{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:24:04Z","timestamp":1791267844447,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"AQUATERRA","award":["GOCE 505428"],"award-info":[{"award-number":["GOCE 505428"]}]},{"name":"MODELKEY","award":["GOCE 511237"],"award-info":[{"award-number":["GOCE 511237"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["CGL2007-64551\/HID"],"award-info":[{"award-number":["CGL2007-64551\/HID"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.envint.2009.10.004","type":"journal-article","created":{"date-parts":[[2009,11,14]],"date-time":"2009-11-14T04:54:06Z","timestamp":1258174446000},"page":"75-84","source":"Crossref","is-referenced-by-count":294,"title":["Drugs of abuse and their metabolites in the Ebro River basin: Occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation"],"prefix":"10.1016","volume":"36","author":[{"given":"Cristina","family":"Postigo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"L\u00f3pez de Alda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e0","family":"Barcel\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.envint.2009.10.004_bib1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.envpol.2008.11.025","article-title":"The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska","volume":"157","author":"Bartelt-Hunt","year":"2009","journal-title":"Environ Pollut"},{"key":"10.1016\/j.envint.2009.10.004_bib2","series-title":"Disposition of toxic drugs and chemicals in man","author":"Baselt","year":"2004"},{"issue":"15","key":"10.1016\/j.envint.2009.10.004_bib3","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1016\/j.chroma.2009.01.067","article-title":"Simultaneous ultra-high-pressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants, cocaine and its metabolites, and a cannabis metabolite in surface water and urban wastewater","volume":"1216","author":"Bijlsma","year":"2009","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.envint.2009.10.004_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chroma.2007.10.029","article-title":"Trace determination of cannabinoids and opiates in wastewater and surface waters by ultra-performance liquid chromatography\u2013tandem mass spectrometry","volume":"1175","author":"Boleda","year":"2007","journal-title":"J Chromatogr A"},{"issue":"4","key":"10.1016\/j.envint.2009.10.004_bib5","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.watres.2008.11.056","article-title":"Monitoring of opiates, cannabinoids and their metabolites in wastewater, surface water and finished water in Catalonia, Spain","volume":"43","author":"Boleda","year":"2009","journal-title":"Water Res"},{"issue":"7","key":"10.1016\/j.envint.2009.10.004_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1039\/b702799k","article-title":"Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals","volume":"9","author":"Bones","year":"2007","journal-title":"J Environ Monit"},{"issue":"1","key":"10.1016\/j.envint.2009.10.004_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0378-4347(01)00386-3","article-title":"Determination of LSD and its metabolites in human biological fluids by high-performance liquid chromatography with electrospray tandem mass spectrometry","volume":"765","author":"Canezin","year":"2001","journal-title":"J Chromatogr B: Biomed Sci Appl"},{"key":"10.1016\/j.envint.2009.10.004_bib8","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1021\/ac061095b","article-title":"Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry","volume":"78","author":"Castiglioni","year":"2006","journal-title":"Anal Chem"},{"issue":"23","key":"10.1016\/j.envint.2009.10.004_bib9","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1021\/es802309v","article-title":"Eliminating solid phase extraction with large-volume injection LC\/MS\/MS: analysis of illicit and legal drugs and human urine indicators in US wastewaters","volume":"42","author":"Chiaia","year":"2008","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.envint.2009.10.004_bib10","series-title":"Partition and adsorption of organic contaminants in environmental systems","author":"Chiou","year":"2002"},{"key":"10.1016\/j.envint.2009.10.004_bib11","series-title":"ACS Symposium Series 791","doi-asserted-by":"crossref","DOI":"10.1021\/bk-2001-0791.ch001","article-title":"Illicit drugs in municipal sewage in pharmaceuticals and personal care products in the environment: scientific and regulatory issues","author":"Daughton","year":"2001"},{"key":"10.1016\/j.envint.2009.10.004_bib12","unstructured":"EMCDDA 2008a. (European Monitoring Centre for Drugs and Drug Addiction) Statistical bulletin 2008, http:\/\/www.emcdda.europa.eu\/stats08?CFID=8388605&CFTOKEN=c3da04ed0a81250d-C08AB256-CC93-6FC3-2DA39AE37773F6B0&jsessionid=383013bf51b0cc97b605807d235f20627020, accesed in April 2009."},{"key":"10.1016\/j.envint.2009.10.004_bib13","series-title":"(European Monitoring Centre for Drugs and Drug Addiction) Annual report on the state of the drugs problem in Europe 2008","author":"EMCDDA","year":"2008"},{"issue":"2","key":"10.1016\/j.envint.2009.10.004_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquatic Toxicol"},{"issue":"4","key":"10.1016\/j.envint.2009.10.004_bib17","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00216-007-1754-5","article-title":"Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry","volume":"391","author":"Gheorghe","year":"2008","journal-title":"Anal Bioanal Chem"},{"issue":"8","key":"10.1016\/j.envint.2009.10.004_bib18","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1897\/06-495R.1","article-title":"Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro River basin (northeast Spain)","volume":"26","author":"Gros","year":"2007","journal-title":"Environ Toxicol and Chem"},{"key":"10.1016\/j.envint.2009.10.004_bib19","first-page":"3821","volume":"79","author":"Huerta-Fontela","year":"2007","journal-title":"Ultraperformance liquid chromatography-tandem mass spectrometry analysis of stimulatory drugs of abuse in wastewater and surface waters"},{"issue":"18","key":"10.1016\/j.envint.2009.10.004_bib20","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1021\/es800768h","article-title":"Stimulatory drugs of abuse in surface waters and their removal in a conventional drinking water treatment plant","volume":"42","author":"Huerta-Fontela","year":"2008","journal-title":"Environ Sci Technol"},{"issue":"1\u20133","key":"10.1016\/j.envint.2009.10.004_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2008.02.057","article-title":"Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain","volume":"397","author":"Huerta-Fontela","year":"2008","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.envint.2009.10.004_bib22","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1021\/es061740w","article-title":"Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry","volume":"40","author":"Hummel","year":"2006","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.envint.2009.10.004_bib23","unstructured":"INEbase, National Statistics Institute on-line database, http:\/\/www.ine.es\/, accesed in April 2009."},{"key":"10.1016\/j.envint.2009.10.004_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00244-004-3146-6","article-title":"Polar organic chemical integrative sampling and liquid chromatography\u2013electrospray\/ion-trap mass spectrometry for assessing selected prescription and illicit drugs in treated sewage effluents","volume":"47","author":"Jones-Lepp","year":"2004","journal-title":"Arch Environ Contam Toxicol"},{"key":"10.1016\/j.envint.2009.10.004_bib24","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.chroma.2007.05.074","article-title":"Multi-residue method for the determination of basic\/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry","volume":"1161","author":"Kasprzyk-Hordern","year":"2007","journal-title":"J Chromatogr A"},{"issue":"4","key":"10.1016\/j.envint.2009.10.004_bib25","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00216-008-1854-x","article-title":"Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry","volume":"391","author":"Kasprzyk-Hordern","year":"2008","journal-title":"Anal Bioanal Chem"},{"issue":"13","key":"10.1016\/j.envint.2009.10.004_bib26","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1016\/j.watres.2008.04.026","article-title":"The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK","volume":"42","author":"Kasprzyk-Hordern","year":"2008","journal-title":"Water Res"},{"issue":"2","key":"10.1016\/j.envint.2009.10.004_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.watres.2008.10.047","article-title":"The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters","volume":"43","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Water Res"},{"issue":"6","key":"10.1016\/j.envint.2009.10.004_bib28","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.envpol.2009.03.017","article-title":"Illicit drugs and pharmaceuticals in the environment\u2013forensic applications of environmental data. Part 1: Estimation of the usage of drugs in local communities","volume":"157","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Environ Pollut"},{"issue":"1\u20132","key":"10.1016\/j.envint.2009.10.004_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0378-4347(92)80530-4","article-title":"Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids","volume":"580","author":"Nelson","year":"1992","journal-title":"J Chromatogr\u2013Biomed Appl"},{"issue":"9","key":"10.1016\/j.envint.2009.10.004_bib30","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/ac702060j","article-title":"Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry","volume":"80","author":"Postigo","year":"2008","journal-title":"Anal Chem"},{"issue":"11","key":"10.1016\/j.envint.2009.10.004_bib31","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.trac.2008.10.002","article-title":"Analysis of drugs of abuse and their human metabolic byproducts in water by LC-MS\/MS: a non-intrusive tool for drug abuse estimation at the community level","volume":"27","author":"Postigo","year":"2008","journal-title":"Trends Anal Chem"},{"issue":"12","key":"10.1016\/j.envint.2009.10.004_bib32","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1021\/ac800660d","article-title":"Environmental mass spectrometry: emerging contaminants and current issues","volume":"80","author":"Richardson","year":"2008","journal-title":"Anal Chem"},{"key":"10.1016\/j.envint.2009.10.004_bib33","unstructured":"SAIHEbro, Automatic Hidrologic Information System of the Ebro River basin, http:\/\/195.55.247.237\/saihebro\/index.php?url=\/principal, accesed in April 2009."},{"key":"10.1016\/j.envint.2009.10.004_bib34","unstructured":"UNODC (United Nations Office on Drugs and Crime) World Drug Report 2008. http:\/\/www.unodc.org\/documents\/wdr\/WDR_2008\/WDR_2008_eng_web.pdf, accesed in April 2009."},{"issue":"1","key":"10.1016\/j.envint.2009.10.004_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.envpol.2008.07.020","article-title":"Cocaine and metabolites in waste and surface water across Belgium","volume":"157","author":"Van Nuijs","year":"2009","journal-title":"Environ Pollut"},{"issue":"5","key":"10.1016\/j.envint.2009.10.004_bib36","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.watres.2008.12.020","article-title":"A Spatial and temporal variations in the occurrence of cocaine and benzoylecgonine in waste- and surface water from Belgium and removal during wastewater treatment.","volume":"43","author":"Van Nuijs","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.envint.2009.10.004_bib37","first-page":"41","article-title":"L'utilizzo dei farmaci enalgesici nella terapia del dolore","volume":"1","author":"Zuccaro","year":"2006","journal-title":"La Rivista Italiana di Cure Palliative"},{"key":"10.1016\/j.envint.2009.10.004_bib38","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1289\/ehp.11022","article-title":"Estimating community drug abuse by wastewater analysis","volume":"116","author":"Zuccato","year":"2008","journal-title":"Environ Health Perspect"},{"issue":"4\u20135","key":"10.1016\/j.envint.2009.10.004_bib39","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.watres.2007.09.010","volume":"42","author":"Zuccato","year":"2008","journal-title":"Water Res"},{"key":"10.1016\/j.envint.2009.10.004_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-069X-4-14","article-title":"Cocaine in surface water: a new evidence-based tool to monitor community drug abuse","volume":"4","author":"Zuccato","year":"2005","journal-title":"Environ Health"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412009002104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412009002104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T10:25:12Z","timestamp":1556274312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412009002104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0160412009002104"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2009.10.004","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}