{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:47:01Z","timestamp":1789494421275,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Government of Japan Ministry of the Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.envint.2022.107318","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T11:23:21Z","timestamp":1653305001000},"page":"107318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Individual and mixed metal maternal blood concentrations in relation to birth size: An analysis of the Japan Environment and Children\u2019s Study (JECS)"],"prefix":"10.1016","volume":"165","author":[{"given":"Tomozumi","family":"Takatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Takatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji F.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kamijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.envint.2022.107318_b0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijheh.2014.08.001","article-title":"Interaction between cadmium (Cd), selenium (Se) and oxidative stress biomarkers in healthy mothers and its impact on birth anthropometric measures","volume":"218","author":"Al-Saleh","year":"2015","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.envint.2022.107318_b0010","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.scitotenv.2017.08.042","article-title":"Selenium status during pregnancy: Influential factors and effects on neuropsychological development among Spanish infants","volume":"610\u2013611","author":"Amoros","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2022.107318_b0015","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.chemosphere.2016.08.023","article-title":"Maternal and fetal exposure to cadmium, lead, manganese and mercury: The MIREC study","volume":"163","author":"Arbuckle","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2022.107318_b0020","doi-asserted-by":"crossref","first-page":"105606","DOI":"10.1016\/j.envint.2020.105606","article-title":"Maternal blood metal and metalloid concentrations in association with birth outcomes in Northern Puerto Rico","volume":"138","author":"Ashrap","year":"2020","journal-title":"Environ. Int."},{"issue":"17","key":"10.1016\/j.envint.2022.107318_b0025","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults","volume":"353","author":"Barker","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.envint.2022.107318_b0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/NRR200239","article-title":"Regulation of placental nutrient transport and implications for fetal growth","volume":"15","author":"Bell","year":"2002","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.envint.2022.107318_b0035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/j.1550-8528.1998.tb00336.x","article-title":"Blood pressure in adolescence and early adulthood related to obesity and birth size","volume":"6","author":"Berkey","year":"1998","journal-title":"Obes. Res."},{"key":"10.1016\/j.envint.2022.107318_b0040","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.7754\/Clin.Lab.2018.180307","article-title":"The Link Between Selenium, Oxidative Stress and Pregnancy Induced Hypertensive Disorders","volume":"64","author":"Bizerea","year":"2018","journal-title":"Clin. Lab."},{"key":"10.1016\/j.envint.2022.107318_b0045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12940-018-0413-y","article-title":"Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression","volume":"17","author":"Bobb","year":"2018","journal-title":"Environ. Health."},{"issue":"1","key":"10.1016\/j.envint.2022.107318_b0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0378-3782(95)01637-I","article-title":"Birth weight: nature or nurture?","volume":"42","author":"Brooks","year":"1995","journal-title":"Early Hum. Dev."},{"issue":"12","key":"10.1016\/j.envint.2022.107318_b0055","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00204-010-0595-8","article-title":"Selenium: a double-edged sword for defense and offence in cancer","volume":"84","author":"Brozmanov\u00e1","year":"2010","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.envint.2022.107318_b0060","doi-asserted-by":"crossref","first-page":"e96580","DOI":"10.1371\/journal.pone.0096580","article-title":"Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology","volume":"9","author":"Cedergreen","year":"2014","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.envint.2022.107318_b0065","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/jes.2014.26","article-title":"Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children","volume":"24","author":"Chen","year":"2014","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"5","key":"10.1016\/j.envint.2022.107318_b0070","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1289\/ehp.1104152","article-title":"Cadmium exposure and neurodevelopmental outcomes in U.S. children","volume":"120","author":"Ciesielski","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.envint.2022.107318_b0075","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.envint.2022.107318_b0080","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/EDE.0b013e3181df8e52","article-title":"Early postnatal blood manganese levels and children's neurodevelopment","volume":"21","author":"Claus Henn","year":"2010","journal-title":"Epidemiology."},{"key":"10.1016\/j.envint.2022.107318_b0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/AOG.0b013e31826804e8","article-title":"Committee opinion No. 533: lead screening during pregnancy and lactation","volume":"120","author":"Committee on Obstetric Practice","year":"2012","journal-title":"Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.envint.2022.107318_b0090","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease","volume":"14","author":"Fairweather-Tait","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.envint.2022.107318_b0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/ije\/dyaa162","article-title":"Association of prenatal maternal blood lead levels with birth outcomes in the Japan Environment and Children's Study (JECS): a nationwide birth cohort study","volume":"50","author":"Goto","year":"2021","journal-title":"Int. J. Epidemiol."},{"issue":"1-2","key":"10.1016\/j.envint.2022.107318_b0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-445X(01)00263-6","article-title":"Role of selenium toxicity and oxidative stress in aquatic birds","volume":"57","author":"Hoffman","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2022.107318_b0105","doi-asserted-by":"crossref","first-page":"110007","DOI":"10.1016\/j.envres.2020.110007","article-title":"Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children's study","volume":"191","author":"Inadera","year":"2020","journal-title":"Environ. Res."},{"issue":"8","key":"10.1016\/j.envint.2022.107318_b0110","first-page":"1271","article-title":"Introduction of the new standard for birth size by gestational ages","volume":"114","author":"Itabashi","year":"2010","journal-title":"J. Jpn. Pediatr. Soc."},{"key":"10.1016\/j.envint.2022.107318_b0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.etap.2016.09.016","article-title":"Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain","volume":"48","author":"Karri","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"9890","key":"10.1016\/j.envint.2022.107318_b0120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(13)60993-9","article-title":"Mortality risk in preterm and small-for-gestational-age infants in low-income and middle-income countries: a pooled country analysis","volume":"382","author":"Katz","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.envint.2022.107318_b0125","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-14-25","article-title":"Rationale and study design of the Japan environment and children's study (JECS)","volume":"14","author":"Kawamoto","year":"2014","journal-title":"BMC Public Health."},{"issue":"4","key":"10.1016\/j.envint.2022.107318_b0130","doi-asserted-by":"crossref","first-page":"047004","DOI":"10.1289\/EHP5838","article-title":"A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.envint.2022.107318_b0135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3109\/01443615.2012.693987","article-title":"Lead exposure, gestational hypertension and pre-eclampsia: a systematic review of cause and effect","volume":"32","author":"Kennedy","year":"2012","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.envint.2022.107318_b0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.envint.2018.09.052","article-title":"Urinary trace metals individually and in mixtures in association with preterm birth","volume":"121","author":"Kim","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2022.107318_b0145","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.envint.2019.01.051","article-title":"Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort","volume":"125","author":"Kobayashi","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2022.107318_b0150","doi-asserted-by":"crossref","first-page":"108832","DOI":"10.1016\/j.envres.2019.108832","article-title":"Combined effects of multiple prenatal exposure to pollutants on birth weight: The Mothers and Children's Environmental Health (MOCEH) study","volume":"181","author":"Lee","year":"2020","journal-title":"Environ. Res."},{"issue":"10","key":"10.1016\/j.envint.2022.107318_b0155","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.3390\/nu11102298","article-title":"The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns","volume":"11","author":"Lewandowska","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.envint.2022.107318_b0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/oxfordjournals.aje.a009621","article-title":"Does paternal occupational lead exposure increase the risks of low birth weight or prematurity?","volume":"148","author":"Lin","year":"1998","journal-title":"Am. J. Epidemiol."},{"issue":"9","key":"10.1016\/j.envint.2022.107318_b0165","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/jat.3283","article-title":"Combined toxicity of heavy metal mixtures in liver cells","volume":"36","author":"Lin","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.envint.2022.107318_b0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jtemb.2019.07.007","article-title":"Common trace metals in rheumatoid arthritis: A systematic review and meta-analysis","volume":"56","author":"Ma","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.envint.2022.107318_b0175","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrendo.2016.127","article-title":"Long-term metabolic risk among children born premature or small for gestational age","volume":"13","author":"Mericq","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.envint.2022.107318_b0180","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuro.2019.07.007","article-title":"The role of zinc, copper, manganese and iron in neurodegenerative diseases","volume":"74","author":"Mezzaroba","year":"2019","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.envint.2022.107318_b0185","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2188\/jea.JE20140186","article-title":"The Japan Environment and Children's Study (JECS): A Preliminary Report on Selected Characteristics of Approximately 10 000 Pregnant Women Recruited During the First Year of the Study","volume":"25","author":"Michikawa","year":"2015","journal-title":"J. Epidemiol."},{"issue":"2","key":"10.1016\/j.envint.2022.107318_b0190","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2188\/jea.JE20170018","article-title":"Baseline Profile of Participants in the Japan Environment and Children's Study (JECS)","volume":"28","author":"Michikawa","year":"2018","journal-title":"J Epidemiol."},{"issue":"4","key":"10.1016\/j.envint.2022.107318_b0195","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.envint.2022.107318_b0200","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41370-019-0139-0","article-title":"Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS)","volume":"29","author":"Nakayama","year":"2019","journal-title":"J Expo Sci Environ Epidemiol."},{"issue":"7","key":"10.1016\/j.envint.2022.107318_b0205","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1089\/ars.2009.2973","article-title":"Selenium and selenoproteins in health and disease","volume":"12","author":"Papp","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.envint.2022.107318_b0210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1097-0274(199907)36:1<213::AID-AJIM30>3.0.CO;2-A","article-title":"Maternal occupational exposure to chemical substances and the risk of infants small-for-gestational-age","volume":"36","author":"Seidler","year":"1999","journal-title":"Am. J. Ind. Med."},{"issue":"5","key":"10.1016\/j.envint.2022.107318_b0215","doi-asserted-by":"crossref","first-page":"e068","DOI":"10.1097\/EE9.0000000000000068","article-title":"Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study","volume":"3","author":"Signes-Pastor","year":"2019","journal-title":"Environ. Epidemiol."},{"key":"10.1016\/j.envint.2022.107318_b0220","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chemosphere.2014.02.080","article-title":"The effects of prenatal exposure to low-level cadmium, lead and selenium on birth outcomes","volume":"108","author":"Sun","year":"2014","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.envint.2022.107318_b0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.braindev.2015.12.013","article-title":"Neurodevelopment in full-term small for gestational age infants: A nationwide Japanese population-based study","volume":"38","author":"Takeuchi","year":"2016","journal-title":"Brain Dev."},{"issue":"2","key":"10.1016\/j.envint.2022.107318_b0230","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/09674845.2009.11730256","article-title":"Recent developments in selenium research","volume":"66","author":"Taylor","year":"2009","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.envint.2022.107318_b9000","unstructured":"The Japanese Society for Pediatric Endocrinology, 2011. Excel-based Clinical Tools for Growth Evaluation of Children. http:\/\/jspe.umin.jp\/medical\/chart_dl.html, Accessed date: 6 July 2020 (in Japanese)."},{"issue":"1","key":"10.1016\/j.envint.2022.107318_b0235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/00039896.1984.10545827","article-title":"Placental transfer of heavy metals in normal pregnant Japanese women","volume":"39","author":"Tsuchiya","year":"1984","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.envint.2022.107318_b0240","doi-asserted-by":"crossref","first-page":"105370","DOI":"10.1016\/j.envint.2019.105370","article-title":"Exposure to multiple metals in early pregnancy and gestational diabetes mellitus: A prospective cohort study","volume":"135","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envint.2022.107318_b0245","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.reprotox.2011.12.006","article-title":"Birth outcomes related to informal e-waste recycling in Guiyu, China","volume":"33","author":"Xu","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.envint.2022.107318_b0250","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.envres.2019.02.007","article-title":"Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS)","volume":"172","author":"Yamamoto","year":"2019","journal-title":"Environ. Res."},{"issue":"10","key":"10.1016\/j.envint.2022.107318_b0255","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.ejcn.1602842","article-title":"Dietary intake and urinary excretion of selenium in the Japanese adult population: the INTERMAP Study Japan","volume":"62","author":"Yoneyama","year":"2008","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.envint.2022.107318_b0260","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fct.2013.12.041","article-title":"Toxicological assessment of combined lead and cadmium: acute and sub-chronic toxicity study in rats","volume":"65","author":"Yuan","year":"2014","journal-title":"Food Chem. Toxicol."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412022002458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412022002458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:24:31Z","timestamp":1758975871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412022002458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":53,"alternative-id":["S0160412022002458"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2022.107318","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individual and mixed metal maternal blood concentrations in relation to birth size: An analysis of the Japan Environment and Children\u2019s Study (JECS)","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2022.107318","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107318"}}