{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:08:50Z","timestamp":1792804130222,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.envint.2022.107531","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T08:44:22Z","timestamp":1663404262000},"page":"107531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium"],"prefix":"10.1016","volume":"169","author":[{"given":"Joshua D.","family":"Breidenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin W.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiya T.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Kleinhenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah K.","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Willey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Hammersley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mark Wooten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai N.","family":"Modyanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin G.","family":"Teeguarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2022.107531_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11070398","article-title":"Sub-ChronicMicrocystin-LR Liver Toxicity in Preexisting Diet-Induced NonalcoholicSteatohepatitis in Rats","volume":"11","author":"Arman","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.envint.2022.107531_b0010","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.1c04296","article-title":"Identification of Novel Microcystins Using High-Resolution MS and MS(n) with Python Code","author":"Baliu-Rodriguez","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2022.107531_b0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.toxicon.2005.01.004","article-title":"The toxicity of microcystin LR in mice following 7 days of inhalation exposure","volume":"45","author":"Benson","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0020","article-title":"Structural Diversity","volume":"11","author":"Bouaicha","year":"2019","journal-title":"Characterization and Toxicology of Microcystins. Toxins (Basel)"},{"key":"10.1016\/j.envint.2022.107531_b0025","article-title":"GeneToList: A WebApplication to Assist with Gene Identifiers for the Non-Bioinformatics-Savvy Scientist","volume":"11","author":"Breidenbach","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.envint.2022.107531_b0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1051\/vetres:2003019","article-title":"Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems","volume":"34","author":"Briand","year":"2003","journal-title":"Vet. Res."},{"key":"10.1016\/j.envint.2022.107531_b0035","doi-asserted-by":"crossref","unstructured":"Brozman, O., Kubickova, B., Babica, P., Laboha, P., 2020. Microcystin-LR Does Not AlterCell Survival and Intracellular Signaling in Human Bronchial Epithelial Cells. Toxins(Basel), 12.","DOI":"10.3390\/toxins12030165"},{"key":"10.1016\/j.envint.2022.107531_b0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxicon.2016.01.066","article-title":"Pulmonary and hepatic injury after sub-chronic exposure to sublethal doses of microcystin-LR","volume":"112","author":"Carvalho","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.toxicon.2010.06.005","article-title":"Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR?","volume":"56","author":"Carvalho","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/2472555217733437","article-title":"Leveraging the IncuCyte Technology for Higher-Throughput and Automated Chemotaxis Assays for Target Validation and Compound Characterization","volume":"23","author":"Chen","year":"2018","journal-title":"SLAS Discov"},{"key":"10.1016\/j.envint.2022.107531_b0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0045-6535(99)00402-6","article-title":"Study on the cytotoxicity of microcystin-LR on cultured cells","volume":"41","author":"Chong","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2022.107531_b0060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/09670269910001736462","article-title":"Cyanobacterial toxins, exposure routes and human health","volume":"34","author":"Codd","year":"1999","journal-title":"Eur. J. Phycol."},{"key":"10.1016\/j.envint.2022.107531_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2013.07.056","article-title":"Cyanobacterial toxins: modes of actions, fate in aquatic and soil ecosystems, phytotoxicity and bioaccumulation in agricultural crops","volume":"96","author":"Corbel","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2022.107531_b0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.taap.2004.08.012","article-title":"Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin","volume":"203","author":"Fischer","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2022.107531_b0075","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3389\/fimmu.2020.00761","article-title":"More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis","volume":"11","author":"Frey","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.envint.2022.107531_b0080","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.3390\/ijms15034795","article-title":"Toxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studies","volume":"15","author":"Frohlich","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2022.107531_b0085","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update","author":"Galaxy","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2022.107531_b0090","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/376745a0","article-title":"Three-dimensional structure of the catalytic subunit of protein serine\/threonine phosphatase-1","volume":"376","author":"Goldberg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.envint.2022.107531_b0095","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.94.12.6001","article-title":"Cilia internal mechanism and metachronal coordination as the result of hydrodynamical coupling","volume":"94","author":"Gueron","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.envint.2022.107531_b0100","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0300-483X(03)00112-4","article-title":"Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice","volume":"188","author":"Gupta","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2022.107531_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2013.12.003","article-title":"Airway epithelial regulation of pulmonary immune homeostasis and inflammation","volume":"151","author":"Hallstrand","year":"2014","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.envint.2022.107531_b0110","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1007\/s11356-016-6073-y","article-title":"A review of neurotoxicity of microcystins","volume":"23","author":"Hu","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.envint.2022.107531_b0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0041-0101(00)00124-0","article-title":"Intratracheal administration of microcystin-LR, and its distribution","volume":"39","author":"Ito","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0120","first-page":"D498","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2022.107531_b0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1165\/ajrcmb\/4.4.320","article-title":"Evidence for accessory cell function by class II MHC antigen-expressing airway epithelial cells","volume":"4","author":"Kalb","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.envint.2022.107531_b0130","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single-cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.envint.2022.107531_b0135","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.envint.2022.107531_b0140","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/17425255.2017.1253679","article-title":"The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions","volume":"13","author":"Kovacsics","year":"2017","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.envint.2022.107531_b0145","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.4049\/jimmunol.1000971","article-title":"Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses","volume":"185","author":"Kreisel","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.envint.2022.107531_b0150","article-title":"D\u2019Anglada, D.P.H.l.a.J.S., Ph.D., Health and Ecological Criteria Division. Drinking Water Health Advisory for the Cyanobacterial Microcystin Toxins. Microcystins Report. Washington, DC 20460: U.S. Environmental Protection Agency, Office of","author":"Lesley","year":"2015","journal-title":"Water"},{"key":"10.1016\/j.envint.2022.107531_b0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.envpol.2015.12.001","article-title":"Chronic exposure to microcystin-LR affected mitochondrial DNA maintenance and caused pathological changes of lung tissue in mice","volume":"210","author":"Li","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2022.107531_b0160","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(90)80245-E","article-title":"Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants","volume":"264","author":"MacKintosh","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.envint.2022.107531_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12090585","article-title":"[D-Leu(1)]MC-LR andMC-LR: A Small-Large Difference: Significantly Different Effects on Phaseolus vulgaris L. (Fabaceae) Growth and Phototropic Response after Single Contact duringImbibition with Each of These Microcystin Variants","volume":"12","author":"Malaissi","year":"2020","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.envint.2022.107531_b0170","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"key":"10.1016\/j.envint.2022.107531_b0175","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.estlett.8b00254","article-title":"Unexpected Contributions of Sea Spray and Lake Spray Aerosol to Inland Particulate Matter","volume":"5","author":"May","year":"2018","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envint.2022.107531_b0180","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2166\/wh.2018.257","article-title":"pH dependent octanol-water partitioning coefficients of microcystin congeners","volume":"16","author":"McCord","year":"2018","journal-title":"J. Water Health"},{"key":"10.1016\/j.envint.2022.107531_b0185","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0041-0101(98)00128-7","article-title":"The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types","volume":"36","author":"McDermott","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0190","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1039\/C7TX00043J","article-title":"Toxic mechanisms of microcystins in mammals","volume":"6","author":"McLellan","year":"2017","journal-title":"Toxicol. Res. (Camb.)"},{"key":"10.1016\/j.envint.2022.107531_b0195","doi-asserted-by":"crossref","first-page":"D394","DOI":"10.1093\/nar\/gkaa1106","article-title":"PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API","volume":"49","author":"Mi","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.envint.2022.107531_b0200","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41596-019-0128-8","article-title":"Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)","volume":"14","author":"Mi","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.envint.2022.107531_b0205","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-60761-175-2_7","article-title":"PANTHER pathway: an ontology-based pathway database coupled with data analysis tools","volume":"563","author":"Mi","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.envint.2022.107531_b0210","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.toxicon.2015.07.331","article-title":"Repeated intranasal exposure to microcystin-LR affects lungs but not nasal epithelium in mice","volume":"104","author":"Oliveira","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0215","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1021\/acs.est.9b07727","article-title":"Harmful Algal Bloom Toxins in Aerosol Generated from Inland Lake Water","volume":"54","author":"Olson","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2022.107531_b0220","doi-asserted-by":"crossref","first-page":"L658","DOI":"10.1152\/ajplung.2000.279.4.L658","article-title":"Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils","volume":"279","author":"Pan","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.envint.2022.107531_b0225","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.envint.2022.107531_b0230","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12931-015-0272-9","article-title":"MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment","volume":"16","author":"Poole","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.envint.2022.107531_b0235","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.envint.2022.107531_b0240","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.envint.2022.107531_b0245","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1517\/17425255.4.8.1075","article-title":"In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter","volume":"4","author":"Rothen-Rutishauser","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.envint.2022.107531_b0250","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.toxicon.2007.04.003","article-title":"Effects of microcystin-LR on mouse lungs","volume":"50","author":"Soares","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189939","article-title":"Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages","volume":"22","author":"Su","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2022.107531_b0260","first-page":"1236","article-title":"Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line","volume":"29","author":"Sun","year":"2014","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.envint.2022.107531_b0265","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00204-019-02524-4","article-title":"Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings","volume":"93","author":"Svircev","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2022.107531_b0270","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/bmj.300.6737.1440","article-title":"Pneumonia associated with contact with cyanobacteria","volume":"300","author":"Turner","year":"1990","journal-title":"BMJ"},{"key":"10.1016\/j.envint.2022.107531_b0275","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tox.2011.12.011","article-title":"Human and rat hepatocyte toxicity and protein phosphatase 1 and 2A inhibitory activity of naturally occurring desmethyl-microcystins and nodularins","volume":"293","author":"Ufelmann","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2022.107531_b0280","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxicon.2016.03.007","article-title":"The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells","volume":"115","author":"Wang","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0285","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.toxicon.2004.10.016","article-title":"Inhibition of embryonic development by microcystin-LR in zebrafish","volume":"45","author":"Wang","year":"2005","journal-title":"Danio rerio. Toxicon"},{"key":"10.1016\/j.envint.2022.107531_b0290","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/00288330.2006.9517447","article-title":"Survey of cyanotoxins in New Zealand water bodies between 2001 and 2004","volume":"40","author":"Wood","year":"2006","journal-title":"New Zeal J. Mar. Fresh"},{"key":"10.1016\/j.envint.2022.107531_b0295","unstructured":"World Health Organization, W., Sanitation, Hygiene and Health Team. Management of cyanobacteria in drinking-water supplies. Information note; 2015."},{"key":"10.1016\/j.envint.2022.107531_b0300","doi-asserted-by":"crossref","first-page":"13031","DOI":"10.1021\/acs.est.9b03726","article-title":"Warming Amplifies the Frequency of Harmful Algal Blooms with Eutrophication in Chinese Coastal Waters","volume":"53","author":"Xiao","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2022.107531_b0305","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2006.09.025","article-title":"Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins","volume":"127","author":"Xing","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.envint.2022.107531_b0310","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fmicb.2019.00451","article-title":"Historical Occurrence of Algal Blooms in the Northern Beibu Gulf of China and Implications for Future Trends","volume":"10","author":"Xu","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.envint.2022.107531_b0315","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/nt.1","article-title":"Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice","volume":"5","author":"Yoshida","year":"1997","journal-title":"Nat. Toxins"},{"key":"10.1016\/j.envint.2022.107531_b0320","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1365-2249.2006.03058.x","article-title":"Association of epithelial damage and signs of neutrophil mobilization in the airways during acute exacerbations of paediatric asthma","volume":"144","author":"Yoshihara","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.envint.2022.107531_b0325","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.toxicon.2018.06.072","article-title":"A proteomic study of the pulmonary injury induced by microcystin-LR in mice","volume":"150","author":"Zhao","year":"2018","journal-title":"Toxicon"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412022004585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412022004585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:25:40Z","timestamp":1758975940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412022004585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":65,"alternative-id":["S0160412022004585"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2022.107531","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2022.107531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107531"}}