{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:56:04Z","timestamp":1778813764702,"version":"3.51.4"},"reference-count":12,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ekir.2021.03.892","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T13:02:27Z","timestamp":1617454947000},"page":"1629-1633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["PODO: Trial Design: Phase 2 Study of PF-06730512 in Focal Segmental Glomerulosclerosis"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-4089","authenticated-orcid":false,"suffix":"Jr.","given":"Laurence H.","family":"Beck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Berasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Brian","family":"Copley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donal","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel I.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chay Ngee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Salant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weining","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2021.03.892_bib1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2215\/CJN.05960616","article-title":"Focal segmental glomerulosclerosis","volume":"12","author":"Rosenberg","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.03.892_bib2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2017090958","article-title":"Differentiating primary, genetic, and secondary FSGS in adults: a clinicopathologic approach","volume":"29","author":"De Vriese","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2021.03.892_bib3","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.3390\/cells9071700","article-title":"Regulation of the actin cytoskeleton in podocytes","volume":"9","author":"Blaine","year":"2020","journal-title":"Cells"},{"issue":"1 suppl 1","key":"10.1016\/j.ekir.2021.03.892_bib4","doi-asserted-by":"crossref","first-page":"A6","DOI":"10.1053\/j.ajkd.2019.09.003","article-title":"US Renal Data System 2019 Annual Data Report: epidemiology of kidney disease in the United States","volume":"75","author":"Saran","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2021.03.892_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.celrep.2012.06.002","article-title":"Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure","volume":"2","author":"Fan","year":"2012","journal-title":"Cell Rep"},{"key":"10.1016\/j.ekir.2021.03.892_bib6","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/dev.132829","article-title":"Slit-Robo signaling","volume":"143","author":"Blockus","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.ekir.2021.03.892_bib7","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86934","article-title":"SLIT2\/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion","volume":"1","author":"Fan","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.ekir.2021.03.892_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajpath.2019.12.009","article-title":"Loss of roundabout guidance receptor 2 (Robo2) in podocytes protects adult mice from glomerular injury by maintaining podocyte foot process structure","volume":"190","author":"Pisarek-Horowitz","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ekir.2021.03.892_bib9","doi-asserted-by":"crossref","unstructured":"Berasi S, Buhlmann J, Shamashkin M, et\u00a0al. A ROBO2 fusion protein (PF-06730512) traps SLIT ligands and therapeutically ameliorates podocyte injury; Abs FR-OR33. Presented virtually at American Society of Nephrology Kidney Week, October 22\u201325,\u00a02020.","DOI":"10.1681\/ASN.20203110S125b"},{"key":"10.1016\/j.ekir.2021.03.892_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/j.ajkd.2009.08.019","article-title":"Phase 1 trial of adalimumab in focal segmental glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) study group","volume":"55","author":"Joy","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2021.03.892_bib11","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ki.2011.33","article-title":"A\u00a0phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis","volume":"79","author":"Trachtman","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2021.03.892_bib12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/ki.2011.195","article-title":"Clinical trial of focal segmental glomerulosclerosis in children and young adults","volume":"80","author":"Gipson","year":"2011","journal-title":"Kidney Int"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024921010408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024921010408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:36:38Z","timestamp":1762832198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024921010408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S2468024921010408"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2021.03.892","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PODO: Trial Design: Phase 2 Study of PF-06730512 in Focal Segmental Glomerulosclerosis","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2021.03.892","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}