{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:16:11Z","timestamp":1787793371191,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700091"],"award-info":[{"award-number":["81700091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770096"],"award-info":[{"award-number":["81770096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800094"],"award-info":[{"award-number":["81800094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82041018"],"award-info":[{"award-number":["82041018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020kfyXGYJ011"],"award-info":[{"award-number":["2020kfyXGYJ011"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2019ZX09301001"],"award-info":[{"award-number":["2019ZX09301001"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Engineering"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.eng.2020.09.009","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T22:42:19Z","timestamp":1603924939000},"page":"1452-1458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Outcomes of Severe or Critical COVID-19 Patients Presenting No Respiratory Symptoms or Fever at Onset"],"prefix":"10.1016","volume":"7","author":[{"given":"Juanjuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshuo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.eng.2020.09.009_b0005","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eng.2020.09.009_b0010","unstructured":"WHO coronavirus disease (COVID-19) dashboard [Internet]. Geneva: WHO; c2020 [updated 2020 Sep 14; cited 2020 Sep 14]. Available from: https:\/\/covid19.who.int\/."},{"issue":"10223","key":"10.1016\/j.eng.2020.09.009_b0015","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","article-title":"A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster","volume":"395","author":"Chan","year":"2020","journal-title":"Lancet"},{"issue":"10223","key":"10.1016\/j.eng.2020.09.009_b0020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"issue":"10223","key":"10.1016\/j.eng.2020.09.009_b0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.eng.2020.09.009_b0030","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"issue":"13","key":"10.1016\/j.eng.2020.09.009_b0035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N Engl J Med"},{"issue":"18","key":"10.1016\/j.eng.2020.09.009_b0040","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1158\/0008-5472.CAN-07-0647","article-title":"Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res"},{"issue":"10223","key":"10.1016\/j.eng.2020.09.009_b0045","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","article-title":"A novel coronavirus outbreak of global health concern","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"issue":"10229","key":"10.1016\/j.eng.2020.09.009_b0050","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.eng.2020.09.009_b0055","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"2","key":"10.1016\/j.eng.2020.09.009_b0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/resp.13196","article-title":"MERS, SARS and other coronaviruses as causes of pneumonia: MERS, SARS and coronaviruses","volume":"23","author":"Yin","year":"2018","journal-title":"Respirology"},{"issue":"20","key":"10.1016\/j.eng.2020.09.009_b0065","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","article-title":"Identification of a novel coronavirus in patients with severe acute respiratory syndrome","volume":"348","author":"Drosten","year":"2003","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.eng.2020.09.009_b0070","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.eng.2020.09.009_b0075","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S1473-3099(20)30114-6","article-title":"Asymptomatic cases in a family cluster with SARS-CoV-2 infection","volume":"20","author":"Pan","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"10.1016\/j.eng.2020.09.009_b0080","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients","volume":"382","author":"Zou","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eng.2020.09.009_b0085","unstructured":"National Health Commission of the People\u2019s Republic of China; National Administration of Traditional Chinese Medicine. Diagnosis and treatment protocol for novel coronavirus pneumonia (trial version 3) [Internet]. Beijing: The State Council of the People\u2019s Republic of China; 2020 Jan 22 [cited 2020 Apr 5]. Available from: http:\/\/www.nhc.gov.cn\/xcs\/zhengcwj\/202001\/f492c9153ea9437bb587ce2ffcbee1fa\/files\/39e7578d85964dbe81117736dd789d8f.pdf. Chinese."},{"key":"10.1016\/j.eng.2020.09.009_b0090","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2012;2:124\u201338."},{"issue":"4","key":"10.1016\/j.eng.2020.09.009_b0095","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/CCM.0000000000004207","article-title":"The Community-Acquired Pneumonia\u2013China Network. Association between cardiac injury and mortality in hospitalized patients infected with avian influenza A (H7N9) virus","volume":"48","author":"Gao","year":"2020","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.eng.2020.09.009_b0100","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","article-title":"CDC definitions for nosocomial infections, 1988","volume":"16","author":"Garner","year":"1988","journal-title":"Am J Infect Control"},{"issue":"15","key":"10.1016\/j.eng.2020.09.009_b0105","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/cid\/ciaa272","article-title":"Clinical features of 69 cases with coronavirus disease 2019 in Wuhan, China","volume":"71","author":"Wang","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.eng.2020.09.009_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajem.2020.03.052","article-title":"Abdominal and testicular pain: an atypical presentation of COVID-19","volume":"38","author":"Kim","year":"2020","journal-title":"Am J Emerg Med"},{"issue":"5","key":"10.1016\/j.eng.2020.09.009_b0115","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jinf.2020.05.035","article-title":"Asymptomatic infection and atypical manifestations of COVID-19: comparison of viral shedding duration","volume":"81","author":"Noh","year":"2020","journal-title":"J Infect"},{"issue":"11","key":"10.1016\/j.eng.2020.09.009_b0120","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1002\/jmv.26157","article-title":"Extrapulmonary and atypical clinical presentations of COVID-19","volume":"92","author":"Abobaker","year":"2020","journal-title":"J Med Virol"},{"issue":"2","key":"10.1016\/j.eng.2020.09.009_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.eng.2020.09.009_b0130","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/jamainternmed.2020.2033","article-title":"Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19","volume":"180","author":"Liang","year":"2020","journal-title":"JAMA Intern Med"},{"issue":"10","key":"10.1016\/j.eng.2020.09.009_b0135","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"Washington State 2019-nCoV Case Investigation Team. First case of 2019 novel coronavirus in the United States","volume":"382","author":"Holshue","year":"2020","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.eng.2020.09.009_b0140","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3201\/eid2605.200146","article-title":"Risk for transportation of coronavirus disease from Wuhan to other cities in China","volume":"26","author":"Du","year":"2020","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.eng.2020.09.009_b0145","doi-asserted-by":"crossref","first-page":"taaa020","DOI":"10.1093\/jtm\/taaa020","article-title":"Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak","volume":"27","author":"Wilder-Smith","year":"2020","journal-title":"J Travel Med"},{"issue":"15","key":"10.1016\/j.eng.2020.09.009_b0150","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/cid\/ciaa201","article-title":"A well infant with coronavirus disease 2019 (COVID-19) with high viral load","volume":"71","author":"Kam","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.eng.2020.09.009_b0155","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3201\/eid2605.200198","article-title":"Potential presymptomatic transmission of SARS-CoV-2, Zhejiang Province, China, 2020","volume":"26","author":"Tong","year":"2020","journal-title":"Emerg Infect Dis"}],"container-title":["Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095809920303040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095809920303040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:25:11Z","timestamp":1761866711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095809920303040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2095809920303040"],"URL":"https:\/\/doi.org\/10.1016\/j.eng.2020.09.009","relation":{},"ISSN":["2095-8099"],"issn-type":[{"value":"2095-8099","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Characteristics and Outcomes of Severe or Critical COVID-19 Patients Presenting No Respiratory Symptoms or Fever at Onset","name":"articletitle","label":"Article Title"},{"value":"Engineering","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eng.2020.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company.","name":"copyright","label":"Copyright"}]}}