{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:33:49Z","timestamp":1791545629682,"version":"4.3.4"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.envint.2020.105887","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T15:34:36Z","timestamp":1593531276000},"page":"105887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":284,"special_numbering":"C","title":["What is new in the exposome?"],"prefix":"10.1016","volume":"143","author":[{"given":"Paolo","family":"Vineis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Chadeau-Hyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Mudway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Dagnino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6312","key":"10.1016\/j.envint.2020.105887_b0005","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1126\/science.aag0299","article-title":"Mutational signatures associated with tobacco smoking in human cancer","volume":"354","author":"Alexandrov","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.envint.2020.105887_b0010","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/EDE.0000000000000847","article-title":"Long-term concentrations of nitrogen dioxide and mortality: a meta-analysis of cohort studies","volume":"29","author":"Atkinson","year":"2018","journal-title":"Epidemiology"},{"issue":"3","key":"10.1016\/j.envint.2020.105887_b0015","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1021\/ac403565m","article-title":"Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures","volume":"86","author":"Balbo","year":"2014","journal-title":"Anal. Chem."},{"issue":"C","key":"10.1016\/j.envint.2020.105887_b0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atmosenv.2012.05.034","article-title":"One way coupling of CMAQ and a road source dispersion model for fine scale air pollution predictions","volume":"59","author":"Beevers","year":"2012","journal-title":"Atmos. Environ."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/jes.2013.6","article-title":"Air pollution dispersion models for human exposure predictions in London","volume":"23","author":"Beevers","year":"2013","journal-title":"J. Expo Sci. Environ. Epidemiol."},{"issue":"3","key":"10.1016\/j.envint.2020.105887_b0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/geronj\/2.3.217","article-title":"Biologic versus Chronoligic age","volume":"2","author":"Benjamin","year":"1947","journal-title":"J. Gerontol."},{"issue":"2","key":"10.1016\/j.envint.2020.105887_b0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/10408444.2019.1579169","article-title":"Regulatory assessment and risk management of chemical mixtures: challenges and ways forward","volume":"49","author":"Bopp","year":"2019","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envint.2020.105887_b0040","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1136\/bmj.l1855","article-title":"Understanding the consequences of education inequality on cardiovascular disease: Mendelian randomisation study","volume":"365","author":"Carter","year":"2019","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.envint.2020.105887_b0045","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s00204-018-2252-6","article-title":"Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures","volume":"92","author":"Chang","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.envint.2020.105887_b0050","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.5194\/amt-12-4643-2019","article-title":"Characterising low-cost sensors in highly portable platforms to quantify personal exposure in diverse environments","volume":"12","author":"Chatzidiakou","year":"2019","journal-title":"Atmos. Meas. Tech."},{"issue":"24","key":"10.1016\/j.envint.2020.105887_b0055","first-page":"4313","article-title":"MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data","volume":"34","author":"Chong","year":"2018","journal-title":"Bioinformatics (Oxford, England)"},{"key":"10.1016\/j.envint.2020.105887_b0060","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.envint.2018.10.041","article-title":"Urinary DNA adductomics \u2013 a novel approach for exposomics","volume":"121","author":"Cooke","year":"2018","journal-title":"Environ. Int."},{"issue":"794","key":"10.1016\/j.envint.2020.105887_b0065","article-title":"Editorial: mass spectrometry for adductomic analysis","volume":"7","author":"Cooke","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.envint.2020.105887_b0070","doi-asserted-by":"crossref","unstructured":"Dagnino, S., 2019. Unravelling the Exposome: Conclusions and Thoughts for the Future. Unraveling the Exposome: A Practical View. S. Dagnino and A. Macherone. Cham, Springer International Publishing, pp. 425\u2013437.","DOI":"10.1007\/978-3-319-89321-1_17"},{"key":"10.1016\/j.envint.2020.105887_b0075","article-title":"Agnostic Cys34-albumin adductomics and DNA methylation: implication of N-acetylcysteine in lung carcinogenesis years before diagnosis","author":"Dagnino","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.envint.2020.105887_b0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mad.2018.01.002","article-title":"Back to the future: epigenetic clock plasticity towards healthy aging","volume":"174","author":"Declerck","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.envint.2020.105887_b0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.envint.2018.07.036","article-title":"Spatial PM2.5, NO2, O3 and BC models for Western Europe - Evaluation of spatiotemporal stability","volume":"120","author":"de Hoogh","year":"2018","journal-title":"Environ. Int."},{"issue":"11","key":"10.1016\/j.envint.2020.105887_b0090","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1021\/es400156t","article-title":"Development of land use regression models for particle composition in twenty study areas in Europe","volume":"47","author":"de Hoogh","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b0095","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12933","article-title":"Filling the gap between chemical carcinogenesis and the hallmarks of cancer: a temporal perspective","volume":"48","author":"Demetriou","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.envint.2020.105887_b0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.envint.2017.10.003","article-title":"Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool","volume":"110","author":"Esp\u00edn-P\u00e9rez","year":"2018","journal-title":"Environ. Int."},{"issue":"Pt A","key":"10.1016\/j.envint.2020.105887_b0105","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.envpol.2018.06.051","article-title":"Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies","volume":"242","author":"Espin-Perez","year":"2018","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.envint.2020.105887_b0110","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/CIRCRESAHA.118.312816","article-title":"Time and the metrics of aging","volume":"123","author":"Ferrucci","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.envint.2020.105887_b0115","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb3004s114","article-title":"Metabolomics by gas chromatography-mass spectrometry: combined targeted and untargeted profiling","volume":"114","author":"Fiehn","year":"2016","journal-title":"Curr. Protoc. Mol. Biol."},{"issue":"7","key":"10.1016\/j.envint.2020.105887_b0120","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.18632\/aging.101900","article-title":"Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis","volume":"11","author":"Fiorito","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"10.1016\/j.envint.2020.105887_b0125","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/em.22153","article-title":"Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: a prospective study in nonsmokers","volume":"59","author":"Fiorito","year":"2018","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.envint.2020.105887_b0130","unstructured":"Food and Drug Administration HHS, 2012. International Conference on Harmonisation; guidance on S2(R1) Genotoxicity Testing and Data Interpretation for Pharmaceuticals intended for Human Use; availability. Notice. Fed Regist 77(110), 33748\u201333749."},{"issue":"8","key":"10.1016\/j.envint.2020.105887_b0135","doi-asserted-by":"crossref","first-page":"568","DOI":"10.18632\/aging.100792","article-title":"Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females","volume":"7","author":"Gentilini","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.envint.2020.105887_b0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.envint.2015.02.003","article-title":"Assessing the human health impacts of exposure to disinfection by-products\u2013a critical review of concepts and methods","volume":"78","author":"Grellier","year":"2015","journal-title":"Environ. Int."},{"issue":"23","key":"10.1016\/j.envint.2020.105887_b0145","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1158\/0008-5472.CAN-19-1529","article-title":"Cys34 adductomics links colorectal cancer with the gut microbiota and redox biology","volume":"79","author":"Grigoryan","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.envint.2020.105887_b0150","doi-asserted-by":"crossref","first-page":"10504","DOI":"10.1021\/acs.analchem.6b02553","article-title":"Adductomics pipeline for untargeted analysis of modifications to Cys34 of human serum albumin","volume":"88","author":"Grigoryan","year":"2016","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.envint.2020.105887_b0155","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/carcin\/bgy042","article-title":"Adductomic signatures of benzene exposure provide insights into cancer induction","volume":"39","author":"Grigoryan","year":"2018","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.envint.2020.105887_b0160","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/hmg\/ddu751","article-title":"Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation","volume":"24","author":"Guida","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.envint.2020.105887_b0165","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1021\/acs.analchem.7b04424","article-title":"METLIN: a technology platform for identifying knowns and unknowns","volume":"90","author":"Guijas","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envint.2020.105887_b0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.envres.2017.10.002","article-title":"Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas","volume":"160","author":"Gulliver","year":"2018","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.envint.2020.105887_b0175","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.envint.2020.105887_b0180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol. Cell."},{"issue":"10","key":"10.1016\/j.envint.2020.105887_b0195","first-page":"R115","article-title":"DNA methylation age of human tissues and cell types [published correction appears in Genome Biol. 2015;16: 96]","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.envint.2020.105887_b0200","unstructured":"IARC, 2020. Exposome-Explorer Database, from http:\/\/exposome-explorer.iarc.fr\/about."},{"key":"10.1016\/j.envint.2020.105887_b0205","unstructured":"IARC, 2016. Working Group on the Evaluation of Carcinogenic Risks to Humans Outdoor Air Pollution. IARC Monogr Eval Carcinog Risks Hum, vol. 109, pp. 9\u2013444."},{"issue":"24","key":"10.1016\/j.envint.2020.105887_b0210","doi-asserted-by":"crossref","first-page":"14435","DOI":"10.1021\/es502568z","article-title":"Development of land use regression models for elemental, organic carbon, PAH, and hopanes\/steranes in 10 ESCAPE\/TRANSPHORM European study areas","volume":"48","author":"Jedynska","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2020.105887_b0215","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.envint.2018.06.025","article-title":"Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases","volume":"119","author":"Jeong","year":"2018","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.envint.2020.105887_b0225","doi-asserted-by":"crossref","first-page":"12866","DOI":"10.3390\/ijerph111212866","article-title":"The public health exposome: a population-based, exposure science approach to health disparities research","volume":"11","author":"Juarez","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2020.105887_b0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ebiom.2017.03.046","article-title":"Biological age predictors","volume":"21","author":"Jylh\u00e4v\u00e4","year":"2017","journal-title":"EBioMedicine."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b0235","first-page":"1866","article-title":"Triangulation in aetiological epidemiology","volume":"45","author":"Lawlor","year":"2016","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.envint.2020.105887_b0240","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"10.1016\/j.envint.2020.105887_b0245","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.004606","article-title":"Profiling Cys(34) adducts of human serum albumin by fixed-step selected reaction monitoring","volume":"10","author":"Li","year":"2011","journal-title":"Mol. Cell. Proteom.: MCP"},{"key":"10.1016\/j.envint.2020.105887_b0250","article-title":"Cys34 adductomes differ between patients with chronic lung or heart disease and healthy controls in Central London","author":"Liu","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b0255","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.envint.2020.105887_b0260","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.envint.2020.105887_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kft251","article-title":"The nature of nurture: refining the definition of the exposome","volume":"137","author":"Miller Gary","year":"2014","journal-title":"Toxicol. Sci."},{"issue":"22","key":"10.1016\/j.envint.2020.105887_b0270","doi-asserted-by":"crossref","first-page":"13469","DOI":"10.1021\/acs.est.8b02215","volume":"52","author":"Maitre","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2020.105887_b0275","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envint.2018.07.026","article-title":"Acute changes in DNA methylation in relation to 24h personal air pollution exposure measurements: a panel study in four European countries","volume":"120","author":"Mostafavi","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.105887_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2015.04.003","article-title":"Inflammatory markers in relation to long-term air pollution","volume":"81","author":"Mostafavi","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.105887_b0285","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/d41586-018-01023-3","article-title":"Robust research needs many lines of evidence","volume":"553","author":"Munafo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.envint.2020.105887_b0290","unstructured":"National Academies of Sciences Engeneering and Medicine, 2017. Using 21st Century Science to Improve Risk-Related Evaluations. Washington, DC."},{"issue":"11","key":"10.1016\/j.envint.2020.105887_b0295","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/cvr\/cvz030","article-title":"Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of cardiometabolic phenotypes","volume":"115","author":"Nikpay","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.envint.2020.105887_b0300","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/MOP.0000000000000875","article-title":"Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome","volume":"32","author":"Petrick","year":"2020","journal-title":"Curr. Opin. Pediatr."},{"issue":"9","key":"10.1016\/j.envint.2020.105887_b0305","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1021\/acs.est.7b06447","article-title":"DNA methylome marks of exposure to particulate matter at three time points in early life","volume":"52","author":"Plusquin","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2020.105887_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124667","article-title":"Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study","volume":"239","author":"Preston","year":"2020","journal-title":"Chemosphere"},{"issue":"6003","key":"10.1016\/j.envint.2020.105887_b0315","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1126\/science.1192603","article-title":"Epidemiology environment and disease risks","volume":"330","author":"Rappaport","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.envint.2020.105887_b0320","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/epirev\/mxs001","article-title":"Is socioeconomic status associated with biological aging as measured by telomere length?","volume":"35","author":"Robertson","year":"2013","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.envint.2020.105887_b0325","article-title":"Determinants of accelerated metabolomic and epigenetic aging in a UK cohort","volume":"00","author":"Robinson","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.envint.2020.105887_b0330","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025163","article-title":"The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span","volume":"6","author":"Sierra","year":"2016","journal-title":"Cold Spring Harb Perspect. Med."},{"issue":"10118","key":"10.1016\/j.envint.2020.105887_b0335","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(17)32643-0","volume":"391","author":"Sinharay","year":"2018","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.envint.2020.105887_b0340","doi-asserted-by":"crossref","first-page":"11760","DOI":"10.1021\/acs.est.6b01817","article-title":"London Hybrid exposure model: improving human exposure estimates to NO2 and PM2.5 in an urban setting","volume":"50","author":"Smith","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"9","key":"10.1016\/j.envint.2020.105887_b0345","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/em.21985","article-title":"Using exposomics to assess cumulative risks and promote health","volume":"56","author":"Smith","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b0350","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1289\/ehp.1509912","article-title":"Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis","volume":"124","author":"Smith","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b9000","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1289\/ehp.1509912","article-title":"Key Characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis","volume":"124","author":"Smith","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"10075","key":"10.1016\/j.envint.2020.105887_b0460","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0140-6736(16)32380-7","article-title":"Socioeconomic status and the 25 \u00d7 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1\u00b77 million men and women","volume":"389","author":"Stringhini","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2020.105887_b9010","doi-asserted-by":"crossref","first-page":"11706","DOI":"10.1021\/acs.analchem.5b02759","article-title":"Screening for DNA alkylation mono and cross-linked adducts with a comprehensive LC-MS(3) adductomic approach","volume":"87","author":"Stornetta","year":"2015","journal-title":"Analyt. Chem."},{"issue":"3","key":"10.1016\/j.envint.2020.105887_b0355","article-title":"A comparison of genetic sampling methodologies for candidate-gene analyses","volume":"5","author":"Sun","year":"2019","journal-title":"J. Transl. Sci."},{"issue":"12","key":"10.1016\/j.envint.2020.105887_b0365","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/acs.chemrestox.6b00179","article-title":"Computational metabolomics: a framework for the million metabolome","volume":"29","author":"Uppal","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2020.105887_b9005","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.analchem.6b01214","article-title":"xMSannotator: An R Package for Network-based annotation of high-resolution metabolomics data","volume":"89","author":"Uppal","year":"2017","journal-title":"Analyt. Chem."},{"issue":"6","key":"10.1016\/j.envint.2020.105887_b0370","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1021\/acs.est.6b05920","article-title":"Land use regression models for ultrafine particles in six European areas","volume":"51","author":"van Nunen","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2020.105887_b0375","first-page":"167","article-title":"Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers","volume":"11","author":"Van Schooten","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.envint.2020.105887_b0380","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.envint.2017.11.017","article-title":"Effects of exposure to water disinfection by-products in a swimming pool: a metabolome-wide association study","volume":"111","author":"van Veldhoven","year":"2018","journal-title":"Environ Int."},{"key":"10.1016\/j.envint.2020.105887_b0385","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.envint.2018.11.034","article-title":"Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies","volume":"123","author":"van Veldhoven","year":"2019","journal-title":"Environ Int."},{"issue":"6476","key":"10.1016\/j.envint.2020.105887_b0390","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.envint.2020.105887_b0395","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijheh.2016.08.001","article-title":"The exposome in practice: design of the EXPOsOMICS project","volume":"220","author":"Vineis","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2020.105887_b0400","article-title":"Health inequalities: embodied evidence across biological layers","volume":"246","author":"Vineis","year":"2019","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.envint.2020.105887_b0405","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1476-069X-8-54","article-title":"The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability","volume":"8","author":"Vineis","year":"2009","journal-title":"Environ. Health"},{"issue":"8","key":"10.1016\/j.envint.2020.105887_b0410","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1158\/1055-9965.EPI-05-0456","article-title":"Complementing the genome with an \u201cexposome\u201d: the outstanding challenge of environmental exposure measurement in molecular epidemiology","volume":"14","author":"Wild","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"1","key":"10.1016\/j.envint.2020.105887_b0415","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ije\/dyr236","article-title":"The exposome: from concept to utility","volume":"41","author":"Wild","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.envint.2020.105887_b0420","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s40471-019-00187-4","article-title":"The metabolome: a key measure for exposome research in epidemiology","volume":"6","author":"Walker","year":"2019","journal-title":"Curr. Epidemiol. Rep."},{"issue":"5","key":"10.1016\/j.envint.2020.105887_b0425","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/ije\/dyw218","article-title":"High-resolution metabolomics of occupational exposure to trichloroethylene","volume":"45","author":"Walker","year":"2016","journal-title":"Int. J. Epidemiol."},{"issue":"6428","key":"10.1016\/j.envint.2020.105887_b0430","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar7785","article-title":"The human gut bacterial genotoxin colibactin alkylates DNA","volume":"363","author":"Wilson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.envint.2020.105887_b0435","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the human metabolome database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.envint.2020.105887_b0440","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1016\/S2542-5196(18)30067-6","article-title":"The Lancet Countdown on health benefits from the UK Climate Change Act: a modelling study for Great Britain","volume":"2","author":"Williams","year":"2018","journal-title":"Lancet Planet Health"},{"issue":"11","key":"10.1016\/j.envint.2020.105887_b0445","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s00216-019-01675-8","article-title":"Untargeted adductomics of Cys34 modifications to human serum albumin in newborn dried blood spots","volume":"411","author":"Yano","year":"2019","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412020318420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412020318420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T11:54:05Z","timestamp":1758974045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412020318420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":89,"alternative-id":["S0160412020318420"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2020.105887","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What is new in the exposome?","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2020.105887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105887"}}