{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:09:34Z","timestamp":1781381374496,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.endinu.2019.09.001","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T01:49:57Z","timestamp":1573696197000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences between patients with isolated GH deficiency based on findings in brain magnetic resonance imaging"],"prefix":"10.1016","volume":"67","author":[{"given":"Ana Belen","family":"Ariza Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Mart\u00ednez Aedo Ollero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"L\u00f3pez Siguero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.endinu.2019.09.001_bib0165","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.beem.2016.11.002","article-title":"Diagnosis of growth hormone deficiency in the paediatric and transitional age","volume":"30","author":"Chinoy","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0170","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1515\/jpem-2015-0404","article-title":"Pituitary volume in children with growth hormone deficiency, idiopathic short stature and controls","volume":"29","author":"Kessler","year":"2016","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/EJE-16-0105","article-title":"Cut-off limits of the peak GH response to stimulation tests for the diagnosis of GH deficiency in children and adolescents: study in patients with organic GHD","volume":"175","author":"Guzzetti","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.endinu.2019.09.001_bib0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4274\/jcrpe.1794","article-title":"Current practice in diagnosis and treatment of growth hormone deficiency in childhood: a survey from Turkey","volume":"7","author":"Poyrazo\u011flu","year":"2015","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"10.1016\/j.endinu.2019.09.001_bib0185","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/archdischild-2014-307228","article-title":"Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence","volume":"101","author":"Murray","year":"2016","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.endinu.2019.09.001_bib0190","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000350829","article-title":"Associations between pituitary imaging abnormalities and clinical and biochemical phenotypes in children with congenital growth hormone deficiency: data from an international observational study","volume":"79","author":"Deal","year":"2013","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000439590","article-title":"Brain magnetic resonance imaging as first-line investigation for growth hormone deficiency diagnosis in early childhood","volume":"84","author":"Pampanini","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000442830","article-title":"High frequency of normal response during GH stimulation tests in patients with ectopic posterior pituitary gland: a source of false-negative diagnosis of pituitary insufficiency","volume":"85","author":"Kochi","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0205","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1515\/jpem-2014-0209","article-title":"Pituitary gland size is a useful marker in diagnosing isolated growth hormone deficiency in short children","volume":"28","author":"Deeb","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0210","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000452150","article-title":"Clinical practice committee publication guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency","volume":"86","author":"Grimberg","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0215","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/cen.12788","article-title":"Relationship between pituitary stalk (PS) visibility and the severity of hormone deficiencies: PS interruption syndrome revisited","volume":"83","author":"Wang","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.endinu.2019.09.001_bib0220","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000289570","article-title":"Height at start, first-year growth response and cause of shortness at birth are major determinants of adult height outcomes of short children born small for gestational age and Silver-Russell syndrome treated with growth hormone: analysis of data from KIG","volume":"74","author":"Ranke","year":"2010","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000181823","article-title":"Evidence of morphological and functional abnormalities in the hypothalamus of growth-hormone-deficient children: a combined magnetic resonance imaging and endocrine study","volume":"34","author":"Bressani","year":"1990","journal-title":"Horm Res"},{"key":"10.1016\/j.endinu.2019.09.001_bib0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11102-011-0321-4","article-title":"Ectopic posterior pituitary and stalk abnormality predicts severity and coexisting hormone deficiencies in patients with congenital growth hormone deficiency","volume":"15","author":"Jagtap","year":"2012","journal-title":"Pituitary"},{"key":"10.1016\/j.endinu.2019.09.001_bib0235","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000448098","article-title":"Long-term outcomes, genetics, and pituitary morphology in patients with isolated growth hormone deficiency and multiple pituitary hormone deficiencies: a single-centre experience of four decades of growth hormone replacement","volume":"86","author":"LRohayem","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0240","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3892\/etm.2014.1778","article-title":"Three-dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children","volume":"8","author":"Han","year":"2014","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.endinu.2019.09.001_bib0245","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1515\/JPEM.2001.14.5.517","article-title":"Diagnostic value of pituitary MRI in differentiation of children with normal growth hormone secretion, isolated growth hormone deficiency and multiple pituitary hormone deficiency","volume":"14","author":"Arslano\u011flu","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0250","first-page":"531","article-title":"Biochemical tests in the diagnosis of childhood growth hormone deficiency","volume":"82","author":"Tillmann","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0255","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1530\/EJE-12-0801","article-title":"Magnetic resonance imaging of CNS in 15,043 children with GH deficiency in KIGS","volume":"168","author":"Maghnie","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.endinu.2019.09.001_bib0260","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4158\/EP14603.OR","article-title":"Trends in growth hormone stimulating testing and growth hormone dosing in adult growth hormone deficiency patients: results from the ANSWER program","volume":"22","author":"Gordon","year":"2016","journal-title":"Endocr Pract"},{"key":"10.1016\/j.endinu.2019.09.001_bib0265","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1210\/jc.2009-0602","article-title":"Reassessment of the growth hormone status in young adults with childhood-onset growth hormone deficiency: reappraisal of insulin tolerance testing","volume":"94","author":"Secco","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0270","first-page":"74","article-title":"Estudios espa\u00f1oles de crecimiento: situaci\u00f3n actual, utilidad y recomendaciones de uso","author":"S\u00e1nchez Gonz\u00e1lez","year":"2011","journal-title":"An Pediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0275","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/RCT.0b013e3181d9c2bb","article-title":"Incidental findings are frequent in young healthy individuals undergoing magnetic resonance imaging in brain research imaging studies: a prospective single-center study","volume":"34","author":"Hartwigsen","year":"2010","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0280","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jns.2005.09.008","article-title":"Incidental findings in magnetic resonance imaging of the brains of healthy young men","volume":"240","author":"Weber","year":"2005","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.endinu.2019.09.001_bib0285","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.surneu.2004.07.049","article-title":"Incidental findings in brain computed tomography scans of 3000 head trauma patients","volume":"63","author":"Eskandary","year":"2005","journal-title":"Surg Neurol"},{"key":"10.1016\/j.endinu.2019.09.001_bib0290","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1515\/jpem-2014-0209","article-title":"Pituitary gland size is a useful marker in diagnosing isolated growth hormone deficiency in short children","volume":"28","author":"Deeb","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0295","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/jpem-2013-0294","article-title":"Effect of growth hormone deficiency on brain MRI findings among children with growth restrictions","volume":"28","author":"Naderi","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0300","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1210\/jcem.86.10.7962","article-title":"Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: the influence of pituitary magnetic resonance imaging findings","volume":"86","author":"Coutant","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.09.001_bib0305","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12098-014-1412-9","article-title":"Response of Indian growth hormone deficient children to growth hormone therapy: association with pituitary size","volume":"82","author":"Khadilkar","year":"2015","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.endinu.2019.09.001_bib0310","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ghir.2015.05.001","article-title":"Growth, development, puberty and adult height before and during treatment in children with congenital isolated growth hormone deficiency","volume":"25","author":"Smuel","year":"2015","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.endinu.2019.09.001_bib0315","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.beem.2008.03.003","article-title":"Optimal use of growth hormone therapy for maximizing adult height in children born small for gestational age","volume":"22","author":"Simon","year":"2008","journal-title":"Best Pr Res Clin Endocrinol Metab [Internet]"},{"key":"10.1016\/j.endinu.2019.09.001_bib0320","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1687-9856-2013-9","article-title":"Characteristics of children with the best and poorest first- and second-year growth during rhGH therapy: data from 25 years of the Genentech national cooperative growth study (NCGS)","volume":"2013","author":"Kaplowitz","year":"2013","journal-title":"Int J Pediatr Endocrinol"}],"container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2530016419302241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2530016419302241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:07:00Z","timestamp":1762866420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2530016419302241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S2530016419302241"],"URL":"https:\/\/doi.org\/10.1016\/j.endinu.2019.09.001","relation":{},"ISSN":["2530-0164"],"issn-type":[{"value":"2530-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences between patients with isolated GH deficiency based on findings in brain magnetic resonance imaging","name":"articletitle","label":"Article Title"},{"value":"Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.endinu.2019.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 SEEN y SED. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}