{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:15:40Z","timestamp":1775286940771,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports\u00ae"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ekir.2025.10.022","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:39:31Z","timestamp":1762389571000},"page":"129-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological Spectrum and Treatment Outcomes of Cryofibrinogen-Associated Nephropathies"],"prefix":"10.1016","volume":"11","author":[{"given":"Julien","family":"Dang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislas","family":"Faguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Jourde-Chiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Javaugue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Bridoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dice","family":"Puissant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Boffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanis","family":"Tamzali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evang\u00e9line","family":"Pillebout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Daugas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e9vin","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaux","family":"Van Wynsberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Guerrot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Legendre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Sanges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Lebas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nans","family":"Florens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ronsin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Mussini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Ferlicot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mouawad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Snanoudj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Essig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Pineton","family":"De Chambrun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Ghillani-Dalbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Zaidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2025.10.022_bib1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1182\/blood.V10.9.945.945","article-title":"Cryofibrinogen in a case of lung neoplasm associated with thrombophlebitis migrans","volume":"10","author":"Korst","year":"1955","journal-title":"Blood"},{"key":"10.1016\/j.ekir.2025.10.022_bib2","first-page":"195","article-title":"Characterization of cryofibrinogen isolated from patients plasma","volume":"10","author":"Stathakis","year":"1981","journal-title":"Haemostasis"},{"key":"10.1016\/j.ekir.2025.10.022_bib3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1055\/a-2075-8204","article-title":"Cryofibrinogen\u2014characteristics and association with cryoglobulin: a retrospective study out of a series of 1712 samples over 7 years","volume":"123","author":"Sarda-Kolopp","year":"2023","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ekir.2025.10.022_bib4","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.amjmed.2009.03.040","article-title":"Cryofibrinogenemia: new insights into clinical and pathogenic features","volume":"122","author":"Saadoun","year":"2009","journal-title":"Am J Med"},{"key":"10.1016\/j.ekir.2025.10.022_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1365-2249.2000.01210.x","article-title":"Cryofibrinogenaemia: a study of 49 patients","volume":"120","author":"Blain","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ekir.2025.10.022_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/rheumatology\/kem341","article-title":"Outcome of essential cryofibrinogenaemia in a series of 61 patients","volume":"47","author":"Belizna","year":"2008","journal-title":"Rheumatology (Oxford, England)"},{"key":"10.1016\/j.ekir.2025.10.022_bib7","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1093\/ndt\/gfr079","article-title":"Prevalence and clinical significance of cryofibrinogenaemia in patients with renal disorders","volume":"26","author":"Terrier","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2025.10.022_bib8","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/ijd.15234","article-title":"High prevalence of cryofibrinogenemia in patients with chilblains during the COVID-19 outbreak","volume":"59","author":"G\u00f3mez-Fern\u00e1ndez","year":"2020","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ekir.2025.10.022_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jdcr.2022.03.025","article-title":"The clot thickens with COVID-19 and cryofibrinogenemia: a thought-provoking association","volume":"24","author":"Perry","year":"2022","journal-title":"JAAD Case Rep"},{"key":"10.1016\/j.ekir.2025.10.022_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/j.ajkd.2016.08.031","article-title":"Cryofibrinogen-associated glomerulonephritis","volume":"69","author":"Sethi","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2025.10.022_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12882-020-1696-0","article-title":"Characteristic electron-microscopic features of cryofibrinogen-associated glomerulonephritis: a case report","volume":"21","author":"Ibuki","year":"2020","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ekir.2025.10.022_bib12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ekir.2025.10.022_bib13","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1681\/ASN.2015020114","article-title":"Spectrum and prognosis of noninfectious renal mixed cryoglobulinemic GN","volume":"27","author":"Zaidan","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2025.10.022_bib14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.kint.2020.04.020","article-title":"Controversies in acute kidney injury: conclusions from a Kidney Disease: improving Global Outcomes (KDIGO) Conference","volume":"98","author":"Ostermann","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2025.10.022_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/ajcp\/58.5.524","article-title":"Cryofibrinogenemia: incidence, clinical correlations, and a review of the literature","volume":"58","author":"Smith","year":"1972","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ekir.2025.10.022_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.revmed.2009.12.019","article-title":"[Cryofibrinogenemia]","volume":"32","author":"Saadoun","year":"2011","journal-title":"Rev Med Intern"},{"key":"10.1016\/j.ekir.2025.10.022_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.revmed.2014.09.007","article-title":"[Cryofibrinogenemia: a single-center study at the University Hospital of Toulouse, France]","volume":"36","author":"Michaud","year":"2015","journal-title":"Rev Med Intern"},{"key":"10.1016\/j.ekir.2025.10.022_bib18","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1515\/cclm-2022-0423","article-title":"Analysis of cryoproteins with a focus on cryofibrinogen: a study on 103 patients","volume":"60","author":"Natali","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ekir.2025.10.022_bib19","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/ajkd.1998.v32.pm9740168","article-title":"Cryofibrinogenemia: an addition to the differential diagnosis of calciphylaxis in end-stage renal disease","volume":"32","author":"Sankarasubbaiyan","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2025.10.022_bib20","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1093\/ndt\/gfm045","article-title":"Nephrotic syndrome and chronic renal insufficiency associated with essential cryofibrinogenemia","volume":"22","author":"Singh","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2025.10.022_bib21","first-page":"83","article-title":"Cryofibrinogen-associated glomerulonephritis diagnosed by mass spectrometry and immunoelectron microscopy","volume":"15","author":"Sudo","year":"2019","journal-title":"Hum Pathol: Case Rep"},{"key":"10.1016\/j.ekir.2025.10.022_bib22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s13730-021-00602-0","article-title":"Cryofibrinogen-associated glomerulonephritis accompanied by advanced gastric cancer","volume":"10","author":"Kakeshita","year":"2021","journal-title":"CEN Case Rep"},{"key":"10.1016\/j.ekir.2025.10.022_bib23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.amjmed.2003.09.033","article-title":"An approach to the diagnosis and treatment of cryofibrinogenemia","volume":"116","author":"Amdo","year":"2004","journal-title":"Am J Med"},{"issue":"Suppl 17","key":"10.1016\/j.ekir.2025.10.022_bib24","first-page":"57","article-title":"Cryofibrinogenaemia and skin ulcers: treatment with plasmapheresis","volume":"101","author":"Copeman","year":"1979","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ekir.2025.10.022_bib25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0140-6736(91)90483-6","article-title":"Stanozolol in treatment of leg ulcers due to cryofibrinogenaemia","volume":"338","author":"Falanga","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ekir.2025.10.022_bib26","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.kint.2023.05.004","article-title":"Cryofibrinogen-associated membranoproliferative glomerulonephritis","volume":"104","author":"Kim","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2025.10.022_bib27","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2169\/internalmedicine.2897-23","article-title":"Discontinuing hemodialysis through corticosteroid treatment in a patient with cryofibrinogen-associated glomerulonephritis","volume":"63","author":"Arai","year":"2024","journal-title":"Intern Med"},{"key":"10.1016\/j.ekir.2025.10.022_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s41100-024-00563-x","article-title":"A case of fulminant cryofibrinogenemia with rapid renal dysfunction and toe necrosis","volume":"10","author":"Kobayashi","year":"2024","journal-title":"Ren Replace Ther"},{"key":"10.1016\/j.ekir.2025.10.022_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1001\/archderm.1979.04010020054017","article-title":"Cryofibrinogenemia, monoclonal gammopathy, and purpura. Report of a case and review of the literature","volume":"115","author":"Martin","year":"1979","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ekir.2025.10.022_bib30","first-page":"769","article-title":"[Cryofibrinogenemia caused by monoclonal antifibrinogen antibodies]","volume":"122","author":"Zeuner","year":"1997","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.ekir.2025.10.022_bib32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.ajkd.2023.07.017","article-title":"Cryoglobulinemic vasculitis in disguise: cryofibrinogenemia as variant of monoclonal gammopathy of renal significance","volume":"83","author":"Gant","year":"2024","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2025.10.022_bib33","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/jcm14051656","article-title":"Cryfibrinogen-associated glomerulonephritis and monoclonal gammopathy of renal significance\u2014case report and literature review","volume":"14","author":"Terzolo","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.ekir.2025.10.022_bib34","article-title":"Cryofibrinogen-associated glomerulonephritis with paraproteinemia","volume":"16","author":"Tang","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.ekir.2025.10.022_bib35","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/cancers15020480","article-title":"Monoclonal gammopathy of thrombotic significance","volume":"15","author":"Gkalea","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ekir.2025.10.022_bib36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1053\/j.ajkd.2021.12.014","article-title":"Complement activation and thrombotic microangiopathy associated with monoclonal gammopathy: a national French case series","volume":"80","author":"Martins","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2025.10.022_bib37","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.autrev.2011.04.009","article-title":"A 5-year prospective follow-up study in essential cryofibrinogenemia patients","volume":"10","author":"Belizna","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ekir.2025.10.022_bib38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000184385","article-title":"Cryoglobulinaemia and cryofibrinogenaemia in IgA nephropathy: a follow-up study","volume":"46","author":"Nagy","year":"1987","journal-title":"Nephron"},{"key":"10.1016\/j.ekir.2025.10.022_bib39","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.kint.2024.06.009","article-title":"Kidney-limited TMA is common in patients with complement dysregulation","volume":"106","author":"van Doorn","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2025.10.022_bib40","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.kint.2024.02.014","article-title":"Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies","volume":"105","author":"Maisons","year":"2024","journal-title":"Kidney Int"}],"container-title":["Kidney International Reports\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024925006667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024925006667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:21:39Z","timestamp":1766481699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024925006667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2468024925006667"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2025.10.022","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological Spectrum and Treatment Outcomes of Cryofibrinogen-Associated Nephropathies","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2025.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}