{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:14:20Z","timestamp":1791314060098,"version":"4.3.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC0702700"],"award-info":[{"award-number":["2017YFC0702700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CCNU18JCXK07"],"award-info":[{"award-number":["CCNU18JCXK07"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CCNU19TS066"],"award-info":[{"award-number":["CCNU19TS066"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.envint.2020.106050","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T05:29:05Z","timestamp":1598419745000},"page":"106050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice"],"prefix":"10.1016","volume":"144","author":[{"given":"Jing","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuge","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2020.106050_b0005","doi-asserted-by":"crossref","unstructured":"Abu-Elmagd, M., Alghamdi, M.A., Shamy, M., Khoder, M.I., Costa, M., Assidi, M., Kadam, R., Alsehli, H., Gari, M., Pushparaj, P.N., Kalamegam, G., Al-Qahtani, M.H., 2017. Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches. Int. J. Environ. Res. Public Health 14, 14.","DOI":"10.20944\/preprints201703.0162.v1"},{"key":"10.1016\/j.envint.2020.106050_b0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.arplant.55.031903.141701","article-title":"Reactive oxygen species: metabolism, oxidative stress, and signal transduction","volume":"55","author":"Apel","year":"2004","journal-title":"Annu Rev Plant Biol"},{"key":"10.1016\/j.envint.2020.106050_b0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envint.2019.105004","article-title":"Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario","volume":"132","author":"Bai","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.106050_b0020","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.clinbiochem.2008.01.027","article-title":"Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients","volume":"41","author":"Battisti","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.envint.2020.106050_b0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiolog. Rev."},{"key":"10.1016\/j.envint.2020.106050_b0030","doi-asserted-by":"crossref","first-page":"18216","DOI":"10.1074\/jbc.M114.629204","article-title":"Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt\/\u03b2-CATENIN SIGNALING PATHWAY","volume":"290","author":"Beier","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envint.2020.106050_b0035","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/s41375-019-0665-8","article-title":"Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease","volume":"34","author":"Bhattarai","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.envint.2020.106050_b0040","article-title":"Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease","author":"Bhattarai","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.envint.2020.106050_b0045","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00204-019-02403-y","article-title":"Particulate matter 2.5 induced arrhythmogenesis mediated by TRPC3 in human induced pluripotent stem cell-derived cardiomyocytes","volume":"93","author":"Cai","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2020.106050_b0050","doi-asserted-by":"crossref","unstructured":"Cerecetto, H., Lopez, G.V., 2007. Antioxidants Derived from Vitamin E: An Overview. Mini Reviews in Medicinal Chemistry.","DOI":"10.2174\/138955707780059871"},{"key":"10.1016\/j.envint.2020.106050_b0055","doi-asserted-by":"crossref","first-page":"84-+","DOI":"10.1016\/j.jaci.2016.02.017","article-title":"House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs","volume":"138","author":"Chan","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.envint.2020.106050_b0060","first-page":"251","article-title":"Analysis of incidence and mortality of leukemia in registration areas of China from 2003 to 2007","volume":"32","author":"Chen","year":"2012","journal-title":"Tumor"},{"key":"10.1016\/j.envint.2020.106050_b0065","unstructured":"Deng, N., 2009. Expression of FANCF\/FANCD2 in acute myeloid leukemia and myelodysplastic syndrome. China medical university."},{"key":"10.1016\/j.envint.2020.106050_b0070","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2172-11-38","article-title":"Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells","volume":"11","author":"Ersvaer","year":"2010","journal-title":"BMC Immunol."},{"key":"10.1016\/j.envint.2020.106050_b0075","article-title":"Formaldehyde exposure inhibits the expression of mammalian target of rapamycin in rat testis","volume":"0748233715592992","author":"Fang","year":"2015","journal-title":"Toxicol. Indus. Health"},{"key":"10.1016\/j.envint.2020.106050_b0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.envint.2020.106050_b0085","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1038\/leu.2013.93","article-title":"mTOR regulates DNA damage response through NF-kappaB-mediated FANCD2 pathway in hematopoietic cells","volume":"27","author":"Guo","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.envint.2020.106050_b0090","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envint.2012.06.020","article-title":"Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study","volume":"48","author":"Hou","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.106050_b0095","series-title":"Monographs on the evaluation of carcinogenic risks to humans -formaldehyde","first-page":"35","author":"IARC","year":"2012"},{"key":"10.1016\/j.envint.2020.106050_b0100","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00204-015-1610-x","article-title":"Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure","volume":"90","author":"Jin","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2020.106050_b0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/10590501.2019.1640581","article-title":"Epigenetic modifications associated with pathophysiological effects of lead exposure","volume":"37","author":"Khalid","year":"2019","journal-title":"J. Environ. Sci. Health Part C-Environ. Carcinogenesis Ecotoxicol. Rev."},{"key":"10.1016\/j.envint.2020.106050_b0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.envint.2014.10.005","article-title":"A review on the human health impact of airborne particulate matter","volume":"74","author":"Kim","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.106050_b0115","first-page":"1023","article-title":"Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo","volume":"53","author":"Kolachana","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.envint.2020.106050_b0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chemosphere.2017.09.098","article-title":"PM2.5 exposure stimulates COX-2-mediated excitatory synaptic transmission via ROS-NF-kappa B pathway","volume":"190","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2020.106050_b0125","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1039\/C7TX00065K","article-title":"Effects of ambient PM2.5 and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in the lungs of rats","volume":"6","author":"Li","year":"2017","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.envint.2020.106050_b0130","doi-asserted-by":"crossref","first-page":"e0152216-","DOI":"10.1371\/journal.pone.0152216","article-title":"Effect of Vitamin E and Omega-3 Fatty Acids on Protecting Ambient PM2.5-Induced Inflammatory Response and Oxidative Stress in Vascular Endothelial Cells","volume":"11","author":"Liang","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.envint.2020.106050_b0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.envint.2018.07.044","article-title":"Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution","volume":"120","author":"Liang","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.106050_b0140","doi-asserted-by":"crossref","first-page":"98567","DOI":"10.18632\/oncotarget.21637","article-title":"At seeming safe concentrations, synergistic effects of PM2.5 and formaldehyde co-exposure induces Alzheimer-like changes in mouse brain","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.envint.2020.106050_b0145","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1188\/13.CJON.312-318","article-title":"Ruxolitinib: a new treatment for myelofibrosis","volume":"17","author":"Lowery","year":"2013","journal-title":"Clin. J. Oncol. Nurs."},{"key":"10.1016\/j.envint.2020.106050_b0150","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1093\/cercor\/bhq002","article-title":"Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs\/RAGE\/NF-kappaB pathway activation","volume":"20","author":"Lu","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.envint.2020.106050_b0155","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.envint.2020.106050_b0160","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/carcin\/bgr297","article-title":"Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment","volume":"33","author":"McHale","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.envint.2020.106050_b0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-kappaB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.envint.2020.106050_b0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tox.2010.02.009","article-title":"Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice","volume":"271","author":"N'Jai","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2020.106050_b0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12033","article-title":"NF-kappaB: roles and regulation in different CD4(+) T-cell subsets","volume":"252","author":"Oh","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.envint.2020.106050_b0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrgentox.2014.01.007","article-title":"In vitro studies on organophosphate pesticides induced oxidative DNA damage in rat lymphocytes","volume":"761","author":"Ojha","year":"2014","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.envint.2020.106050_b0185","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1182\/blood-2005-06-2450","article-title":"Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at MD Anderson Cancer Center","volume":"107","author":"Oki","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.envint.2020.106050_b0190","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.envint.2018.12.052","article-title":"Children environmental exposure to particulate matter and polycyclic aromatic hydrocarbons and biomonitoring in school environments: A review on indoor and outdoor exposure levels, major sources and health impacts","volume":"124","author":"Oliveira","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.106050_b0195","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.envres.2018.03.001","article-title":"Assessing the recent estimates of the global burden of disease for ambient air pollution: Methodological changes and implications for low- and middle-income countries","volume":"166","author":"Ostro","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2020.106050_b0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molcel.2015.08.020","article-title":"Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen","volume":"60","author":"Pontel","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.envint.2020.106050_b0205","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s00204-012-0863-x","article-title":"Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM2.5 exposure in human bronchial epithelial cells","volume":"86","author":"Ramgolam","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2020.106050_b0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00204-012-0911-6","article-title":"The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines","volume":"87","author":"Ren","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2020.106050_b0215","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atmosenv.2012.07.036","article-title":"Attributing health effects to individual particulate matter constituents","volume":"62","author":"Rohr","year":"2012","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.envint.2020.106050_b0220","doi-asserted-by":"crossref","unstructured":"Romieu, I., Sienra-Monge, J.J., Ramfrez-Aguilar, M., Tellez-Rojo, M.M., Moreno-Macias, H., Reyes-Ruiz, N.I., Rfo-Navarro, B.E.d., Ruiz-Navarro, M.X., Hatch, G., Slade, R., 2002. Antioxidant Supplementation and Lung Functions among Children with Asthma Exposed to High Levels of Air Pollutants. Am. J. Respir. Crit. Care Med. 166, pp. 703\u2013709.","DOI":"10.1164\/rccm.2112074"},{"key":"10.1016\/j.envint.2020.106050_b0225","doi-asserted-by":"crossref","unstructured":"Salonen, J.T., Nyyss?nen, K., Salonen, R., Lakka, H.-M., Kaikkonen, J., Porkkala, E.-S., Voutilainen, S., Lakka, T.A., Rissanen, T., Leskinen, L., 2000. The effect of vitamin E and vitamin C on 3-year progression of carotid atherosclerosis: The antioxidant supplementation in atherosclerosis prevention (ASAP) study. 151, 25.","DOI":"10.1016\/S0021-9150(00)80112-4"},{"key":"10.1016\/j.envint.2020.106050_b0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/REVEH.2009.24.1.15","article-title":"Neurotoxic effects and biomarkers of lead exposure: a review","volume":"24","author":"Sanders","year":"2009","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.envint.2020.106050_b0235","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fimmu.2013.00204","article-title":"Regulation of hematopoietic stem cell activity by inflammation","volume":"4","author":"Schuettpelz","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2020.106050_b0240","unstructured":"SEPA, S.E.P.A., 2017. 2016 Report on the State of the Environment in China."},{"key":"10.1016\/j.envint.2020.106050_b0245","doi-asserted-by":"crossref","unstructured":"Shen, C., Oswald, D., Phelps, D., Cam, H., Pelloski, C.E., Pang, Q., Houghton, P.J., 2013. Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks. Cancer Res. 73, 3393\u20133401.","DOI":"10.1158\/0008-5472.CAN-12-4282"},{"key":"10.1016\/j.envint.2020.106050_b0250","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.fct.2016.11.016","article-title":"Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin","volume":"99","author":"Shen","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.envint.2020.106050_b0255","doi-asserted-by":"crossref","unstructured":"Shieh, J.H., A, M.M., 1989. Hematopoietic growth factor receptors. Cytotechnology 2.","DOI":"10.1007\/BF00364993"},{"key":"10.1016\/j.envint.2020.106050_b0260","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.3390\/ijerph9082875","article-title":"Leukemia and benzene","volume":"9","author":"Snyder","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2020.106050_b0265","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1038\/s41598-017-11833-6","article-title":"Mediating Role of TRPV1 Ion Channels in the Co-exposure to PM2.5 and Formaldehyde of Balb\/c Mice Asthma Model","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2020.106050_b0270","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.etap.2017.02.011","article-title":"Exposure to PM2.5 induces aberrant activation of NF-kappa B in human airway epithelial cells by downregulating miR-331 expression","volume":"50","author":"Song","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2020.106050_b0275","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1182\/blood-2013-02-486142","article-title":"Deletion of the NF-kappaB subunit p65\/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function","volume":"121","author":"Stein","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.envint.2020.106050_b0280","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envint.2020.106050_b0285","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.envres.2011.03.009","article-title":"Risk of leukemia as a result of community exposure to gasoline vapors: A follow-up study","volume":"111","author":"Talbott","year":"2011","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2020.106050_b0290","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.envint.2009.06.002","article-title":"Formaldehyde in China: production, consumption, exposure levels, and health effects","volume":"35","author":"Tang","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2020.106050_b0295","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mrfmmm.2015.06.011","article-title":"Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem\/progenitor cells","volume":"779","author":"Thys","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.envint.2020.106050_b0300","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1124\/jpet.105.084780","article-title":"Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons","volume":"314","author":"van Grevenynghe","year":"2005","journal-title":"J. Pharmacol. Exper. Therapeutics"},{"key":"10.1016\/j.envint.2020.106050_b0305","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10654-012-9727-1","article-title":"Leukemia risk in children exposed to benzene and PM10 from vehicular traffic: a case-control study in an Italian population","volume":"27","author":"Vinceti","year":"2012","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.envint.2020.106050_b0310","unstructured":"Wan, Y., 2009. Study of combined toxicity of formaldehyde and benzene on DNA damage of bone marrow cells of femal mice. J. Xinjiang Medical University."},{"key":"10.1016\/j.envint.2020.106050_b0315","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00204-016-1760-5","article-title":"Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem\/progenitor cells and enhances benzene-induced adverse effects","volume":"91","author":"Wei","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2020.106050_b0320","unstructured":"WHO., 2014. Health and the environment: addressing the health impact of air pollution. J. Chem. Phys. 19, 1345\u20131351."},{"key":"10.1016\/j.envint.2020.106050_b0325","doi-asserted-by":"crossref","unstructured":"Winters, N., Goldberg, M.S., Hystad, P., Villeneuve, P.J., Johnson, K.C., Canadian Canc Registries, E., 2015. Exposure to ambient air pollution in Canada and the risk of adult leukemia. Sci. Total Environ. 526, 153\u2013176.","DOI":"10.1016\/j.scitotenv.2015.03.149"},{"key":"10.1016\/j.envint.2020.106050_b0330","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1582-4934.2003.tb00250.x","article-title":"Interleukin-17 in acute myeloid leukemia","volume":"7","author":"Wrobel","year":"2003","journal-title":"J. Cellular Mol. Med."},{"key":"10.1016\/j.envint.2020.106050_b0335","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2249.2009.04011.x","article-title":"Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia","volume":"158","author":"Wu","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.envint.2020.106050_b0340","unstructured":"Xiong, M., 2012. Study on mechanism of hematopoietic toxicity and cell malignant transformation by benzene, Study on mechanism of hematopoietic toxicity and cell malignant transformation by benzene. South East University."},{"key":"10.1016\/j.envint.2020.106050_b0345","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.mrrev.2008.07.002","article-title":"Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms","volume":"681","author":"Zhang","year":"2009","journal-title":"Mutat. Res.\/Rev. Mutat. Res."},{"key":"10.1016\/j.envint.2020.106050_b0350","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1158\/1055-9965.EPI-09-0762","article-title":"Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells","volume":"19","author":"Zhang","year":"2010","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.envint.2020.106050_b0355","first-page":"295","article-title":"Genotoxicity of Formaldehyde and Benzene Joint Inhalation on Bone-marrow Cells of Male Mice","volume":"27","author":"Zhang","year":"2010","journal-title":"J. Environ. Occupat. Med."},{"key":"10.1016\/j.envint.2020.106050_b0360","article-title":"Bone Marrow Injury Induced via Oxidative Stress in Mice by Inhalation Exposure to Formaldehyde","volume":"8","author":"Zhang","year":"2013","journal-title":"Plos One"},{"key":"10.1016\/j.envint.2020.106050_b0365","article-title":"PM2.5 induces cell cycle arrest through regulating mTOR\/P70S6K1 signaling pathway","author":"Zhang","year":"2019","journal-title":"Exper. Therapeutic Med."},{"key":"10.1016\/j.envint.2020.106050_b0370","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/toxsci\/kfy166","article-title":"Cadmium Activates Noncanonical Wnt Signaling to Impair Hematopoietic Stem Cell Function in Mice","volume":"165","author":"Zhao","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2020.106050_b0375","doi-asserted-by":"crossref","first-page":"15010","DOI":"10.1074\/jbc.M110.103713","article-title":"Involvement of oxidative stress in the relapse of acute myeloid leukemia","volume":"285","author":"Zhou","year":"2010","journal-title":"J. Biol. Chem."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412020320055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412020320055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:03:48Z","timestamp":1758974628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412020320055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":75,"alternative-id":["S0160412020320055"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2020.106050","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2020.106050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106050"}}