{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:40:18Z","timestamp":1760082018128,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n (English ed.)"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.endien.2025.501636","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:23:50Z","timestamp":1759879430000},"page":"501636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ectopic Cushing's syndrome in a patient with DIPNECH and metastatic lung carcinoid"],"prefix":"10.1016","volume":"72","author":[{"given":"Sara","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telma","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Lume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa C.","family":"Couto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o","family":"Souto-Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Varela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Belo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.endien.2025.501636_bib0145","series-title":"WHO classification of tumours of the lung, pleura, thymus and heart","first-page":"412","author":"Travis","year":"2015"},{"key":"10.1016\/j.endien.2025.501636_bib0150","doi-asserted-by":"crossref","first-page":"e230051","DOI":"10.1530\/ERC-23-0051","article-title":"DIPNECH: pragmatic approach, uncertainties, notable associations, and a proposal for an improved definition","volume":"30","author":"Samhouri","year":"2023","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.endien.2025.501636_bib0155","doi-asserted-by":"crossref","first-page":"2101058","DOI":"10.1183\/13993003.01058-2021","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: clinical characteristics and progression to carcinoid tumour","volume":"59","author":"Sun","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.endien.2025.501636_bib0160","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.3390\/jcm10132950","article-title":"Long-term imaging follow-up in DIPNECH: multicenter experience","volume":"10","author":"Chung","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.endien.2025.501636_bib0165","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJM199210293271806","article-title":"Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease","volume":"327","author":"Aguayo","year":"1992","journal-title":"N Engl J Med"},{"article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","year":"2021","series-title":"WHO classification of tumours","key":"10.1016\/j.endien.2025.501636_bib0170"},{"key":"10.1016\/j.endien.2025.501636_bib0175","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.chest.2020.08.012","article-title":"Clinical characteristics of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a retrospective analysis","volume":"159","author":"Almquist","year":"2021","journal-title":"Chest"},{"issue":"Suppl. 7","key":"10.1016\/j.endien.2025.501636_bib0180","doi-asserted-by":"crossref","first-page":"vii65","DOI":"10.1093\/annonc\/mdq380","article-title":"Advances in neuroendocrine lung tumors","volume":"21","author":"Travis","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.endien.2025.501636_bib0185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11864-021-00828-1","article-title":"An update on the management of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)","volume":"22","author":"Al-Toubah","year":"2021","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.endien.2025.501636_bib0190","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/cncr.26200","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity","volume":"118","author":"Gorshtein","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.endien.2025.501636_bib0195","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/PAS.0000000000001033","article-title":"Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) syndrome and carcinoid tumors with\/without NECH: a clinicopathologic, radiologic, and immunomolecular comparison study","volume":"42","author":"Mengoli","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.endien.2025.501636_bib0200","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/thx.2006.063065","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease","volume":"62","author":"Davies","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.endien.2025.501636_bib0205","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.21037\/tlcr-22-415","article-title":"A multidisciplinary approach to the work up and management of pulmonary carcinoid tumors and DIPNECH: a narrative review","volume":"11","author":"Ramirez","year":"2022","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.endien.2025.501636_bib0210","doi-asserted-by":"crossref","first-page":"e228536","DOI":"10.1136\/bcr-2018-228536","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) with liver metastases","volume":"12","author":"Flint","year":"2019","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.endien.2025.501636_bib0215","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/ijc.30400","article-title":"The epidemiology of metastases in neuroendocrine tumors","volume":"139","author":"Riihimaki","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1016\/j.endien.2025.501636_bib0220","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.humpath.2004.02.016","article-title":"TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location","volume":"35","author":"Du","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.endien.2025.501636_bib0225","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/hupa.2002.31299","article-title":"Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids","volume":"33","author":"Sturm","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1016\/j.endien.2025.501636_bib0230","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/01.MP.0000086073.92773.55","article-title":"Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays","volume":"16","author":"Moskaluk","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.endien.2025.501636_bib0235","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13550-015-0130-2","article-title":"Somatostatin receptor PET\/CT in restaging of typical and atypical lung carcinoids","volume":"5","author":"Prasad","year":"2015","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.endien.2025.501636_bib0240","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1259\/bjr\/91375895","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an unusual cause of cyclical ectopic adrenocorticotrophic syndrome","volume":"84","author":"Cameron","year":"2011","journal-title":"Br J Radiol"},{"key":"10.1016\/j.endien.2025.501636_bib0245","doi-asserted-by":"crossref","first-page":"luae128","DOI":"10.1210\/jcemcr\/luae128","article-title":"Ectopic cushing syndrome secondary to diffuse idiopathic neuroendocrine cell hyperplasia \u2013 a report of 2 cases","volume":"2","author":"Lopez Fanas","year":"2024","journal-title":"JCEM Case Rep"},{"key":"10.1016\/j.endien.2025.501636_bib0250","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1440-1843.2004.00571.x","article-title":"Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly","volume":"9","author":"Fessler","year":"2004","journal-title":"Respirology"},{"key":"10.1016\/j.endien.2025.501636_bib0255","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1164\/rccm.201010-1685PP","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a systematic overview","volume":"184","author":"Nassar","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.endien.2025.501636_bib0260","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/annonc\/mdv041","article-title":"Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids","volume":"26","author":"Caplin","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.endien.2025.501636_bib0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000443167","article-title":"ENETS consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN of unknown primary site","volume":"103","author":"Pavel","year":"2016","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.endien.2025.501636_bib0270","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s12094-024-03607-0","article-title":"Management of typical and atypical metastatic lung carcinoids: present and future perspectives","volume":"27","author":"Rodrigues","year":"2025","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.endien.2025.501636_bib0275","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000475526","article-title":"ENETS consensus guidelines for the standards of care in neuroendocrine neoplasia: peptide receptor radionuclide therapy with radiolabeled somatostatin analogues","volume":"105","author":"Hicks","year":"2017","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.endien.2025.501636_bib0280","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa1607427","article-title":"Phase 3 trial of (177)Lu-dotatate for midgut neuroendocrine tumors","volume":"376","author":"Strosberg","year":"2017","journal-title":"N Engl J Med"}],"container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n (English ed.)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2530018025001088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2530018025001088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:23:39Z","timestamp":1760081019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2530018025001088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2530018025001088"],"URL":"https:\/\/doi.org\/10.1016\/j.endien.2025.501636","relation":{},"ISSN":["2530-0180"],"issn-type":[{"type":"print","value":"2530-0180"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ectopic Cushing's syndrome in a patient with DIPNECH and metastatic lung carcinoid","name":"articletitle","label":"Article Title"},{"value":"Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n (English ed.)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.endien.2025.501636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Espa\u00f1a, S.L.U. on behalf of SEEN and SED.","name":"copyright","label":"Copyright"}],"article-number":"501636"}}