{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:00:51Z","timestamp":1793052051093,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFC1000101"],"award-info":[{"award-number":["2016YFC1000101"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFC1000501"],"award-info":[{"award-number":["2016YFC1000501"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.envint.2021.106425","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T05:28:34Z","timestamp":1612934914000},"page":"106425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring"],"prefix":"10.1016","volume":"150","author":[{"given":"Mingkun","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2021.106425_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2018.02.028","article-title":"Quantitative estimation of mercury intake by toxicokinetic modelling based on total mercury levels in humans","volume":"114","author":"Abass","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106425_b0010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/archpedi.1979.02130020064013","article-title":"Prenatal methylmercury poisoning. Clinical observations over five years","volume":"133","author":"Amin-Zaki","year":"1979","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.envint.2021.106425_b0015","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1289\/ehp.02110523","article-title":"Inorganic mercury and methylmercury in placentas of Swedish women","volume":"110","author":"Ask","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2021.106425_b0020","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrn1986","article-title":"Neural tube defects and folate: case far from closed","volume":"7","author":"Blom","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.envint.2021.106425_b0025","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJM199911113412006","article-title":"Neural-tube defects","volume":"341","author":"Botto","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envint.2021.106425_b0030","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.puhe.2013.12.001","article-title":"Economic burden of neural tube defects in Germany","volume":"128","author":"Bowles","year":"2014","journal-title":"Public Health"},{"key":"10.1016\/j.envint.2021.106425_b0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.envres.2005.08.003","article-title":"Maternal exposure to arsenic, cadmium, lead, and mercury and neural tube defects in offspring","volume":"101","author":"Brender","year":"2006","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2021.106425_b0040","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00005072-197811000-00001","article-title":"Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero","volume":"37","author":"Choi","year":"1978","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.envint.2021.106425_b0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1289\/ehp.02110s111","article-title":"The three modern faces of mercury","volume":"110","author":"Clarkson","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2021.106425_b0050","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.envint.2021.106425_b0055","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1021\/es071948x","article-title":"Human exposure to methylmercury through rice intake in mercury mining areas, Guizhou province","volume":"42","author":"Feng","year":"2008","journal-title":"China. Environ Sci Technol"},{"key":"10.1016\/j.envint.2021.106425_b0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.freeradbiomed.2009.05.013","article-title":"Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase","volume":"47","author":"Franco","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.envint.2021.106425_b0065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-neuro-062012-170354","article-title":"Neural tube defects","volume":"37","author":"Greene","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.envint.2021.106425_b0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study","volume":"338","author":"MRC Vitamin Study Research Group","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.envint.2021.106425_b0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2016.03.040","article-title":"Exposure of methyl mercury in utero and the risk of neural tube defects in a Chinese population","volume":"61","author":"Jin","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2021.106425_b0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.reprotox.2012.10.015","article-title":"Placental concentrations of mercury, lead, cadmium, and arsenic and the risk of neural tube defects in a Chinese population","volume":"35","author":"Jin","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2021.106425_b0085","doi-asserted-by":"crossref","first-page":"46545","DOI":"10.1038\/srep46545","article-title":"Mercury pollution in vegetables, grains and soils from areas surrounding coal-fired power plants","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2021.106425_b0090","first-page":"81","article-title":"Effects of methylmercury on embryonic cell behavior and expression of related gene","volume":"33","author":"Li","year":"1999","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"10.1016\/j.envint.2021.106425_b0095","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/aje\/kwr108","article-title":"Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China","volume":"174","author":"Li","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.envint.2021.106425_b0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.freeradbiomed.2018.01.004","article-title":"Oxidative stress and apoptosis in benzo[a]pyrene-induced neural tube defects","volume":"116","author":"Lin","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.envint.2021.106425_b0105","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1021\/acs.est.7b06209","article-title":"A highly resolved mercury emission inventory of Chinese coal-fired power plants","volume":"52","author":"Liu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2021.106425_b0110","first-page":"600","article-title":"Environmental mercury pollution and its effects on reproductive and fertility function of female residents in Shanxi province, Chinese","volume":"26","author":"Lu","year":"2010","journal-title":"J. Public Health"},{"key":"10.1016\/j.envint.2021.106425_b0115","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41370-019-0139-0","article-title":"Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS)","volume":"29","author":"Nakayama","year":"2019","journal-title":"J. Expo Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2021.106425_b0120","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/bdra.20360","article-title":"Health care expenditures of children and adults with spina bifida in a privately insured U.S. population","volume":"79","author":"Ouyang","year":"2007","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.envint.2021.106425_b0125","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5324","article-title":"Diet as a source of exposure to environmental contaminants for pregnant women and children from six European countries","volume":"127","author":"Papadopoulou","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2021.106425_b0130","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.envpol.2018.07.112","article-title":"Concentrations of selected heavy metals in placental tissues and risk for neonatal orofacial clefts","volume":"242","author":"Pi","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2021.106425_b0135","first-page":"911","article-title":"Differences in diet intake frequency of adults: findings from half a million people in 10 areas in China","volume":"36","author":"Qin","year":"2015","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"10.1016\/j.envint.2021.106425_b0140","doi-asserted-by":"crossref","first-page":"12770","DOI":"10.1073\/pnas.1105209108","article-title":"Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects","volume":"108","author":"Ren","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.envint.2021.106425_b0145","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.reprotox.2010.05.009","article-title":"Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure","volume":"30","author":"Robinson","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2021.106425_b0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.envres.2006.03.004","article-title":"Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population","volume":"103","author":"Sakamoto","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2021.106425_b0155","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.envres.2016.04.023","article-title":"Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury","volume":"149","author":"Sakamoto","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2021.106425_b0160","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.envint.2013.08.007","article-title":"Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: potential use as indicators for prenatal exposure","volume":"60","author":"Sakamoto","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106425_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/biom10060821","article-title":"Mercury exposure assessment in mother-infant pairs from continental and coastal croatia","volume":"10","author":"Sekovanic","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.envint.2021.106425_b0170","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/tera.1420050208","article-title":"Effects of methylmercury on prenatal development in mice","volume":"5","author":"Spyker","year":"1972","journal-title":"Teratology"},{"key":"10.1016\/j.envint.2021.106425_b0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0300-483X(01)00390-0","article-title":"Release of mercury from dental amalgam fillings in pregnant rats and distribution of mercury in maternal and fetal tissues","volume":"163","author":"Takahashi","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2021.106425_b0180","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnmol.2018.00125","article-title":"Exposure to inorganic mercury causes oxidative stress, cell death, and functional deficits in the motor cortex","volume":"11","author":"Teixeira","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.envint.2021.106425_b0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00128-009-9722-8","article-title":"Effects of mercury released from gold extraction by amalgamation on renal function and environment in Shanxi, China","volume":"83","author":"Tian","year":"2009","journal-title":"Bull Environ Contam Toxicol"},{"key":"10.1016\/j.envint.2021.106425_b0190","first-page":"R939","article-title":"Maternal-fetal distribution of mercury (203Hg) released from dental amalgam fillings","volume":"258","author":"Vimy","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.envint.2021.106425_b0195","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0960-9822(06)00125-4","article-title":"Is programmed cell death required for neural tube closure?","volume":"7","author":"Weil","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.envint.2021.106425_b0200","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfn263","article-title":"Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer","volume":"108","author":"Wells","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2021.106425_b0205","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0161-813X(03)00032-9","article-title":"Methylmercury induces apoptosis in cultured rat dorsal root ganglion neurons","volume":"24","author":"Wilke","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envint.2021.106425_b0210","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1620\/tjem.196.79","article-title":"Placental to fetal transfer of mercury and fetotoxicity","volume":"196","author":"Yoshida","year":"2002","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.envint.2021.106425_b0215","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00297110","article-title":"Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation","volume":"58","author":"Yoshida","year":"1986","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2021.106425_b0220","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/19393210.2020.1741690","article-title":"Total mercury and methylmercury in Chinese rice and dietary exposure assessment","volume":"13","author":"Zhao","year":"2020","journal-title":"Food Addit Contam Part B Surveill"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412021000490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412021000490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:03:58Z","timestamp":1758974638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412021000490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":44,"alternative-id":["S0160412021000490"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2021.106425","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2021.106425","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106425"}}