{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:28:05Z","timestamp":1793741285824,"version":"4.6.1"},"reference-count":9,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007773","name":"Danone","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kireports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International Reports"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ekir.2026.107090","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:30:24Z","timestamp":1789972224000},"page":"107090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Creatinine: Refining Kidney Function End Points in ADPKD Clinical Trials"],"prefix":"10.1016","volume":"11","author":[{"given":"Gopala","family":"Rangan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ekir.2026.107090_bib1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0140-6736(26)00046-2","article-title":"Autosomal dominant polycystic kidney disease","volume":"407","author":"Ong","year":"2026","journal-title":"Lancet"},{"key":"10.1016\/j.ekir.2026.107090_bib2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2215\/CJN.05360522","article-title":"Current challenges and perspectives on developing a clinical trial design for ADPKD","volume":"17","author":"Ostroff","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ekir.2026.107090_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ekir.2016.08.001","article-title":"Prognostic enrichment design in clinical trials for autosomal dominant polycystic kidney disease: the TEMPO 3:4 clinical trial","volume":"1","author":"Irazabal","year":"2016","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ekir.2026.107090_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2022.100538","article-title":"The STAGED-PKD 2-stage adaptive study with a patient enrichment strategy and treatment effect modeling for improved study design efficiency in patients with ADPKD","volume":"4","author":"Perrone","year":"2022","journal-title":"Kidney Med"},{"key":"10.1016\/j.ekir.2026.107090_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1053\/j.ajkd.2019.07.019","article-title":"Change in albuminuria and estimated GFR as end points for clinical trials in early stages of CKD: a perspective from European regulators","volume":"75","author":"Holtkamp","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2026.107090_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1053\/j.ajkd.2019.06.009","article-title":"Change in albuminuria and GFR as end points for clinical trials in early stages of CKD: a scientific workshop sponsored by the National Kidney Foundation in collaboration with the US Food and Drug Administration and European Medicines Agency","volume":"75","author":"Levey","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ekir.2026.107090_bib7","article-title":"Combining cystatin C and creatinine increases eGFR slope accuracy in ADPKD","volume":"11","author":"Bais","year":"2026","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ekir.2026.107090_bib8","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/j.ekir.2026.107090_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmrv.2025.150935","article-title":"A practical review of adaptive platform trials","volume":"39","author":"Angeloni","year":"2025","journal-title":"Transfus Med Rev"}],"container-title":["Kidney International Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246802492603322X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246802492603322X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:30:30Z","timestamp":1793737830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246802492603322X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S246802492603322X"],"URL":"https:\/\/doi.org\/10.1016\/j.ekir.2026.107090","relation":{},"ISSN":["2468-0249"],"issn-type":[{"value":"2468-0249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond Creatinine: Refining Kidney Function End Points in ADPKD Clinical Trials","name":"articletitle","label":"Article Title"},{"value":"Kidney International Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2026.107090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ekir.2026.107008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2026 Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}],"article-number":"107090"}}