{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:32:23Z","timestamp":1790357543332,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment, Government of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.envint.2019.01.051","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T14:26:27Z","timestamp":1549808787000},"page":"418-429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-8637","authenticated-orcid":false,"given":"Sumitaka","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-9269","authenticated-orcid":false,"given":"Reiko","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6211-8202","authenticated-orcid":false,"given":"Yasuaki","family":"Saijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5468-8988","authenticated-orcid":false,"given":"Koji","family":"Oba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3065-262X","authenticated-orcid":false,"given":"Atsuko","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-3631","authenticated-orcid":false,"given":"Chihiro","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Minatoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-4757","authenticated-orcid":false,"given":"Yu","family":"Ait Bamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tosiya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji F.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9235-1227","authenticated-orcid":false,"given":"Tomohiko","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.envint.2019.01.051_bb0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(93)91513-R","article-title":"The role of sulfhydryl groups and calcium in the mercuric chloride-induced inhibition of glutamate uptake in rat primary astrocyte cultures","volume":"607","author":"Albrecht","year":"1993","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.envint.2019.01.051_bb0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(93)90680-L","article-title":"Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures","volume":"602","author":"Aschner","year":"1993","journal-title":"Brain Res."},{"issue":"2\u20133","key":"10.1016\/j.envint.2019.01.051_bb0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0197-0186(00)00023-1","article-title":"Methylmercury alters glutamate transport in astrocytes","volume":"37","author":"Aschner","year":"2000","journal-title":"Neurochem. Int."},{"issue":"17","key":"10.1016\/j.envint.2019.01.051_bb0020","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults","volume":"353","author":"Barker","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.envint.2019.01.051_bb0025","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1056\/NEJMoa035698","article-title":"Relation of serial changes in childhood body mass index to impaired glucose tolerance in young adulthood","volume":"350","author":"Bhargava","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.envint.2019.01.051_bb0030","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1471-4159.1989.tb07419.x","article-title":"Inhibition of amino acid transport and protein synthesis by HgCl2 and methylmercury in astrocytes: selectivity and reversibility","volume":"53","author":"Brookes","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.envint.2019.01.051_bb0035","author":"Chemical Society of Japan"},{"issue":"5","key":"10.1016\/j.envint.2019.01.051_bb0040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/jes.2014.26","article-title":"Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children","volume":"24","author":"Chen","year":"2014","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"9","key":"10.1016\/j.envint.2019.01.051_bb0045","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1007\/s00216-011-5040-1","article-title":"Mercury speciation analysis in seafood by species-specific isotope dilution: method validation and occurrence data","volume":"401","author":"Cl\u00e9mens","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.envint.2019.01.051_bb0050","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s00125-002-1012-5","article-title":"Early adiposity rebound in childhood and risk of type 2 diabetes in adult life","volume":"46","author":"Eriksson","year":"2003","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.envint.2019.01.051_bb0055","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/oxfordjournals.aje.a115660","article-title":"Dietary intake of methylmercury as a correlate of gestational length and birth weight among newborns in Greenland","volume":"132","author":"Foldspang","year":"1990","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.envint.2019.01.051_bb0060","author":"Food Safety Communication Japan"},{"issue":"10","key":"10.1016\/j.envint.2019.01.051_bb0065","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1289\/ehp.1206115","article-title":"Dietary predictors of maternal prenatal blood mercury levels in the ALSPAC birth cohort study","volume":"121","author":"Golding","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.envint.2019.01.051_bb0070","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2337\/dc12-1842","article-title":"Mercury exposure in young adulthood and incidence of diabetes later in life: the CARDIA Trace Element Study","volume":"36","author":"He","year":"2013","journal-title":"Diabetes Care"},{"issue":"1\u20132","key":"10.1016\/j.envint.2019.01.051_bb0075","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0006-8993(96)00017-0","article-title":"Purkinje cells express neuronal nitric oxide synthase after methylmercury administration","volume":"718","author":"Himi","year":"1996","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.envint.2019.01.051_bb0080","first-page":"21","article-title":"Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China","volume":"60","author":"Hu","year":"2015","journal-title":"J. Reprod. Med."},{"issue":"1\u20133","key":"10.1016\/j.envint.2019.01.051_bb0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0048-9697(99)00116-3","article-title":"Methylmercury production and distribution in aquatic systems","volume":"234","author":"Ikingura","year":"1999","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.envint.2019.01.051_bb0090","first-page":"1271","article-title":"Introduction of the new standard for birth size by gestational ages","volume":"114","author":"Itabashi","year":"2010","journal-title":"J. Jpn. Pediatr. Soc."},{"issue":"3","key":"10.1016\/j.envint.2019.01.051_bb0095","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12011-007-8004-8","article-title":"Selenium and mercury in pelagic fish in the central north pacific near Hawaii","volume":"119","author":"Kaneko","year":"2007","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.envint.2019.01.051_bb0100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2458-14-25","article-title":"Rationale and study design of the Japan Environment and Children's Study (JECS)","volume":"14","author":"Kawamoto","year":"2014","journal-title":"BMC Public Health"},{"issue":"8","key":"10.1016\/j.envint.2019.01.051_bb0105","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0891-5849(03)00027-3","article-title":"Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress","volume":"34","author":"Komatsu","year":"2003","journal-title":"Free Radic. Biol. Med."},{"issue":"1\u20133","key":"10.1016\/j.envint.2019.01.051_bb0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12011-014-0007-7","article-title":"Protective roles of selenium on nitric oxide-mediated apoptosis of immune organs induced by cadmium in chickens","volume":"159","author":"Liu","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"issue":"5","key":"10.1016\/j.envint.2019.01.051_bb0115","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1289\/ehp.6587","article-title":"Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000","volume":"112","author":"Mahaffey","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.envint.2019.01.051_bb0120","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2188\/jea.JE20140186","article-title":"The Japan Environment and Children's Study (JECS): a preliminary report on selected characteristics of approximately 10000 pregnant women recruited during the first year of the study","volume":"25","author":"Michikawa","year":"2015","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.envint.2019.01.051_bb0125","author":"Ministry of Agriculture, Forestry and Fisheries, Japan"},{"key":"10.1016\/j.envint.2019.01.051_bb0130","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.scitotenv.2015.06.108","article-title":"Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size","volume":"533","author":"Miyashita","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.envint.2019.01.051_bb0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3177\/jnsv.50.309","article-title":"Dietary habits and selenium intake of residents in mountain and coastal communities in Japan","volume":"50","author":"Miyazaki","year":"2004","journal-title":"Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.envint.2019.01.051_bb0140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envres.2016.07.003","article-title":"Prenatal mercury exposure and birth outcomes","volume":"151","author":"Murcia","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2019.01.051_bb0145","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.chemosphere.2014.07.038","article-title":"Elevated prenatal methylmercury exposure in Nigeria: evidence from maternal and cord blood","volume":"119","author":"Obi","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2019.01.051_bb0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.envres.2013.02.003","article-title":"Associations of blood and urinary mercury with hypertension in U.S. adults: the NHANES 2003\u20132006","volume":"123","author":"Park","year":"2013","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.envint.2019.01.051_bb0155","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/BF00400663","article-title":"Insulin resistance as a programmed response to fetal undernutrition","volume":"39","author":"Phillips","year":"1996","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.envint.2019.01.051_bb0160","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3945\/ajcn.2009.27944","article-title":"Fish consumption during pregnancy, prenatal mercury exposure, and anthropometric measures at birth in a prospective mother-infant cohort study in Spain","volume":"90","author":"Ram\u00f3n","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.envint.2019.01.051_bb0165","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1503\/cmaj.101095","article-title":"Maternal selenium status during early gestation and risk for preterm birth","volume":"183","author":"Rayman","year":"2011","journal-title":"CMAJ"},{"issue":"1","key":"10.1016\/j.envint.2019.01.051_bb0170","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.envres.2006.03.004","article-title":"Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population","volume":"103","author":"Sakamoto","year":"2007","journal-title":"Environ. Res."},{"issue":"Suppl. 3","key":"10.1016\/j.envint.2019.01.051_bb0175","first-page":"451","article-title":"Identifying critical windows of exposure for children's health","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.envint.2019.01.051_bb0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-0029-1237427","article-title":"Developmental origins of health and disease: environmental exposures","volume":"27","author":"Swanson","year":"2009","journal-title":"Semin. Reprod. Med."},{"issue":"3\u20134","key":"10.1016\/j.envint.2019.01.051_bb0185","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0753-3322(03)00035-0","article-title":"The antioxidant role of selenium and seleno-compounds","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.envint.2019.01.051_bb0190","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12199-017-0635-6","article-title":"Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury, and lead on birth weight in Japanese male and female newborns","volume":"22","author":"Tatsuta","year":"2017","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.envint.2019.01.051_bb0195","author":"The Japanese Society for Pediatric Endocrinology"},{"issue":"1","key":"10.1016\/j.envint.2019.01.051_bb0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/00039896.1984.10545827","article-title":"Placental transfer of heavy metals in normal pregnant Japanese women","volume":"39","author":"Tsuchiya","year":"1984","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envint.2019.01.051_bb0205","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.2010.05456.x","article-title":"Bioaccumulation syndrome: identifying factors that make some stream food webs prone to elevated mercury bioaccumulation","volume":"1195","author":"Ward","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.envint.2019.01.051_bb0210","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1289\/ehp.1408596","article-title":"Cord blood methylmercury and fetal growth outcomes in Baltimore newborns: potential confounding and effect modification by omega-3 fatty acids, selenium, and sex","volume":"124","author":"Wells","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.envint.2019.01.051_bb0215","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.annepidem.2014.01.002","article-title":"Prenatal exposure to methylmercury and LCPUFA in relation to birth weight","volume":"24","author":"van Wijngaarden","year":"2014","journal-title":"Ann. Epidemiol."},{"issue":"2","key":"10.1016\/j.envint.2019.01.051_bb0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2796.2010.02338.x","article-title":"Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study","volume":"270","author":"Xun","year":"2011","journal-title":"J. Intern. Med."},{"issue":"2\u20133","key":"10.1016\/j.envint.2019.01.051_bb0225","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0304-4165(96)00108-0","article-title":"Role of nitric oxide in the cerebellar degeneration during methylmercury intoxication","volume":"1334","author":"Yamashita","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.envint.2019.01.051_bb0230","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/nu5020388","article-title":"Selenium content in seafood in Japan","volume":"5","author":"Yamashita","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.envint.2019.01.051_bb0235","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4327\/jsnfs.45.485","article-title":"Selenium intake and blood selenium level in Japanese","volume":"45","author":"Yoshida","year":"1992","journal-title":"J. Jpn. Soc. Nutr. Food Sci."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412018322359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412018322359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:39:31Z","timestamp":1758973171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412018322359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":47,"alternative-id":["S0160412018322359"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2019.01.051","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2019.01.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}