{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:28:29Z","timestamp":1777508909888,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Regional Development Fund-European Social Fund","award":["SAF2012-37344"],"award-info":[{"award-number":["SAF2012-37344"]}]},{"name":"Canary Islands Government","award":["ACIISI PI2010"],"award-info":[{"award-number":["ACIISI PI2010"]}]},{"name":"Alfredo Martin-Reyes Foundation (Arehucas)-FICIC"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinolog\u00eda y Nutrici\u00f3n"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.endonu.2015.11.004","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T14:34:27Z","timestamp":1452177267000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sex steroids and growth hormone interactions"],"prefix":"10.1016","volume":"63","author":[{"given":"Leandro","family":"Fern\u00e1ndez-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"de Mirecki-Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"D\u00edaz-Chico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.endonu.2015.11.004_bib0365","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tig.2007.10.006","article-title":"How growth hormone controls growth, obesity and sexual dimorphism","volume":"24","author":"Lichanska","year":"2008","journal-title":"Trends Genet"},{"key":"10.1016\/j.endonu.2015.11.004_bib0370","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/er.2008-0027","article-title":"Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects","volume":"30","author":"Moller","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0375","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrendo.2010.123","article-title":"The growth hormone receptor: mechanism of activation and clinical implications","volume":"6","author":"Brooks","year":"2010","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0380","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fendo.2011.00032","article-title":"The intricate role of growth hormone in metabolism","volume":"2","author":"Vijayakumar","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.endonu.2015.11.004_bib0385","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.2011.06100.x","article-title":"Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism","volume":"1229","author":"Baik","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.endonu.2015.11.004_bib0390","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/er.2010-0009","article-title":"Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR\u2212\/\u2212) mouse","volume":"32","author":"List","year":"2011","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0395","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/ncpendmet0477","article-title":"Recognizing rare disorders: aromatase deficiency","volume":"3","author":"Jones","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0400","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1152\/ajpendo.00504.2009","article-title":"Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice","volume":"298","author":"Ribas","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0405","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cmet.2011.08.009","article-title":"Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction","volume":"14","author":"Xu","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0410","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1210\/er.2012-1055","article-title":"The role of estrogens in control of energy balance and glucose homeostasis","volume":"34","author":"Mauvais-Jarvis","year":"2013","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0415","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tem.2010.10.002","article-title":"Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity","volume":"22","author":"Mauvais-Jarvis","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0420","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/er.2004-0013","article-title":"The decline of androgen levels in elderly men and its clinical and therapeutic implications","volume":"26","author":"Kaufman","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0425","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrendo.2013.122","article-title":"Testosterone and insulin resistance in the metabolic syndrome and T2DM in men","volume":"9","author":"Rao","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0430","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1210\/er.2015-1034","article-title":"Determinants of receptor- and tissue-specific actions in androgen signaling","volume":"36","author":"Pihlajamaa","year":"2015","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0435","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/oby.21033","article-title":"The role of androgens in metabolism, obesity, and diabetes in males and females","volume":"23","author":"Navarro","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.endonu.2015.11.004_bib0440","first-page":"281","article-title":"The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence","volume":"13","author":"Kerrigan","year":"1992","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0445","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/03602530600570057","article-title":"Sex and the liver \u2013 a journey through five decades","volume":"38","author":"Mode","year":"2006","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0450","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/er.2003-0035","article-title":"Estrogen regulation of growth hormone action","volume":"25","author":"Leung","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0455","first-page":"2410","article-title":"Relation of estrogen and its receptor to rat liver growth and regeneration","volume":"44","author":"Fisher","year":"1984","journal-title":"Cancer Res"},{"key":"10.1016\/j.endonu.2015.11.004_bib0460","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1073\/pnas.97.10.5474","article-title":"Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice","volume":"97","author":"Vidal","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.endonu.2015.11.004_bib0465","doi-asserted-by":"crossref","first-page":"16625","DOI":"10.1074\/jbc.M602723200","article-title":"Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity","volume":"281","author":"Yamamoto","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.endonu.2015.11.004_bib0470","doi-asserted-by":"crossref","DOI":"10.1093\/carcin\/bgr094","article-title":"The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis","author":"Bigsby","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.endonu.2015.11.004_bib0475","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cmet.2011.01.002","article-title":"Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1","volume":"13","author":"Della Torre","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0480","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1096\/fj.08-128215","article-title":"Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a\/b: linking growth hormone to the androgen receptor","volume":"23","author":"Klover","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.endonu.2015.11.004_bib0485","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/carcin\/bgt304","article-title":"SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer","volume":"35","author":"Iglesias-Gato","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.endonu.2015.11.004_bib0490","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1073\/pnas.94.14.7239","article-title":"Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression","volume":"94","author":"Udy","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.endonu.2015.11.004_bib0495","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1210\/en.2010-0537","article-title":"GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism","volume":"152","author":"Barclay","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.endonu.2015.11.004_bib0500","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1172\/JCI42894","article-title":"Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2","volume":"121","author":"Sos","year":"2011","journal-title":"J Clin Investig"},{"key":"10.1016\/j.endonu.2015.11.004_bib0505","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1096\/fj.12-205583","article-title":"SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice","volume":"26","author":"Zadjali","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.endonu.2015.11.004_bib0510","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fendo.2014.00218","article-title":"Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice","volume":"5","author":"Fan","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.endonu.2015.11.004_bib0515","first-page":"e24911","article-title":"Interaction of JAK with steroid receptor function","volume":"2","author":"Gupta","year":"2013","journal-title":"JAKSTAT"},{"key":"10.1016\/j.endonu.2015.11.004_bib0520","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/edrv.22.1.0419","article-title":"The somatomedin hypothesis: 2001","volume":"22","author":"Le Roith","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0525","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1210\/er.2009-0010","article-title":"The role of liver-derived insulin-like growth factor-I","volume":"30","author":"Ohlsson","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0530","doi-asserted-by":"crossref","first-page":"e96305","DOI":"10.1371\/journal.pone.0096305","article-title":"Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver","volume":"9","author":"Fernandez-Perez","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.endonu.2015.11.004_bib0535","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/me.2006-0096","article-title":"In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver","volume":"21","author":"Vidal","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0540","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ymgme.2006.10.006","article-title":"Multiple mechanisms of growth hormone-regulated gene transcription","volume":"90","author":"Cesena","year":"2007","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0545","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1210\/me.2007-0549","article-title":"Sex-specific early growth hormone response genes in rat liver","volume":"22","author":"Wauthier","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0550","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1210\/me.2006-0007","article-title":"Growth hormone regulation of sex-dependent liver gene expression","volume":"20","author":"Waxman","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0555","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/me.2005-0170","article-title":"Negative regulation of growth hormone receptor signaling","volume":"20","author":"Flores-Morales","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0560","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cytogfr.2013.03.005","article-title":"Suppression of cytokine signaling: the SOCS perspective","volume":"24","author":"Linossi","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2012.03.026","article-title":"Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development","volume":"361","author":"Mueller","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0570","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/me.2004-0486","article-title":"Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes","volume":"19","author":"Bjornstrom","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0575","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1210\/mend.16.6.0845","article-title":"Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)","volume":"16","author":"Greenhalgh","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0580","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1210\/en.2006-1431","article-title":"Postnatal body growth is dependent on the transcription factors signal transducers and activators of transcription 5a\/b in muscle: a role for autocrine\/paracrine insulin-like growth factor I","volume":"148","author":"Klover","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.endonu.2015.11.004_bib0585","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ncpendmet0427","article-title":"Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1","volume":"3","author":"LeRoith","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0590","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/physiolgenomics.00093.2002","article-title":"Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles","volume":"16","author":"Tollet-Egnell","year":"2004","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.endonu.2015.11.004_bib0595","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1210\/jc.2006-0368","article-title":"Clinical and biochemical characteristics of a male patient with a novel homozygous STAT5b mutation","volume":"91","author":"Vidarsdottir","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0600","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrd4280","article-title":"Liver X receptors in lipid metabolism: opportunities for drug discovery","volume":"13","author":"Hong","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.endonu.2015.11.004_bib0605","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/HMBCI.2011.125","article-title":"Liver X receptor agonist downregulates growth hormone signaling in the liver","volume":"8","author":"Zadjali","year":"2011","journal-title":"Horm Mol Biol Clin Investig"},{"key":"10.1016\/j.endonu.2015.11.004_bib0610","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/153537020222700301","article-title":"Growth hormone-induced alterations in the insulin-signaling system","volume":"227","author":"Dominici","year":"2002","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.endonu.2015.11.004_bib0615","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1210\/en.2006-0518","article-title":"The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats","volume":"147","author":"Cho","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.endonu.2015.11.004_bib0620","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1172\/JCI200417763","article-title":"Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice","volume":"113","author":"Yakar","year":"2004","journal-title":"J Clin Investig"},{"key":"10.1016\/j.endonu.2015.11.004_bib0625","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cytogfr.2006.09.008","article-title":"Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions","volume":"17","author":"Rico-Bautista","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0630","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fendo.2015.00061","article-title":"Sexual dimorphism in glucose and lipid metabolism during fasting, hypoglycemia, and exercise","volume":"6","author":"Hedrington","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.endonu.2015.11.004_bib0635","doi-asserted-by":"crossref","first-page":"12309","DOI":"10.1073\/pnas.94.23.12309","article-title":"Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone","volume":"94","author":"Lahuna","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.endonu.2015.11.004_bib0640","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1210\/mend.14.2.0423","article-title":"Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone","volume":"14","author":"Lahuna","year":"2000","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.endonu.2015.11.004_bib0645","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00026.2006","article-title":"Estrogen receptors: how do they signal and what are their targets","volume":"87","author":"Heldring","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.endonu.2015.11.004_bib0650","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep.26951","article-title":"Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor\/Liver X receptor pathway in mice","volume":"59","author":"Han","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.endonu.2015.11.004_bib0655","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.beem.2015.04.001","article-title":"Overlapping nongenomic and genomic actions of thyroid hormone and steroids","volume":"29","author":"Hammes","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0660","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1056\/NEJM196701262760401","article-title":"The pancreatic beta cell. Structure and function","volume":"276","author":"Lacy","year":"1967","journal-title":"N Engl J Med"},{"key":"10.1016\/j.endonu.2015.11.004_bib0665","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2265.2006.02676.x","article-title":"Modulation of growth hormone action by sex steroids","volume":"65","author":"Meinhardt","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.endonu.2015.11.004_bib0670","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1359\/JBMR.050811","article-title":"Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis","volume":"20","author":"Venken","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.endonu.2015.11.004_bib0675","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1210\/jcem-72-2-374","article-title":"Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women","volume":"72","author":"Weissberger","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0680","first-page":"550","article-title":"Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women","volume":"82","author":"Burman","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0685","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ghir.2008.08.009","article-title":"Short-term oral oestrogen therapy dissociates the growth hormone\/insulin-like growth factor-I axis without altering energy metabolism in premenopausal women","volume":"19","author":"Huang","year":"2009","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.endonu.2015.11.004_bib0690","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1210\/jcem-30-1-85","article-title":"Anabolic and androgenic affect of testosterone in sexually immature boys and its dependency on growth hormone","volume":"30","author":"Zachmann","year":"1970","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.endonu.2015.11.004_bib0695","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0022-3476(76)80619-1","article-title":"Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism","volume":"89","author":"Aynsley-Green","year":"1976","journal-title":"J Pediatr"},{"key":"10.1016\/j.endonu.2015.11.004_bib0700","doi-asserted-by":"crossref","first-page":"E266","DOI":"10.1152\/ajpendo.00483.2004","article-title":"Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men","volume":"289","author":"Gibney","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"Suppl. 1","key":"10.1016\/j.endonu.2015.11.004_bib0705","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000329184","article-title":"Growth hormone and testosterone: anabolic effects on muscle","volume":"76","author":"Urban","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.endonu.2015.11.004_bib0710","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.2337\/db13-1505","article-title":"Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome","volume":"63","author":"Yu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.endonu.2015.11.004_bib0715","doi-asserted-by":"crossref","first-page":"e001","DOI":"10.1621\/nrs.11001","article-title":"Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone\/muscle, metabolic syndrome and neuron\/immune systems: lessons learned from mice lacking AR in specific cells","volume":"11","author":"Chang","year":"2013","journal-title":"Nucl Recept Signal"},{"key":"10.1016\/j.endonu.2015.11.004_bib0720","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/jc.2009-1251","article-title":"Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study","volume":"95","author":"Srinivas-Shankar","year":"2010","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Endocrinolog\u00eda y Nutrici\u00f3n"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1575092215003356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1575092215003356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T17:38:46Z","timestamp":1718300326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1575092215003356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1575092215003356"],"URL":"https:\/\/doi.org\/10.1016\/j.endonu.2015.11.004","relation":{},"ISSN":["1575-0922"],"issn-type":[{"value":"1575-0922","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex steroids and growth hormone interactions","name":"articletitle","label":"Article Title"},{"value":"Endocrinolog\u00eda y Nutrici\u00f3n","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.endonu.2015.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 SEEN. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}