{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:48:34Z","timestamp":1758152914043,"version":"3.44.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ekir.2025.06.014","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T02:42:50Z","timestamp":1750300970000},"page":"3138-3149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Chronic Thrombo-Inflammation in Anti\u2013Glomerular Basement Membrane Disease Despite Immune Complex Removal"],"prefix":"10.1016","volume":"10","author":[{"given":"M\u00e9lodie","family":"Dout\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn\u00e9a","family":"Tyrberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn\u00e8s","family":"Youssfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"Bajema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"M\u00f6lne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Caligiuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e5rten","family":"Segelmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Clement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2025.06.014_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ekir.2025.06.014_bib2","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/ndt\/gfy327","article-title":"Anti-glomerular basement membrane disease: an update on subgroups, pathogenesis and therapies","volume":"34","author":"Segelmark","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2025.06.014_bib3","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1056\/NEJMra022296","article-title":"Alport\u2019s syndrome, Goodpasture\u2019s syndrome, and type iv collagen","volume":"348","author":"Hudson","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ekir.2025.06.014_bib4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.2215\/CJN.01380217","article-title":"Anti-glomerular basement membrane disease","volume":"12","author":"McAdoo","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2025.06.014_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2215\/CJN.04290417","article-title":"Predicting outcome in patients with anti-gbm glomerulonephritis","volume":"13","author":"van Daalen","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2025.06.014_bib6","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/emboj\/21.7.1607","article-title":"Ides, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G","volume":"21","author":"von Pawel-Rammingen","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.ekir.2025.06.014_bib7","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/ndt\/gfq115","article-title":"Successful treatment of experimental glomerulonephritis with ides and endos, igg-degrading streptococcal enzymes","volume":"25","author":"Yang","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2025.06.014_bib8","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.kint.2019.06.019","article-title":"The igg-degrading enzyme of streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease","volume":"96","author":"Soveri","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2025.06.014_bib9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1681\/ASN.2021111460","article-title":"Endopeptidase cleavage of anti-glomerular basement membrane antibodies in vivo in severe kidney disease: an open-label phase 2a study","volume":"33","author":"Uhlin","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2025.06.014_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/ndt\/gfad132","article-title":"Using imlifidase to elucidate the characteristics and importance of anti-gbm antibodies produced after start of treatment","volume":"39","author":"Tyrberg","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2025.06.014_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41577-023-00834-4","article-title":"The role of platelets in immune-mediated inflammatory diseases","volume":"23","author":"Scherlinger","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ekir.2025.06.014_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41568-023-00639-6","article-title":"The dynamic role of platelets in cancer progression and their therapeutic implications","volume":"24","author":"Li","year":"2024","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ekir.2025.06.014_bib13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/jth.15265","article-title":"Platelet fcgammariia in immunity and thrombosis: adaptive immunothrombosis","volume":"19","author":"Patel","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ekir.2025.06.014_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135738","article-title":"Platelet activation and thrombus formation over igg immune complexes requires integrin alphaiibbeta3 and lyn kinase","volume":"10","author":"Zhi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ekir.2025.06.014_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aan5997","article-title":"Platelets expressing igg receptor fcgammariia\/cd32a determine the severity of experimental anaphylaxis","volume":"3","author":"Beutier","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.ekir.2025.06.014_bib16","doi-asserted-by":"crossref","first-page":"E1550","DOI":"10.1073\/pnas.1720553115","article-title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","volume":"115","author":"Cloutier","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ekir.2025.06.014_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.trsl.2020.04.014","article-title":"Pathogenesis of heparin-induced thrombocytopenia","volume":"225","author":"Arepally","year":"2020","journal-title":"Transl Res"},{"key":"10.1016\/j.ekir.2025.06.014_bib18","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1182\/blood.2020004974","article-title":"Fcgammariia expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus","volume":"136","author":"Melki","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.06.014_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platel et alpha-granules: basic biology and clinical correlates","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev"},{"key":"10.1016\/j.ekir.2025.06.014_bib20","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1182\/bloodadvances.2018017756","article-title":"Trem-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice","volume":"2","author":"Smith","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.ekir.2025.06.014_bib21","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1182\/blood-2004-01-0315","article-title":"A trem family member, tlt-1, is found exclusively in the alpha-granules of megakaryocytes and platelets","volume":"104","author":"Washington","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.06.014_bib22","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.4049\/jimmunol.2001218","article-title":"Tlt-1 promotes platelet-monocyte aggregate formation to induce IL-10-producing B cells in tuberculosis","volume":"208","author":"Wang","year":"2022","journal-title":"J Immunol"},{"key":"10.1016\/j.ekir.2025.06.014_bib23","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1182\/blood-2018-03-841593","article-title":"Platelet-derived tlt-1 is a prognostic indicator in ali\/ards and prevents tissue damage in the lungs in a mouse model","volume":"132","author":"Morales-Ortiz","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.06.014_bib24","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2353\/ajpath.2010.091143","article-title":"Platelet recruitment to the inflamed glomerulus occurs via an alphaiibbeta3\/gpvi-dependent pathway","volume":"177","author":"Devi","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ekir.2025.06.014_bib25","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1681\/ASN.0000000000000127","article-title":"Thrombopoietin-Dependent Myelo-Megakaryopoiesis Fuels Thromboinflammation and Worsens Antibody-Mediated Chronic Renal Microvascular Injury","volume":"34","author":"Doute","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2025.06.014_bib26","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1681\/ASN.0000000000000153","article-title":"Kidney-derived thrombopoietin and platelet generation-a proinflammatory loop in ckd","volume":"34","author":"Hickey","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2025.06.014_bib27","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood.2020009302","article-title":"Don\u2019t you forget about me(gakaryocytes)","volume":"139","author":"Tilburg","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.06.014_bib28","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1073\/pnas.96.6.3132","article-title":"Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia","volume":"96","author":"Ihara","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ekir.2025.06.014_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/stem.160001","article-title":"Hematopoietic deficiencies in c-mpl and tpo knockout mice","volume":"16","author":"Murone","year":"1998","journal-title":"Stem Cells"},{"key":"10.1016\/j.ekir.2025.06.014_bib30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.201410052","article-title":"IL-1alpha induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs","volume":"209","author":"Nishimura","year":"2015","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ekir.2025.06.014_bib31","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood.V98.9.2720","article-title":"Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis","volume":"98","author":"Kaser","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.06.014_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.kint.2018.08.042","article-title":"Platelet retention in inflamed glomeruli occurs via selective prolongation of interactions with immune cells","volume":"95","author":"Finsterbusch","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2025.06.014_bib33","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.4049\/jimmunol.176.11.6991","article-title":"Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling","volume":"176","author":"Kuligowski","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.ekir.2025.06.014_bib34","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1182\/blood-2010-09-267492","article-title":"Functional architecture of weibel-palade bodies","volume":"117","author":"Valentijn","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.06.014_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(23)00427-1","article-title":"Safety and efficacy of platelet glycoprotein vi inhibition in acute ischaemic stroke (actimis): a randomised, double-blind, placebo-controlled, phase 1b\/2a trial","volume":"23","author":"Mazighi","year":"2024","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ekir.2025.06.014_bib36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/FJC.0000000000000233","article-title":"First-in-man study with inclacumab, a human monoclonal antibody against P-selectin","volume":"65","author":"Schmitt","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.ekir.2025.06.014_bib37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.stem.2015.07.007","article-title":"Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors","volume":"17","author":"Haas","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ekir.2025.06.014_bib38","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153920","article-title":"Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression","volume":"132","author":"Valet","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ekir.2025.06.014_bib39","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/bloodadvances.2023012367","article-title":"Sars-cov-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow","volume":"8","author":"Allaeys","year":"2024","journal-title":"Blood Adv"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024925003833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024925003833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T17:39:53Z","timestamp":1758130793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024925003833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2468024925003833"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2025.06.014","relation":{},"ISSN":["2468-0249"],"issn-type":[{"type":"print","value":"2468-0249"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent Chronic Thrombo-Inflammation in Anti\u2013Glomerular Basement Membrane Disease Despite Immune Complex Removal","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2025.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}