{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:05:02Z","timestamp":1778004302131,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301104"],"award-info":[{"award-number":["81301104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ens-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eNeurologicalSci"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.ensci.2016.11.005","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T02:30:28Z","timestamp":1478226628000},"page":"16-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders"],"prefix":"10.1016","volume":"6","author":[{"given":"Yu-Xing","family":"Ge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ensci.2016.11.005_bb0005","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1056\/NEJMra022567","article-title":"Mitochondrial respiratory-chain diseases","volume":"348","author":"DiMauro","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ensci.2016.11.005_bb0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1203\/01.pdr.0000190572.68191.13","article-title":"Retrospective, multicentric study of 180 children with cytochrome C oxidase deficiency","volume":"59","author":"Bohm","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ensci.2016.11.005_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1212\/WNL.42.3.545","article-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation","volume":"42","author":"Goto","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.ensci.2016.11.005_bb0020","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mito.2006.12.004","article-title":"Population prevalence of the MELAS A3243G mutation","volume":"7","author":"Manwaring","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.ensci.2016.11.005_bb0025","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.0954-6820.1952.tb13411.x","article-title":"Metabolic enzymes of mitochondria","volume":"266","author":"Kalckar","year":"1952","journal-title":"Acta Medica Scand. Suppl."},{"key":"10.1016\/j.ensci.2016.11.005_bb0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ar.1091140304","article-title":"The fine structure of mitochondria","volume":"114","author":"Palade","year":"1952","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ensci.2016.11.005_bb0035","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0021-9258(19)51289-3","article-title":"Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria","volume":"179","author":"Kennedy","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ensci.2016.11.005_bb0040","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1046\/j.1365-2265.1996.00856.x","article-title":"Hypoparathyroidism and insulin-dependent diabetes mellitus in a patient with Kearns-Sayre syndrome harbouring a mitochondrial DNA deletion","volume":"45","author":"Isotani","year":"1996","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ymgme.2007.09.007","article-title":"Variable outcome of growth hormone administration in respiratory chain deficiency","volume":"93","author":"Romano","year":"2008","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ensci.2016.11.005_bb0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0009-8981(94)90056-6","article-title":"Reference charts for respiratory chain activities in human tissues","volume":"228","author":"Chretien","year":"1994","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ensci.2016.11.005_bb0055","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/088307380001501108","article-title":"Endocrine disorders in two sisters affected by MELAS syndrome","volume":"15","author":"Balestri","year":"2000","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2265.1995.tb01922.x","article-title":"MELAS syndrome associated with diabetes mellitus and hyperthyroidism: a case report from Taiwan","volume":"43","author":"Yang","year":"1995","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0065","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0022-510X(93)90270-9","article-title":"Content of mutant mitochondrial DNA and organ dysfunction in a patient with a MELAS subgroup of mitochondrial encephalomyopathies","volume":"120","author":"Shiraiwa","year":"1993","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ensci.2016.11.005_bb0070","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1017\/S1092852900015303","article-title":"Psychiatric comorbidity in 36 adults with mitochondrial cytopathies","volume":"12","author":"Fattal","year":"2007","journal-title":"CNS Spectr"},{"key":"10.1016\/j.ensci.2016.11.005_bb0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archneurol.2008.526","article-title":"Protean phenotypic features of the A3243G mitochondrial DNA mutation","volume":"66","author":"Kaufmann","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0080","first-page":"CS66","article-title":"Psychiatric symptoms in a patient with the clinical features of MELAS","volume":"8","author":"Kiejna","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ensci.2016.11.005_bb0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00467-003-1318-7","article-title":"A boy with mitochondrial disease: asymptomatic proteinuria without neuromyopathy","volume":"19","author":"Ueda","year":"2004","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0090","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1212\/WNL.57.10.1930","article-title":"A mutation in mt tRNALeu(UUR) causing a neuropsychiatric syndrome with depression and cataract","volume":"57","author":"Jaksch","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.ensci.2016.11.005_bb0095","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1212\/WNL.55.4.600","article-title":"Psychosis and progressing dementia: presenting features of a mitochondriopathy","volume":"55","author":"Amemiya","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ensci.2016.11.005_bb0100","first-page":"303","article-title":"Activity of Na+\/K+-ATPase and of Ca++-ATPase under the action of adenosine triphosphate in experimental myocardial hypertrophy","volume":"35","author":"Moisin","year":"1998","journal-title":"Rom. J. Physiol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0105","first-page":"1089","article-title":"Alteration of Na+ homeostasis as a critical step in the development of irreversible hepatocyte injury after adenosine triphosphate depletion","volume":"21","author":"Carini","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.ensci.2016.11.005_bb0110","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1085\/jgp.95.4.591","article-title":"Relationships between the neuronal sodium\/potassium pump and energy metabolism. Effects of K+, Na+, and adenosine triphosphate in isolated brain synaptosomes","volume":"95","author":"Erecinska","year":"1990","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/j.ensci.2016.11.005_bb0115","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jemt.1051","article-title":"Calcium signalling in cells of oligodendroglial lineage","volume":"52","author":"Soliven","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ensci.2016.11.005_bb0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF02527712","article-title":"Release of intracellular calcium stores leads to retraction of membrane sheets and cell death in mature mouse oligodendrocytes","volume":"21","author":"Benjamins","year":"1996","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ensci.2016.11.005_bb0125","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-016-9949-4","article-title":"High Ca2+ influx during traumatic brain injury leads to caspase-1-dependent neuroinflammation and cell death","author":"Abdul-Muneer","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ensci.2016.11.005_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2016.04.005","article-title":"Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy","author":"La Rovere","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ensci.2016.11.005_bb0135","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1523\/JNEUROSCI.4496-09.2010","article-title":"Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice","volume":"30","author":"Ruiz","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ensci.2016.11.005_bb0140","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1523\/JNEUROSCI.0139-07.2007","article-title":"Differential regulation of action potential- and metabotropic glutamate receptor-induced Ca2+ signals by inositol 1,4,5-trisphosphate in dopaminergic neurons","volume":"27","author":"Cui","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ensci.2016.11.005_bb0145","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ceca.2005.11.006","article-title":"Dopamine-induced graded intracellular Ca2+ elevation via the Na+Ca2+ exchanger operating in the Ca2+-entry mode in cockroach salivary ducts","volume":"39","author":"Hille","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ensci.2016.11.005_bb0150","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1523\/JNEUROSCI.4717-04.2005","article-title":"Calcium sensitivity of neurotransmitter release differs at phasic and tonic synapses","volume":"25","author":"Millar","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ensci.2016.11.005_bb0155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nature18914","article-title":"Systems neuroscience: a modern map of the human cerebral cortex","volume":"536","author":"Yeo","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ensci.2016.11.005_bb0160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ensci.2016.11.005_bb0165","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jmri.24789","article-title":"Reproducibility of T2 * mapping in the human cerebral cortex in vivo at 7tesla MRI","volume":"42","author":"Govindarajan","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ensci.2016.11.005_bb0170","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4088\/JCP.11r07237","article-title":"The psychiatric manifestations of mitochondrial disorders: a case and review of the literature","volume":"73","author":"Anglin","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.ensci.2016.11.005_bb0175","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fpsyt.2016.00021","article-title":"DTI and myelin plasticity in bipolar disorder: integrating neuroimaging and neuropathological findings","volume":"7","author":"Bellani","year":"2016","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.ensci.2016.11.005_bb0180","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1017\/S0033291716000180","article-title":"Abnormal white matter integrity as a structural endophenotype for bipolar disorder","volume":"46","author":"Saricicek","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ensci.2016.11.005_bb0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/mp.2015.141","article-title":"Molecular substrates of schizophrenia: homeostatic signaling to connectivity","volume":"21","author":"Landek-Salgado","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ensci.2016.11.005_bb0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neubiorev.2014.02.001","article-title":"Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies","volume":"42","author":"Stuart","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ensci.2016.11.005_bb0195","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/YCO.0b013e3283387b50","article-title":"Thyroid disease and mental disorders: cause and effect or only comorbidity?","volume":"23","author":"Bunevicius","year":"2010","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.ensci.2016.11.005_bb0200","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1590\/S1516-44462007000200013","article-title":"Subclinical hypothyroidism: psychiatric disorders and symptoms","volume":"29","author":"Almeida","year":"2007","journal-title":"Rev. Bras. Psiquiatr."}],"container-title":["eNeurologicalSci"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405650216300375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405650216300375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T10:22:13Z","timestamp":1718878933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405650216300375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":40,"alternative-id":["S2405650216300375"],"URL":"https:\/\/doi.org\/10.1016\/j.ensci.2016.11.005","relation":{},"ISSN":["2405-6502"],"issn-type":[{"value":"2405-6502","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders","name":"articletitle","label":"Article Title"},{"value":"eNeurologicalSci","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ensci.2016.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}