{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:49:06Z","timestamp":1793735346362,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE14-0040-01"],"award-info":[{"award-number":["ANR-21-CE14-0040-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003386","name":"SFNDT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ekir.2022.04.008","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:47:12Z","timestamp":1650023232000},"page":"1557-1564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Chronic Lithium Therapy and Urine-Concentrating Ability in Individuals With Bipolar Disorder: Association Between Daily Dose and Resistance to Vasopressin and Polyuria"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-0163","authenticated-orcid":false,"given":"Nahid","family":"Tabibzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Vidal-Petiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Cheddani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Haymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Etain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bellivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Marlinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Delavest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vrtovsnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Flamant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2022.04.008_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1176\/appi.ajp.161.2.217","article-title":"Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials","volume":"161","author":"Geddes","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ekir.2022.04.008_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0140-6736(09)61828-6","article-title":"Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial","volume":"375","author":"Geddes","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ekir.2022.04.008_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S2215-0366(14)70314-1","article-title":"Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis","volume":"1","author":"Miura","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.ekir.2022.04.008_bib4","doi-asserted-by":"crossref","first-page":"f3646","DOI":"10.1136\/bmj.f3646","article-title":"Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis","volume":"346","author":"Cipriani","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.ekir.2022.04.008_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.revmed.2019.01.006","article-title":"Chronic metabolic and renal disorders related to lithium salts treatment","volume":"40","author":"Tabibzadeh","year":"2019","journal-title":"Rev Med Intern"},{"key":"10.1016\/j.ekir.2022.04.008_bib6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrneph.2009.43","article-title":"Lithium nephrotoxicity revisited","volume":"5","author":"Gr\u00fcnfeld","year":"2009","journal-title":"Nat Rev Nephrol"},{"issue":"suppl 16","key":"10.1016\/j.ekir.2022.04.008_bib7","first-page":"S43","article-title":"Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings","volume":"23","author":"Trepiccione","year":"2010","journal-title":"J\u00a0Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1523-1755.2005.00081.x","article-title":"Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers","volume":"67","author":"Walker","year":"2005","journal-title":"Kidney Int Janv"},{"key":"10.1016\/j.ekir.2022.04.008_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0272-6386(87)80098-7","article-title":"Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy","volume":"10","author":"Boton","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2022.04.008_bib10","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1681\/ASN.2015080907","article-title":"Lithium in the kidney: friend and foe?","volume":"27","author":"Alsady","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib11","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1073\/pnas.0800001105","article-title":"Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation","volume":"105","author":"Nielsen","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ekir.2022.04.008_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.784298","article-title":"Kidney function and long-term treatment with lithium salts for bipolar disorder determinants of mGFR and accuracy of kidney microcysts detection in the diagnosis of CKD","author":"Tabibzadeh","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ekir.2022.04.008_bib13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/HJH.0000000000001609","article-title":"External validation and comparison of formulae estimating 24-h sodium intake from a fasting morning urine sample","volume":"36","author":"Vidal-Petiot","year":"2018","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.ekir.2022.04.008_bib14","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1681\/ASN.2016040448","article-title":"Urine osmolality, response to tolvaptan, and outcome in autosomal dominant polycystic kidney disease: results from the TEMPO 3:4 trial","volume":"28","author":"Devuyst","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib15","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/ndt\/gfy333","article-title":"Impaired urinary concentration ability is a sensitive predictor of renal disease progression in Joubert syndrome","volume":"35","author":"Nuovo","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2022.04.008_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41572-019-0103-2","article-title":"Diabetes insipidus","volume":"5","author":"Christ-Crain","year":"2019","journal-title":"Nat Rev Dis Primer"},{"key":"10.1016\/j.ekir.2022.04.008_bib17","series-title":"Diagnostic checking in regression relationships","author":"Zeileis","year":"2015"},{"key":"10.1016\/j.ekir.2022.04.008_bib18","series-title":"An R companion to applied regression third edition","year":"2019"},{"key":"10.1016\/j.ekir.2022.04.008_bib20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(11)61516-X","article-title":"Lithium toxicity profile: a systematic review and meta-analysis","volume":"379","author":"McKnight","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ekir.2022.04.008_bib21","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/ndt\/9.9.1250","article-title":"Kidney damage in long-term lithium patients: a cross-sectional study of patients with 15 years or more on lithium","volume":"9","author":"Bendz","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2022.04.008_bib22","first-page":"23","article-title":"Impairment of renal function in patients on long-term lithium treatment","volume":"18","author":"Wallin","year":"1982","journal-title":"Clin Nephrol Juill"},{"key":"10.1016\/j.ekir.2022.04.008_bib23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ki.1981.28","article-title":"Lithium and the kidney","volume":"19","author":"Singer","year":"1981","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2022.04.008_bib24","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1210\/jc.2014-2295","article-title":"Comparison between copeptin and vasopressin in a population from the community and in people with chronic kidney disease","volume":"99","author":"Roussel","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ekir.2022.04.008_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1192\/bjp.130.2.144","article-title":"Plasma levels of antidiuretic hormone in patients receiving prolonged lithium therapy","volume":"130","author":"Padfield","year":"1977","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.ekir.2022.04.008_bib26","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ki.2012.225","article-title":"Autosomal dominant polycystic kidney disease is associated with central and nephrogenic defects in osmoregulation","volume":"82","author":"Ho","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2022.04.008_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2215\/CJN.04560510","article-title":"Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease","volume":"6","author":"Meijer","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ekir.2017.01.006","article-title":"The effect of renal function and hemodialysis treatment on plasma vasopressin and copeptin levels","volume":"2","author":"Ettema","year":"2017","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ekir.2022.04.008_bib29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1053\/j.ajkd.2018.12.024","article-title":"Fasting urinary osmolality, CKD progression, and mortality: a prospective observational study","volume":"73","author":"Tabibzadeh","year":"2019","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2022.04.008_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nrneph.2013.22","article-title":"Vasopressin: a novel target for the prevention and retardation of kidney disease?","volume":"9","author":"Bankir","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib31","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ki.2009.325","article-title":"Vasopressin in chronic kidney disease, an elephant in the room?","volume":"76","author":"Torres","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2022.04.008_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13756","article-title":"MRI based kidney radiomics analysis during chronic lithium treatment: validation of a texture index associated with decreased kidney function","author":"Beunon","year":"2022","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ekir.2022.04.008_bib33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/bdi.12235","article-title":"Risk factors for polyuria in a cross-section of community psychiatric lithium-treated patients","volume":"17","author":"Kinahan","year":"2015","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.ekir.2022.04.008_bib34","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrneph.2015.89","article-title":"Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus","volume":"11","author":"Bockenhauer","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib35","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1471-2369-14-246","article-title":"Factors associated with 24-hour urinary volume: the Swiss salt survey","volume":"14","author":"Schoen","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ekir.2022.04.008_bib36","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00500.2006","article-title":"Sex difference in urine concentration across differing ages, sodium intake, and level of kidney disease","volume":"292","author":"Perucca","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ekir.2022.04.008_bib37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1176\/ajp.148.2.189","article-title":"Less frequent lithium administration and lower urine volume","volume":"148","author":"Bowen","year":"1991","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ekir.2022.04.008_bib38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/070674370805300507","article-title":"Lithium treatments: single and multiple daily dosing","volume":"53","author":"Ljubicic","year":"2008","journal-title":"Can J Psychiatry Rev Can Psychiatr"},{"key":"10.1016\/j.ekir.2022.04.008_bib39","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1136\/bmj.2.6201.1332","article-title":"Effect of sustained-release lithium tablets on renal function","volume":"2","author":"Wallin","year":"1979","journal-title":"Br Med J"},{"key":"10.1016\/j.ekir.2022.04.008_bib40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/070674371305801009","article-title":"An updated review of the optimal lithium dosage regimen for renal protection","volume":"58","author":"Carter","year":"2013","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.ekir.2022.04.008_bib41","first-page":"305","article-title":"Effect of lithium on water and electrolyte metabolism","volume":"48","author":"Galla","year":"1975","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.ekir.2022.04.008_bib42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.7326\/0003-4819-88-5-607","article-title":"Water disturbances in patients treated with oral lithium carbonate","volume":"88","author":"Baylis","year":"1978","journal-title":"Ann Intern Med"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024922012645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024922012645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:42:26Z","timestamp":1762832546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024922012645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S2468024922012645"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2022.04.008","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.01.28.22270045","asserted-by":"object"}]},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic Lithium Therapy and Urine-Concentrating Ability in Individuals With Bipolar Disorder: Association Between Daily Dose and Resistance to Vasopressin and Polyuria","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2022.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}