{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:32:06Z","timestamp":1784838726900,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.envint.2019.105378","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T13:59:43Z","timestamp":1576159183000},"page":"105378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Evaluation of the splenic injury following exposure of mice to bisphenol S: A mass spectrometry-based lipidomics and imaging analysis"],"prefix":"10.1016","volume":"135","author":[{"given":"Chao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2019.105378_b0005","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMoa012918","article-title":"Blood levels of long-chain n-3 fatty acids and the risk of sudden death","volume":"346","author":"Albert","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envint.2019.105378_b0010","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.envres.2015.11.029","article-title":"Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia","volume":"150","author":"Asimakopoulos","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2019.105378_b0015","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1210\/en.2015-1872","article-title":"Bisphenol S induces adipogenesis in primary human preadipocytes from female donors","volume":"157","author":"Boucher","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.envint.2019.105378_b0020","doi-asserted-by":"crossref","unstructured":"Boucher, J. G., Gagne,\u0301 R., Rowan-Carroll, A., Boudreau, A., Yauk, C. L., Atlas, E. 2016b. Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 11, e0163318.","DOI":"10.1371\/journal.pone.0163318"},{"key":"10.1016\/j.envint.2019.105378_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/jat.2874","article-title":"Review: toxicometabolomics","volume":"33","author":"Bouhifd","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envint.2019.105378_b0030","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.envint.2019.105378_b0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tox.2008.09.024","article-title":"Genotoxic and endocrine activities of bis (hydroxyphenyl) methane (bisphenol F) and its derivatives in the HepG2 cell line","volume":"255","author":"Cabaton","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2019.105378_b0040","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1289\/ehp.1205588","article-title":"Effects of low doses of bisphenol A on the metabolome of perinatally exposed CD-1 mice","volume":"121","author":"Cabaton","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2019.105378_b0045","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: Environmental occurrence, human exposure, and toxicity-a review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2019.105378_b0050","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1111\/bph.13135","article-title":"Future technology insight: mass spectrometry imaging as a tool in drug research and development","volume":"172","author":"Cobice","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.envint.2019.105378_b0055","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s13273-013-0049-5","article-title":"Bisphenol A impairs mitochondrial function in spleens of mice via oxidative stress","volume":"9","author":"Dong","year":"2013","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.envint.2019.105378_b0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2478\/10004-1254-64-2013-2319","article-title":"Mutagenicity and DNA damage of bisphenol A and its structural analogues in HepG2 cells","volume":"64","author":"Fic","year":"2013","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.envint.2019.105378_b0065","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature09968","article-title":"Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity","volume":"473","author":"Fu","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.envint.2019.105378_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-00961-8","article-title":"Impacts of bisphenol A and ethinyl estradiol on male and female CD-1 mouse spleen","volume":"7","author":"Gear","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2019.105378_b0075","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/jcb.20053","article-title":"Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system","volume":"92","author":"Goetzl","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.envint.2019.105378_b0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccr.2005.09.008","article-title":"ATP citrate lyase inhibition can suppress tumor cell growth","volume":"8","author":"Hatzivassiliou","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.envint.2019.105378_b0085","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.reprotox.2016.06.020","article-title":"Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI","volume":"65","author":"Hessel","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2019.105378_b0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jprot.2016.05.008","article-title":"Potential of MALDI imaging for the toxicological evaluation of environmental pollutants","volume":"144","author":"Lagarrigue","year":"2016","journal-title":"J. Proteomics"},{"key":"10.1016\/j.envint.2019.105378_b0095","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/hep.24685","article-title":"Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver","volume":"55","author":"Marmugi","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.envint.2019.105378_b0100","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.envint.2019.105378_b0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1289\/ehp.0901259","article-title":"Maternal bisphenol a exposure promotes the development of experimental asthma in mouse pups","volume":"118","author":"Midoro-Horiuti","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2019.105378_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/1476-069X-11-8","article-title":"Fetal exposure to bisphenol A as a risk factor for the development of childhood asthma: an animal model study","volume":"11","author":"Nakajima","year":"2012","journal-title":"Environ. Health."},{"key":"10.1016\/j.envint.2019.105378_b0115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1289\/ehp.9378","article-title":"Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators","volume":"115","author":"Narita","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2019.105378_b0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2016.09.018","article-title":"Metabolomics and Metabolic Diseases: Where Do We Stand?","volume":"25","author":"Newgard","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.envint.2019.105378_b0125","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/4551054a","article-title":"Systems biology: metabonomics","volume":"455","author":"Nicholson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.envint.2019.105378_b0130","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.132384699","article-title":"Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity","volume":"99","author":"Ntambi","year":"2002","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2019.105378_b0135","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1016\/j.jprot.2012.07.028","article-title":"Mass spectrometry imaging for drug distribution studies","volume":"75","author":"Prideaux","year":"2012","journal-title":"J. Proteome."},{"key":"10.1016\/j.envint.2019.105378_b0140","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI44442","article-title":"Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans","volume":"121","author":"Rhee","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envint.2019.105378_b0145","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2007.06.004","article-title":"In vivo effects of bisphenol A in laboratory rodent studies","volume":"24","author":"Richter","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2019.105378_b0150","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s40572-015-0066-8","article-title":"The impact of bisphenol A and phthalates on allergy, asthma, and immune function: a review of latest findings","volume":"2","author":"Robinson","year":"2015","journal-title":"Curr. Envir. Health Rpt."},{"key":"10.1016\/j.envint.2019.105378_b0155","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: a review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2019.105378_b0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/toxsci\/kfu030","article-title":"Are structural analogues to bisphenol A safe alternatives?","volume":"139","author":"Rosenmai","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2019.105378_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038448","article-title":"developmental exposure to bisphenol A modulates innate but not adaptive immune responses to influenza a virus infection","volume":"7","author":"Roy","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.envint.2019.105378_b0175","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s10545-007-0632-9","article-title":"The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease","volume":"30","author":"Schuchman","year":"2007","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.envint.2019.105378_b0180","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/MEG.0b013e3283229b40","article-title":"Could inflammatory markers help diagnose nonalcoholic steatohepatitis ?","volume":"21","author":"Tarantino","year":"2009","journal-title":"Eur. J. Gastroen. Hepat."},{"key":"10.1016\/j.envint.2019.105378_b0185","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2265.2012.04500.x","article-title":"Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis","volume":"78","author":"Tarantino","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.envint.2019.105378_b0190","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3748\/wjg.v19.i23.3534","article-title":"Liver-spleen axis: intersection between immunity, infections and metabolism","volume":"19","author":"Tarantino","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.envint.2019.105378_b0195","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10590500600936482","article-title":"Human health risk on environmental exposure to Bisphenol-A: a review","volume":"24","author":"Tsai","year":"2006","journal-title":"J. Environ. Sci. Health Part C: Environ. Carcinog. Ecotoxicol. Rev."},{"key":"10.1016\/j.envint.2019.105378_b0205","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"Van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.envint.2019.105378_b0210","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/ac504294s","article-title":"MALDI-TOF MS imaging of metabolites with a N-(1-naphthyl) ethylenediamine dihydrochloride matrix and its application to colorectal cancer liver metastasis","volume":"87","author":"Wang","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envint.2019.105378_b0215","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1289\/ehp.10829","article-title":"Exposure to Bisphenol A prenatally or in adulthood promotes Th2 cytokine production associated with reduction of CD4 CD25 regulatory T cells","volume":"116","author":"Yan","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2019.105378_b0220","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2567.2004.01900.x","article-title":"Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice","volume":"112","author":"Yoshino","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.envint.2019.105378_b0225","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/sj.bjp.0705166","article-title":"Effects of bisphenol A on antigen-specific antibody production, proliferative responses of lymphoid cells, and TH1 and TH2 immune responses in mice","volume":"138","author":"Yoshino","year":"2003","journal-title":"Brit. J. Pharmacol."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412019330636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412019330636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:43:54Z","timestamp":1758973434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412019330636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":43,"alternative-id":["S0160412019330636"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2019.105378","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the splenic injury following exposure of mice to bisphenol S: A mass spectrometry-based lipidomics and imaging analysis","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2019.105378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105378"}}