{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:44:10Z","timestamp":1786988650501,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.envint.2021.106911","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T16:54:27Z","timestamp":1633366467000},"page":"106911","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Inhalation and ingestion of Synthetic musks in pregnant women: In silico spontaneous abortion risk evaluation and control"],"prefix":"10.1016","volume":"158","author":[{"given":"Xixi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.envint.2021.106911_b0005","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1016\/j.bmcl.2006.09.030","article-title":"3D QSAR studies of AChE inhibitors based on molecular docking scores and CoMFA","volume":"16","author":"Akula","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.envint.2021.106911_b0010","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/med.20067","article-title":"Combining docking and molecular dynamic simulations in drug design","volume":"26","author":"Alonso","year":"2006","journal-title":"Med. Res. Rev."},{"issue":"6","key":"10.1016\/j.envint.2021.106911_b0015","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1210\/jc.2007-2813","article-title":"Estrogen and progesterone metabolism in the cervix during pregnancy and parturition","volume":"93","author":"Andersson","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.envint.2021.106911_b0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1021\/es020115y","article-title":"Sorption inetics and microbial biodegradation activity of hydrophobic chemicals in sewage sludge: Model and measurements based on free concentrations","volume":"37","author":"Artola-Garicano","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2021.106911_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106216","article-title":"Occupational human exposure to mercury in artisanal small-scale gold mining communities of Colombia","volume":"146","author":"Calao-Ramos","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106911_b0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.mcat.2018.06.013","article-title":"A 3D-QSAR assisted activity prediction strategy for expanding substrate spectra of an aldehyde ketone reductase","volume":"455","author":"Cheng","year":"2018","journal-title":"Mol. Catal."},{"issue":"1","key":"10.1016\/j.envint.2021.106911_b0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0301-2115(00)00363-8","article-title":"Dietary factors and risk of spontaneous abortion","volume":"95","author":"Di Cintio","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.envint.2021.106911_b0040","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.scitotenv.2019.05.033","article-title":"Deriving aquatic life criteria for galaxolide (HHCB) and ecological risk assessment","volume":"681","author":"Fan","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2021.106911_b0045","doi-asserted-by":"crossref","first-page":"460474","DOI":"10.1016\/j.chroma.2019.460474","article-title":"A new tetrapeptide biomimetic chromatographic resin for antibody separation with high adsorption capacity and selectivity","volume":"1604","author":"Fang","year":"2019","journal-title":"J. Chromatogr. A"},{"issue":"83","key":"10.1016\/j.envint.2021.106911_b0050","doi-asserted-by":"crossref","first-page":"52923","DOI":"10.1039\/C6RA27357B","article-title":"Metabolomics biomarker analysis of threatened abortion in polycystic ovary syndrome: a clinical discovery study","volume":"7","author":"Feng","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.envint.2021.106911_b0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.watres.2016.08.055","article-title":"Bioaccumulation and ecotoxicity increase during indirect photochemical transformation of polycyclic musk tonalide: A modeling study","volume":"105","author":"Gao","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.envint.2021.106911_b0060","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jhazmat.2018.09.060","article-title":"Environmentally friendly polychlorinated naphthalenes (PCNs) derivatives designed using 3D-QSAR and screened using molecular docking, density functional theory and health-based risk assessment","volume":"363","author":"Gu","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2021.106911_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122753","article-title":"Plant-microorganism combined remediation of polychlorinated naphthalenes contaminated soils based on molecular directed transformation and taguchi experimental design-assisted dynamics simulation","volume":"396","author":"Gu","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2021.106911_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124139","article-title":"Combined remediation of polychlorinated naphthalene-contaminated soil under multiple scenarios: An integrated method of genetic engineering and environmental remediation technology","volume":"405","author":"Gu","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"9","key":"10.1016\/j.envint.2021.106911_b0075","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/etc.258","article-title":"Occurrence of synthetic musk fragrances in human blood from 11 cities in China","volume":"29","author":"Hu","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.envint.2021.106911_b0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijheh.2009.12.002","article-title":"Higher blood concentrations of synthetic musks in women above fifty years than in younger women","volume":"213","author":"Hutter","year":"2010","journal-title":"Int. J. Hyg. Envir. Eal."},{"key":"10.1016\/j.envint.2021.106911_b0085","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhazmat.2015.12.031","article-title":"Modification of PBDEs (BDE-15, BDE-47, BDE-85 and BDE-126) biological toxicity, bio-concentration, persistence and atmospheric long-range transport potential based on the pharmacophore modeling assistant with the full factor experimental design","volume":"307","author":"Jiang","year":"2016","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.envint.2021.106911_b0090","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/jaoacint\/qsaa051","article-title":"A selective and sensitive gas chromatography-tandem mass spectrometry method for quantitation of synthetic musks in human serum","volume":"103","author":"Katuri","year":"2020","journal-title":"J. AOAC Int."},{"issue":"7","key":"10.1016\/j.envint.2021.106911_b0105","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.3390\/nu11071560","article-title":"Pregnant women in four low-middle income countries have a high prevalence of inadequate dietary intakes that are improved by dietary diversity","volume":"11","author":"Lander","year":"2019","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.envint.2021.106911_b0110","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.chemosphere.2012.09.056","article-title":"Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells","volume":"90","author":"Li","year":"2013","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.envint.2021.106911_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11270-020-04574-2","article-title":"Molecular design of environment-friendly PAE derivatives based on 3D-QSAR assisted with a comprehensive evaluation method combining toxicity and estrogen activities","volume":"231","author":"Li","year":"2020","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.envint.2021.106911_b0120","article-title":"Functional modification of HHCB: Strategy for obtaining environmentally friendly derivatives","volume":"126116","author":"Lia","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2021.106911_b0125","article-title":"3D-QSAR-aided toxicity assessment of synthetic musks and their transformation by-products","volume":"1\u201313","author":"Lib","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.envint.2021.106911_b0130","first-page":"1","article-title":"Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women","volume":"10","author":"Lim","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.envint.2021.106911_b0135","doi-asserted-by":"crossref","first-page":"e0222858","DOI":"10.1371\/journal.pone.0222858","article-title":"Optimising poly (lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach","volume":"14","author":"Mensah","year":"2019","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.envint.2021.106911_b0140","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/molecules23051113","article-title":"A 3D-QSAR study on the antitrypanosomal and cytotoxic activities of steroid alkaloids by comparative molecular field analysis","volume":"23","author":"Nnadi","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.envint.2021.106911_b0145","doi-asserted-by":"crossref","first-page":"105284","DOI":"10.1016\/j.envint.2019.105284","article-title":"Binding specificities of estrogen receptor with perfluorinated compounds: A cross species comparison","volume":"134","author":"Qiu","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2021.106911_b0150","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.3390\/ijerph16173161","article-title":"Fuzzy comprehensive evaluation assistant 3D-QSAR of environmentally friendly FQs to reduce ADRs","volume":"16","author":"Ren","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2021.106911_b0155","doi-asserted-by":"crossref","first-page":"126667","DOI":"10.1016\/j.jhazmat.2021.126667","article-title":"Control strategies for the vertical gene transfer of quinolone ARGs in Escherichia coli through molecular modification and molecular dynamics","volume":"420","author":"Ren","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2021.106911_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106702","article-title":"Pharmaceuticals and other urban contaminants threaten Amazonian freshwater ecosystems","volume":"155","author":"Rico","year":"2021","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.envint.2021.106911_b0165","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00044-012-0151-6","article-title":"Quasi 4D-QSAR and 3D-QSAR study of the pan class I phosphoinositide-3-kinase (PI3K) inhibitors","volume":"22","author":"Safavi-Sohi","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.envint.2021.106911_b0170","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ecoenv.2013.11.019","article-title":"3D-QSAR studies on the toxicity of substituted benzenes to Tetrahymena pyriformis: CoMFA, CoMSIA and VolSurf approaches","volume":"105","author":"Salahinejad","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.envint.2021.106911_b0175","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.foodchem.2016.01.017","article-title":"Synthetic musk in seafood products from south Europe using a quick, easy, cheap, effective, rugged and safe extraction method","volume":"200","author":"Saraiva","year":"2016","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.envint.2021.106911_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2002.9458","article-title":"Transcriptional activation of estrogen receptor ER\u03b1 and ER\u03b2 by polycyclic musks is cell type dependent","volume":"183","author":"Schreurs","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2021.106911_b0185","doi-asserted-by":"crossref","first-page":"113598","DOI":"10.1016\/j.jpba.2020.113598","article-title":"Method development for the determination of synthetic musks and organophosphorus pesticides in human adipose tissue","volume":"191","author":"Sousa","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.envint.2021.106911_b0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.foodpol.2017.08.018","article-title":"Can household-based food consumption surveys be used to make inferences about nutrient intakes and inadequacies? A Bangladesh case study","volume":"72","author":"Sununtnasuk","year":"2017","journal-title":"Food Policy"},{"issue":"1","key":"10.1016\/j.envint.2021.106911_b0195","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/cells9010071","article-title":"Autophagy attenuation hampers progesterone synthesis during the development of pregnant corpus luteum","volume":"9","author":"Tang","year":"2019","journal-title":"Cells."},{"key":"10.1016\/j.envint.2021.106911_b0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-069X-13-14","article-title":"Human exposure to nitro musks and the evaluation of their potential toxicity: an overview","volume":"13","author":"Taylor","year":"2014","journal-title":"Environ. Health"},{"key":"10.1016\/j.envint.2021.106911_b0205","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.trac.2015.03.022","article-title":"Recent approaches for the determination of synthetic musk fragrances in environmental samples","volume":"72","author":"Vallecillos","year":"2015","journal-title":"Trac-Trend. Anal. Chem."},{"key":"10.1016\/j.envint.2021.106911_b0210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.scitotenv.2014.02.017","article-title":"Theoretical and experimental evidences of medium range atmospheric transport processes of polycyclic musk fragrances","volume":"481","author":"Villa","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2021.106911_b0215","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jsbmb.2017.09.010","article-title":"Maternal early pregnancy vitamin D status in relation to low birth weight and small-for-gestational-age offspring. J","volume":"175","author":"Wang","year":"2018","journal-title":"Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.envint.2021.106911_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106061","article-title":"Elevated non-essential metals and the disordered metabolism of essential metals are associated to abnormal pregnancy with spontaneous abortion","volume":"144","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envint.2021.106911_b0225","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/en14010246","article-title":"Multi-criteria evaluation of distributed energy system based on order relation-anti-entropy weight method","volume":"14","author":"Wang","year":"2021","journal-title":"Energies"},{"issue":"3","key":"10.1016\/j.envint.2021.106911_b0230","first-page":"100124","article-title":"Intramuscular progesterone in women with twins and a prior singleton spontaneous preterm birth","volume":"2","author":"Ward","year":"2020","journal-title":"A. J. O. G. MFM"},{"issue":"4","key":"10.1016\/j.envint.2021.106911_b0235","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10822-018-0106-1","article-title":"Sparse QSAR modelling methods for therapeutic and regenerative medicine","volume":"32","author":"Winkler","year":"2018","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"3","key":"10.1016\/j.envint.2021.106911_b0240","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/polym13030356","article-title":"Establishment of a CoMFA model based on the combined activity of bioconcentration, long-Range transport, and highest infrared signal intensity and molecular design of environmentally friendly PBB derivatives","volume":"13","author":"Yang","year":"2021","journal-title":"Polymers"},{"issue":"7","key":"10.1016\/j.envint.2021.106911_b0245","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1080\/19440049.2016.1201219","article-title":"Occurrence of synthetic musks in human breast milk samples from 12 provinces in China","volume":"33","author":"Yin","year":"2016","journal-title":"Food Addit. Contam. Part A"},{"key":"10.1016\/j.envint.2021.106911_b0250","doi-asserted-by":"crossref","first-page":"122715","DOI":"10.1016\/j.jclepro.2020.122715","article-title":"Multi-directional selective toxicity effects on farmland ecosystems: A novel design of green substitutes for neonicotinoid insecticides","volume":"272","author":"Zhao","year":"2020","journal-title":"J. Clean. Prod."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412021005365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412021005365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T18:03:06Z","timestamp":1727805786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412021005365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":48,"alternative-id":["S0160412021005365"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2021.106911","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhalation and ingestion of Synthetic musks in pregnant women: In silico spontaneous abortion risk evaluation and control","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2021.106911","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106911"}}