{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:17:12Z","timestamp":1770646632045,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.endinu.2019.11.002","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T08:17:46Z","timestamp":1579681066000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retraso diagn\u00f3stico y terap\u00e9utico en el hiperparatiroidismo primario. Un problema no resuelto"],"prefix":"10.1016","volume":"67","author":[{"given":"Miguel","family":"Paja-Fano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela-Leyre","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andoni","family":"Monz\u00f3n-Mendiolea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.endinu.2019.11.002_bib0145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198001243020402","article-title":"Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community","volume":"302","author":"Heath","year":"1980","journal-title":"N Engl J Med"},{"issue":"Suppl 2","key":"10.1016\/j.endinu.2019.11.002_bib0150","first-page":"N18","article-title":"Epidemiology of primary hyperparathyroidism in Europe","volume":"17","author":"Adami","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.endinu.2019.11.002_bib0155","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1210\/jc.2014-3255","article-title":"Safety and efficacy of percutaneous parathyroid ethanol ablation in patients with recurrent primary hyperparathyroidism and multiple endocrine neoplasia type 1","volume":"100","author":"Singh Ospina","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0160","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-114-7-593","article-title":"Diagnosis and management of asymptomatic primary hyperparathyroidism: Consensus development conference statement","volume":"114","year":"1991","journal-title":"Ann Intern Med."},{"key":"10.1016\/j.endinu.2019.11.002_bib0165","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1210\/jc.2002-021370","article-title":"Summary statement from a workshop on asymptomatic primary hyperparathyroidism: A perspective for the 21st century","volume":"87","author":"Bilezikian","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0170","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1210\/jc.2008-1763","article-title":"Third International Workshop on the Management of Asymptomatic Primary Hyperthyroidism Guidelines for the management of asymptomatic primary hyperparathyroidism: Summary statement from the third international workshop","volume":"94","author":"Bilezikian","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0175","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: Summary statement from the Fourth International Workshop","volume":"99","author":"Bilezikian","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0180","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American Association of Endocrine Surgeons Guidelines for definitive management of primary hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg"},{"key":"10.1016\/j.endinu.2019.11.002_bib0185","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1308\/003588411X13020175704352","article-title":"Primary hyperparathyroidism: How many cases are being missed?","volume":"93","author":"Shapey","year":"2011","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.endinu.2019.11.002_bib0190","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.surg.2013.06.051","article-title":"The prevalence of undiagnosed and unrecognized primary hyperparathyroidism: A population-based analysis from the electronic medical record","volume":"154","author":"Press","year":"2013","journal-title":"Surgery"},{"key":"10.1016\/j.endinu.2019.11.002_bib0195","doi-asserted-by":"crossref","first-page":"e828","DOI":"10.1634\/theoncologist.2018-0424","article-title":"Failure to diagnose and treat hyperparathyroidism among patients with hypercalcemia: Opportunities for intervention at the patient and physician level to increase surgical referral","volume":"24","author":"Asban","year":"2019","journal-title":"Oncologist."},{"key":"10.1016\/j.endinu.2019.11.002_bib0200","doi-asserted-by":"crossref","DOI":"10.1001\/jamainternmed.2019.1747","article-title":"Diagnosis and management of primary hyperparathyroidism across the veterans affairs health care system","author":"Alore","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.endinu.2019.11.002_bib0205","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jc.2006-1836","article-title":"Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: A prospective, randomized trial","volume":"92","author":"Bollerslev","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0210","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1210\/jc.2007-0219","article-title":"Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: A prospective, randomized clinical trial","volume":"92","author":"Ambrogini","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0215","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1210\/jc.2007-1215","article-title":"The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years","volume":"93","author":"Rubin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0220","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.surg.2004.06.059","article-title":"Early parathyroidectomy increases bone mineral density in patients with mild primary hyperparathyroidism: A prospective and randomized study","volume":"136","author":"Almqvist","year":"2004","journal-title":"Surgery"},{"key":"10.1016\/j.endinu.2019.11.002_bib0225","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1210\/jc.2011-0569","article-title":"Nephrolithiasis and renal calcifications in primary hyperparathyroidism","volume":"96","author":"Rejnmark","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endinu.2019.11.002_bib0230","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ando.2015.03.002","article-title":"Primary hyperparathyroidism and nephrolithiasis","volume":"76","author":"Vestergaard","year":"2015","journal-title":"Ann Endocrinol (Paris)"},{"key":"10.1016\/j.endinu.2019.11.002_bib0235","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1530\/EJE-16-0430","article-title":"Mechanisms in endocrinology: Kidney involvement in patients with primary hyperparathyroidism: An update on clinical and molecular aspects","volume":"176","author":"Verdelli","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.endinu.2019.11.002_bib0240","first-page":"21","article-title":"Nephrolithiasis-induced end stage renal disease","volume":"3","author":"Ounissi","year":"2010","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"10.1016\/j.endinu.2019.11.002_bib0245","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.surg.2015.03.054","article-title":"Improvement in patient-reported physical and mental health after parathyroidectomy for primary hyperparathyroidism","volume":"158","author":"Zanocco","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.endinu.2019.11.002_bib0250","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/EC-15-0053","article-title":"Health-related quality of life is impaired in primary hyperparathyroidism and significantly improves after surgery: A prospective study using the 15D instrument","volume":"4","author":"Ryh\u00e4nen","year":"2015","journal-title":"Endocr Connect"},{"key":"10.1016\/j.endinu.2019.11.002_bib0255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/cen.13865","article-title":"Health-related quality of life improves 1 year after parathyroidectomy in primary hyperparathyroidism: A prospective cohort study","volume":"90","author":"Ejlsmark-Svensson","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.endinu.2019.11.002_bib0260","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1001\/archsurg.138.8.867","article-title":"Parathyroidectomy for primary hyperparathyroidism in octogenarians and nonagenarians: A plea for early surgical referral","volume":"138","author":"Kebebew","year":"2003","journal-title":"Arch Surg"},{"key":"10.1016\/j.endinu.2019.11.002_bib0265","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1634\/theoncologist.2010-0158","article-title":"Parathyroid surgery in the elderly","volume":"15","author":"Morris","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.endinu.2019.11.002_bib0270","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1177\/000313481408000819","article-title":"Hypercalcemia in the emergency department: A missed opportunity","volume":"80","author":"Royer","year":"2014","journal-title":"Am Surg"},{"key":"10.1016\/j.endinu.2019.11.002_bib0275","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ajem.2012.11.010","article-title":"Hypercalcemia in the ED: Prevalence, etiology, and outcome","volume":"31","author":"Lindner","year":"2013","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.endinu.2019.11.002_bib0280","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bone.2013.05.011","article-title":"Serum calcium (S-Ca), the forgotten test: Preliminary results of an appropriateness strategy to detect primary hyperparathyroidism (pHPT)","volume":"56","author":"Salinas","year":"2013","journal-title":"Bone"}],"container-title":["Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S253001642030001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S253001642030001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:06:46Z","timestamp":1762866406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S253001642030001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S253001642030001X"],"URL":"https:\/\/doi.org\/10.1016\/j.endinu.2019.11.002","relation":{},"ISSN":["2530-0164"],"issn-type":[{"value":"2530-0164","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retraso diagn\u00f3stico y terap\u00e9utico en el hiperparatiroidismo primario. Un problema no resuelto","name":"articletitle","label":"Article Title"},{"value":"Endocrinolog\u00eda, Diabetes y Nutrici\u00f3n","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.endinu.2019.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 SEEN y SED. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}