{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:42Z","timestamp":1788871542082,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH-NIMH","award":["R01MH094609"],"award-info":[{"award-number":["R01MH094609"]}]},{"name":"NIH-NIEHS","award":["R01ES022223"],"award-info":[{"award-number":["R01ES022223"]}]},{"name":"NIH-NIEHS","award":["R01ES022223-03S"],"award-info":[{"award-number":["R01ES022223-03S"]}]},{"name":"NIH-NIEHS","award":["P01ES022832"],"award-info":[{"award-number":["P01ES022832"]}]},{"name":"NIH-NIEHS","award":["P42ES007373"],"award-info":[{"award-number":["P42ES007373"]}]},{"name":"NIH-NIEHS","award":["P30ES023515"],"award-info":[{"award-number":["P30ES023515"]}]},{"name":"NIH-NIEHS","award":["R24ES028507"],"award-info":[{"award-number":["R24ES028507"]}]},{"name":"NIH-NIGMS","award":["P20GM104416"],"award-info":[{"award-number":["P20GM104416"]}]},{"name":"US-EPA","award":["RD83544201"],"award-info":[{"award-number":["RD83544201"]}]},{"name":"NIH-NIEHS","award":["K99ES029571-01"],"award-info":[{"award-number":["K99ES029571-01"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.envint.2018.08.010","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T10:23:31Z","timestamp":1534501411000},"page":"373-381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network"],"prefix":"10.1016","volume":"120","author":[{"given":"Maya A.","family":"Deyssenroth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Gennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley H.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouneng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lambertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Karagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen J.","family":"Marsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2018.08.010_bb0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijheh.2014.08.001","article-title":"Interaction between cadmium (Cd), selenium (Se) and oxidative stress biomarkers in healthy mothers and its impact on birth anthropometric measures","volume":"218","author":"Al-Saleh","year":"2015","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2018.08.010_bb0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/uog.11112","article-title":"Neurodevelopmental delay in small babies at term: a systematic review","volume":"40","author":"Arcangeli","year":"2012","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.envint.2018.08.010_bb0015","author":"ATSDR"},{"key":"10.1016\/j.envint.2018.08.010_bb0020","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12967-015-0654-2","article-title":"Assessment of ten trace elements in umbilical cord blood and maternal blood: association with birth weight","volume":"13","author":"Berm\u00fadez","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.envint.2018.08.010_bb0025","series-title":"bkmr: Bayesian Kernel Machine Regression","author":"Bobb","year":"2017"},{"key":"10.1016\/j.envint.2018.08.010_bb0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","article-title":"Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures","volume":"16","author":"Bobb","year":"2015","journal-title":"Biostatistics"},{"key":"10.1016\/j.envint.2018.08.010_bb0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2014","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"10.1016\/j.envint.2018.08.010_bb0040","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.placenta.2015.12.007","article-title":"Relationship between folate transporters expression in human placentas at term and birth weights","volume":"38","author":"Caviedes","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2018.08.010_bb0045","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1007\/s11356-013-2465-4","article-title":"Manganese concentrations in maternal-infant blood and birth weight","volume":"21","author":"Chen","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envint.2018.08.010_bb0050","doi-asserted-by":"crossref","first-page":"12650","DOI":"10.1038\/srep12650","article-title":"PPAR\u03b3 stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPAR\u03b3 regulating fetal growth","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2018.08.010_bb0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/ijerph14010058","article-title":"Critical windows of prenatal exposure to cadmium and size at birth","volume":"14","author":"Cheng","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2018.08.010_bb0060","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1476-069X-10-94","article-title":"Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan","volume":"10","author":"Chou","year":"2011","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2018.08.010_bb0065","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1289\/ehp.1510070","article-title":"Prenatal arsenic exposure and birth outcomes among a population residing near a mining-related superfund site","volume":"124","author":"Claus Henn","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2018.08.010_bb0070","first-page":"159","article-title":"Assessment of weighted quantile sum regression for modeling chemical mixtures and cancer risk","volume":"14","author":"Czarnota","year":"2015","journal-title":"Cancer Informat."},{"key":"10.1016\/j.envint.2018.08.010_bb0075","doi-asserted-by":"crossref","first-page":"D972","DOI":"10.1093\/nar\/gkw838","article-title":"The comparative toxicogenomics database: update 2017","volume":"45","author":"Davis","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2018.08.010_bb0080","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/s12864-017-3878-0","article-title":"Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth","volume":"18","author":"Deyssenroth","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.envint.2018.08.010_bb0085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/jn\/nxx005","article-title":"Better diet quality during pregnancy is associated with a reduced likelihood of an infant born small for gestational age: an analysis of the prospective New Hampshire birth cohort study","volume":"148","author":"Emond","year":"2018","journal-title":"J. Nutr."},{"key":"10.1016\/j.envint.2018.08.010_bb0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.envres.2017.06.016","article-title":"Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes","volume":"158","author":"Everson","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2018.08.010_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.envint.2018.08.010_bb0100","first-page":"493","article-title":"Toenail trace element levels as biomarkers: reproducibility over a 6-year period","volume":"2","author":"Garland","year":"1993","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"Suppl. 1","key":"10.1016\/j.envint.2018.08.010_bb0105","first-page":"S2","article-title":"Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium","volume":"6","author":"Garrett","year":"2013","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.envint.2018.08.010_bb0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1095\/biolreprod.115.128066","article-title":"The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight","volume":"92","author":"Green","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.envint.2018.08.010_bb0115","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10354-012-0074-3","article-title":"The role of the placenta in fetal exposure to heavy metals","volume":"162","author":"Gundacker","year":"2012","journal-title":"Wien. Med. Wochenschr."},{"key":"10.1016\/j.envint.2018.08.010_bb0120","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1007\/s00204-016-1816-6","article-title":"Genetics of the human placenta: implications for toxicokinetics","volume":"90","author":"Gundacker","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2018.08.010_bb0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/01443615.2016.1209170","article-title":"Placental leptin mRNA expression and serum leptin levels in pre-eclampsia associated with HIV infection","volume":"37","author":"Haffejee","year":"2017","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.envint.2018.08.010_bb0130","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/10937400902902062","article-title":"The effects of metals as endocrine disruptors","volume":"12","author":"Iavicoli","year":"2009","journal-title":"J. Toxicol. Environ. Health, Part B"},{"key":"10.1016\/j.envint.2018.08.010_bb0135","first-page":"47","article-title":"Children born small for gestational age (SGA)","volume":"33","author":"Jancevska","year":"2012","journal-title":"Prilozi"},{"key":"10.1016\/j.envint.2018.08.010_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109661","article-title":"Maternal cadmium levels during pregnancy associated with lower birth weight in infants in a North Carolina cohort","volume":"9","author":"Johnston","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2018.08.010_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2015.1073881","article-title":"Placental expression profile of imprinted genes impacts birth weight","author":"Kappil","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.envint.2018.08.010_bb0150","doi-asserted-by":"crossref","first-page":"565","DOI":"10.21873\/invivo.11095","article-title":"Clinical significance of INHBA gene expression in patients with gastric cancer who receive curative resection followed by adjuvant S-1 chemotherapy","volume":"31","author":"Katayama","year":"2017","journal-title":"In Vivo"},{"key":"10.1016\/j.envint.2018.08.010_bb0155","doi-asserted-by":"crossref","first-page":"31920","DOI":"10.1074\/jbc.M112.360362","article-title":"Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation","volume":"287","author":"Kim","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envint.2018.08.010_bb0160","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00204-011-0787-x","article-title":"Cadmium modulates expression of aryl hydrocarbon receptor-associated genes in rat uterus by interaction with the estrogen receptor","volume":"86","author":"Kluxen","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2018.08.010_bb0165","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.480","article-title":"Attrition in a 30-year follow-up of a perinatal birth risk cohort: factors change with age","volume":"2","author":"Launes","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.envint.2018.08.010_bb0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/pr.2016.187","article-title":"Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth: a Scandinavian case-cohort study","volume":"81","author":"Lauritzen","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.envint.2018.08.010_bb0175","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.mce.2013.07.024","article-title":"Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors","volume":"381","author":"Lesseur","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.envint.2018.08.010_bb0180","article-title":"Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures","author":"Liu","year":"2017","journal-title":"Biostatistics"},{"key":"10.1016\/j.envint.2018.08.010_bb0185","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/00039896.1992.9938357","article-title":"Placental cadmium and birthweight in women living near a lead smelter","volume":"47","author":"Loiacono","year":"1992","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envint.2018.08.010_bb0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.reprotox.2014.05.007","article-title":"Evidence that birth weight is decreased by maternal lead levels below 5\u202f\u03bcg\/dl in male newborns","volume":"47","author":"Nishioka","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2018.08.010_bb0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0009-9120(00)00052-7","article-title":"Toxic and essential elements in placentas of Swedish women","volume":"33","author":"Osman","year":"2000","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.envint.2018.08.010_bb0200","doi-asserted-by":"crossref","first-page":"23907","DOI":"10.1038\/srep23907","article-title":"Tobacco control policies and perinatal health: a national quasi-experimental study","volume":"6","author":"Peelen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2018.08.010_bb0205","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1021\/acs.est.5b05316","article-title":"Placental metal concentrations in relation to maternal and infant toenails in a U.S. cohort","volume":"50","author":"Punshon","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2018.08.010_bb0210","series-title":"gWQS: Generalized Weighted Quantile Sum Regression","author":"Renzetti","year":"2016"},{"key":"10.1016\/j.envint.2018.08.010_bb0215","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000360535","article-title":"Differential placental gene expression in term pregnancies affected by fetal growth restriction and macrosomia","volume":"36","author":"Sabri","year":"2014","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.envint.2018.08.010_bb0220","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4161\/epi.25926","article-title":"Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation","volume":"8","author":"Severson","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.envint.2018.08.010_bb0225","first-page":"4690","article-title":"Four trace elements in pregnant women and their relationships with adverse pregnancy outcomes","volume":"19","author":"Shen","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.envint.2018.08.010_bb0230","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1385\/BTER:107:2:113","article-title":"Profiles of trace elements in toenails of Arab-Americans in the Detroit Area, Michigan","volume":"107","author":"Slotnick","year":"2005","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envint.2018.08.010_bb0235","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s40572-017-0162-z","article-title":"Statistical approaches to address multi-pollutant mixtures and multiple exposures: the state of the science","volume":"4","author":"Stafoggia","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.envint.2018.08.010_bb0240","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/1933719108322436","article-title":"Environmental exposures and adverse pregnancy outcomes: a review of the science","volume":"15","author":"Stillerman","year":"2008","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.envint.2018.08.010_bb0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chemosphere.2014.02.080","article-title":"The effects of prenatal exposure to low-level cadmium, lead and selenium on birth outcomes","volume":"108","author":"Sun","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2018.08.010_bb0250","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/1471-0528.12756","article-title":"Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: a prospective birth cohort study","volume":"122","author":"Taylor","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.envint.2018.08.010_bb0255","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.envres.2015.04.018","article-title":"Metals exposure and risk of small-for-gestational age birth in a Canadian birth cohort: the MIREC study","volume":"140","author":"Thomas","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2018.08.010_bb0260","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.envint.2018.05.030","article-title":"Urine and toenail cadmium levels in pregnant women: a reliability study","volume":"118","author":"White","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2018.08.010_bb0265","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12889-016-2816-4","article-title":"Maternal urinary manganese and risk of low birth weight: a case\u2013control study","volume":"16","author":"Xia","year":"2016","journal-title":"BMC Public Health"},{"key":"10.1016\/j.envint.2018.08.010_bb0270","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1468-3083.2009.03426.x","article-title":"Growth rate of human fingernails and toenails in healthy American young adults","volume":"24","author":"Yaemsiri","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.envint.2018.08.010_bb0275","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbrc.2014.11.015","article-title":"Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3","volume":"455","author":"Yamagishi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412018309863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412018309863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:36:17Z","timestamp":1758972977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412018309863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":55,"alternative-id":["S0160412018309863"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2018.08.010","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2018.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}