{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:57:21Z","timestamp":1792205841925,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Swiss Federal Office of Public Health"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.envint.2018.05.047","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T20:07:22Z","timestamp":1529006842000},"page":"245-256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Aggregate consumer exposure to isothiazolinones via household care and personal care products: Probabilistic modelling and benzisothiazolinone risk assessment"],"prefix":"10.1016","volume":"118","author":[{"given":"Elena","family":"Garcia-Hidalgo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dovil\u00e9","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"von Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan","family":"Delmaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Siegrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Hungerb\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2018.05.047_bb0005","author":"A.I.S.E"},{"key":"10.1016\/j.envint.2018.05.047_bb0010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cod.12449","article-title":"Methylisothiazolinone in selected consumer products in Belgium: adding fuel to the fire?","volume":"73","author":"Aerts","year":"2015","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0015","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/cod.12670","article-title":"Octylisothiazolinone, an additional cause of allergic contact dermatitis caused by leather: case series and potential implications for the study of cross-reactivity with methylisothiazolinone","volume":"75","author":"Aerts","year":"2016","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chroma.2012.10.063","article-title":"Determination of isothiazolinone preservatives in cosmetics and household products by matrix solid-phase dispersion followed by high-performance liquid chromatography\u2013tandem mass spectrometry","volume":"1270","author":"Alvarez-Rivera","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.envint.2018.05.047_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cod.12795","article-title":"Airborne allergic contact dermatitis caused by isothiazolinones in water-based paints: a retrospective study of 44 cases","volume":"77","author":"Amsler","year":"2017","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0536.1985.tb01061.x","article-title":"Biocide patch tests","volume":"12","author":"Andersen","year":"1985","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0035","series-title":"Special Issue on QRA","author":"Api","year":"2008"},{"key":"10.1016\/j.envint.2018.05.047_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2007.10.008","article-title":"Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients","volume":"52","author":"Api","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3109\/15569520903351151","article-title":"Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment","volume":"29","author":"Basketter","year":"2010","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.envint.2018.05.047_bb0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yrtph.2015.11.013","article-title":"Skin sensitization quantitative risk assessment: a review of underlying assumptions","volume":"74","author":"Basketter","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0055","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0536.1999.tb06013.x","article-title":"Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides","volume":"40","author":"Basketter","year":"1999","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0060","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.0105-1873.2005.00707.x","article-title":"Predictive identification of human skin sensitization thresholds","volume":"53","author":"Basketter","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fct.2012.11.014","article-title":"Usage patterns of personal care products: important factors for exposure assessment","volume":"55","author":"Biesterbos","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2018.05.047_bb0070","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1600-0536.2000.042004196.x","article-title":"Airborne contact dermatitis from methylchloroisothiazolinone in wall paint. Abolition of symptoms by chemical allergen inactivation","volume":"42","author":"Bohn","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/cod.12079","article-title":"Airborne sensitization to isothiazolinones observed in a 3-month-old boy","volume":"69","author":"Bregnbak","year":"2013","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0080","series-title":"Incompetence and Failure to Regulate Methylisothiazolinone","author":"Bruze","year":"2015"},{"key":"10.1016\/j.envint.2018.05.047_bb0085","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.yrtph.2015.05.012","article-title":"Novel database for exposure to fragrance ingredients in cosmetics and personal care products","volume":"72","author":"Comiskey","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0090","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.0105-1873.2006.00872.x","article-title":"Fragrance allergy: assessing the risk from washed fabrics","volume":"55","author":"Corea","year":"2006","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0095","series-title":"ConsExpo-consumer Exposure and Uptake Models-Program Manual","author":"Delmaar","year":"2006"},{"key":"10.1016\/j.envint.2018.05.047_bb0100","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/jes.2014.68","article-title":"Validation of an aggregate exposure model for substances in consumer products: a case study of diethyl phthalate in personal care products","volume":"25","author":"Delmaar","year":"2015","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2018.05.047_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envint.2015.03.006","article-title":"The probabilistic aggregate consumer exposure model (PACEM): validation and comparison to a lower-tier assessment for the cyclic siloxane D5","volume":"79","author":"Dudzina","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2018.05.047_bb0110","author":"ECETOC"},{"key":"10.1016\/j.envint.2018.05.047_bb0115","author":"EEAHC"},{"key":"10.1016\/j.envint.2018.05.047_bb0120","series-title":"Dermal Exposure Assessment: A Summary of Epa Approaches","author":"EPA. U.S","year":"2007"},{"key":"10.1016\/j.envint.2018.05.047_bb0125","author":"EPHECT"},{"key":"10.1016\/j.envint.2018.05.047_bb0130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/cod.12221","article-title":"Natural rubber gloves might not protect against skin penetration of methylisothiazolinone","volume":"70","author":"Espasand\u00edn-Arias","year":"2014","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/0272-4332.00024","article-title":"A random walk model of skin permeation","volume":"22","author":"Frasch","year":"2002","journal-title":"Risk Anal."},{"key":"10.1016\/j.envint.2018.05.047_bb0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/jes.2013.23","article-title":"Analysis of finite dose dermal absorption data: implications for dermal exposure assessment","volume":"24","author":"Frasch","year":"2014","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2018.05.047_bb0145","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/cod.12235","article-title":"Isothiazolinones in commercial products at Danish workplaces","volume":"71","author":"Friis","year":"2014","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0150","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fct.2016.10.030","article-title":"Use-patterns of personal care and household cleaning products in Switzerland","volume":"99","author":"Garcia-Hidalgo","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2018.05.047_bb0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/cod.12700","article-title":"Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland","volume":"76","author":"Garcia-Hidalgo","year":"2017","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0165","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.yrtph.2012.10.004","article-title":"Quantitative risk assessment for skin sensitisation: consideration of a simplified approach for hair dye ingredients","volume":"64","author":"Goebel","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0170","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/jes.2013.33","article-title":"Aggregate exposure approaches for parabens in personal care products: a case assessment for children between 0 and 3\u202fyears old","volume":"24","author":"Gosens","year":"2014","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2018.05.047_bb0175","author":"IDEA"},{"key":"10.1016\/j.envint.2018.05.047_bb0180","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.1021\/es502513w","article-title":"SHEDS-HT: an integrated probabilistic exposure model for prioritizing exposures to chemicals with near-field and dietary sources","volume":"48","author":"Isaacs","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2018.05.047_bb0185","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MOP.0000000000000513","article-title":"Diagnosis and management of allergic contact dermatitis in children: Common allergens that can be easily missed","volume":"29","author":"Jacob","year":"2017","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.envint.2018.05.047_bb0190","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/jps.21074","article-title":"An evaluation of mathematical models for predicting skin permeability","volume":"97","author":"Lian","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.envint.2018.05.047_bb0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/17435390.2010.484554","article-title":"Potential exposure of German consumers to engineered nanoparticles in cosmetics and personal care products","volume":"5","author":"Lorenz","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.envint.2018.05.047_bb0200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0536.2008.01501.x","article-title":"Contamination versus preservation of cosmetics: a review on legislation, usage, infections, and contact allergy","volume":"60","author":"Lundov","year":"2009","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0205","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1600-0536.2011.01924.x","article-title":"Two cases of airborne allergic contact dermatitis caused by methylisothiazolinone in paint","volume":"65","author":"Lundov","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0210","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/cod.12570","article-title":"Contact allergy to 1,2\u2011benzisothiazolin\u20113\u2011one","volume":"75","author":"Madsen","year":"2016","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0215","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.3390\/ijerph10072778","article-title":"Use patterns of leave-on personal care products among Swiss-German children, adolescents, and adults","volume":"10","author":"Manov\u00e1","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2018.05.047_bb0220","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/bjd.13372","article-title":"Ultraviolet filter contact and photocontact allergy: consumer exposure and risk assessment for octocrylene from personal care products and sunscreens","volume":"171","author":"Manov\u00e1","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.envint.2018.05.047_bb0225","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.envint.2014.09.008","article-title":"Aggregate consumer exposure to UV filter ethylhexyl methoxycinnamate via personal care products","volume":"74","author":"Manov\u00e1","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2018.05.047_bb0230","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.fct.2007.06.037","article-title":"Probabilistic modelling of European consumer exposure to cosmetic products","volume":"45","author":"McNamara","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2018.05.047_bb0235","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/cod.12642","article-title":"Occupational allergic contact dermatitis caused by Benzisothiazolinone in printing ink and soap","volume":"76","author":"Meysman","year":"2017","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0240","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jps.10048","article-title":"A theoretical analysis of permeation of small hydrophobic solutes across the stratum corneum based on scaled particle theory","volume":"91","author":"Mitragotri","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.envint.2018.05.047_bb0245","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/cod.12068","article-title":"Allergic contact dermatitis from Octylisothiazolinone","volume":"69","author":"Mose","year":"2013","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0250","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yrtph.2015.06.004","article-title":"Quantitative risk assessment of the aggregate dermal exposure to the sensitizing fragrance geraniol in personal care products and household cleaning agents","volume":"73","author":"Nijkamp","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0255","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.fct.2013.02.006","article-title":"Estimation of the safe use concentrations of the preservative 1,2\u2011benzisothiazolin\u20113\u2011one (BIT) in consumer cleaning products and sunscreens","volume":"56","author":"Novick","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2018.05.047_bb0260","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1015810312465","article-title":"Predicting skin permeability","volume":"9","author":"Potts","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.envint.2018.05.047_bb0265","series-title":"Sensitivity Analysis, R-package 1.10.1","author":"Pujol","year":"2017"},{"key":"10.1016\/j.envint.2018.05.047_bb0270","series-title":"Eur Union:L353","article-title":"No. 1272\/2008 of the European parliament and of the council, on classification, labeling and packaging of substances and mixtures, amending and repealing directives 67\/548\/eec and 1999\/45\/ec, and amending regulation (EC.) No. 1907\/2006","author":"Regulation EC","year":"2008"},{"key":"10.1016\/j.envint.2018.05.047_bb0275","article-title":"No. 1223\/2009 of 30 November 2009 on cosmetic products","volume":"L342\/59","author":"Regulation EC","year":"2009","journal-title":"Official Journal of the European Union"},{"key":"10.1016\/j.envint.2018.05.047_bb0280","article-title":"No. 1003\/2014 of 18 September 2014 amending Annex V to regulation (EC.) No. 1223\/2009 of the European parliament and of the council on cosmetic products","volume":"L282\/1","author":"Regulation EC","year":"2014","journal-title":"Official Journal of the European Union"},{"key":"10.1016\/j.envint.2018.05.047_bb0285","article-title":"No. 2016\/1198 of 22 July 2016 amending Annex V to regulation (EC.) No. 1223\/2009 of the European parliament and of the council on cosmetic products","volume":"L198\/10","author":"Regulation EC","year":"2016","journal-title":"Official Journal of the European Union"},{"key":"10.1016\/j.envint.2018.05.047_bb0290","series-title":"Textbook of Contact Dermatitis","author":"Rycroft","year":"2013"},{"key":"10.1016\/j.envint.2018.05.047_bb0295","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yrtph.2015.05.017","article-title":"Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products","volume":"72","author":"Safford","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0300","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cpc.2009.09.018","article-title":"Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity index","volume":"181","author":"Saltelli","year":"2010","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.envint.2018.05.047_bb0305","series-title":"Opinion on Dermal Sensitisation Quantitative Risk Assessment (Citral, Farnesol and Phenylacetaldehyde)","author":"SCCP","year":"2008"},{"key":"10.1016\/j.envint.2018.05.047_bb0310","author":"SCCS"},{"key":"10.1016\/j.envint.2018.05.047_bb0315","author":"SCCS"},{"key":"10.1016\/j.envint.2018.05.047_bb0320","series-title":"Request for a Scientific Opinion: Submission on Skin Sensitisation Quantitative Risk","author":"SCCS","year":"2017"},{"key":"10.1016\/j.envint.2018.05.047_bb0325","author":"SCCS"},{"key":"10.1016\/j.envint.2018.05.047_bb0330","first-page":"1","article-title":"Urinary excretion kinetics of the metabolite N\u2011methylmalonamic acid (NMMA) after oral dosage of chloromethylisothiazolinone and methylisothiazolinone in human volunteers","author":"Schettgen","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2018.05.047_bb0335","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2133.1998.02126.x","article-title":"Patch testing with preservatives, antimicrobials and industrial biocides. Results from multicentre study","volume":"138","author":"Schnuch","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.envint.2018.05.047_bb0340","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1398-9995.2007.01590.x","article-title":"Polysensitization and increased susceptibility in contact allergy: a review","volume":"63","author":"Schnuch","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.envint.2018.05.047_bb0345","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0536.2010.01800.x","article-title":"Genetic factors in contact allergy\u2014review and future goals","volume":"64","author":"Schnuch","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0350","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/cod.12322","article-title":"Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries","volume":"72","author":"Schwensen","year":"2015","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0355","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/cod.12733","article-title":"The epidemic of methylisothiazolinone: a European prospective study","volume":"76","author":"Schwensen","year":"2016","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0360","series-title":"Population","author":"SFSO","year":"2015"},{"key":"10.1016\/j.envint.2018.05.047_bb0365","series-title":"Current Concepts in Cutaneous Toxicity","first-page":"41","article-title":"Planning, conduct and interpretation of human predictive sensitization patch tests","volume":"41","author":"Stotts","year":"1980"},{"key":"10.1016\/j.envint.2018.05.047_bb0370","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cod.12123","article-title":"Risk factors associated with methylisothiazolinone contact sensitization","volume":"69","author":"Uter","year":"2013","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.envint.2018.05.047_bb0375","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1382-6689(96)00072-5","article-title":"Risk assessment and management of new and existing chemicals","volume":"2","author":"Van Leeuwen","year":"1996","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2018.05.047_bb0380","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1539-6924.2009.01345.x","article-title":"Bisphenol a: how the most relevant exposure sources contribute to total consumer exposure","volume":"30","author":"Von Goetz","year":"2010","journal-title":"Risk Anal."},{"key":"10.1016\/j.envint.2018.05.047_bb0385","series-title":"International Programme on Chemical Safety Harmonization Project Document","article-title":"Guidance for immunotoxicity risk assessment for chemicals","author":"WHO","year":"2012"},{"key":"10.1016\/j.envint.2018.05.047_bb0390","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/0045-6535(95)00023-2","article-title":"Estimating skin permeation. The validation of five mathematical skin permeation models","volume":"30","author":"Wilschut","year":"1995","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2018.05.047_bb0395","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/ajd.12384","article-title":"Airborne exposure to methylisothiazolinone in paint causing allergic contact dermatitis: an Australian perspective","volume":"57","author":"Wright","year":"2016","journal-title":"Aust. J. Dermatol."},{"key":"10.1016\/j.envint.2018.05.047_bb0400","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/psp4.6","article-title":"Sobol sensitivity analysis: a tool to guide the development and evaluation of systems pharmacology models","volume":"4","author":"Zhang","year":"2015","journal-title":"CPT Pharmacometrics Syst. Pharmacol."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412017316550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412017316550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:34:28Z","timestamp":1758972868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412017316550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":79,"alternative-id":["S0160412017316550"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2018.05.047","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aggregate consumer exposure to isothiazolinones via household care and personal care products: Probabilistic modelling and benzisothiazolinone risk assessment","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2018.05.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}