{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:43:36Z","timestamp":1791848616150,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82041019"],"award-info":[{"award-number":["82041019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171818"],"award-info":[{"award-number":["82171818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703048"],"award-info":[{"award-number":["81703048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101919"],"award-info":[{"award-number":["82101919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z201100005420024"],"award-info":[{"award-number":["Z201100005420024"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Engineering"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.eng.2022.12.007","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T12:04:17Z","timestamp":1674475457000},"page":"127-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity"],"prefix":"10.1016","volume":"27","author":[{"given":"Yilong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangze","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.eng.2022.12.007_b0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41591-021-01301-0","article-title":"Vaccine development for emerging infectious diseases","volume":"27","author":"Excler","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.eng.2022.12.007_b0010","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.3389\/fimmu.2018.01963","article-title":"New vaccine technologies to combat outbreak situations","volume":"9","author":"Rauch","year":"2018","journal-title":"Front Immunol"},{"issue":"10321","key":"10.1016\/j.eng.2022.12.007_b0015","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(21)02753-7","volume":"399","author":"Halperin","year":"2022","journal-title":"Lancet"},{"issue":"10249","key":"10.1016\/j.eng.2022.12.007_b0020","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0140-6736(20)31605-6","article-title":"Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"396","author":"Zhu","year":"2020","journal-title":"Lancet"},{"issue":"10240","key":"10.1016\/j.eng.2022.12.007_b0025","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/S0140-6736(20)31208-3","article-title":"Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial","volume":"395","author":"Zhu","year":"2020","journal-title":"Lancet"},{"issue":"10069","key":"10.1016\/j.eng.2022.12.007_b0030","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(16)32619-8","article-title":"Safety and immunogenicity of a recombinant adenovirus vector-based Ebola vaccine","volume":"389","author":"Grobusch","year":"2017","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.eng.2022.12.007_b0035","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1410863","article-title":"Chimpanzee adenovirus vector Ebola vaccine","volume":"376","author":"Ledgerwood","year":"2017","journal-title":"N Engl J Med"},{"issue":"9984","key":"10.1016\/j.eng.2022.12.007_b0040","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0140-6736(15)60553-0","article-title":"Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial","volume":"385","author":"Zhu","year":"2015","journal-title":"Lancet"},{"issue":"10069","key":"10.1016\/j.eng.2022.12.007_b0045","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(16)32617-4","article-title":"Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"389","author":"Zhu","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.eng.2022.12.007_b0050","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/infdis\/jiy187","article-title":"Immunization with a novel human type 5 adenovirus-vectored vaccine expressing the premembrane and envelope proteins of Zika virus provides consistent and sterilizing protection in multiple immunocompetent and immunocompromised animal models","volume":"218","author":"Guo","year":"2018","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0055","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1038\/s41598-020-60238-5","article-title":"Characterization of a species E adenovirus vector as a Zika virus vaccine","volume":"10","author":"Bullard","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.eng.2022.12.007_b0060","article-title":"A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity","volume":"5(205):205ra134","author":"Smaill","year":"2013","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.eng.2022.12.007_b0065","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/rccm.201603-0654OC","article-title":"Safety and immunogenicity of adenovirus 35 tuberculosis vaccine candidate in adults with active or previous tuberculosis. A randomized trial","volume":"195","author":"Van Zyl-Smit","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.eng.2022.12.007_b0070","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.4161\/hv.29594","article-title":"Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what's important?","volume":"10","author":"Fausther-Bovendo","year":"2014","journal-title":"Hum Vaccin Immunother"},{"issue":"6","key":"10.1016\/j.eng.2022.12.007_b0075","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/14760584.2019.1588113","article-title":"A review of 65 years of human adenovirus seroprevalence","volume":"18","author":"Mennechet","year":"2019","journal-title":"Expert Rev Vaccines"},{"issue":"9","key":"10.1016\/j.eng.2022.12.007_b0080","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/jmv.23325","article-title":"Seroprevalence of neutralizing antibodies to human adenovirus type 5 in healthy adults in China","volume":"84","author":"Yu","year":"2012","journal-title":"J Med Virol"},{"issue":"10249","key":"10.1016\/j.eng.2022.12.007_b0085","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0140-6736(20)31604-4","article-title":"Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1\/2, single-blind, randomised controlled trial","volume":"396","author":"Folegatti","year":"2020","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.eng.2022.12.007_b0090","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa2101544","article-title":"Safety and efficacy of single-dose Ad26.COV2.S vaccine against COVID-19","volume":"384","author":"Sadoff","year":"2021","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.eng.2022.12.007_b0095","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1128\/JVI.02696-06","article-title":"Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D","volume":"81","author":"Abbink","year":"2007","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.eng.2022.12.007_b0100","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.coi.2009.05.016","article-title":"Heterologous prime-boost vaccination","volume":"21","author":"Lu","year":"2009","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"10.1016\/j.eng.2022.12.007_b0105","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1021\/nn8000565","article-title":"Nanoengineering artificial lipid envelopes around adenovirus by self-assembly","volume":"2","author":"Singh","year":"2008","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.eng.2022.12.007_b0110","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1089\/10430349950018021","article-title":"PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo","volume":"10","author":"O'Riordan","year":"1999","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.eng.2022.12.007_b0115","first-page":"985","article-title":"Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus","volume":"7","author":"Zeng","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.eng.2022.12.007_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109650","article-title":"Effects of air pollutants on the transmission and severity of respiratory viral infections","volume":"187","author":"Domingo","year":"2020","journal-title":"Environ Res"},{"key":"10.1016\/j.eng.2022.12.007_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115471","article-title":"Machine learning reveals that prolonged exposure to air pollution is associated with SARS-CoV-2 mortality and infectivity in Italy","volume":"267","author":"Cazzolla Gatti","year":"2020","journal-title":"Environ Pollut"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12989-016-0181-1","article-title":"Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection","volume":"14","author":"Sattler","year":"2017","journal-title":"Part Fibre Toxicol"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12985-017-0909-z","article-title":"Single-walled carbon nanotubes modulate pulmonary immune responses and increase pandemic influenza a virus titers in mice","volume":"14","author":"Chen","year":"2017","journal-title":"Virol J"},{"issue":"5","key":"10.1016\/j.eng.2022.12.007_b0140","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.nano.2016.01.021","article-title":"Potential application of silver nanoparticles to control the infectivity of Rift Valley fever virus in vitro and in vivo","volume":"12","author":"Borrego","year":"2016","journal-title":"Nanomedicine"},{"issue":"3","key":"10.1016\/j.eng.2022.12.007_b0145","doi-asserted-by":"crossref","first-page":"L481","DOI":"10.1152\/ajplung.00104.2020","article-title":"Titanium dioxide nanoparticles exaggerate respiratory syncytial virus-induced airway epithelial barrier dysfunction","volume":"319","author":"Smallcombe","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5","key":"10.1016\/j.eng.2022.12.007_b0150","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00280-011-1621-0","article-title":"A phase 2 study of weekly albumin-bound paclitaxel (Abraxane\u00ae) given as a two-hour infusion","volume":"68","author":"Paik","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nnano.2009.341","article-title":"A novel intracellular protein delivery platform based on single-protein nanocapsules","volume":"5","author":"Yan","year":"2010","journal-title":"Nat Nanotechnol"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0160","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1038\/s41467-020-17972-1","article-title":"A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge","volume":"11","author":"Wu","year":"2020","journal-title":"Nat Commun"},{"issue":"39","key":"10.1016\/j.eng.2022.12.007_b0165","doi-asserted-by":"crossref","first-page":"e1902469","DOI":"10.1002\/adma.201902469","article-title":"Real-time quantification of cell internalization kinetics by functionalized boluminescent nanoprobes","volume":"31","author":"Wu","year":"2019","journal-title":"Adv Mater"},{"issue":"9","key":"10.1016\/j.eng.2022.12.007_b0170","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1515\/BC.2005.100","article-title":"Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor","volume":"386","author":"Werk","year":"2005","journal-title":"Biol Chem"},{"issue":"10","key":"10.1016\/j.eng.2022.12.007_b0175","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.1128\/JVI.72.10.7909-7915.1998","article-title":"The coxsackievirus\u2013adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F","volume":"72","author":"Roelvink","year":"1998","journal-title":"J Virol"},{"issue":"11","key":"10.1016\/j.eng.2022.12.007_b0180","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.4049\/jimmunol.174.11.7179","article-title":"Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein","volume":"174","author":"Sumida","year":"2005","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.eng.2022.12.007_b0185","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/infdis\/jiaa418","article-title":"Induction of the coxsackievirus and adenovirus receptor in macrophages during the formation of atherosclerotic plaques","volume":"222","author":"Nilchian","year":"2020","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.eng.2022.12.007_b0190","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1073\/pnas.94.7.3352","article-title":"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses","volume":"94","author":"Tomko","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 1","key":"10.1016\/j.eng.2022.12.007_b0195","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1099\/vir.0.036269-0","article-title":"Accessibility of the coxsackievirus and adenovirus receptor and its importance in adenovirus gene transduction efficiency","volume":"93","author":"Sharma","year":"2012","journal-title":"J Gen Virol"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/bbrc.2001.4527","article-title":"Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors","volume":"282","author":"Okada","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.eng.2022.12.007_b0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1165\/ajrcmb.20.3.3398","article-title":"Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie\/adenovirus receptor","volume":"20","author":"Kaner","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0210","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/mthe.1999.0013","article-title":"Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells","volume":"1","author":"Worgall","year":"2000","journal-title":"Mol Ther"},{"key":"10.1016\/j.eng.2022.12.007_b0215","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3389\/fimmu.2020.00909","article-title":"Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines","volume":"11","author":"Coughlan","year":"2020","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.eng.2022.12.007_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41565-020-0739-9","article-title":"Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health","volume":"16","author":"Fries","year":"2021","journal-title":"Nat Nanotechnol"},{"issue":"8","key":"10.1016\/j.eng.2022.12.007_b0225","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41565-020-0737-y","article-title":"COVID-19 vaccine development and a potential nanomaterial path forward","volume":"15","author":"Shin","year":"2020","journal-title":"Nat Nanotechnol"},{"issue":"12","key":"10.1016\/j.eng.2022.12.007_b0230","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat Rev Mater"},{"issue":"2","key":"10.1016\/j.eng.2022.12.007_b0235","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12560-016-9232-x","article-title":"Aggregation of adenovirus 2 in source water and impacts on disinfection by chlorine","volume":"8","author":"Kahler","year":"2016","journal-title":"Food Environ Virol"},{"issue":"35","key":"10.1016\/j.eng.2022.12.007_b0240","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1016\/j.biomaterials.2014.08.010","article-title":"Encapsulation of adenovirus serotype 5 in anionic lecithin liposomes using a bead-based immunoprecipitation technique enhances transfection efficiency","volume":"35","author":"Mendez","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.eng.2022.12.007_b0245","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/sj.mt.6300306","article-title":"Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies","volume":"16","author":"Wortmann","year":"2008","journal-title":"Mol Ther"},{"issue":"14","key":"10.1016\/j.eng.2022.12.007_b0250","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1002\/anie.201913708","article-title":"Amphiphilic polyphenylene dendron conjugates for surface remodeling of adenovirus 5","volume":"59","author":"Wagner","year":"2020","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.eng.2022.12.007_b0255","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biomaterials.2017.03.007","article-title":"Engineering intravaginal vaccines to overcome mucosal and epithelial barriers","volume":"128","author":"Ji","year":"2017","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.eng.2022.12.007_b0260","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0006-3495(04)74197-1","article-title":"Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation","volume":"86","author":"Davis","year":"2004","journal-title":"Biophys J"},{"issue":"3","key":"10.1016\/j.eng.2022.12.007_b0265","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1128\/jvi.1.3.478-488.1967","article-title":"Virus aggregation as the cause of the non-neutralizable persistent fraction","volume":"1","author":"Wallis","year":"1967","journal-title":"J Virol"},{"issue":"12","key":"10.1016\/j.eng.2022.12.007_b0270","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S1473-3099(21)00396-0","article-title":"Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial","volume":"21","author":"Wu","year":"2021","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"10.1016\/j.eng.2022.12.007_b0275","doi-asserted-by":"crossref","first-page":"e1805116","DOI":"10.1002\/adma.201805116","article-title":"Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium","volume":"31","author":"Patel","year":"2019","journal-title":"Adv Mater"},{"issue":"28","key":"10.1016\/j.eng.2022.12.007_b0280","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1073\/pnas.1502281112","article-title":"Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy","volume":"112","author":"Mastorakos","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.eng.2022.12.007_b0285","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.nano.2015.11.002","article-title":"Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells","volume":"12","author":"Fromen","year":"2016","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.eng.2022.12.007_b0290","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41565-020-0669-6","article-title":"Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing","volume":"15","author":"Cheng","year":"2020","journal-title":"Nat Nanotechnol"}],"container-title":["Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095809923000103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095809923000103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:34:16Z","timestamp":1761867256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095809923000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":58,"alternative-id":["S2095809923000103"],"URL":"https:\/\/doi.org\/10.1016\/j.eng.2022.12.007","relation":{},"ISSN":["2095-8099"],"issn-type":[{"value":"2095-8099","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity","name":"articletitle","label":"Article Title"},{"value":"Engineering","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eng.2022.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company.","name":"copyright","label":"Copyright"}]}}