{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:32:41Z","timestamp":1793917961224,"version":"4.8.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000139","name":"US Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.envint.2021.106666","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T13:46:34Z","timestamp":1623159994000},"page":"106666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction"],"prefix":"10.1016","volume":"155","author":[{"given":"Audrey J.","family":"Gaskins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Hood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Laden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2021.106666_b0005","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.envres.2017.08.039","article-title":"A spatio-temporal prediction model based on support vector machine regression: Ambient Black Carbon in three New England States","volume":"159","author":"Abu Awad","year":"2017","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.envint.2021.106666_b0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11882-018-0768-8","article-title":"Impact of particulate air pollution on cardiovascular health","volume":"18","author":"An","year":"2018","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"5","key":"10.1016\/j.envint.2021.106666_b0015","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150197","article-title":"Tryptophan metabolism, disposition and utilization in pregnancy","volume":"35","author":"Badawy","year":"2015","journal-title":"Biosci. Rep."},{"issue":"4","key":"10.1016\/j.envint.2021.106666_b0020","first-page":"323","article-title":"Serum metabolites as predictive molecular markers of ovarian response to controlled stimulation: a pilot study","volume":"23","author":"Borges","year":"2019","journal-title":"JBRA Assist. Reprod."},{"issue":"10","key":"10.1016\/j.envint.2021.106666_b0025","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/humrep\/dez128","article-title":"Ambient air pollution and in vitro fertilization treatment outcomes","volume":"34","author":"Boulet","year":"2019","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.envint.2021.106666_b0030","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.fertnstert.2009.04.040","article-title":"The antral follicle count: practical recommendations for better standardization","volume":"94","author":"Broekmans","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envint.2021.106666_b0035","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1803222115","article-title":"Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter","author":"Burnett","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"10.1016\/j.envint.2021.106666_b0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12940-017-0291-8","article-title":"Does air pollution play a role in infertility?: a systematic review","volume":"16","author":"Carre","year":"2017","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2021.106666_b0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejogrb.2016.12.012","article-title":"Influence of air quality on the results of in vitro fertilization attempts: a retrospective study","volume":"210","author":"Carr\u00e9","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"10","key":"10.1016\/j.envint.2021.106666_b0050","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.envint.2021.106666_b0055","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.fertnstert.2016.07.1110","article-title":"Outdoor air pollution and human infertility: a systematic review","volume":"106","author":"Checa Vizca\u00edno","year":"2016","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.envint.2021.106666_b0060","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/humrep\/dey076","article-title":"Association between ambient air pollution and pregnancy rate in women who underwent IVF","volume":"33","author":"Choe","year":"2018","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.envint.2021.106666_b0065","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3945\/jn.113.180588","article-title":"Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women","volume":"143","author":"da Silva","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.envint.2021.106666_b0070","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.envpol.2015.10.044","article-title":"Association between air pollution and sperm quality: a systematic review and meta-analysis","volume":"208","author":"Deng","year":"2016","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.envint.2021.106666_b0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/10962247.2016.1200159","article-title":"A hybrid model for spatially and temporally resolved ozone exposures in the continental United States","volume":"67","author":"Di","year":"2017","journal-title":"J. Air Waste Manag. Assoc."},{"issue":"12","key":"10.1016\/j.envint.2021.106666_b0080","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4103\/0366-6999.207472","article-title":"Ovarian damages produced by aerosolized fine particulate matter (PM2.5) pollution in mice: possible protective medications and mechanisms","volume":"130","author":"Gai","year":"2017","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"7","key":"10.1016\/j.envint.2021.106666_b0085","doi-asserted-by":"crossref","first-page":"077002","DOI":"10.1289\/EHP4601","article-title":"Time-varying exposure to air pollution and outcomes of in vitro fertilization among couples from a fertility clinic","volume":"127","author":"Gaskins","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.envint.2021.106666_b0090","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/humrep\/dez111","article-title":"Air pollution exposure and risk of spontaneous abortion in the Nurses' Health Study II","volume":"34","author":"Gaskins","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envint.2021.106666_b0095","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.envint.2018.03.029","article-title":"Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization","volume":"115","author":"Gaskins","year":"2018","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.envint.2021.106666_b0100","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/EDE.0000000000001029","article-title":"Exposure to fine particulate matter and ovarian reserve among women from a fertility clinic","volume":"30","author":"Gaskins","year":"2019","journal-title":"Epidemiology"},{"key":"10.1016\/j.envint.2021.106666_b0105","doi-asserted-by":"crossref","first-page":"110201","DOI":"10.1016\/j.envres.2020.110201","article-title":"Ambient air pollution and risk of pregnancy loss among women undergoing assisted reproduction","volume":"191","author":"Gaskins","year":"2020","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.envint.2021.106666_b0110","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/toxsci\/kfv198","article-title":"Reference standardization for mass spectrometry and high-resolution metabolomics applications to exposome research","volume":"148","author":"Go","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.envint.2021.106666_b0115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11306-007-0081-3","article-title":"Proposed minimum reporting standards for data analysis in metabolomics","volume":"3","author":"Goodacre","year":"2007","journal-title":"Metabolomics"},{"key":"10.1016\/j.envint.2021.106666_b0120","series-title":"Air Pollution and Cancer","author":"I International Agency for Research on Cancer (IARC)","year":"2013"},{"issue":"3","key":"10.1016\/j.envint.2021.106666_b0125","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s40572-020-00284-3","article-title":"Air pollution and adverse pregnancy and birth outcomes: mediation analysis using metabolomic profiles","volume":"7","author":"Inoue","year":"2020","journal-title":"Curr. Environ. Health Rep."},{"issue":"1","key":"10.1016\/j.envint.2021.106666_b0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12958-018-0430-2","article-title":"Air pollution from natural and anthropic sources and male fertility","volume":"16","author":"Jurewicz","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"1","key":"10.1016\/j.envint.2021.106666_b0135","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/EDE.0000000000000918","article-title":"Traffic-related air pollution and pregnancy loss","volume":"30","author":"Kioumourtzoglou","year":"2019","journal-title":"Epidemiology"},{"key":"10.1016\/j.envint.2021.106666_b0140","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.atmosenv.2014.07.014","article-title":"A New Hybrid Spatio-Temporal Model For Estimating Daily Multi-Year PM2.5 Concentrations Across Northeastern USA Using High Resolution Aerosol Optical Depth Data","volume":"95","author":"Kloog","year":"2014","journal-title":"Atmos. Environ."},{"issue":"4","key":"10.1016\/j.envint.2021.106666_b0145","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.fertnstert.2016.08.022","article-title":"Outdoor air pollution and sperm quality","volume":"106","author":"Lafuente","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envint.2021.106666_b0150","doi-asserted-by":"crossref","first-page":"e2015011","DOI":"10.5620\/eht.e2015011","article-title":"A meta-analysis of exposure to particulate matter and adverse birth outcomes","volume":"30","author":"Lamichhane","year":"2015","journal-title":"Environ. Health Toxicol."},{"issue":"4","key":"10.1016\/j.envint.2021.106666_b0155","first-page":"2305","article-title":"Daily ambient NO2 concentration predictions using satellite ozone monitoring instrument NO2 data and land use regression","volume":"48","author":"Lee","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.envint.2021.106666_b0160","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/humrep\/deq021","article-title":"Effect of air quality on assisted human reproduction","volume":"25","author":"Legro","year":"2010","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.envint.2021.106666_b0165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.fertnstert.2018.10.028","article-title":"Acute effects of air pollutants on spontaneous pregnancy loss: a case-crossover study","volume":"111","author":"Leiser","year":"2019","journal-title":"Fertil. Steril."},{"issue":"47","key":"10.1016\/j.envint.2021.106666_b0170","doi-asserted-by":"crossref","first-page":"13450","DOI":"10.1073\/pnas.1614947113","article-title":"Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"7","key":"10.1016\/j.envint.2021.106666_b0175","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/CIRCULATIONAHA.116.026796","article-title":"Particulate matter exposure and stress hormone levels: a randomized, double-blind, crossover trial of air purification","volume":"136","author":"Li","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.envint.2021.106666_b0180","doi-asserted-by":"crossref","first-page":"114973","DOI":"10.1016\/j.envpol.2020.114973","article-title":"Ambient air pollution exposed during preantral-antral follicle transition stage was sensitive to associate with clinical pregnancy for women receiving IVF","volume":"265","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.envint.2021.106666_b0185","doi-asserted-by":"crossref","first-page":"e1003123","DOI":"10.1371\/journal.pcbi.1003123","article-title":"Predicting network activity from high throughput metabolomics","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.envint.2021.106666_b0190","doi-asserted-by":"crossref","first-page":"110506","DOI":"10.1016\/j.envres.2020.110506","article-title":"Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution","volume":"193","author":"Li","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2021.106666_b0195","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.envint.2019.04.003","article-title":"Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma","volume":"127","author":"Liang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106666_b0200","doi-asserted-by":"crossref","unstructured":"Liang, D., Li, Z., Vlaanderen, J., Tang, Z., Vermeulen, R., Sarnat, J.A., 2020. Systematic Review on Untargeted Metabolomics Application for Air Pollution Health Research: Current Progress, Analytical Challenges, and Future Direction. Presented at the Annual Meeting of the International Society for Exposure Science.","DOI":"10.1289\/isee.2020.virtual.P-0002"},{"key":"10.1016\/j.envint.2021.106666_b0205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.envint.2018.07.044","article-title":"Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution","volume":"120","author":"Liang","year":"2018","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.envint.2021.106666_b0210","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/STROKEAHA.116.015739","article-title":"Ambient PM2.5 and stroke: effect modifiers and population attributable risk in six low- and middle-income countries","volume":"48","author":"Lin","year":"2017","journal-title":"Stroke"},{"issue":"13","key":"10.1016\/j.envint.2021.106666_b0215","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1021\/acs.analchem.0c00338","article-title":"Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics","volume":"92","author":"Liu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.envint.2021.106666_b0220","unstructured":"MassGIS Data - Massachusetts Department of Transportation (MassDOT) Roads. The Massachusetts Department of Transportation - Office of Transportation Planning; 2014. Available: http:\/\/www.mass.gov\/anf\/research-and-tech\/it-serv-and-support\/application-serv\/office-of-geographic-information-massgis\/datalayers\/eotroads.html [accessed June 2 2017]."},{"key":"10.1016\/j.envint.2021.106666_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/603167","article-title":"Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome: The Case for Metabolomics Studies","volume":"2013","author":"McRae","year":"2013","journal-title":"Int. J. Reprod. Med."},{"issue":"2","key":"10.1016\/j.envint.2021.106666_b0230","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoy001","article-title":"The Environment and Reproductive Health (EARTH) Study: A Prospective Preconception Cohort","volume":"2018","author":"Messerlian","year":"2018","journal-title":"Hum. Reprod. Open"},{"key":"10.1016\/j.envint.2021.106666_b0235","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.envint.2014.05.005","article-title":"Air pollution and human fertility rates","volume":"70","author":"Nieuwenhuijsen","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106666_b0240","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"O'Mahony","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.envint.2021.106666_b0245","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.fertnstert.2013.01.103","article-title":"Intrauterine exposure to diesel exhaust diminishes adult ovarian reserve","volume":"99","author":"Ogliari","year":"2013","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.envint.2021.106666_b0250","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/metabo10110454","article-title":"Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health","volume":"10","author":"Ore\u0161i\u010d","year":"2020","journal-title":"Metabolites"},{"issue":"7","key":"10.1016\/j.envint.2021.106666_b0255","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10815-010-9419-2","article-title":"Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF\/ET)","volume":"27","author":"Perin","year":"2010","journal-title":"J. Assist. Reprod. Genet."},{"issue":"1","key":"10.1016\/j.envint.2021.106666_b0260","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.fertnstert.2009.06.031","article-title":"Effects of exposure to high levels of particulate air pollution during the follicular phase of the conception cycle on pregnancy outcome in couples undergoing in vitro fertilization and embryo transfer","volume":"93","author":"Perin","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.envint.2021.106666_b0265","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.reprotox.2019.07.005","article-title":"Associations between ambient air pollution and pregnancy rate in women who underwent in vitro fertilization in Shenyang, China","volume":"89","author":"Qiu","year":"2019","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.envint.2021.106666_b0270","doi-asserted-by":"crossref","first-page":"e036","DOI":"10.1097\/EE9.0000000000000036","article-title":"Ambient air pollution exposure and fecundability in women undergoing in vitro fertilization","volume":"3","author":"Quraishi","year":"2019","journal-title":"Environ. Epidemiol."},{"issue":"11","key":"10.1016\/j.envint.2021.106666_b0275","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1158\/0008-5472.CAN-12-3831","article-title":"The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress","volume":"73","author":"Sahm","year":"2013","journal-title":"Cancer Res."},{"issue":"1-2","key":"10.1016\/j.envint.2021.106666_b0280","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cca.2005.06.013","article-title":"Monitoring tryptophan metabolism in chronic immune activation","volume":"364","author":"Schr\u00f6cksnadel","year":"2006","journal-title":"Clin. Chim. Acta"},{"issue":"2","key":"10.1016\/j.envint.2021.106666_b0285","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.envint.2010.10.009","article-title":"Air pollution and birth outcomes: a systematic review","volume":"37","author":"Shah","year":"2011","journal-title":"Environ. Int."},{"issue":"24","key":"10.1016\/j.envint.2021.106666_b0290","doi-asserted-by":"crossref","first-page":"11725","DOI":"10.1021\/ac402503m","article-title":"Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web-based resources","volume":"85","author":"Sim\u00f3n-Manso","year":"2013","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.envint.2021.106666_b0295","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1620\/tjem.244.243","article-title":"Vitamin B3 nicotinamide: a promising candidate for treating preeclampsia and improving fetal growth","volume":"244","author":"Takahashi","year":"2018","journal-title":"Tohoku J. Exp. Med."},{"issue":"5","key":"10.1016\/j.envint.2021.106666_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v059.i05","article-title":"Mediation: R package for causal mediation analysis","volume":"59","author":"Tingley","year":"2014","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.envint.2021.106666_b0305","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2105-14-15","article-title":"xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data","volume":"14","author":"Uppal","year":"2013","journal-title":"BMC Bioinf."},{"issue":"12","key":"10.1016\/j.envint.2021.106666_b0310","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/acs.chemrestox.6b00179","article-title":"Computational metabolomics: a framework for the million metabolome","volume":"29","author":"Uppal","year":"2016","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.envint.2021.106666_b0315","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.envres.2009.03.006","article-title":"Chronic exposure to fine particulate matter emitted by traffic affects reproductive and fetal outcomes in mice","volume":"109","author":"Veras","year":"2009","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.envint.2021.106666_b0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s40471-019-00187-4","article-title":"The metabolome: a key measure for exposome research in epidemiology","volume":"6","author":"Walker","year":"2019","journal-title":"Curr Epidemiol Rep"},{"issue":"3","key":"10.1016\/j.envint.2021.106666_b0325","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/humrep\/dey386","article-title":"Association between outdoor air pollution during in vitro culture and the outcomes of frozen-thawed embryo transfer","volume":"34","author":"Wang","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.envint.2021.106666_b0330","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3389\/fimmu.2017.01957","article-title":"Kynurenic acid: the Janus-Faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions","volume":"8","author":"Wirthgen","year":"2017","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.envint.2021.106666_b0335","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.3390\/ijms18071595","article-title":"Redox properties of tryptophan metabolism and the concept of tryptophan use in pregnancy","volume":"18","author":"Xu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt 1","key":"10.1016\/j.envint.2021.106666_b0340","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.envint.2018.10.013","article-title":"Association between fertility rate reduction and pre-gestational exposure to ambient fine particles in the United States, 2003\u20132011","volume":"121","author":"Xue","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106666_b0345","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.scitotenv.2018.06.075","article-title":"Increment of ambient exposure to fine particles and the reduced human fertility rate in China, 2000\u20132010","volume":"642","author":"Xue","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2021.106666_b0350","doi-asserted-by":"crossref","first-page":"104872","DOI":"10.1016\/j.envint.2019.05.066","article-title":"Maternal serum metabolome and traffic-related air pollution exposure in pregnancy","volume":"130","author":"Yan","year":"2019","journal-title":"Environ. Int."},{"issue":"15","key":"10.1016\/j.envint.2021.106666_b0355","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/bioinformatics\/btp291","article-title":"apLCMS\u2013adaptive processing of high-resolution LC\/MS data","volume":"25","author":"Yu","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2021.106666_b0360","doi-asserted-by":"crossref","first-page":"109304","DOI":"10.1016\/j.envres.2020.109304","article-title":"Association between Ambient Air Pollution and Pregnancy Outcomes in Patients Undergoing In Vitro Fertilization in Chengdu, China: A retrospective study","volume":"184","author":"Zeng","year":"2020","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.envint.2021.106666_b0365","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4062\/biomolther.2019.061","article-title":"Niacinamide protects skin cells from oxidative stress induced by particulate matter","volume":"27","author":"Zhen","year":"2019","journal-title":"Biomol. Ther. (Seoul)"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412021002919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412021002919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:15:32Z","timestamp":1758975332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412021002919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":73,"alternative-id":["S0160412021002919"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2021.106666","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2021.106666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106666"}}