{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:51:38Z","timestamp":1792252298449,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.envint.2020.105943","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:59:23Z","timestamp":1594385963000},"page":"105943","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The multiplex interactions and molecular mechanism on genotoxicity induced by formaldehyde and acrolein mixtures on human bronchial epithelial BEAS-2B cells"],"prefix":"10.1016","volume":"143","author":[{"given":"Sen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2020.105943_b0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10408449891344164","article-title":"Toxicological evaluation and risk assessment of chemical mixtures","volume":"28","author":"Cassee","year":"1998","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envint.2020.105943_b0010","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.tiv.2013.02.003","article-title":"In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells","volume":"27","author":"Cheah","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.envint.2020.105943_b0015","first-page":"30","article-title":"Effect of typical aldehyde pollutants on the DNA damage of spleen lymphocytes of mice","volume":"29","author":"Danfeng","year":"2000","journal-title":"J. Hyg. Res."},{"key":"10.1016\/j.envint.2020.105943_b0020","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1289\/ehp.1409557","article-title":"Synergistic and antagonistic mutation responses of human MCL-5 cells to mixtures of benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: dose-related variation in the joint effects of common dietary carcinogens","volume":"124","author":"David","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2020.105943_b0025","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1073\/pnas.0607031103","article-title":"Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair","volume":"103","author":"Feng","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2020.105943_b0030","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.6828890","article-title":"Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells","volume":"220","author":"Grafstr\u00f6m","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.envint.2020.105943_b0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0009-2797(93)90110-K","article-title":"Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-nitroso-N-methylurea","volume":"86","author":"Grafstr\u00f6m","year":"1993","journal-title":"Chem-Biol. Interact."},{"key":"10.1016\/j.envint.2020.105943_b0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxlet.2013.08.024","article-title":"Genotoxicity evaluation of individual cigarette smoke toxicants using the in vitro \u03b3H2AX assay by High Content Screening","volume":"223","author":"Garcia-Canton","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.envint.2020.105943_b0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fuel.2016.02.005","article-title":"Formaldehyde, acetaldehyde and other aldehyde emissions from HCCI\/SI gasoline engine equipped with prototype catalyst","volume":"175","author":"Hasan","year":"2016","journal-title":"Fuel"},{"key":"10.1016\/j.envint.2020.105943_b0055","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/carcin\/bgs373","article-title":"Genetic variation in a hsa-let-7 binding site in RAD52 is associated with breast cancer susceptibility","volume":"34","author":"Jiang","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envint.2020.105943_b0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/10715760802008114","article-title":"The role of oxidative stress in acrolein-induced DNA damage in HepG2 cells","volume":"42","author":"Li","year":"2008","journal-title":"Free Radical Res."},{"key":"10.1016\/j.envint.2020.105943_b0065","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2741\/1856","article-title":"Studies on formation and repair of formaldehyde-damaged DNA by detection of DNA-protein crosslinks and DNA breaks","volume":"11","author":"Liu","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.envint.2020.105943_b0070","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1021\/tx5001046","article-title":"Molecular mechanisms of aldehyde toxicity: A chemical perspective","volume":"27","author":"LoPachin","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2020.105943_b0075","first-page":"3172","article-title":"DNA-dependent protease activity of human Spartan facilitates replication of DNA-protein crosslink-containing DNA","volume":"45","author":"M\u00f3rocz","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2020.105943_b0080","unstructured":"OECD, 2014. OECD Guidelines for the testing of chemicals: In vitro mammalian cell micronucleus test(TG 487). Organisation for Economic Co-operation and Development."},{"key":"10.1016\/j.envint.2020.105943_b0085","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.ajpath.2016.06.022","article-title":"Formaldehyde is a potent proteotoxic stressor causing rapid heat shock transcription factor 1 activation and Lys48-linked polyubiquitination of proteins","volume":"186","author":"Ortega-Atienza","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.envint.2020.105943_b0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/toxsci\/kfu087","article-title":"Acrolein decreases endothelial cell migration and insulin sensitivity through induction of let-7a","volume":"140","author":"O\u2019Toole","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2020.105943_b0095","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0940-9602(01)80039-X","article-title":"Microtubules and vimentin associated filaments (VIFs) in cultured human gingival fibroblasts (HGFs) after exposure to acrolein and acetaldehyde","volume":"183","author":"Poggi","year":"2001","journal-title":"Ann. Anat."},{"key":"10.1016\/j.envint.2020.105943_b0100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-018-3385-x","article-title":"Response of DNA damage genes in acrolein-treated lung adenocarcinoma cells","volume":"450","author":"Sarkar","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.envint.2020.105943_b0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-4827(75)90547-9","article-title":"Action of glutaraldehyde and formaldehyde on segmentation mitoses","volume":"95","author":"Sentein","year":"1975","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.envint.2020.105943_b0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mrfmmm.2013.11.007","article-title":"Investigations on potential co-mutagenic effects of formaldehyde","volume":"760","author":"Speit","year":"2013","journal-title":"Mutat. Res.-Fund. Mol. M."},{"key":"10.1016\/j.envint.2020.105943_b0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tiv.2017.04.003","article-title":"Studies on the contributions of smoke constituents, individually and in mixtures, in a range of in vitro bioactivity assays","volume":"42","author":"Stabbert","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.envint.2020.105943_b0120","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.bbrc.2014.03.081","article-title":"Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: the materialization of the hormesis concept","volume":"446","author":"Sthijns","year":"2014","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.envint.2020.105943_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cell.2014.04.053","article-title":"A DNA-dependent protease involved in DNA-protein crosslink repair","volume":"158","author":"Stingele","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.envint.2020.105943_b0130","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/tx8001934","article-title":"Genome-wide transcriptional responses to acrolein","volume":"21","author":"Thompson","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2020.105943_b0135","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.yjmcc.2008.03.020","article-title":"Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKC\u03b5 signaling and cardioprotection","volume":"44","author":"Wang","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.envint.2020.105943_b0140","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1074\/jbc.M111.329623","article-title":"Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envint.2020.105943_b0145","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/tx800369y","article-title":"Mutagenicity and sequence specificity of acrolein-DNA adducts","volume":"22","author":"Wang","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2020.105943_b0150","doi-asserted-by":"crossref","first-page":"E6152","DOI":"10.1073\/pnas.1804869115","article-title":"Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis","volume":"115","author":"Weng","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2020.105943_b0155","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/carcin\/20.9.1769","article-title":"Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji","volume":"20","author":"Yang","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envint.2020.105943_b0160","doi-asserted-by":"crossref","first-page":"25306","DOI":"10.1007\/s11356-018-2584-z","article-title":"Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro","volume":"25","author":"Zhang","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2020.105943_b0165","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.envpol.2019.03.118","article-title":"Combined cytotoxicity of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells","volume":"250","author":"Zhang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2020.105943_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125482","article-title":"Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action","volume":"244","author":"Zhang","year":"2020","journal-title":"Chemosphere"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412020318985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412020318985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:01:44Z","timestamp":1758974504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412020318985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":33,"alternative-id":["S0160412020318985"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2020.105943","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The multiplex interactions and molecular mechanism on genotoxicity induced by formaldehyde and acrolein mixtures on human bronchial epithelial BEAS-2B cells","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2020.105943","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105943"}}