{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:47:01Z","timestamp":1781801221578,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.envint.2020.105664","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T01:06:41Z","timestamp":1584580001000},"page":"105664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Indoor microbiome, environmental characteristics and asthma among junior high school students in Johor Bahru, Malaysia"],"prefix":"10.1016","volume":"138","author":[{"given":"Xi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Norb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal Hisham","family":"Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zailina","family":"Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faridah","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Xin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Dho","family":"Spangfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.envint.2020.105664_b0005","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/ismej.2013.28","article-title":"Dispersal in microbes: fungi in indoor air are dominated by outdoor air and show dispersal limitation at short distances","volume":"7","author":"Adams","year":"2013","journal-title":"ISME J."},{"issue":"31","key":"10.1016\/j.envint.2020.105664_b0010","doi-asserted-by":"crossref","first-page":"13748","DOI":"10.1073\/pnas.1000454107","article-title":"Indoor fungal composition is geographically patterned and more diverse in temperate zones than in the tropics","volume":"107","author":"Amend","year":"2010","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.envint.2020.105664_b0015","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/ina.12261","article-title":"Fungal compositions and diversities on indoor surfaces with visible mold growths in residential buildings in the Seoul Capital Area of South Korea","volume":"26","author":"An","year":"2016","journal-title":"Indoor Air"},{"key":"10.1016\/j.envint.2020.105664_b0020","doi-asserted-by":"crossref","unstructured":"Barberan, A., Dunn, R.R., Reich, B.J., Pacifici, K., Laber, E.B., Menninger, H.L., et al., 2015. The ecology of microscopic life in household dust. Proc. Biol. Sci. 282(1814).","DOI":"10.1098\/rspb.2015.1139"},{"issue":"18","key":"10.1016\/j.envint.2020.105664_b0025","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1073\/pnas.1420815112","article-title":"Continental-scale distributions of dust-associated bacteria and fungi","volume":"112","author":"Barberan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6410","key":"10.1016\/j.envint.2020.105664_b0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1126\/science.aau8816","article-title":"Preserving microbial diversity","volume":"362","author":"Bello","year":"2018","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.envint.2020.105664_b0035","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1097\/MPG.0000000000001264","article-title":"Clostridium difficile infection in children: a review","volume":"63","author":"Borali","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"3","key":"10.1016\/j.envint.2020.105664_b0040","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1399-3038.2010.01127.x","article-title":"Fungal DNA, allergens, mycotoxins and associations with asthmatic symptoms among pupils in schools from Johor Bahru, Malaysia","volume":"22","author":"Cai","year":"2011","journal-title":"Pediatric Allergy Immunol.: Off. Publ. Eur. Soc. Pediatric Allergy Immunol."},{"issue":"5","key":"10.1016\/j.envint.2020.105664_b0045","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"issue":"6","key":"10.1016\/j.envint.2020.105664_b0050","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jaip.2016.05.003","article-title":"Risk and protective factors for childhood asthma: what is the evidence?","volume":"4","author":"Castro-Rodriguez","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"3","key":"10.1016\/j.envint.2020.105664_b0055","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/ina.12072","article-title":"Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development","volume":"24","author":"Dannemiller","year":"2014","journal-title":"Indoor Air"},{"issue":"1","key":"10.1016\/j.envint.2020.105664_b0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaci.2015.11.027","article-title":"Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children","volume":"138","author":"Dannemiller","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.envint.2020.105664_b0065","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/ina.12313","article-title":"Fungal and bacterial growth in floor dust at elevated relative humidity levels","volume":"27","author":"Dannemiller","year":"2017","journal-title":"Indoor Air"},{"issue":"1","key":"10.1016\/j.envint.2020.105664_b0070","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ppul.23498","article-title":"Asthma in adolescence: is there any news?","volume":"52","author":"de Benedictis","year":"2017","journal-title":"Pediatr. Pulmonol."},{"issue":"21","key":"10.1016\/j.envint.2020.105664_b0075","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1056\/NEJMra054308","article-title":"The asthma epidemic","volume":"355","author":"Eder","year":"2006","journal-title":"New Engl. J. Med."},{"issue":"8","key":"10.1016\/j.envint.2020.105664_b0080","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"New Engl. J. Med."},{"issue":"1","key":"10.1016\/j.envint.2020.105664_b0085","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1038\/s41467-018-07240-8","article-title":"High throughput in situ metagenomic measurement of bacterial replication at ultra-low sequencing coverage","volume":"9","author":"Emiola","year":"2018","journal-title":"Nat. Commun."},{"issue":"46","key":"10.1016\/j.envint.2020.105664_b0090","doi-asserted-by":"crossref","first-page":"23299","DOI":"10.1073\/pnas.1908493116","article-title":"Microbial communities in the tropical air ecosystem follow a precise diel cycle","volume":"116","author":"Gusareva","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.envint.2020.105664_b0095","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1099\/ijsem.0.002171","article-title":"Izhakiella australiensis sp. nov. isolated from an Australian desert soil","volume":"67","author":"Ji","year":"2017","journal-title":"Int. J. Syst. Evol. Microbiol."},{"issue":"7","key":"10.1016\/j.envint.2020.105664_b0100","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41591-019-0469-4","article-title":"Farm-like indoor microbiota in non-farm homes protects children from asthma development","volume":"25","author":"Kirjavainen","year":"2019","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.envint.2020.105664_b0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.jea.7500165","article-title":"The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants","volume":"11","author":"Klepeis","year":"2001","journal-title":"J. Expo. Anal. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2020.105664_b0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-6685-1_9","article-title":"Analysis of 16S rRNA gene amplicon sequences using the QIIME software package","volume":"1537","author":"Lawley","year":"2017","journal-title":"Meth. Mol. Biol. (Clifton, NJ)."},{"issue":"Pt 1","key":"10.1016\/j.envint.2020.105664_b0115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1099\/00221287-148-1-257","article-title":"Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set","volume":"148","author":"Nadkarni","year":"2002","journal-title":"Microbiology (Reading, England)."},{"issue":"2","key":"10.1016\/j.envint.2020.105664_b0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/ina.12182","article-title":"Indoor fungi: companions and contaminants","volume":"25","author":"Nevalainen","year":"2015","journal-title":"Indoor Air"},{"issue":"2","key":"10.1016\/j.envint.2020.105664_b0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1001\/jama.2013.284692","article-title":"Smoking prevalence and cigarette consumption in 187 countries, 1980\u20132012","volume":"311","author":"Ng","year":"2014","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.envint.2020.105664_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088303","article-title":"Endotoxin, ergosterol, fungal DNA and allergens in dust from schools in Johor Bahru, Malaysia- associations with asthma and respiratory infections in pupils","volume":"9","author":"Norback","year":"2014","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.envint.2020.105664_b0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147996","article-title":"Rhinitis, ocular, throat and dermal symptoms, headache and tiredness among students in schools from Johor Bahru, Malaysia: associations with Fungal DNA and mycotoxins in classroom dust","volume":"11","author":"Norback","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.envint.2020.105664_b0140","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.10.148","article-title":"Respiratory symptoms and fractional exhaled nitric oxide (FeNO) among students in Penang, Malaysia in relation to signs of dampness at school and fungal DNA in school dust","volume":"577","author":"Norback","year":"2017","journal-title":"Sci. Tot. Environ."},{"issue":"4","key":"10.1016\/j.envint.2020.105664_b0145","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jaci.2017.06.040","article-title":"Early-life home environment and risk of asthma among inner-city children","volume":"141","author":"O'Connor","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.envint.2020.105664_b0150","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1183\/09031936.05.00120104","article-title":"Operational definitions of asthma in studies on its aetiology","volume":"26","author":"Pekkanen","year":"2005","journal-title":"Eur. Eespiratory J."},{"issue":"2","key":"10.1016\/j.envint.2020.105664_b0155","doi-asserted-by":"crossref","first-page":"1701241","DOI":"10.1183\/13993003.01241-2017","article-title":"Indoor bacteria and asthma in adults: a multicentre case\u2013control study within ECRHS II","volume":"51","author":"Pekkanen","year":"2018","journal-title":"Eur. Respir. J."},{"issue":"11","key":"10.1016\/j.envint.2020.105664_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047526","article-title":"Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis","volume":"7","author":"Quansah","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.envint.2020.105664_b0165","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2014.07.002","article-title":"Indoor fungal diversity and asthma: a meta-analysis and systematic review of risk factors","volume":"135","author":"Sharpe","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.envint.2020.105664_b0170","doi-asserted-by":"crossref","first-page":"16020","DOI":"10.1038\/nrdp.2016.20","article-title":"Clostridium difficile infection","volume":"2","author":"Smits","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7681","key":"10.1016\/j.envint.2020.105664_b0175","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature24460","article-title":"Quantitative microbiome profiling links gut community variation to microbial load","volume":"551","author":"Vandeputte","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.envint.2020.105664_b0180","doi-asserted-by":"crossref","unstructured":"Wang, J., Pindus, M., Janson, C., Sigsgaard, T., Kim, J.L., Holm, M., et al., 2019. Dampness, mould, onset and remission of adult respiratory symptoms, asthma and rhinitis. Eur. Respirat. J. 53(5).","DOI":"10.1183\/13993003.01921-2018"},{"issue":"21","key":"10.1016\/j.envint.2020.105664_b0185","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.5194\/bg-12-6337-2015","article-title":"Characterization of active and total fungal communities in the atmosphere over the Amazon rainforest","volume":"12","author":"Womack","year":"2015","journal-title":"Biogeosciences"},{"issue":"12","key":"10.1016\/j.envint.2020.105664_b0190","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11882-016-0667-9","article-title":"Fungal exposure and asthma: IgE and non-IgE-mediated mechanisms","volume":"16","author":"Zhang","year":"2016","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"1","key":"10.1016\/j.envint.2020.105664_b0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5455\/jice.20141128051842","article-title":"Evaluation of probiotic potential of yeasts isolated from traditional cheeses manufactured in Serbia and Croatia","volume":"4","author":"Zivkovic","year":"2015","journal-title":"J. Intercult. Ethnopharmacol."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412019346653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412019346653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:55:57Z","timestamp":1758974157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412019346653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":39,"alternative-id":["S0160412019346653"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2020.105664","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indoor microbiome, environmental characteristics and asthma among junior high school students in Johor Bahru, Malaysia","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2020.105664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105664"}}