{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:15:28Z","timestamp":1791810928161,"version":"4.3.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.envint.2023.107806","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T12:30:15Z","timestamp":1675686615000},"page":"107806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes"],"prefix":"10.1016","volume":"173","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabrouk","family":"Elsabagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.envint.2023.107806_b0005","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jhep.2019.01.026","article-title":"Autophagy in liver diseases: Time for translation?","volume":"70","author":"Allaire","year":"2019","journal-title":"J. Hepatol."},{"issue":"2S","key":"10.1016\/j.envint.2023.107806_b0010","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"pt3","key":"10.1016\/j.envint.2023.107806_b0015","article-title":"Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors","volume":"287","author":"Cao","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107806_b0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2019.12.004","article-title":"Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway","volume":"147","author":"Cao","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.envint.2023.107806_b0025","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/molehr\/gaq004","article-title":"Endocrine disruptor, dioxin (TCDD)-induced mitochondrial dysfunction and apoptosis in human trophoblast-like JAR cells","volume":"16","author":"Chen","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.envint.2023.107806_b0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2015.06.036","article-title":"Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-kappaB and P53 signaling pathways","volume":"239","author":"Chtourou","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.envint.2023.107806_b0035","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.freeradbiomed.2012.05.029","article-title":"Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells","volume":"53","author":"Cole-Ezea","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"S1","key":"10.1016\/j.envint.2023.107806_b0040","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.placenta.2014.11.018","article-title":"Endocrine regulation of placental phenotype","volume":"36","author":"Fowden","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2023.107806_b0045","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.envint.2015.10.006","article-title":"Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A","volume":"86","author":"Gauderat","year":"2016","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph20010014","article-title":"Oestrogenic activity in girls with signs of precocious puberty as exposure biomarker to endocrine disrupting chemicals: A pilot study","volume":"20","author":"Gea","year":"2022","journal-title":"Int. J. Env. Res. Pub. He."},{"issue":"5","key":"10.1016\/j.envint.2023.107806_b0055","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s00204-018-2191-2","article-title":"Gestational bisphenol S impairs placental endocrine function and the fusogenic trophoblast signaling pathway","volume":"92","author":"Gingrich","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-0035-1570031","article-title":"Animal models to study placental development and function throughout normal and dysfunctional human pregnancy","volume":"34","author":"Grigsby","year":"2016","journal-title":"Semin. Reprod. Med."},{"issue":"2","key":"10.1016\/j.envint.2023.107806_b0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/jcm7020036","article-title":"Blood mononuclear cell mitochondrial respiratory chain complex IV activity is decreased in multiple sclerosis patients: effects of \u03b2-interferon treatment","volume":"7","author":"Hargreaves","year":"2018","journal-title":"J. Clin. Med."},{"issue":"13","key":"10.1016\/j.envint.2023.107806_b9020","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1089\/scd.2013.0329","article-title":"Establishment of bovine trophoblast stem-like cells from in vitro-produced blastocyst-stage embryos using two inhibitors","volume":"23","author":"Huang","year":"2014","journal-title":"Stem. Cells. DEV."},{"issue":"7","key":"10.1016\/j.envint.2023.107806_b0070","doi-asserted-by":"crossref","first-page":"789","DOI":"10.7150\/ijbs.9168","article-title":"Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts","volume":"10","author":"Huang","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.envint.2023.107806_b0075","doi-asserted-by":"crossref","unstructured":"Huang, Q., Chen, H., Li, J., Oliver, M., Ma, X., Byck, D., Gao, Y., Jiang, S., W., 2014b. Epigenetic and non-epigenetic regulation of syncytin-1 expression in human placenta and cancer tissues. Cell Signal 26 (3), 648\u2013656.","DOI":"10.1016\/j.cellsig.2013.11.002"},{"issue":"11","key":"10.1016\/j.envint.2023.107806_b0080","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.1021\/acs.est.7b00801","article-title":"Prenatal Nonylphenol and Bisphenol A Exposures and Inflammation Are Determinants of Oxidative\/Nitrative Stress: A Taiwanese Cohort Study","volume":"51","author":"Huang","year":"2017","journal-title":"Environ. Sci. Tech."},{"issue":"3\u20134","key":"10.1016\/j.envint.2023.107806_b0085","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.anireprosci.2005.06.003","article-title":"Trophoblast cells of ruminant placentas\u2013A minireview","volume":"93","author":"Igwebuike","year":"2006","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.envint.2023.107806_b0090","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxrep.2017.12.013","article-title":"Bisphenol A (BPA) the mighty and the mutagenic","volume":"5","author":"Jalal","year":"2017","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.102.014977","article-title":"Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia","volume":"69","author":"Kaufmann","year":"2003","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0100","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1038\/s41598-019-41134-z","article-title":"Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation","volume":"9","author":"Kelley","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0105","first-page":"5","article-title":"Health risk of exposure to Bisphenol A(BPA)","volume":"66","author":"Konieczna","year":"2015","journal-title":"Rocz. Panstw. Zakl. Hig."},{"issue":"6","key":"10.1016\/j.envint.2023.107806_b0110","first-page":"327","article-title":"Bcl-2\/Bax: a rheostat that regulates an anti-oxidant pathway and cell death","volume":"4","author":"Korsmeyer","year":"1993","journal-title":"Semin. Canc. Biol."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0115","first-page":"63","article-title":"Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family","volume":"1271","author":"Korsmeyer","year":"1995","journal-title":"BBA"},{"issue":"4","key":"10.1016\/j.envint.2023.107806_b0120","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2009.05.004","article-title":"Mitochondria and reactive oxygen species","volume":"47","author":"Kowaltowski","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"31","key":"10.1016\/j.envint.2023.107806_b0125","doi-asserted-by":"crossref","first-page":"51507","DOI":"10.18632\/oncotarget.17882","article-title":"Bisphenol A exposure promotes HTR-8\/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-beta1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways","volume":"8","author":"Lan","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0130","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3892\/mmr.2012.1123","article-title":"Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells","volume":"7","author":"Li","year":"2013","journal-title":"Mol. Med. Rep."},{"issue":"20","key":"10.1016\/j.envint.2023.107806_b0135","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.7150\/thno.46467","article-title":"Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4\/TRAF3\/MFN1 pathway","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.envint.2023.107806_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114697","article-title":"3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages","volume":"265","author":"Liu","year":"2020","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/antiox11010055","article-title":"Cis-9, Trans-11 CLA Alleviates Lipopolysaccharide-Induced Depression of Fatty Acid Synthesis by Inhibiting Oxidative Stress and Autophagy in Bovine Mammary Epithelial Cells","volume":"11","author":"Ma","year":"2021","journal-title":"Antioxidants"},{"issue":"9","key":"10.1016\/j.envint.2023.107806_b0150","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1073\/pnas.1919563117","article-title":"Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta\u2013brain axis","volume":"117","author":"Mao","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7","key":"10.1016\/j.envint.2023.107806_b0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1289\/ehp.95103s73","article-title":"Symposium on estrogens in the environment","volume":"103","author":"McLachlan","year":"1995","journal-title":"III. Environ Health Perspect"},{"key":"10.1016\/j.envint.2023.107806_b0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.freeradbiomed.2015.11.022","article-title":"Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K\/Akt and MAPK signaling pathways","volume":"90","author":"Mi","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.envint.2023.107806_b0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00418-018-1699-0","article-title":"Human trophoblast invasion: new and unexpected routes and functions","volume":"150","author":"Moser","year":"2018","journal-title":"Histochem. Cell Biol."},{"issue":"9","key":"10.1016\/j.envint.2023.107806_b0170","doi-asserted-by":"crossref","first-page":"e1008191","DOI":"10.1371\/journal.pcbi.1008191","article-title":"Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms","volume":"16","author":"Mukherjee","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.envint.2023.107806_b9005","series-title":"Nutrient requirements of small ruminants: sheep, goats, cervids, and new world camelids","author":"NRC","year":"2007"},{"key":"10.1016\/j.envint.2023.107806_b0175","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/218493","article-title":"Cell death and inflammatory bowel diseases: Apoptosis, necrosis, and autophagy in the intestinal epithelium","volume":"2014","author":"Nunes","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.envint.2023.107806_b0180","first-page":"203","article-title":"Isolation and culture of term human trophoblast cells [M]\/\/Placenta and Trophoblast","volume":"2006","author":"Petroff","year":"2006","journal-title":"Humana Press"},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0185","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1210\/en.2011-1502","article-title":"PPAR\u03b3 agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets","volume":"153","author":"Pipatpiboon","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/138161210789941810","article-title":"Understanding Autophagy in Cell Death Control","volume":"16","author":"Platini","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"9","key":"10.1016\/j.envint.2023.107806_b0195","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1021\/acs.chemrestox.5b00093","article-title":"Bisphenol A increases BeWo trophoblast survival in stress-induced paradigms through regulation of oxidative stress and apoptosis","volume":"28","author":"Ponniah","year":"2015","journal-title":"Chem. Res. Toxicol."},{"issue":"2","key":"10.1016\/j.envint.2023.107806_b0200","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1440-1746.2000.02059.x","article-title":"Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions","volume":"15","author":"Ramachandran","year":"2000","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.envint.2023.107806_b0205","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: a review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.envint.2023.107806_b9000","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S0021859600024874","article-title":"Subjective assessment of body fat in live sheep","volume":"72","author":"Russel","year":"1969","journal-title":"J. Agric. Sci."},{"issue":"12","key":"10.1016\/j.envint.2023.107806_b0210","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1210\/en.2006-0805","article-title":"Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function","volume":"147","author":"Savabieasfahani","year":"2006","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0215","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.envint.2023.107806_b0220","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.3892\/mmr.2017.7409","article-title":"Autophagy and ER stress in LPS\/GalN-induced acute liver injury","volume":"16","author":"Shi","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"13","key":"10.1016\/j.envint.2023.107806_b0225","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.115.020502","article-title":"Response by Shirakabe et al to Letter Regarding Article, \u201cDrp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure\u201d","volume":"133","author":"Shirakabe","year":"2016","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.envint.2023.107806_b0230","doi-asserted-by":"crossref","first-page":"27003","DOI":"10.1289\/EHP3730","article-title":"The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) in Mono(2-ethylhexyl) Phthalate (MEHP)- Mediated Cytotrophoblast Differentiation","volume":"127","author":"Shoaito","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0921-4488(95)00709-1","article-title":"Foetal age estimation in sheep and goats","volume":"19","author":"Sivachelvan","year":"1996","journal-title":"Small Ruminant Res"},{"key":"10.1016\/j.envint.2023.107806_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125301","article-title":"Developmental programming: Prenatal bisphenol A treatment disrupts mediators of placental function in sheep","volume":"243","author":"Song","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107806_b0245","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2015.05.023","article-title":"Low concentrations of Bisphenol A and para-nonylphenol affect extravillous pathway of human trophoblast cells","volume":"412","author":"Spagnoletti","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.envint.2023.107806_b0250","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1210\/er.2005-0003","article-title":"The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy","volume":"26","author":"Straszewski-Chavez","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.envint.2023.107806_b0255","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2015.08.015","article-title":"Fluoride induces oxidative damage and SIRT1\/autophagy through ROS-mediated JNK signaling","volume":"89","author":"Suzuki","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.envint.2023.107806_b0260","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/jat.3176","article-title":"Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice","volume":"35","author":"Tait","year":"2015","journal-title":"J. Appl. Toxicol."},{"issue":"3","key":"10.1016\/j.envint.2023.107806_b0265","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/ijms19030848","article-title":"Epidermal growth factor, through alleviating oxidative stress, protect IPEC-J2 cells from lipopolysaccharides-induced apoptosis","volume":"19","author":"Tang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.envint.2023.107806_b0270","first-page":"351","article-title":"Growth and metabolism of the placenta after unilateral fetectomy in twin pregnant ewes","volume":"15","author":"Vatnick","year":"1991","journal-title":"J. Dev. Physiol."},{"issue":"1","key":"10.1016\/j.envint.2023.107806_b0275","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/en.2012-1401","article-title":"Maternal and fetal exposure to bisphenol A is associated with alterations of thyroid function in pregnant ewes and their newborn lambs","volume":"154","author":"Vigui\u00e9","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.envint.2023.107806_b0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ntt.2015.11.007","article-title":"Cadmium induced inhibition of autophagy is associated with microtubule disruption and mitochondrial dysfunction in primary rat cerebral cortical neurons","volume":"53","author":"Wang","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"issue":"2","key":"10.1016\/j.envint.2023.107806_b0285","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jphs.2016.03.001","article-title":"Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-kappaB\/p53 pathway","volume":"131","author":"Wei","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.envint.2023.107806_b0290","first-page":"223","article-title":"Comparative aspects of placental efficiency","volume":"58","author":"Wilson","year":"2001","journal-title":"Reprod. Suppl."},{"key":"10.1016\/j.envint.2023.107806_b0295","doi-asserted-by":"crossref","unstructured":"Xu, X., Li, M., Chen, W., Yu, H., Yang, Y., Hang, L., 2016. Apigenin attenuates oxidative injury in ARPE-19 cells thorough activation of Nrf2 pathway. Oxid Med Cell Longev 2016.","DOI":"10.1155\/2016\/4378461"},{"key":"10.1016\/j.envint.2023.107806_b0300","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chemosphere.2018.03.192","article-title":"Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes","volume":"204","author":"Yang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107806_b0305","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.chemosphere.2019.05.133","article-title":"A mechanism for the effect of endocrine disrupting chemicals on placentation","volume":"231","author":"Yang","year":"2019","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.envint.2023.107806_b0310","doi-asserted-by":"crossref","first-page":"e1002831","DOI":"10.1371\/journal.pmed.1002831","article-title":"Mediating roles of preterm birth and restricted fetal growth in the relationship between maternal education and infant mortality: a Danish population-based cohort study","volume":"16","author":"Yu","year":"2019","journal-title":"PLoS Med."},{"key":"10.1016\/j.envint.2023.107806_b0315","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Shi, J., Liu, S., 2016c. Establishment and characterization of a telomerase-immortalized sheep trophoblast cell line. Biomed Res Int 2016.","DOI":"10.1155\/2016\/5808575"},{"key":"10.1016\/j.envint.2023.107806_b0320","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.etap.2017.07.014","article-title":"Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell","volume":"55","author":"Zhang","year":"2017","journal-title":"Environ. Toxicol. Phar."},{"issue":"5","key":"10.1016\/j.envint.2023.107806_b0325","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.2527\/jas.2015-9587","article-title":"Dietary N-carbamylglutamate and rumen-protected l-arginine supplementation ameliorate fetal growth restriction in undernourished ewes","volume":"94","author":"Zhang","year":"2016","journal-title":"J. Anim. Sci."},{"issue":"6","key":"10.1016\/j.envint.2023.107806_b0330","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1530\/REP-16-0067","article-title":"N-carbamylglutamate and L-arginine improved maternal and placental development in underfed ewes","volume":"151","author":"Zhang","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.envint.2023.107806_b0335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fcvm.2017.00029","article-title":"Role of endoplasmic reticulum stress, autophagy, and inflammation in cardiovascular disease","volume":"4","author":"Zhang","year":"2017","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.envint.2023.107806_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114613","article-title":"Selenium mitigates cadmium-induced crosstalk between autophagy and endoplasmic reticulum stress via regulating calcium homeostasis in avian leghorn male hepatoma (LMH) cells","volume":"265","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.envint.2023.107806_b0345","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1071\/RD18047","article-title":"Dietary N-carbamylglutamate and rumen-protected L-arginine supplementation during intrauterine growth restriction in undernourished ewes improve fetal thymus development and immune function","volume":"30","author":"Zhang","year":"2018","journal-title":"Reprod. Fertil. Dev."},{"issue":"4","key":"10.1016\/j.envint.2023.107806_b0350","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.aninu.2021.06.004","article-title":"Dietary rumen-protected L-arginine or N-carbamylglutamate attenuated fetal hepatic inflammation in undernourished ewes suffering from intrauterine growth restriction","volume":"7","author":"Zhang","year":"2021","journal-title":"Anim Nutr"},{"key":"10.1016\/j.envint.2023.107806_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124489","article-title":"Melatonin ameliorates ochratoxin A induced liver inflammation, oxidative stress and mitophagy in mice involving in intestinal microbiota and restoring the intestinal barrier function","volume":"407","author":"Zhang","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"9","key":"10.1016\/j.envint.2023.107806_b9010","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3390\/antiox11091727","article-title":"Effects of the gut microbiota and barrier function on melatonin efficacy in alleviating liver injury","volume":"11","author":"Zhang","year":"2022","journal-title":"Antioxidants."},{"issue":"17","key":"10.1016\/j.envint.2023.107806_b0360","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.1007\/s00253-014-5829-x","article-title":"Clostridium butyricum reduce lipogenesis through bacterial wall components and butyrate","volume":"98","author":"Zhao","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.envint.2023.107806_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.112991","article-title":"Activation of autophagy inhibits cadmium-triggered apoptosis in human placental trophoblasts and mouse placenta","volume":"254","author":"Zhu","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107806_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127268","article-title":"Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation","volume":"424","author":"Zhu","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.envint.2023.107806_b0375","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.placenta.2009.02.001","article-title":"Down-regulation of growth signaling pathways linked to a reduced cotyledonary vascularity in placentomes of over-nourished, obese pregnant ewes","volume":"30","author":"Zhu","year":"2009","journal-title":"Placenta"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016041202300079X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016041202300079X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:27:48Z","timestamp":1758976068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016041202300079X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":79,"alternative-id":["S016041202300079X"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2023.107806","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2023.107806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107806"}}