{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:17:15Z","timestamp":1790691435607,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ekir.2022.05.011","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T16:20:57Z","timestamp":1652890857000},"page":"1802-1818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Phenome-Wide Association Study of UMOD Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank"],"prefix":"10.1016","volume":"7","author":[{"given":"Elvis A.","family":"Akwo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson L.","family":"Triozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia P.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayush","family":"Giri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Alp","family":"Ikizler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QiPing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-7046","authenticated-orcid":false,"given":"Cassianne","family":"Robinson-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-1608","authenticated-orcid":false,"given":"Adriana M.","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2022.05.011_bib1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.2215\/CJN.04480413","article-title":"Thick ascending limb of the loop of Henle","volume":"9","author":"Mount","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ki.2011.134","article-title":"The rediscovery of uromodulin (Tamm-Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease","volume":"80","author":"Rampoldi","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2022.05.011_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3181\/00379727-74-17825","article-title":"Characterization and separation of an inhibitor of viral hemagglutination present in urine","volume":"74","author":"Tamm","year":"1950","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib4","first-page":"236","article-title":"Tamm-Horsfall protein excretion during chronic alterations in urinary concentration and protein intake in the rat","volume":"14","author":"Bachmann","year":"1991","journal-title":"Ren Physiol Biochem"},{"key":"10.1016\/j.ekir.2022.05.011_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1042\/bj1890533","article-title":"Effects of freezing on the estimated amounts of Tamm-Horsfall glycoprotein in urine, as determined by radioimmunoassay","volume":"189","author":"Goodall","year":"1980","journal-title":"Biochem J"},{"key":"10.1016\/j.ekir.2022.05.011_bib6","doi-asserted-by":"crossref","first-page":"20784","DOI":"10.1016\/S0021-9258(17)45284-7","article-title":"Uromodulin (Tamm-Horsfall glycoprotein\/uromucoid) is a phosphatidylinositol-linked membrane protein","volume":"265","author":"Rindler","year":"1990","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ekir.2022.05.011_bib7","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0272-6386(03)00829-1","article-title":"Tamm-Horsfall glycoprotein: biology and clinical relevance","volume":"42","author":"Serafini-Cessi","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2022.05.011_bib8","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/ndt\/gfh851","article-title":"Tamm-Horsfall protein or uromodulin: new ideas about an old molecule","volume":"20","author":"Devuyst","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2022.05.011_bib9","doi-asserted-by":"crossref","first-page":"30200","DOI":"10.1074\/jbc.M111.222968","article-title":"Activation of the bumetanide-sensitive Na+,K+,2Cl\u2212 cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner","volume":"286","author":"Mutig","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ekir.2022.05.011_bib10","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1074\/jbc.M110.149880","article-title":"Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function","volume":"286","author":"Renigunta","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ekir.2022.05.011_bib11","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1074\/jbc.M008610200","article-title":"Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors","volume":"276","author":"Pak","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ekir.2022.05.011_bib12","doi-asserted-by":"crossref","first-page":"F795","DOI":"10.1152\/ajprenal.00357.2003","article-title":"Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli","volume":"286","author":"Mo","year":"2004","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.ekir.2022.05.011_bib13","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1681\/ASN.2015070830","article-title":"The uromodulin gene locus shows evidence of pathogen adaptation through human evolution","volume":"27","author":"Ghirotto","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1523-1755.2004.00867.x","article-title":"Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation","volume":"66","author":"Mo","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2022.05.011_bib15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI200522720","article-title":"Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism","volume":"115","author":"Saemann","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ekir.2022.05.011_bib16","doi-asserted-by":"crossref","first-page":"F534","DOI":"10.1152\/ajprenal.00083.2008","article-title":"Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression","volume":"295","author":"El-Achkar","year":"2008","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.ekir.2022.05.011_bib17","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"K\u00f6ttgen","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib18","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1038\/ncomms10023","article-title":"Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function","volume":"7","author":"Pattaro","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ekir.2022.05.011_bib19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1681\/ASN.2017070716","article-title":"The UMOD locus: insights into the pathogenesis and prognosis of kidney disease","volume":"29","author":"Devuyst","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrneph.2016.107","article-title":"Insights into kidney diseases from genome-wide association studies","volume":"12","author":"Wuttke","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib21","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41588-019-0407-x","article-title":"A\u00a0catalog of genetic loci associated with kidney function from analyses of a million individuals","volume":"51","author":"Wuttke","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001177","article-title":"Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension","volume":"6","author":"Padmanabhan","year":"2010","journal-title":"PLOS Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib23","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1681\/ASN.2013070781","article-title":"Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis","volume":"25","author":"Olden","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib24","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/nm.3384","article-title":"Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression","volume":"19","author":"Trudu","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ajhg.2019.08.012","article-title":"Harmonizing genetic ancestry and self-identified race\/ethnicity in genome-wide association studies","volume":"105","author":"Fang","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib26","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nbt.2749","article-title":"Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data","volume":"31","author":"Denny","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ekir.2022.05.011_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003087","article-title":"Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) network","volume":"9","author":"Pendergrass","year":"2013","journal-title":"PLOS Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrg.2015.36","article-title":"Unravelling the human genome-phenome relationship using phenome-wide association studies","volume":"17","author":"Bush","year":"2016","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib29","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nbt.3183","article-title":"Opportunities for drug repositioning from phenome-wide association studies","volume":"33","author":"Rastegar-Mojarad","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ekir.2022.05.011_bib30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jclinepi.2015.09.016","article-title":"Million Veteran Program: a mega-biobank to study genetic influences on health and disease","volume":"70","author":"Gaziano","year":"2016","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.ekir.2022.05.011_bib31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCULATIONAHA.118.036589","article-title":"Association of APOL1 risk alleles with cardiovascular disease in Blacks in the Million Veteran Program","volume":"140","author":"Bick","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ekir.2022.05.011_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41588-018-0303-9","article-title":"Trans-ethnic association study of blood pressure determinants in over 750,000 individuals","volume":"51","author":"Giri","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib33","doi-asserted-by":"crossref","unstructured":"Hunter-Zinck H, Shi Y, Li M, et\u00a0al. Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP). bioRxiv. Published online January 7, 2020. https:\/\/doi.org\/10.1101\/2020.01.06.896613","DOI":"10.1101\/2020.01.06.896613"},{"key":"10.1016\/j.ekir.2022.05.011_bib34","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","article-title":"Robust relationship inference in genome-wide association studies","volume":"26","author":"Manichaikul","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ekir.2022.05.011_bib35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A\u00a0global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ekir.2022.05.011_bib36","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3679","article-title":"Reference-based phasing using the Haplotype Reference Consortium panel","volume":"48","author":"Loh","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib37","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A\u00a0map of human genome variation from population-scale sequencing","volume":"467","author":"Consortium","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ekir.2022.05.011_bib38","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib39","doi-asserted-by":"crossref","first-page":"e93766","DOI":"10.1371\/journal.pone.0093766","article-title":"Fast principal component analysis of large-scale genome-wide data","volume":"9","author":"Abraham","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ekir.2022.05.011_bib40","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"Winkler","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ekir.2022.05.011_bib41","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41588-018-0222-9","article-title":"Genetics of blood lipids among \u223c300,000 multi-ethnic participants of the Million Veteran Program","volume":"50","author":"Klarin","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib42","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/ng.3623","article-title":"Identification of 15 genetic loci associated with risk of major depression in individuals of European descent","volume":"48","author":"Hyde","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A\u00a0global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ekir.2022.05.011_bib44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrneph.2017.101","article-title":"Uromodulin: from physiology to rare and complex kidney disorders","volume":"13","author":"Devuyst","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib45","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/jamacardio.2018.2287","article-title":"Association of interleukin 6 receptor variant with cardiovascular disease effects of interleukin 6 receptor blocking therapy: a phenome-wide association study","volume":"3","author":"Cai","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.ekir.2022.05.011_bib46","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/bioinformatics\/btq126","article-title":"PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations","volume":"26","author":"Denny","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ekir.2022.05.011_bib47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/oxfordjournals.pan.a004868","article-title":"Logistic regression in rare events data","volume":"9","author":"King","year":"2001","journal-title":"Pol Anal"},{"key":"10.1016\/j.ekir.2022.05.011_bib48","doi-asserted-by":"crossref","DOI":"10.1289\/EHP334","article-title":"Statistical approaches for estimating sex-specific effects in endocrine disruptors research","volume":"125","author":"Buckley","year":"2017","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ekir.2022.05.011_bib49","first-page":"859","article-title":"Using the correct statistical test for the equality of regression coefficients","volume":"36","author":"Paternoster","year":"1998","journal-title":"Criminology (Beverly Hills)"},{"key":"10.1016\/j.ekir.2022.05.011_bib50","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/clpt.2008.89","article-title":"Development of a large-scale de-identified DNA biobank to enable personalized medicine","volume":"84","author":"Roden","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.ekir.2022.05.011_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLOS Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib52","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1093\/hmg\/ddu399","article-title":"Rare mutations associating with serum creatinine and chronic kidney disease","volume":"23","author":"Sveinbjornsson","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib53","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ajhg.2016.07.012","article-title":"Trans-ethnic fine mapping highlights kidney-function genes linked to salt sensitivity","volume":"99","author":"Mahajan","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib73","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41746-021-00428-1","article-title":"Medical records-based chronic kidney disease phenotype for clinical care and \u201cbig data\u201d observational and genetic studies","volume":"4","author":"Shang","year":"2021","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002264","article-title":"Genetic association for renal traits among participants of African ancestry reveals new loci for renal function","volume":"7","author":"Liu","year":"2011","journal-title":"PLOS Genet"},{"key":"10.1016\/j.ekir.2022.05.011_bib55","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa011303","article-title":"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes","volume":"345","author":"Lewis","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib56","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"Brenner","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib57","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib58","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib59","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1056\/NEJMoa1515920","article-title":"Empagliflozin and progression of kidney disease in type 2 diabetes","volume":"375","author":"Wanner","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib60","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib61","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2213-8587(18)30141-4","article-title":"Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials","volume":"6","author":"Perkovic","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.ekir.2022.05.011_bib62","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa2025845","article-title":"Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes","volume":"383","author":"Bakris","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ekir.2022.05.011_bib63","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1038\/s41467-019-11704-w","article-title":"Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program","volume":"10","author":"Hellwege","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ekir.2022.05.011_bib64","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.114.03132","article-title":"Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension","volume":"64","author":"Padmanabhan","year":"2014","journal-title":"Hypertens (Dallas: Tex"},{"key":"10.1016\/j.ekir.2022.05.011_bib65","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1046\/j.1523-1755.2002.00341.x","article-title":"Monitoring changes in gene expression in renal ischemia-reperfusion in the rat","volume":"61","author":"Yoshida","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2022.05.011_bib66","doi-asserted-by":"crossref","first-page":"F1066","DOI":"10.1152\/ajprenal.00543.2012","article-title":"Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury","volume":"304","author":"El-Achkar","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.ekir.2022.05.011_bib67","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1128\/iai.56.10.2623-2630.1988","article-title":"Identification of factors in human urine that inhibit the binding of Escherichia coli adhesins","volume":"56","author":"Parkkinen","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.ekir.2022.05.011_bib68","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.chom.2016.08.013","article-title":"Inflammation-induced adhesin-receptor interaction provides a fitness advantage to uropathogenic E. coli during chronic infection","volume":"20","author":"Conover","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ekir.2022.05.011_bib69","doi-asserted-by":"crossref","first-page":"F469","DOI":"10.1152\/ajprenal.00243.2010","article-title":"Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein","volume":"299","author":"Liu","year":"2010","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.ekir.2022.05.011_bib70","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.2215\/CJN.11321210","article-title":"Pathophysiology-based treatment\u00a0of idiopathic calcium kidney stones","volume":"6","author":"Coe","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2022.05.011_bib71","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10719-005-2142-z","article-title":"N-Glycans carried by Tamm-Horsfall glycoprotein have a crucial role in the defense against urinary tract diseases","volume":"22","author":"Serafini-Cessi","year":"2005","journal-title":"Glycoconj J"},{"key":"10.1016\/j.ekir.2022.05.011_bib72","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.aaz9866","article-title":"Architecture and function of human uromodulin filaments in urinary tract infections","volume":"369","author":"Weiss","year":"2020","journal-title":"Science"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024922013997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024922013997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T15:53:58Z","timestamp":1660233238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024922013997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2468024922013997"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2022.05.011","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenome-Wide Association Study of UMOD Gene Variants and Differential Associations With Clinical Outcomes Across Populations in the Million Veteran Program a Multiethnic Biobank","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2022.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}