{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:39:00Z","timestamp":1786988340344,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocrinolog\u00eda y Nutrici\u00f3n"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.endonu.2010.09.006","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T04:31:35Z","timestamp":1294115495000},"page":"9-15","source":"Crossref","is-referenced-by-count":17,"title":["Serum free triiodothyronine (T3) to free thyroxine (T4) ratio in treated central hypothyroidism compared with primary hypothyroidism and euthyroidism"],"prefix":"10.1016","volume":"58","author":[{"given":"Gemma","family":"Sesmilo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Sim\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Choque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Casamitjana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.endonu.2010.09.006_bib0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1210\/edrv-2-1-87","article-title":"Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications","volume":"2","author":"Larsen","year":"1981","journal-title":"Endocr Rev."},{"key":"10.1016\/j.endonu.2010.09.006_bib0010","unstructured":"Larsen PR, Davies TF, Schlumberger M-J, Hay ID. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR., editors. William's Textbook of Endocrinology. Philadelphia, Saunders, 2008. P. 299\u2013332."},{"key":"10.1016\/j.endonu.2010.09.006_bib0015","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1172\/JCI111138","article-title":"Sources and quantity of 3,5,3\u2019-triiodothyronine in several tissues of the rat","volume":"72","author":"Van Doorn","year":"1983","journal-title":"J Clin Invest."},{"key":"10.1016\/j.endonu.2010.09.006_bib0020","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1210\/endo-117-3-1201","article-title":"Concentrations of thyroxine and 3,5,3\u2019-triiodothyronine at 34 different sites in euthyroid rats as determined by an isotopic equilibrium technique","volume":"117","author":"Van Doorn","year":"1985","journal-title":"Endocrinology."},{"key":"10.1016\/j.endonu.2010.09.006_bib0025","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1056\/NEJM198703263161302","article-title":"Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans","volume":"316","author":"Fish","year":"1987","journal-title":"N Engl J Med."},{"key":"10.1016\/j.endonu.2010.09.006_bib0030","doi-asserted-by":"crossref","first-page":"120","DOI":"10.14310\/horm.2002.11120","article-title":"The serum triiodothyronine to thyroxine (T3\/T4) ratio in various thyroid disorders and after Levothyroxine replacement therapy","volume":"3","author":"Mortoglou","year":"2004","journal-title":"Hormones (Athens)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0035","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jcem-41-5-911","article-title":"Opposite effects of dexamethasone on serum concentrations of 3,3\u2019,5\u2019-triiodothyronine (reverse T3) and 3,3\u20195-triiodothyronine (T3)","volume":"41","author":"Chopra","year":"1975","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0040","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/jcem-39-6-1151","article-title":"Effect of single dose dexamethasone on the concentration of serum triiodothyronine in man","volume":"39","author":"Duick","year":"1974","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0045","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1677\/joe.1.05974","article-title":"Developmentally defined regulation of thyroid hormone metabolism by glucocorticoids in the rat","volume":"185","author":"Van der","year":"2005","journal-title":"J Endocrinol."},{"key":"10.1016\/j.endonu.2010.09.006_bib0050","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1210\/jc.86.4.1518","article-title":"Effects of growth hormone (GH) administration on homocyst(e)ine levels in men with GH deficiency: a randomized controlled trial","volume":"86","author":"Sesmilo","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0055","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1210\/jc.84.3.924","article-title":"Evaluation of the adequacy of levothyroxine replacement therapy in patients with central hypothyroidism","volume":"84","author":"Ferretti","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1365-2265.1999.00650.x","article-title":"Life expectancy following surgery for pituitary tumours","volume":"50","author":"Bates","year":"1999","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","article-title":"Increased cerebrovascular mortality in patients with hypopituitarism","volume":"46","author":"Bulow","year":"1997","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0070","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1210\/jc.87.7.3509","article-title":"Excess vascular mortality in hypopituitarism: is it the result of estrogen or GH deficiency?","volume":"87","author":"Elhadd","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2265.2006.02545.x","article-title":"Hypopituitarism and mortality in pituitary adenoma","volume":"65","author":"Lindholm","year":"2006","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism","volume":"336","author":"Rosen","year":"1990","journal-title":"Lancet."},{"key":"10.1016\/j.endonu.2010.09.006_bib0085","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet."},{"key":"10.1016\/j.endonu.2010.09.006_bib0090","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2265.1994.tb01826.x","article-title":"Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults","volume":"41","author":"Jorgensen","year":"1994","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0095","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1210\/jc.2005-2555","article-title":"Thyroid morphology and function in adults with untreated isolated growth hormone deficiency","volume":"91","author":"Alc\u00e2ntara","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0100","first-page":"101","article-title":"TSH and thyroid hormones concentrations in patients with hypothyroidism receiving replacement therapy with L-thyroxine alone or in combination with L-triiodothyronine","volume":"4","author":"Fadeyev","year":"2005","journal-title":"Hormones (Athens)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0105","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1210\/en.137.6.2490","article-title":"Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat","volume":"137","author":"Escobar-Morreale","year":"1996","journal-title":"Endocrinology."},{"key":"10.1016\/j.endonu.2010.09.006_bib0110","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1210\/jc.2007-0297","article-title":"Thyroid hormone replacement for central hypothyroidism: a randomized controlled trial comparing two doses of thyroxine (T4) with a combination of T4 and triiodothyronine","volume":"92","author":"Slawik","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0115","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJM199902113400603","article-title":"Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism","volume":"340","author":"Bunevicius","year":"1999","journal-title":"N Engl J Med."},{"key":"10.1016\/j.endonu.2010.09.006_bib0120","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1001\/jama.290.22.2952","article-title":"Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial","volume":"290","author":"Clyde","year":"2003","journal-title":"JAMA."},{"key":"10.1016\/j.endonu.2010.09.006_bib0125","doi-asserted-by":"crossref","first-page":"412","DOI":"10.7326\/0003-4819-142-6-200503150-00007","article-title":"Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone","volume":"142","author":"Escobar-Morreale","year":"2005","journal-title":"Ann Intern Med."},{"key":"10.1016\/j.endonu.2010.09.006_bib0130","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1210\/jc.2004-1672","article-title":"Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial","volume":"90","author":"Saravanan","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0135","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1210\/jc.2003-030139","article-title":"Does a combination regimen of thyroxine (T4) and 3,5,3\u2019-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial","volume":"88","author":"Sawka","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0140","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1365-2265.2004.02050.x","article-title":"Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14: 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism","volume":"60","author":"Siegmund","year":"2004","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.1016\/j.endonu.2010.09.006_bib0145","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.2003-030249","article-title":"Combined thyroxine\/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism","volume":"88","author":"Walsh","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.endonu.2010.09.006_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/eje.0.1500001","article-title":"Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients","volume":"150","author":"Alexopoulou","year":"2004","journal-title":"Eur J Endocrinol."},{"key":"10.1016\/j.endonu.2010.09.006_bib0155","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/105072502760339406","article-title":"Thyrotropin suppression by thyroid hormone replacement is correlated with thyroxine level normalization in central hypothyroidism","volume":"12","author":"Shimon","year":"2002","journal-title":"Thyroid."},{"key":"10.1016\/j.endonu.2010.09.006_bib0160","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1210\/jc.82.4.1118","article-title":"Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement","volume":"82","author":"al Adsani","year":"1997","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Endocrinolog\u00eda y Nutrici\u00f3n"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1575092210002652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1575092210002652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T15:29:15Z","timestamp":1544023755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1575092210002652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1575092210002652"],"URL":"https:\/\/doi.org\/10.1016\/j.endonu.2010.09.006","relation":{},"ISSN":["1575-0922"],"issn-type":[{"value":"1575-0922","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}