{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:36:06Z","timestamp":1759178166682},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.endinu.2016.09.002","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T23:15:55Z","timestamp":1486250155000},"page":"82-91","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Caracterizaci\u00f3n de ensayos cl\u00ednicos relacionados con el tratamiento del s\u00edndrome metab\u00f3lico, 1980-2015"],"prefix":"10.1016","volume":"64","author":[{"given":"Santiago","family":"Cardona Vel\u00e1squez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Guzm\u00e1n Vivares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaiberth Antonio","family":"Cardona-Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0200","first-page":"25","article-title":"Epidemiolog\u00eda, diagn\u00f3stico, control, prevenci\u00f3n y tratamiento del s\u00edndrome metab\u00f3lico en adultos","volume":"18","year":"2010","journal-title":"Revista ALAD."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0205","first-page":"31","article-title":"Nueva definici\u00f3n mundial de la FID del s\u00edndrome metab\u00f3lico: Argumentos y resultados","volume":"50","author":"Zimmet","year":"2005","journal-title":"Diabetes Voice."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0210","first-page":"22","article-title":"Tratamiento de la hipertensi\u00f3n arterial en el paciente con s\u00edndrome metab\u00f3lico","volume":"17","author":"L\u00f3pez","year":"2010","journal-title":"Rev. Colomb. Cardiol."},{"issue":"4","key":"10.1016\/j.endinu.2016.09.002_bib0215","doi-asserted-by":"crossref","first-page":"315","DOI":"10.15381\/anales.v74i4.2705","article-title":"S\u00edndrome metab\u00f3lico: concepto y aplicaci\u00f3n pr\u00e1ctica","volume":"74","author":"Lizazaburu","year":"2013","journal-title":"An Fac med."},{"issue":"4","key":"10.1016\/j.endinu.2016.09.002_bib0220","doi-asserted-by":"crossref","first-page":"469","DOI":"10.7705\/biomedica.v31i4.626","article-title":"Las enfermedades cardiovasculares: un problema de salud p\u00fablica y un reto global","volume":"31","author":"G\u00f3mez","year":"2011","journal-title":"Biom\u00e9dica."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0225","first-page":"891","article-title":"Dimensi\u00f3n econ\u00f3mica del sobrepeso y la obesidad como problemas de salud p\u00fablica","volume":"16","author":"Garc\u00eda","year":"2010","journal-title":"Salud Tab."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0230","first-page":"250","article-title":"Epidemiolog\u00eda y prevenci\u00f3n del s\u00edndrome metab\u00f3lico","volume":"50","author":"El\u00edas","year":"2012","journal-title":"Rev Cubana Hig Epidemiol."},{"key":"10.1016\/j.endinu.2016.09.002_bib0235","first-page":"12","article-title":"S\u00edndrome metab\u00f3lico","volume":"174","author":"L\u00f3pez","year":"2007","journal-title":"Rev Posgrado la VIa C\u00e1tedra Med."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0240","first-page":"40","article-title":"S\u00edndrome metab\u00f3lico en el suroccidente de Barranquilla (Colombia)","volume":"24","author":"Navarro","year":"2008","journal-title":"Salud Uninorte."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0245","first-page":"111","article-title":"S\u00edndrome metab\u00f3lico: una mirada interdisciplinaria","volume":"15","author":"Barrera","year":"2008","journal-title":"Rev. Col. Cardiol."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0250","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.numecd.2013.09.018","article-title":"White fish reduces cardiovascular risk factors in patients with metabolic syndrome: the WISH-CARE study, a multicenter randomized clinical trial","volume":"24","author":"Vazquez","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis."},{"issue":"5","key":"10.1016\/j.endinu.2016.09.002_bib0255","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejim.2015.04.007","article-title":"Effects of a long-term lifestyle intervention program with Mediterranean diet and exercise for the management of patients with metabolic syndrome in a primary care setting","volume":"26","author":"Gomez","year":"2015","journal-title":"Eur J Intern Med."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0260","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.metabol.2013.11.016","article-title":"The one year exercise and lifestyle intervention program KLAKS: Effects on anthropometric parameters, cardiometabolic risk factors and glycemic control in childhood obesity","volume":"63","author":"Bl\u00fcher","year":"2015","journal-title":"Metabolism."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0265","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.atherosclerosis.2015.10.007","article-title":"Mesoglycan improves vascular reactivity and insulin sensitivity in patients with metabolic syndrome","volume":"243","author":"Valvano","year":"2015","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.endinu.2016.09.002_bib0270","unstructured":"Higgins JPT, Green S. (editors). Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011 [consultado 26 Nov 2015]. Disponible en: www.cochrane-handbook.org"},{"issue":"11","key":"10.1016\/j.endinu.2016.09.002_bib0275","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.medcli.2010.01.015","article-title":"Declaraci\u00f3n PRISMA. Una propuesta para mejorar la publicaci\u00f3n de revisiones sistem\u00e1ticas y metaan\u00e1lisis","volume":"135","author":"Urrutia","year":"2010","journal-title":"Medicina Cl\u00ednica."},{"issue":"10","key":"10.1016\/j.endinu.2016.09.002_bib0280","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/00004872-200018100-00021","article-title":"Haemodynamic and metabolic effects of rilmenidine in hypertensive patients with metabolic syndrome X. A double-blind parallel study versus amlodipine","volume":"18","author":"De Luca","year":"2000","journal-title":"J Hypertens."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0285","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9150(99)00283-X","article-title":"Effects of gemfibrozil on insulin sensitivity and on haemostatic variables in hypertriglyceridemic patients","volume":"148","author":"Mussoni","year":"2000","journal-title":"Atherosclerosis."},{"issue":"6","key":"10.1016\/j.endinu.2016.09.002_bib0290","first-page":"530","article-title":"PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin","volume":"36","author":"Willerson","year":"2009","journal-title":"Tex Heart Inst J."},{"issue":"7","key":"10.1016\/j.endinu.2016.09.002_bib0295","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.phymed.2009.10.014","article-title":"Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)","volume":"17","author":"Gurrola-D\u00edaz","year":"2010","journal-title":"Phytomedicine."},{"issue":"5","key":"10.1016\/j.endinu.2016.09.002_bib0300","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/S0004-27302010000500006","article-title":"Effect of n-3 fatty acids in glycemic and lipid profiles, oxidative stress and total antioxidant capacity in patients with the metabolic syndrome]","volume":"54","author":"Sim\u00e3o","year":"2010","journal-title":"Arq Bras Endocrinol Metabol."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0305","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.nut.2010.01.015","article-title":"Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome","volume":"27","author":"Basu","year":"2011","journal-title":"Nutrition."},{"issue":"6","key":"10.1016\/j.endinu.2016.09.002_bib0310","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.numecd.2011.11.006","article-title":"The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome","volume":"23","author":"Manning","year":"2013","journal-title":"Nutr Metab Cardiovasc Dis."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0315","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3736\/jintegrmed2013032","article-title":"Effects of chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial","volume":"11","author":"Wang","year":"2013","journal-title":"J Integ Med."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0320","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jdiacomp.2013.12.001","article-title":"Restorative yoga and metabolic risk factors: the Practicing Restorative Yoga vs. Stretching for the Metabolic Syndrome (PRYSMS) randomized trial","volume":"28","author":"Kanaya","year":"2014","journal-title":"J Diabetes Complications."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0325","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ebiom.2014.11.001","article-title":"Mild electrical stimulation with heat shock reduces visceral adiposity and improves metabolic abnormalities in subjects with metabolic syndrome or type 2 diabetes: randomized crossover trials","volume":"1","author":"Kondo","year":"2014","journal-title":"EBioMedicine."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0330","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atherosclerosis.2013.10.014","article-title":"Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome","volume":"232","author":"Tousoulis","year":"2014","journal-title":"Atherosclerosis."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0335","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ctim.2015.01.008","article-title":"Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial","volume":"23","author":"Amin","year":"2015","journal-title":"Complement Ther Med."},{"key":"10.1016\/j.endinu.2016.09.002_bib0340","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jcs.2015.05.008","article-title":"The consumption of a bread enriched with dietary fibre and l-carnitine improves glucose homoeostasis and insulin sensitivity in patients with metabolic syndrome","volume":"64","author":"Ba\u00f1uls","year":"2015","journal-title":"Journal of Cereal Science."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0345","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pec.2014.10.013","article-title":"Effects of an internet-based lifestyle intervention on cardio-metabolic risks and stress in Korean workers with metabolic syndrome: a controlled trial","volume":"98","author":"Kim","year":"2015","journal-title":"Patient Educ Couns."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0350","article-title":"Intervenci\u00f3n con rumba y educaci\u00f3n nutricional para modificar factores de riesgo cardiovascular en adultos con s\u00edndrome metab\u00f3lico","volume":"37","author":"P\u00e9rez-Id\u00e1rraga","year":"2015","journal-title":"Rev Panam Salud Publica."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0355","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.diabres.2012.09.037","article-title":"Prevalence of metabolic syndrome and prediction of diabetes using IDF versus ATPIII criteria in a Middle East population","volume":"98","author":"Hajat","year":"2012","journal-title":"Diabetes Res Clin Pract."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0360","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.diabres.2011.09.034","article-title":"High-intensity aerobic training improves endothelium-dependent vasodilation in patients with metabolic syndrome and type 2 diabetes mellitus","volume":"95","author":"Da Silva","year":"2012","journal-title":"Diabetes Res Clin Pract."},{"key":"10.1016\/j.endinu.2016.09.002_bib0365","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ypmed.2014.11.006","article-title":"Physical activity patterns and metabolic syndrome in Costa Rica","volume":"70","author":"Hastert","year":"2015","journal-title":"Prev Med."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0370","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.amjcard.2004.09.034","article-title":"Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome","volume":"95","author":"Deedwania","year":"2005","journal-title":"Am J Cardiol."},{"issue":"9311","key":"10.1016\/j.endinu.2016.09.002_bib0375","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0140-6736(02)08090-X","article-title":"Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol","volume":"359","author":"Lindholm Ibsen","year":"2002","journal-title":"Lancet."},{"issue":"2","key":"10.1016\/j.endinu.2016.09.002_bib0380","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1445-5994.2007.01238.x","article-title":"Metabolic effects of pioglitazone and rosiglitazone in patients with diabetes and metabolic syndrome treated with metformin","volume":"37","author":"Derosa","year":"2007","journal-title":"Intern Med J."},{"issue":"1","key":"10.1016\/j.endinu.2016.09.002_bib0385","first-page":"65","article-title":"La bio\u00e9tica y el uso de placebo en ensayos cl\u00ednicos controlados","volume":"41","author":"Villase\u00f1or","year":"2003","journal-title":"Rev Med IMSS."},{"issue":"3","key":"10.1016\/j.endinu.2016.09.002_bib0390","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4067\/S0718-48162008000400007","article-title":"Criterios para el uso del placebo: Aspectos \u00e9ticos","volume":"68","author":"Celed\u00f3n","year":"2008","journal-title":"Rev. Otorrinolaringol. Cir. Cabeza Cuello"}],"container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2530016416300027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2530016416300027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T22:51:28Z","timestamp":1636239088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2530016416300027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S2530016416300027"],"URL":"https:\/\/doi.org\/10.1016\/j.endinu.2016.09.002","relation":{},"ISSN":["2530-0164"],"issn-type":[{"type":"print","value":"2530-0164"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caracterizaci\u00f3n de ensayos cl\u00ednicos relacionados con el tratamiento del s\u00edndrome metab\u00f3lico, 1980-2015","name":"articletitle","label":"Article Title"},{"value":"Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.endinu.2016.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 SEEN. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}