{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:48:23Z","timestamp":1785750503078,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ekir.2026.106583","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:41:49Z","timestamp":1778283709000},"page":"106583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomized Controlled Study of Sirolimus-Coated Balloons for Dysfunctional Hemodialysis Fistulas"],"prefix":"10.1016","volume":"11","author":[{"given":"Chieh Suai","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru Yu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Tieng Chek Choke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Wooi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Ren Kwang Tng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gek Hsiang","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien Ts\u2019ung","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Da Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Jie","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Vijaykumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Kang Lie Aw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Tec","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang Hiong","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suh Chien","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2026.106583_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2019.12.001","article-title":"KDOQI clinical practice guideline for vascular access: 2019 update","volume":"75","author":"Lok","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2026.106583_bib2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/sdi.12658","article-title":"The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: optimism unfulfilled","volume":"31","author":"Viecelli","year":"2018","journal-title":"Semin Dial"},{"key":"10.1016\/j.ekir.2026.106583_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1053\/j.ackd.2015.06.010","article-title":"New developments in our understanding of neointimal hyperplasia","volume":"22","author":"Lee","year":"2015","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.ekir.2026.106583_bib4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/snep.2002.31739","article-title":"Angioplasty for arteriovenous grafts and fistulae","volume":"22","author":"Beathard","year":"2002","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ekir.2026.106583_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMoa1914617","article-title":"Drug-coated balloons for dysfunctional dialysis arteriovenous fistulas","volume":"383","author":"Lookstein","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ekir.2026.106583_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.kint.2023.03.015","article-title":"Prospective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis","volume":"104","author":"Dolmatch","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2026.106583_bib7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.kint.2025.01.006","article-title":"Six-month safety and efficacy outcomes from the randomized-controlled arm of the WRAPSODY Arteriovenous Access Efficacy (WAVE) trial","volume":"107","author":"Razavi","year":"2025","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2026.106583_bib8","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.2215\/CJN.03490413","article-title":"Novel paradigms for dialysis vascular access: downstream vascular biology--is there a final common pathway?","volume":"8","author":"Lee","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2026.106583_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.ajkd.2003.09.015","article-title":"Highly increased cell proliferation activity in the restenotic hemodialysis vascular access after percutaneous transluminal angioplasty: implication in prevention of restenosis","volume":"43","author":"Chang","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2026.106583_bib10","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1681\/ASN.2005050615","article-title":"Hemodialysis vascular access dysfunction: a cellular and molecular viewpoint","volume":"17","author":"Roy-Chaudhury","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2026.106583_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5301\/jva.5000271","article-title":"The eternal tale of dialysis access vessels and restenosis: are drug-eluting balloons the solution?","volume":"15","author":"Portugaller","year":"2014","journal-title":"J Vasc Access"},{"key":"10.1016\/j.ekir.2026.106583_bib12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/01.CIR.96.2.636","article-title":"Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery","volume":"96","author":"Axel","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ekir.2026.106583_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1053\/j.semvascsurg.2016.08.002","article-title":"Drug-coated balloon angioplasty for dialysis access fistula stenosis","volume":"29","author":"Boitet","year":"2016","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.ekir.2026.106583_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.21037\/cdt-22-497","article-title":"Choosing the right treatment for the right lesion, Part II: A narrative review of drug-coated balloon angioplasty and its evolving role in dialysis access maintenance","volume":"13","author":"DePietro","year":"2023","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.ekir.2026.106583_bib15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jvir.2019.01.012","article-title":"Drug-coated balloon angioplasty in hemodialysis circuits: A systematic review and meta-analysis","volume":"30","author":"Kennedy","year":"2019","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.ekir.2026.106583_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/0886022X.2022.2029487","article-title":"Paclitaxel coated balloon versus conventional balloon angioplasty in dysfunctional dialysis arteriovenous fistula: a systematic review and meta-analysis of randomized controlled trials","volume":"44","author":"Luo","year":"2022","journal-title":"Ren Fail"},{"key":"10.1016\/j.ekir.2026.106583_bib17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ejvs.2021.06.006","article-title":"Drug coated balloons for dysfunctional haemodialysis venous access: a patient level meta-analysis of randomised controlled trials","volume":"62","author":"Fong","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ekir.2026.106583_bib18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1177\/11297298211005290","article-title":"Plain versus paclitaxel-coated balloon angioplasty in arteriovenous fistula and graft stenosis: an umbrella review","volume":"23","author":"Lazarides","year":"2022","journal-title":"J Vasc Access"},{"key":"10.1016\/j.ekir.2026.106583_bib19","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2215\/CJN.14231217","article-title":"Drug coated balloon angioplasty in failing AV fistulas: A randomized controlled trial","volume":"13","author":"Trerotola","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2026.106583_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.kint.2021.02.040","article-title":"A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas","volume":"100","author":"Karunanithy","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2026.106583_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/j.ajkd.2020.11.022","article-title":"Efficacy and safety of paclitaxel-coated balloon angioplasty for dysfunctional arteriovenous fistulas: a multicenter randomized controlled trial","volume":"78","author":"Yin","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2026.106583_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2215\/CJN.0000000000000359","article-title":"Drug-coated balloon angioplasty for dysfunctional arteriovenous hemodialysis fistulae: a randomized controlled trial","volume":"19","author":"Zhao","year":"2024","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2026.106583_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ndt\/14.1.118","article-title":"Sites of stenosis in AV fistulae for haemodialysis access","volume":"14","author":"Sivanesan","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ekir.2026.106583_bib24","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2214\/AJR.15.14650","article-title":"Arteriovenous fistulas and their characteristic sites of stenosis","volume":"205","author":"Quencer","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ekir.2026.106583_bib25","first-page":"508","article-title":"Magic Touch(R): preliminary clinical evidence with a novel sirolimus drug coated balloon","volume":"66","author":"Cortese","year":"2018","journal-title":"Minerva Cardioangiol"},{"key":"10.1016\/j.ekir.2026.106583_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.003543","article-title":"Novel sirolimus-coated balloon catheter: in vivo evaluation in a porcine coronary model","volume":"9","author":"Clever","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"issue":"Suppl 1","key":"10.1016\/j.ekir.2026.106583_bib27","first-page":"S13","article-title":"Choosing a drug-eluting stent: a comparison between CYPHER and TAXUS","volume":"6","author":"Perin","year":"2005","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.ekir.2026.106583_bib28","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa042831","article-title":"Sirolimus for Kaposi\u2019s sarcoma in renal-transplant recipients","volume":"352","author":"Stallone","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ekir.2026.106583_bib29","doi-asserted-by":"crossref","first-page":"E462","DOI":"10.1111\/ctr.12139","article-title":"Epstein-Barr virus-associated smooth muscle tumors after kidney transplantation: treatment and outcomes in a single center","volume":"27","author":"Tan","year":"2013","journal-title":"Clin Transpl"},{"key":"10.1016\/j.ekir.2026.106583_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.avsg.2023.12.096","article-title":"MagicTouch PTA sirolimus-coated balloon for femoropopliteal and below-the-knee disease: 3-year outcomes of the XTOSI trial","volume":"106","author":"Choke","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.ekir.2026.106583_bib31","first-page":"625","article-title":"Comparison of sirolimus-versus paclitaxel-coated balloons in coronary artery disease: one-year results of two real-world prospective registries","volume":"106","author":"Vlieger","year":"2025","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.ekir.2026.106583_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jvir.2020.11.010","article-title":"Single-center prospective pilot study of sirolimus drug-coated balloon angioplasty in maintaining the patency of thrombosed arteriovenous graft","volume":"32","author":"Tan","year":"2021","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.ekir.2026.106583_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241321","article-title":"Early (6 months) results of a pilot prospective study to investigate the efficacy and safety of sirolimus coated balloon angioplasty for dysfunctional arterio-venous fistulas: MAgicTouch Intervention Leap for Dialysis Access (MATILDA) Trial","volume":"15","author":"Tang","year":"2020","journal-title":"PLOS One"},{"key":"10.1016\/j.ekir.2026.106583_bib34","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1177\/11297298211067059","article-title":"Endovascular salvage of failing arterio-venous fistulas utilising sirolimus eluting balloons: six months results from the ISABELLA trial","volume":"24","author":"Tang","year":"2023","journal-title":"J Vasc Access"},{"key":"10.1016\/j.ekir.2026.106583_bib35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/11297298221104310","article-title":"Sirolimus-coated balloon angioplasty in maintaining the patency of thrombosed arteriovenous graft: 1-year results of a prospective study","volume":"25","author":"Tan","year":"2024","journal-title":"J Vasc Access"},{"key":"10.1016\/j.ekir.2026.106583_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s42155-022-00287-1","article-title":"Utility of the selution SLR sirolimus eluting balloon to rescue failing arterio-venous fistulas \u221212 month results of the ISABELLA Registry from Singapore","volume":"5","author":"Tang","year":"2022","journal-title":"CVIR Endovasc"},{"key":"10.1016\/j.ekir.2026.106583_bib37","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/nep.13591","article-title":"Paclitaxel-coated balloon in the treatment of recurrent dysfunctional arteriovenous access, real-world experience and longitudinal follow up","volume":"24","author":"Phang","year":"2019","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.ekir.2026.106583_bib38","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1186\/s13063-021-05920-3","article-title":"SIroliMus coated angioplasty versus plain balloon angioplasty in the tREatment of dialySis acceSs dysfunctION (impression): study protocol for a randomized controlled trial","volume":"22","author":"Pang","year":"2021","journal-title":"Trials"},{"key":"10.1016\/j.ekir.2026.106583_bib39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/14796678.2024.2345023","article-title":"Magic Touch sirolimus-coated balloon: animal and clinical evidence of a coronary sirolimus drug-coated balloon","volume":"20","author":"Cortese","year":"2024","journal-title":"Future Cardiol"},{"key":"10.1016\/j.ekir.2026.106583_bib40","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41581-022-00542-7","article-title":"Epidemiology of haemodialysis outcomes","volume":"18","author":"Bello","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ekir.2026.106583_bib41","series-title":"Singapore Renal Registry Annual Report 2022","year":"2024"},{"key":"10.1016\/j.ekir.2026.106583_bib42","series-title":"2023 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States","year":"2023"},{"key":"10.1016\/j.ekir.2026.106583_bib43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.21037\/cdt-22-375","article-title":"Choosing the right treatment for the right lesion, part I: A narrative review of the role of plain balloon angioplasty in dialysis access maintenance","volume":"13","author":"DePietro","year":"2022","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.ekir.2026.106583_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvir.2019.08.035","article-title":"The Lutonix AV randomized trial of paclitaxel-coated balloons in arteriovenous fistula stenosis: 2-year results and subgroup analysis","volume":"31","author":"Trerotola","year":"2020","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.ekir.2026.106583_bib45","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jvir.2022.03.606","article-title":"IN.PACT AV access randomized trial: 12-month clinical results demonstrating the sustained treatment effect of drug-coated balloons","volume":"33","author":"Holden","year":"2022","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.ekir.2026.106583_bib46","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jacc.2007.06.047","article-title":"A meta-analysis of 16 randomized trials of sirolimus-eluting stents versus paclitaxel-eluting stents in patients with coronary artery disease","volume":"50","author":"Schomig","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ekir.2026.106583_bib47","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1056\/NEJMoa1510188","article-title":"Paclitaxel-eluting versus everolimus-eluting coronary stents in diabetes","volume":"373","author":"Kaul","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ekir.2026.106583_bib48","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJMoa0910496","article-title":"Everolimus-eluting versus paclitaxel-eluting stents in coronary artery disease","volume":"362","author":"Stone","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ekir.2026.106583_bib49","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/1526602819872154","article-title":"Mortality after paclitaxel-coated device use in dialysis access: a systematic review and meta-analysis","volume":"26","author":"Dinh","year":"2019","journal-title":"J Endovasc Ther"},{"key":"10.1016\/j.ekir.2026.106583_bib50","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(25)01584-3","article-title":"Paclitaxel-coated versus uncoated devices for infrainguinal endovascular revascularisation in patients with intermittent claudication (SWEDEPAD 2): a multicentre, participant-masked, registry-based, randomised controlled trial","volume":"406","author":"Nordanstig","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.ekir.2026.106583_bib51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jvir.2013.10.020","article-title":"Randomized clinical trial of cutting balloon angioplasty versus high-pressure balloon angioplasty in hemodialysis arteriovenous fistula stenoses resistant to conventional balloon angioplasty","volume":"25","author":"Aftab","year":"2014","journal-title":"J Vasc Interv Radiol"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024926028159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468024926028159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:33:12Z","timestamp":1785749592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468024926028159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2468024926028159"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2026.106583","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized Controlled Study of Sirolimus-Coated Balloons for Dysfunctional Hemodialysis Fistulas","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2026.106583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}],"article-number":"106583"}}