{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:53:46Z","timestamp":1792702426778,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2016YFD0200202"],"award-info":[{"award-number":["2016YFD0200202"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002365","name":"China Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.envint.2023.107830","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:34:19Z","timestamp":1676428459000},"page":"107830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Intergenerational reproductive toxicity of parental exposure to prothioconazole and its metabolite on offspring and epigenetic regulation associated with DNA methylation in zebrafish"],"prefix":"10.1016","volume":"173","author":[{"given":"Sinuo","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2023.107830_b0005","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and mate fertility","volume":"308","author":"Anway","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.envint.2023.107830_b0010","first-page":"5","article-title":"Transgenerational effects from early developmental exposures to bisphenol A or 17 alpha-ethinylestradiol in medaka, Oryzias latipes","author":"Bhandari","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2023.107830_b0015","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1007\/s11356-021-12691-6","article-title":"DNA methylation and gene expression alterations in zebrafish embryos exposed to cadmium","volume":"28","author":"Bian","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2023.107830_b0020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.chemosphere.2015.12.083","article-title":"Regulation of vitellogenin (vtg1) and estrogen receptor (er) gene expression in zebrafish (Danio rerio) following the administration of Cd2+ and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"147","author":"Chen","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107830_b0025","doi-asserted-by":"crossref","first-page":"155610","DOI":"10.1016\/j.scitotenv.2022.155610","article-title":"Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior","volume":"838","author":"Chen","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.107830_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156785","article-title":"Molecular mechanism of ethylparaben on zebrafish embryo cardiotoxicity based on transcriptome analyses","volume":"842","author":"Fan","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.107830_b0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aquatox.2003.10.008","article-title":"Aromatase modulation alters gonadal differentiation in developing zebrafish (Danio rerio)","volume":"67","author":"Fenske","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2023.107830_b0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrg3724","article-title":"Gene expression regulation mediated through reversible m(6)A RNA methylation","volume":"15","author":"Fu","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.envint.2023.107830_b0045","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2085496","article-title":"Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants","volume":"2019","author":"Grova","year":"2019","journal-title":"Int. J. Genomics"},{"key":"10.1016\/j.envint.2023.107830_b0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1155\/2007\/291538","article-title":"The role of RASSF1A methylation in cancer","volume":"23","author":"Hesson","year":"2007","journal-title":"Dis. Markers"},{"key":"10.1016\/j.envint.2023.107830_b0055","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1158\/0008-5472.CAN-06-0516","article-title":"Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4","volume":"66","author":"Ho","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.envint.2023.107830_b0060","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/sj.onc.1204389","article-title":"AP-1 in mouse development and tumorigenesis","volume":"20","author":"Jochum","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.envint.2023.107830_b0065","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nrg2651","article-title":"OPINION Rethinking how DNA methylation patterns are maintained","volume":"10","author":"Jones","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.envint.2023.107830_b0070","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/toxsci\/kfq179","article-title":"Human Primordial Germ Cell Formation Is Diminished by Exposure to Environmental Toxicants Acting through the AHR Signaling Pathway","volume":"117","author":"Kee","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107830_b0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF01103366","article-title":"The effects of pollution on reproduction in fish","volume":"5","author":"Kime","year":"1995","journal-title":"Rev. Fish Biol. Fish."},{"key":"10.1016\/j.envint.2023.107830_b0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gde.2016.04.001","article-title":"Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals","volume":"36","author":"Klosin","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.envint.2023.107830_b0085","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/15592294.2016.1182272","article-title":"Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)","volume":"11","author":"Laing","year":"2016","journal-title":"Epigenetics"},{"key":"10.1016\/j.envint.2023.107830_b0090","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.envint.2023.107830_b0095","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.fishres.2009.08.009","article-title":"Gonadosomatic index and gonad histopathology of Gobius niger (Gobiidea, Teleost) from Bizerta lagoon (Tunisia): Evidence of reproduction disturbance","volume":"100","author":"Louiz","year":"2009","journal-title":"Fish. Res."},{"key":"10.1016\/j.envint.2023.107830_b0100","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7150\/ijbs.11218","article-title":"DNA Methylation, Its Mediators and Genome Integrity","volume":"11","author":"Meng","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.envint.2023.107830_b0105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12210-015-0476-4","article-title":"Effects of some environmental factors on the population density and species diversity of phytoplankton in Bitter Lakes","volume":"27","author":"Nassar","year":"2016","journal-title":"Egypt. Rendiconti Lincei-Scienze Fisiche E Naturali"},{"key":"10.1016\/j.envint.2023.107830_b0110","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1038\/sj.onc.1202746","article-title":"MYC oncogenes and human neoplastic disease","volume":"18","author":"Nesbit","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.envint.2023.107830_b0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cbpc.2014.05.004","article-title":"Impacts of TCDD and MeHg on DNA methylation in zebrafish (Danio rerio) across two generations","volume":"165","author":"Olsvik","year":"2014","journal-title":"Comp. Biochem. Physiol. C-Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2023.107830_b0120","doi-asserted-by":"crossref","first-page":"14275","DOI":"10.1021\/acs.est.0c02871","article-title":"Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis","volume":"54","author":"Qian","year":"2020","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107830_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123009","article-title":"Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring","volume":"399","author":"Qiu","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107830_b0130","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.5740\/jaoacint.SGE_Raina","article-title":"Determination of Azole Fungicides in Atmospheric Samples Collected in the Canadian Prairies by LC\/MS\/MS","volume":"95","author":"Raina","year":"2012","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.envint.2023.107830_b0135","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbcan.2009.03.004","article-title":"The RASSF proteins in cancer; from epigenetic silencing to functional characterization","volume":"1796","author":"Richter","year":"2009","journal-title":"Biochim. Biophys. Acta-Rev. Cancer"},{"key":"10.1016\/j.envint.2023.107830_b0140","first-page":"11","article-title":"Levels of Selected Persistent Organic Pollutants (PCB, PBDE) and Pesticides in Honey Bee Pollen Sampled in Poland","author":"Roszko","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.envint.2023.107830_b0145","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg2072","article-title":"Transposable elements and the epigenetic regulation of the genome","volume":"8","author":"Slotkin","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.envint.2023.107830_b0150","first-page":"199","article-title":"Long-term trends of pesticides in Norwegian agricultural streams and potential future challenges in northern climate","volume":"65","author":"Stenrod","year":"2015","journal-title":"Acta Agric. Scand. Sect. B-Soil Plant Sci."},{"key":"10.1016\/j.envint.2023.107830_b0155","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3835(00)00518-8","article-title":"Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors","volume":"158","author":"Tao","year":"2000","journal-title":"Cancer Lett."},{"key":"10.1016\/j.envint.2023.107830_b0160","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.envpol.2017.10.063","article-title":"Effects of the bioconcentration and parental transfer of environmentally relevant concentrations of difenoconazole on endocrine disruption in zebrafish (Danio rerio)","volume":"233","author":"Teng","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107830_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105384","article-title":"Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio)","volume":"135","author":"Teng","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107830_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109310","article-title":"Chronic exposure of zebrafish (Danio rerio) to flutolanil leads to endocrine disruption and reproductive disorders","volume":"184","author":"Teng","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.107830_b0175","doi-asserted-by":"crossref","unstructured":"Tian, S.; Yan, S.; Meng, Z.; Sun, W.; Yan, J.; Huang, S.; Wang, Y.; Zhou, Z.; Diao, J.; Li, L.; Zhu, W. Widening the Lens on Prothioconazole and Its Metabolite Prothioconazole-Desthio: Aryl Hydrocarbon Receptor-Mediated Reproductive Disorders through in Vivo, in Vitro, and in Silico Studies. Environmental science & technology 2022b.","DOI":"10.1021\/acs.est.2c06236"},{"key":"10.1016\/j.envint.2023.107830_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126100","article-title":"New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1","volume":"418","author":"Tian","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107830_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104983","article-title":"Prothioconazole and prothioconazole-desthio induced different hepatotoxicities via interfering with glycolipid metabolism in mice","volume":"180","author":"Tian","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.envint.2023.107830_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107830_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113297","article-title":"Gonadal disruption after single dose exposure of prothioconazole and prothioconazole-desthio in male lizards (Eremias argus)","volume":"255","author":"Xie","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107830_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125408","article-title":"Exposure of adult zebrafish (Danio rerio) to Tetrabromobisphenol A causes neurotoxicity in larval offspring, an adverse transgenerational effect","volume":"414","author":"Yu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107830_b0205","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.aquatox.2016.06.018","article-title":"Reproductive toxicity of inorganic mercury exposure in adult zebrafish: Histological damage, oxidative stress, and alterations of sex hormone and gene expression in the hypothalamic-pituitary-gonadal axis","volume":"177","author":"Zhang","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.envint.2023.107830_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153714","article-title":"Intergenerational toxic effects of parental exposure to bisphenol AF on offspring and epigenetic modulations in zebrafish","volume":"823","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.107830_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122756","article-title":"Stereoselective uptake and metabolism of prothioconazole caused oxidative stress in zebrafish (Danio rerio)","volume":"396","author":"Zhang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107830_b0220","doi-asserted-by":"crossref","first-page":"154443","DOI":"10.1016\/j.scitotenv.2022.154443","article-title":"Transgenerational effects of zinc in zebrafish following early life stage exposure","volume":"828","author":"Zheng","year":"2022","journal-title":"Sci. Total Environ."}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023001034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023001034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:25:15Z","timestamp":1758975915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412023001034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":44,"alternative-id":["S0160412023001034"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2023.107830","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intergenerational reproductive toxicity of parental exposure to prothioconazole and its metabolite on offspring and epigenetic regulation associated with DNA methylation in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2023.107830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107830"}}