.6103","article-title":"Intestinal and hemodynamic impairment following mesenteric ischemia\/reperfusion","volume":"99","author":"Khanna","year":"2001","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.ekir.2021.02.008_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2215\/CJN.04610510","article-title":"Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease","volume":"6","author":"McIntyre","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib4","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0016-5085(77)80025-5","article-title":"Endotoxin and bacteria in portal blood","volume":"72","author":"Jacob","year":"1977","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ekir.2021.02.008_bib5","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0140-6736(72)91108-7","article-title":"Endotoxemia in man","volume":"299","author":"Caridis","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/j.ekir.2021.02.008_bib6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1525-139X.2010.00782.x","article-title":"Recurrent circulatory stress: the dark side of dialysis","volume":"23","author":"McIntyre","year":"2010","journal-title":"Semin Dialysis"},{"key":"10.1016\/j.ekir.2021.02.008_bib7","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.2215\/CJN.02010606","article-title":"Dialysis-induced regional left ventricular dysfunction is ameliorated by cooling the dialysate","volume":"1","author":"Selby","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib8","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.2215\/CJN.00200115","article-title":"Randomized controlled trial of individualized dialysate cooling for cardiac protection in hemodialysis patients","volume":"10","author":"Odudu","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1681\/ASN.2013101086","article-title":"Randomized clinical trial of dialysate cooling and effects on brain white matter","volume":"26","author":"Eldehni","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib10","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1681\/ASN.2018121194","article-title":"Renal perfusion during hemodialysis: intradialytic blood flow decline and effects of dialysate cooling","volume":"30","author":"Marants","year":"2019","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5527\/wjn.v5.i2.166","article-title":"Cooling dialysate during in-center hemodialysis: Beneficial and deleterious effects","volume":"5","author":"Toth-Manikowski","year":"2016","journal-title":"World J Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/sdi.12782","article-title":"Hepato-splanchnic circulatory stress: an important effect of hemodialysis","volume":"32","author":"Grant","year":"2019","journal-title":"Semin Dialysis"},{"key":"10.1016\/j.ekir.2021.02.008_bib13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1159\/000189099","article-title":"Liver blood flow in chronic hemodialysis patients","volume":"73","author":"Leblanc","year":"1996","journal-title":"Nephron"},{"key":"10.1016\/j.ekir.2021.02.008_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-018-1150-8","article-title":"Effect of ultrafiltration during hemodialysis on hepatic and total-body water: an observational study","volume":"19","author":"Grant","year":"2018","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-015-0017-5","article-title":"Effect of cool vs. warm dialysate on toxin removal: rationale and study design","volume":"16","author":"Maheshwari","year":"2015","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib16","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/00004647-199812000-00011","article-title":"An adiabatic approximation to the tissue homogeneity model for water exchange in the brain: I. theoretical derivation","volume":"18","author":"St. Lawrence","year":"1998","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.ekir.2021.02.008_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2342-13-7","article-title":"Quantification of heterogeneity observed in medical images","volume":"13","author":"Brooks","year":"2013","journal-title":"BMC Med Imaging"},{"key":"10.1016\/j.ekir.2021.02.008_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3181\/00379727-99-24229","article-title":"Hepatic uptake and biliary excretion of indocyanine green in the dog","volume":"99","author":"Wheeler","year":"1958","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ekir.2021.02.008_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.47102\/annals-acadmedsg.V30N2p192","article-title":"Pulse dye densitometry: a novel bedside monitor of circulating blood volume","volume":"30","author":"Goy","year":"2001","journal-title":"Ann Acad Med Singapore"},{"key":"10.1016\/j.ekir.2021.02.008_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1007339924083","article-title":"Cardiac output and circulating blood volume analysis by pulse dye-densitometry","volume":"13","author":"Iijima","year":"1997","journal-title":"J\u00a0Clin Monit"},{"key":"10.1016\/j.ekir.2021.02.008_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0676.1987.tb00336.x","article-title":"Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man","volume":"7","author":"Skak","year":"1987","journal-title":"Liver"},{"key":"10.1016\/j.ekir.2021.02.008_bib22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0168-8278(87)80552-4","article-title":"Hepatic clearance and liver blood flow","volume":"4","author":"Keiding","year":"1987","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.ekir.2021.02.008_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00534-004-0965-9","article-title":"Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test","volume":"12","author":"Imamura","year":"2005","journal-title":"J\u00a0Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.ekir.2021.02.008_bib24","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12","author":"Brenchley","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.ekir.2021.02.008_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000324199","article-title":"Individualised dialysate temperature improves intradialytic haemodynamics and abrogates haemodialysis-induced myocardial stunning, without compromising tolerability","volume":"32","author":"Jefferies","year":"2011","journal-title":"Blood Purif"},{"key":"10.1016\/j.ekir.2021.02.008_bib26","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.2215\/CJN.04470709","article-title":"Hemodialysis-induced repetitive myocardial injury results in global and segmental reduction in systolic cardiac function","volume":"4","author":"Burton","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pst.185","article-title":"Sample size of 12 per group rule of thumb for a pilot study","volume":"4","author":"Julious","year":"2005","journal-title":"Pharm Stat"},{"key":"10.1016\/j.ekir.2021.02.008_bib28","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/0962280215588241","article-title":"Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable","volume":"25","author":"Whitehead","year":"2016","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.ekir.2021.02.008_bib29","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1088\/0031-9155\/53\/16\/003","article-title":"Hepatic perfusion in a tumor model using DCE-CT: an accuracy and precision study","volume":"53","author":"Stewart","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ekir.2021.02.008_bib30","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.3748\/wjg.v16.i48.6046","article-title":"Regulation of hepatic blood flow: the hepatic arterial buffer response revisited","volume":"16","author":"Eipel","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ekir.2021.02.008_bib31","doi-asserted-by":"crossref","DOI":"10.1109\/TSMC.1973.4309314","article-title":"Textural features for image classification","author":"Haralick","year":"1973","journal-title":"IEEE T Syst Man Cyb"},{"key":"10.1016\/j.ekir.2021.02.008_bib32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/ciun.1993.1024","article-title":"A\u00a0review of recent texture segmentation and feature extraction techniques","volume":"57","author":"Reed","year":"1993","journal-title":"CVGIP-Imag Understan"},{"key":"10.1016\/j.ekir.2021.02.008_bib33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0026-2862(02)00008-0","article-title":"Characterization of hepatic parenchymous perfusion heterogeneity and regional flow kinetics after porcine liver transplantation","volume":"65","author":"Mehrabi","year":"2003","journal-title":"Microvasc Res"},{"key":"10.1016\/j.ekir.2021.02.008_bib34","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00024382-199605000-00003","article-title":"Zonal heterogeneity of hepatic injury following shock\/resuscitation: relationship of xanthine oxidase activity to localization of neutrophil accumulation and central lobular necrosis","volume":"5","author":"Mayumi","year":"1996","journal-title":"Shock"},{"key":"10.1016\/j.ekir.2021.02.008_bib35","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/jmri.20192","article-title":"Reversible heterogeneous arterial phase liver perfusion associated with transient acute hepatitis: findings on gadolinium-enhanced MRI","volume":"20","author":"Martin","year":"2004","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.ekir.2021.02.008_bib36","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1097\/01.ASN.0000082998.50730.FA","article-title":"Serial determinations of absolute plasma volume with indocyanine green during hemodialysis","volume":"14","author":"Mitra","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0145411","article-title":"Increased hepato-splanchnic vasoconstriction in diabetics during regular hemodialysis","volume":"10","author":"Ribitsch","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ekir.2021.02.008_bib38","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/anae.12755","article-title":"Green light for liver function monitoring using indocyanine green? An overview of current clinical applications","volume":"69","author":"Vos","year":"2014","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ekir.2021.02.008_bib39","first-page":"56","article-title":"Time course of cellular distribution of endotoxin in liver, lungs and kidneys of rats","volume":"63","author":"Freudenberg","year":"1982","journal-title":"Brit J Exp Pathol"},{"key":"10.1016\/j.ekir.2021.02.008_bib40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0168-8278(99)80018-X","article-title":"Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function","volume":"30","author":"Plevris","year":"1999","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.ekir.2021.02.008_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/SHK.0b013e318199352b","article-title":"Endothelin-1 contributes to hemoglobin glutamer-200-mediated hepatocellular dysfunction after hemorrhagic shock","volume":"32","author":"Kubulus","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.ekir.2021.02.008_bib42","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1097\/00007890-200111270-00019","article-title":"Comparison of hepatic artery and portal vein reperfusion during orthotopic liver transplantation","volume":"72","author":"Sadler","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.ekir.2021.02.008_bib43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/lt.500030206","article-title":"Primary graft dysfunction after liver transplantation: from pathogenesis to prevention","volume":"3","author":"Bzeizi","year":"1997","journal-title":"Liver Transplant Sur"},{"key":"10.1016\/j.ekir.2021.02.008_bib44","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/ndt\/gfg074","article-title":"Oxidative stress in end-stage renal disease: an emerging threat to patient outcome","volume":"18","author":"Locatelli","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2021.02.008_bib45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1492-7535.2005.01116.x","article-title":"Overproduction of reactive oxygen species in end-stage renal disease patients: a potential component of hemodialysis-associated inflammation","volume":"9","author":"Morena","year":"2005","journal-title":"Hemodial Int"},{"key":"10.1016\/j.ekir.2021.02.008_bib46","doi-asserted-by":"crossref","first-page":"G858","DOI":"10.1152\/ajpgi.2001.280.5.G858","article-title":"Endotoxin-induced reduction in biliary indocyanine green excretion rate in a chronically catheterized rat model","volume":"280","author":"Beno","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ekir.2021.02.008_bib47","first-page":"178","article-title":"Functional disturbance of biliary indocyanine green excretion in rat cerulein pancreatitis followed by endotoxemia: role of the prime and the second attack","volume":"4","author":"Okabe","year":"2003","journal-title":"J\u00a0Pancreas"},{"key":"10.1016\/j.ekir.2021.02.008_bib48","doi-asserted-by":"crossref","first-page":"F203","DOI":"10.1152\/ajprenal.00070.2017","article-title":"Free circulating active elastase contributes to chronic inflammation in patients on hemodialysis","volume":"314","author":"Khatib-Massalha","year":"2018","journal-title":"Am J Physiol Renal"},{"key":"10.1016\/j.ekir.2021.02.008_bib49","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1097\/01.fjc.0000166215.50415.36","article-title":"Plasma endothelin-1 in hemodialysis treatment \u2014 the influence of hypertension","volume":"44","author":"Stefanidis","year":"2004","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.ekir.2021.02.008_bib50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1525-1594.1990.tb02986.x","article-title":"Leukotriene B4 in hemodialysis","volume":"14","author":"Tridon","year":"1990","journal-title":"Artif Organs"},{"key":"10.1016\/j.ekir.2021.02.008_bib51","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/039139889201500204","article-title":"Leukotriene release from neutrophils of patients on hemodialysis with cellulose membranes","volume":"15","author":"J\u00f6rres","year":"1992","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.ekir.2021.02.008_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc11240","article-title":"Subclinical AKI is still AKI","volume":"16","author":"Ronco","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.ekir.2021.02.008_bib53","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/ndt\/gft091","article-title":"Renohepatic crosstalk: does acute kidney injury cause liver dysfunction?","volume":"28","author":"Lane","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2021.02.008_bib54","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3390\/ijms15022538","article-title":"Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism","volume":"15","author":"Dixon","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ekir.2021.02.008_bib55","first-page":"1","article-title":"Long-term and short-term effects of hemodialysis on liver function evaluated using the galactose single-point test","volume":"2014","author":"Hou","year":"2014","journal-title":"Sci World J"},{"key":"10.1016\/j.ekir.2021.02.008_bib56","doi-asserted-by":"crossref","first-page":"e0164978","DOI":"10.1371\/journal.pone.0164978","article-title":"Is endotoxemia in stable hemodialysis patients an artefact? Limitations of the limulus amebocyte lysate assay and role of (1\u21923)-\u03b2-D glucan","volume":"11","author":"Wong","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ekir.2021.02.008_bib57","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.2215\/CJN.11211210","article-title":"The impact of antihypertensive drug therapy on endotoxemia in elderly patients with chronic kidney disease","volume":"6","author":"John","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.02.008_bib58","doi-asserted-by":"crossref","first-page":"e40209","DOI":"10.1371\/journal.pone.0040209","article-title":"Endotoxaemia in haemodialysis: a novel factor in erythropoetin resistance?","volume":"7","author":"Harrison","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ekir.2021.02.008_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000366519","article-title":"Circulating endotoxaemia and frequent haemodialysis schedules","volume":"128","author":"Jefferies","year":"2014","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.ekir.2021.02.008_bib60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/sdi.12280","article-title":"Endotoxemia in end-stage kidney disease","volume":"28","author":"Wong","year":"2014","journal-title":"Semin Dialysis"},{"key":"10.1016\/j.ekir.2021.02.008_bib61","first-page":"520","article-title":"Gastric intramucosal acidosis in patients with chronic kidney failure","volume":"113","author":"Diebel","year":"1993","journal-title":"Surgery"},{"key":"10.1016\/j.ekir.2021.02.008_bib62","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/ki.1997.270","article-title":"Splanchnic erythrocyte content decreases during hemodialysis: a new compensatory mechanism for hypovolemia","volume":"51","author":"Yu","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2021.02.008_bib63","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1097\/00003246-200107000-00015","article-title":"Splanchnic perfusion during hemodialysis: evidence for marginal tissue perfusion","volume":"29","author":"Jakob","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ekir.2021.02.008_bib64","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.acra.2012.01.007","article-title":"Assessment of splenic perfusion in patients with malignant hematologic diseases and spleen involvement, liver cirrhosis and controls using volume perfusion CT (VPCT): a pilot study","volume":"19","author":"Sauter","year":"2012","journal-title":"Acad Radiol"},{"key":"10.1016\/j.ekir.2021.02.008_bib65","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0676.1995.tb00104.x","article-title":"The role of the spleen in endotoxin-induced liver injury","volume":"15","author":"Hiraoka","year":"1995","journal-title":"Liver"},{"key":"10.1016\/j.ekir.2021.02.008_bib66","first-page":"384","article-title":"Effect of cooled dialysate on serum catecholamines and blood pressure stability","volume":"29","author":"Mahida","year":"1983","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"10.1016\/j.ekir.2021.02.008_bib67","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1542-4758.2009.00355.x","article-title":"Cool dialysate reduces asymptomatic intradialytic hypotension and increases baroreflex variability","volume":"13","author":"Chesterton","year":"2009","journal-title":"Hemodial Int"},{"key":"10.1016\/j.ekir.2021.02.008_bib68","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0272-6386(99)70427-0","article-title":"Midodrine and cool dialysate are effective therapies for symptomatic intradialytic hypotension","volume":"33","author":"Cruz","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2021.02.008_bib69","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.injury.2011.03.027","article-title":"Therapeutic hypothermia: benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury","volume":"42","author":"Moore","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.ekir.2021.02.008_bib70","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.shk.0000223124.49265.10","article-title":"Brain cooling causes attenuation of cerebral oxidative stress, systemic inflammation, activated coagulation, and tissue ischemia\/injury during heatstroke","volume":"26","author":"Hsu","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.ekir.2021.02.008_bib71","first-page":"361","article-title":"Comparison of prevention methods of intradialytic hypotension","volume":"18","author":"Rezki","year":"2007","journal-title":"Saudi J Kidney Dis Transplant"},{"key":"10.1016\/j.ekir.2021.02.008_bib72","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1046\/j.1523-1755.2001.0590031175.x","article-title":"Preventing dialysis hypotension: a comparison of usual protective maneuvers","volume":"59","author":"Dheenan","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2021.02.008_bib73","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00380-013-0329-y","article-title":"Remote ischemic preconditioning in hemodialysis: a pilot study","volume":"29","author":"Park","year":"2014","journal-title":"Heart Vessels"},{"key":"10.1016\/j.ekir.2021.02.008_bib74","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ekir.2019.08.016","article-title":"Remote ischemic preconditioning protects against hemodialysis-induced cardiac injury","volume":"5","author":"Salerno","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ekir.2021.02.008_bib75","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000014481","article-title":"Variations in hematocrit induced by hemodialysis","volume":"19","author":"Di lorio","year":"2001","journal-title":"Blood Purif"},{"key":"10.1016\/j.ekir.2021.02.008_bib76","doi-asserted-by":"crossref","first-page":"e0220764","DOI":"10.1371\/journal.pone.0220764","article-title":"Hemodialysis-induced changes in hematocrit, hemoglobin and total protein: implications for relative blood volume monitoring","volume":"14","author":"Pstras","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ekir.2021.02.008_bib77","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1525-1594.2003.07156.x","article-title":"Endotoxin adsorption of various dialysis membranes: in\u00a0vitro study","volume":"27","author":"Takemoto","year":"2003","journal-title":"Artif Organs"},{"key":"10.1016\/j.ekir.2021.02.008_bib78","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1525-1594.2008.00592.x","article-title":"In\u00a0vitro assessment of dialysis membrane as an endotoxin transfer barrier: geometry, morphology, and permeability","volume":"32","author":"Henrie","year":"2008","journal-title":"Artif Organs"},{"key":"10.1016\/j.ekir.2021.02.008_bib79","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF02925628","article-title":"Properties and participation of \"free\" endotoxin in the toxic activity of Morganella morganii","volume":"33","author":"Bartkova","year":"1988","journal-title":"Folia Mierobiol"},{"key":"10.1016\/j.ekir.2021.02.008_bib80","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/iai.59.2.689-695.1991","article-title":"Endotoxin shedding by enterobacteria: free and cell-bound endotoxin differ in limulus activity","volume":"59","author":"Mattsby-Baltzer","year":"1991","journal-title":"Infect Immun"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024921000796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024921000796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:37:23Z","timestamp":1762832243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024921000796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S2468024921000796"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2021.02.008","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the Link Between Hepatic Perfusion and Endotoxemia in Hemodialysis","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2021.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}