{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:10:48Z","timestamp":1793362248627,"version":"4.5.0"},"reference-count":147,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013263","name":"State Key Laboratory in Marine Pollution","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42207335"],"award-info":[{"award-number":["42207335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["PJ9448002"],"award-info":[{"award-number":["PJ9448002"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["2022QNRC001"],"award-info":[{"award-number":["2022QNRC001"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC3201000"],"award-info":[{"award-number":["2021YFC3201000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environment International"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.envint.2023.107951","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:14:20Z","timestamp":1682561660000},"page":"107951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":228,"special_numbering":"C","title":["Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes"],"prefix":"10.1016","volume":"175","author":[{"given":"Lihui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefei","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.Y.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.envint.2023.107951_b0005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/toxsci\/kfm110","article-title":"Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha","volume":"98","author":"Abbott","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0010","doi-asserted-by":"crossref","first-page":"20170408","DOI":"10.1098\/rsif.2017.0408","article-title":"A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity","volume":"14","author":"Alves","year":"2017","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.envint.2023.107951_b0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfm270","article-title":"Perfluoroalkyl acids and related chemistries\u2014toxicokinetics and modes of action","volume":"102","author":"Andersen","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0020","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jnutbio.2010.01.005","article-title":"Liver fatty acid-binding protein and obesity","volume":"21","author":"Atshaves","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.envint.2023.107951_b0025","article-title":"Serum concentrations of perfluoroalkyl substances and their association with osteoporosis in a population in Jeddah","volume":"187","author":"Banjabi","year":"2020","journal-title":"Saudi Arabia. Environmental Research"},{"key":"10.1016\/j.envint.2023.107951_b0030","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chemosphere.2016.08.112","article-title":"Screening for perfluoroalkyl acids in consumer products, building materials and wastes","volume":"164","author":"Becanova","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0035","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1021\/es505399w","article-title":"Isomer-specific binding affinity of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) to serum proteins","volume":"49","author":"Beesoon","year":"2015","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104700","article-title":"Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)","volume":"62","author":"Behr","year":"2020","journal-title":"Toxicology in vitro: an international journal published in association with BIBRA"},{"key":"10.1016\/j.envint.2023.107951_b0045","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/toxsci\/kfq379","article-title":"Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro","volume":"120","author":"Benninghoff","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/15209150260007381","article-title":"Physiological and therapeutic roles of peroxisome proliferator-activated receptors","volume":"4","author":"Berger","year":"2002","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.envint.2023.107951_b0055","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.06.012","article-title":"Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes","volume":"288","author":"Bjork","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2023.107951_b0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/toxsci\/kfp093","article-title":"Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures","volume":"111","author":"Bjork","year":"2009","journal-title":"Toxicol Science"},{"key":"10.1016\/j.envint.2023.107951_b0733","doi-asserted-by":"crossref","first-page":"10900","DOI":"10.3390\/ijerph182010900","article-title":"Trends in the Regulation of Per- and Polyfluoroalkyl Substances (PFAS): A Scoping Review","volume":"18","author":"Brennan","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.envint.2023.107951_b0065","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1172\/JCI60047","article-title":"Mechanisms of thyroid hormone action","volume":"122","author":"Brent","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.envint.2023.107951_b0070","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/acs.chemrestox.2c00078","article-title":"Cellular Interactions and Fatty Acid Transporter CD36-Mediated Uptake of Per- and Polyfluorinated Alkyl Substances (PFAS)","author":"Camdzic","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0075","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/acs.est.8b05564","article-title":"Screening of Potential PFOS Alternatives To Decrease Liver Bioaccumulation: Experimental and Computational Approaches","volume":"53","author":"Cao","year":"2019","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0080","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acs.est.1c07176","article-title":"Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0085","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1074\/jbc.275.6.4507","article-title":"Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta","volume":"275","author":"Cha","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.envint.2023.107951_b0090","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.tox.2007.10.014","article-title":"Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)","volume":"243","author":"Chang","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2023.107951_b0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/cmi.2009.3","article-title":"Cell Death Mechanisms Induced by Cytotoxic Lymphocytes","volume":"6","author":"Ch\u00e1vez-Gal\u00e1n","year":"2009","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.envint.2023.107951_b0100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/taap.2000.9107","article-title":"Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis","volume":"170","author":"Chen","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.107951_b0105","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1021\/acs.est.7b02602","article-title":"A permeability-limited physiologically based pharmacokinetic (PBPK) model for perfluorooctanoic acid (PFOA) in male rats","volume":"51","author":"Cheng","year":"2017","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0110","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1021\/acs.est.8b01268","article-title":"Predicting relative protein affinity of novel per-and polyfluoroalkyl substances (PFASs) by an efficient molecular dynamics approach","volume":"52","author":"Cheng","year":"2018","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0115","doi-asserted-by":"crossref","first-page":"13970","DOI":"10.1021\/acs.est.9b04833","article-title":"Using Machine Learning to Classify Bioactivity for 3486 Per- and Polyfluoroalkyl Substances (PFASs) from the OECD List","volume":"53","author":"Cheng","year":"2019","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0120","doi-asserted-by":"crossref","first-page":"599","DOI":"10.5483\/BMBRep.2014.47.11.174","article-title":"Revisiting PPARgamma as a target for the treatment of metabolic disorders","volume":"47","author":"Choi","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.envint.2023.107951_b0125","article-title":"Thyroid disrupting effects of old and new generation PFAS","volume":"11","author":"Coperchini","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.envint.2023.107951_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115330","article-title":"Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones","volume":"266","author":"Cui","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107951_b0135","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1039\/D0AN02005B","article-title":"Native mass spectrometry for the design and selection of protein bioreceptors for perfluorinated compounds","volume":"146","author":"Daems","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.envint.2023.107951_b0140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/ijms21020399","article-title":"Increased cardiovascular risk associated with chemical sensitivity to perfluoro\u2013octanoic acid: role of impaired platelet aggregation","volume":"21","author":"De Toni","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0145","doi-asserted-by":"crossref","first-page":"29166","DOI":"10.1021\/acsomega.1c04592","article-title":"Computational Analysis of the Binding Mechanism of GenX and HSA","volume":"6","author":"Delva-Wiley","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.envint.2023.107951_b0150","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.scitotenv.2017.12.101","article-title":"Multiple approaches to assess the effects of F-53B, a Chinese PFOS alternative, on thyroid endocrine disruption at environmentally relevant concentrations","volume":"624","author":"Deng","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.107951_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116840","article-title":"Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via SIRT1-induced upregulation of UCP2 expression","volume":"278","author":"Duan","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107951_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.112903","article-title":"Changes in plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with changes in plasma lipids - A longitudinal study over 10 years","volume":"211","author":"Dunder","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.107951_b0165","unstructured":"EEA. Emerging Chemical Risks in Europe: \u201cPFAS\u201d. https:\/\/www.eea.europa.eu\/themes\/human\/chemicals\/emerging-chemical-risks-in-europe. 2019."},{"key":"10.1016\/j.envint.2023.107951_b0170","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1021\/acs.est.2c00865","article-title":"Applicability Domain of Polyparameter Linear Free Energy Relationship Models Evaluated by Leverage and Prediction Interval Calculation","volume":"56","author":"Endo","year":"2022","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116136","article-title":"In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays","volume":"449","author":"Evans","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.107951_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128083","article-title":"Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by (19)F NMR","volume":"263","author":"Fedorenko","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105324","article-title":"Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma","volume":"137","author":"Forsthuber","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107951_b0190","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s00216-021-03762-1","article-title":"Development and validation of an LC-MS\/MS method for the quantitation of 30 legacy and emerging per- and polyfluoroalkyl substances (PFASs) in human plasma, including HFPO-DA, DONA, and cC6O4","volume":"414","author":"Frigerio","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.envint.2023.107951_b0195","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd2589","article-title":"Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets","volume":"7","author":"Furuhashi","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.envint.2023.107951_b0200","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1289\/ehp.1104436","article-title":"Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure","volume":"120","author":"Gallo","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0205","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1021\/es304030x","article-title":"Assessment of estrogenic activity of perfluoroalkyl acids based on ligand-induced conformation state of human estrogen receptor","volume":"47","author":"Gao","year":"2013","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0210","doi-asserted-by":"crossref","first-page":"6953","DOI":"10.1021\/acs.est.5b00778","article-title":"Differential accumulation and elimination behavior of perfluoroalkyl Acid isomers in occupational workers in a manufactory in China","volume":"49","author":"Gao","year":"2015","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0215","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1021\/acs.est.9b00715","article-title":"Prenatal exposure to per-and polyfluoroalkyl substances (PFASs) and association between the placental transfer efficiencies and dissociation constant of serum proteins\u2013PFAS complexes","volume":"53","author":"Gao","year":"2019","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0220","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/es001834k","article-title":"Global distribution of perfluorooctane sulfonate in wildlife","volume":"35","author":"Giesy","year":"2001","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0225","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chemosphere.2016.01.010","article-title":"Experimental and computational study of membrane affinity for selected energetic compounds","volume":"148","author":"Golius","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138839","article-title":"Investigation of levels of perfluoroalkyl substances in surface water, sediment and fish tissue in New Jersey, USA","volume":"729","author":"Goodrow","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.envint.2023.107951_b0235","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yrtph.2010.09.008","article-title":"Toxicological evaluation of ammonium 4,8-dioxa-3H-perfluorononanoate, a new emulsifier to replace ammonium perfluorooctanoate in fluoropolymer manufacturing","volume":"59","author":"Gordon","year":"2011","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.envint.2023.107951_b0240","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/tx034005w","article-title":"Binding of Perfluorooctanoic Acid to Rat and Human Plasma Proteins","volume":"16","author":"Han","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0245","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1289\/ehp.0900800","article-title":"The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling","volume":"117","author":"Henley","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0250","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1039\/D1EW00501D","article-title":"Proteins as adsorbents for PFAS removal from water","volume":"8","author":"Hernandez","year":"2022","journal-title":"Environ. Sci. Water Res. Technol."},{"key":"10.1016\/j.envint.2023.107951_b0255","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0009-2797(92)90003-4","article-title":"COVALENT BINDING OF ERFLUORINATED FATTY ACIDS TO PROTEINS IN THE PLASMA","volume":"82","author":"Heuvel","year":"1992","journal-title":"LIVER AND TESTES OF RATS Chemico-biological Interactions"},{"key":"10.1016\/j.envint.2023.107951_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152789","article-title":"Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure","volume":"457","author":"Houck","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2023.107951_b0660","first-page":"77","article-title":"Alterations in cell membrane properties caused by perfluorinated compounds","volume":"135","author":"Hu","year":"2003","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.envint.2023.107951_b0265","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/toxsci\/68.2.429","article-title":"Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo","volume":"68","author":"Hu","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124491","article-title":"Developmental toxicity of the novel PFOS alternative OBS in developing zebrafish: An emphasis on cilia disruption","volume":"409","author":"Huang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107951_b0275","doi-asserted-by":"crossref","first-page":"12291","DOI":"10.1021\/acs.est.1c01200","article-title":"Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry","volume":"55","author":"Jackson","year":"2021","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0280","article-title":"Health-related toxicity of emerging per- and polyfluoroalkyl substances: Comparison to legacy PFOS and PFOA","volume":"212","author":"Jane","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.107951_b0285","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1897\/02-553","article-title":"Binding of perfluorinated fatty acids to serum proteins","volume":"22","author":"Jones","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envint.2023.107951_b0290","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.chemosphere.2017.06.024","article-title":"Endocrine-disrupting activity of per- and polyfluoroalkyl substances: Exploring combined approaches of ligand and structure based modeling","volume":"184","author":"Kar","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0295","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/toxics9030045","article-title":"Perfluoroalkyl acid binding with peroxisome proliferator-activated receptors \u03b1, \u03b3, and \u03b4, and fatty acid binding proteins by equilibrium dialysis with a comparison of methods","volume":"9","author":"Khazaee","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.envint.2023.107951_b0300","doi-asserted-by":"crossref","first-page":"bqab194","DOI":"10.1210\/endocr\/bqab194","article-title":"PFAS and potential adverse effects on bone and adipose tissue through interactions with PPAR\u03b3","volume":"162","author":"Kirk","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.envint.2023.107951_b0305","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1007\/s11356-013-1753-3","article-title":"Perfluorinated compounds affect the function of sex hormone receptors","volume":"20","author":"Kjeldsen","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.envint.2023.107951_b0310","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.taap.2008.10.008","article-title":"Mechanism of cytotoxic action of perfluorinated acids. I. alteration in plasma membrane potential and intracellular pH level","volume":"234","author":"Kleszczynski","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.107951_b0315","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.taap.2011.01.002","article-title":"Mechanism of cytotoxic action of perfluorinated acids. III. Disturbance in Ca(2)+ homeostasis","volume":"251","author":"Kleszczynski","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.107951_b0320","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.taap.2008.11.021","article-title":"Mechanism of cytotoxic action of perfluorinated acids II. Disruption of mitochondrial bioenergetics","volume":"235","author":"Kleszczynski","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.envint.2023.107951_b0325","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fphar.2018.00037","article-title":"Biology of platelet purinergic receptors and implications for platelet heterogeneity","volume":"9","author":"Koupenova","year":"2018","journal-title":"Front Pharmacology"},{"key":"10.1016\/j.envint.2023.107951_b0330","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.placenta.2015.07.119","article-title":"Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system","volume":"36","author":"Kummu","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.envint.2023.107951_b0335","doi-asserted-by":"crossref","first-page":"14514","DOI":"10.1021\/acs.est.0c03468","article-title":"Evaluation of the Estrogenic\/Antiestrogenic Activities of Perfluoroalkyl Substances and Their Interactions with the Human Estrogen Receptor by Combining In Vitro Assays and In Silico Modeling","volume":"54","author":"Li","year":"2020","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.122506","article-title":"Short-chain per- and polyfluoroalkyl substances in aquatic systems: Occurrence, impacts and treatment","volume":"380","author":"Li","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.envint.2023.107951_b0345","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chemosphere.2017.09.116","article-title":"Perfluorooctane sulfonate impairs rat Leydig cell development during puberty","volume":"190","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0350","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1039\/C9EM00218A","article-title":"Investigation of binding and activity of perfluoroalkyl substances to the human peroxisome proliferator-activated receptor beta\/delta","volume":"21","author":"Li","year":"2019","journal-title":"Environ. Sci. Processes Impacts"},{"key":"10.1016\/j.envint.2023.107951_b0355","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1021\/acs.est.8b06978","article-title":"Adipogenic activity of oligomeric hexafluoropropylene oxide (perfluorooctanoic acid alternative) through peroxisome proliferator-activated receptor \u03b3 pathway","volume":"53","author":"Li","year":"2019","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0360","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envpol.2017.10.039","article-title":"Bioaccumulation and effects of novel chlorinated polyfluorinated ether sulfonate in freshwater alga Scenedesmus obliquus","volume":"233","author":"Liu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107951_b0365","first-page":"1","article-title":"Prenatal and postnatal transfer of perfluoroalkyl substances from mothers to their offspring","author":"Liu","year":"2021","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.envint.2023.107951_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124378","article-title":"Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China","volume":"407","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107951_b0375","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1021\/es1038694","article-title":"Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant","volume":"45","author":"Lopez-Espinosa","year":"2011","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116460","article-title":"The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4","volume":"273","author":"Lu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107951_b0385","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/tx300112p","article-title":"Structural evidence of perfluorooctane sulfonate transport by human serum albumin","volume":"25","author":"Luo","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125991","article-title":"The molecular-level understanding of the uptake of PFOS and its alternatives (6:2 Cl-PFESA and OBS) into phospholipid bilayers","volume":"417","author":"Lv","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.envint.2023.107951_b0395","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/bit.27981","article-title":"Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances","volume":"119","author":"Mann","year":"2022","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.envint.2023.107951_b0400","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/toxsci\/kfm065","article-title":"Toxicogenomic Study of Triazole Fungicides and Perfluoroalkyl Acids in Rat Livers Predicts Toxicity and Categorizes Chemicals Based on Mechanisms of Toxicity","volume":"97","author":"Martin","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0405","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/pro.4036","article-title":"Unveiling the binding mode of perfluorooctanoic acid to human serum albumin","volume":"30","author":"Maso","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.envint.2023.107951_b0410","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1289\/ehp.0901584","article-title":"Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey","volume":"118","author":"Melzer","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0415","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.706352","article-title":"Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence","volume":"12","author":"Meneguzzi","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.envint.2023.107951_b0420","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0031-6997(25)00055-9","article-title":"Renal organic anion transport system: pharmacological physiological, and biochemical aspects","volume":"34","author":"Moller","year":"1982","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.envint.2023.107951_b0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.comtox.2020.100120","article-title":"Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus)","volume":"13","author":"Mortensen","year":"2020","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-7843.2007.00155.x","article-title":"Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid","volume":"103","author":"Nakagawa","year":"2008","journal-title":"Basic Clin. Paharmacol. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0435","doi-asserted-by":"crossref","first-page":"12306","DOI":"10.1021\/acs.est.5b03000","article-title":"Exploring the Use of Molecular Docking to Identify Bioaccumulative Perfluorinated Alkyl Acids (PFAAs)","volume":"49","author":"Ng","year":"2015","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0440","article-title":"Predicting the effects of per-and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro","volume":"153024","author":"Nielsen","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2023.107951_b0445","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/25931","article-title":"Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-g","volume":"395","author":"Nolte","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.envint.2023.107951_b0731","unstructured":"OECD, 2018. Toward a new comprehensive global database of per- and polyfluoroalkyl substances (PFASs). http:\/\/www.oecd.org\/chemicalsafety\/risk-management\/global-database-of-per-and-polyfluoroalkyl-substances.xlsx; http:\/\/www.oecd.org\/officialdocuments\/publicdisplaydocumentpdf\/?cote=ENV-JM-MONO(2018)7&doclanguage=en (methodology report) (021\/9\/1)."},{"key":"10.1016\/j.envint.2023.107951_b0455","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0460","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.envres.2017.05.013","article-title":"Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000\u20132015","volume":"157","author":"Olsen","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.107951_b0465","article-title":"PPAR\u03b2\/\u03b4 at the crossroads of energy metabolism, mitochondrial quality control and redox balance","volume":"29","author":"Palioura","year":"2022","journal-title":"Journal of Biological Research - Thessaloniki"},{"key":"10.1016\/j.envint.2023.107951_b0470","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1021\/acs.est.7b02259","article-title":"First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern","volume":"51","author":"Pan","year":"2017","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.envint.2023.107951_b0475","doi-asserted-by":"crossref","first-page":"14501","DOI":"10.1289\/EHP4555","article-title":"A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing","volume":"127","author":"Patlewicz","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0480","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"Perez","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107951_b0485","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00894-018-3878-2","article-title":"Perfluorinated compounds binding to estrogen receptor of different species: a molecular dynamic modeling","volume":"25","author":"Qu","year":"2018","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.envint.2023.107951_b0490","first-page":"1655","article-title":"Covalent binding of fluorotelomer unsaturated aldehydes (FTUALs) and carboxylic acids (FTUCAs) to proteins","volume":"47","author":"Rand","year":"2013","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0495","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00204-014-1258-y","article-title":"Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor","volume":"89","author":"Ren","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0500","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2016.08.011","article-title":"Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications","volume":"366\u2013367","author":"Ren","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.envint.2023.107951_b0505","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1021\/bi000314z","article-title":"Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions","volume":"39","author":"Richieri","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.envint.2023.107951_b0510","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/acs.estlett.0c00036","article-title":"Field Sampling Materials Unlikely Source of Contamination for Perfluoroalkyl and Polyfluoroalkyl Substances in Field Samples","volume":"7","author":"Rodowa","year":"2020","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.envint.2023.107951_b0515","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/A:1010851130136","article-title":"Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells","volume":"219","author":"Schroeder","year":"2001","journal-title":"Mol. Cell. Biochem."},{"issue":"1\u20132","key":"10.1016\/j.envint.2023.107951_b0520","first-page":"1","article-title":"Definitely quantitative structure-activity relationship (QSAR) models together with molecular simulation methods were permitted to predict health adverse impacts","volume":"622","author":"Schultza","year":"2003","journal-title":"J. Mol. Struct. (Thoechem)"},{"key":"10.1016\/j.envint.2023.107951_b0525","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/toxsci\/68.1.249","article-title":"Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys","volume":"68","author":"Seacat","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0530","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1021\/acs.jpcb.0c00980","article-title":"Cholesterol-like condensing effect of perfluoroalkyl substances on a phospholipid bilayer","volume":"124","author":"Shen","year":"2020","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.envint.2023.107951_b0535","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00204-014-1391-7","article-title":"Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein","volume":"90","author":"Sheng","year":"2016","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.envint.2023.107951_b0540","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-017-2055-1","article-title":"Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein","volume":"92","author":"Sheng","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0545","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1021\/acs.chemrestox.0c00075","article-title":"Interactions of perfluorooctanesulfonate and 6: 2 chlorinated polyfluorinated ether sulfonate with human serum albumin: a comparative study","volume":"33","author":"Sheng","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.envint.2023.107951_b0550","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/etc.1758","article-title":"Tissue distribution of perfluorinated compounds in farmed freshwater fish and human exposure by consumption","volume":"31","author":"Shi","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.envint.2023.107951_b0555","doi-asserted-by":"crossref","first-page":"14156","DOI":"10.1021\/acs.est.5b04299","article-title":"Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F-53B in Crucian Carp (Carassius carassius): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern","volume":"49","author":"Shi","year":"2015","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0560","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/acs.est.5b05849","article-title":"Human exposure and elimination kinetics of chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs)","volume":"50","author":"Shi","year":"2016","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0565","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.chemosphere.2015.08.066","article-title":"Poly- and perfluoroalkyl substances (PFASs) in indoor dust and food packaging materials in Egypt: Trends in developed and developing countries","volume":"144","author":"Shoeib","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107203","article-title":"Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars)","volume":"163","author":"Soderstrom","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107951_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110690","article-title":"PFAS and cancer, a scoping review of the epidemiologic evidence","volume":"194","author":"Steenland","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.envint.2023.107951_b0585","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Eposure Sci. Environ. Epidemiol."},{"key":"10.1016\/j.envint.2023.107951_b0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132417","article-title":"Experimental insights into anodic oxidation of hexafluoropropylene oxide dimer acid (GenX) on boron-doped diamond anodes","volume":"288","author":"Suresh Babu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0595","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chemosphere.2010.10.040","article-title":"Removal of PFOS, PFOA and other perfluoroalkyl acids at water reclamation plants in South East Queensland Australia","volume":"82","author":"Thompson","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0600","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1021\/acs.est.9b03820","article-title":"Bioconcentration and metabolic effects of emerging PFOS alternatives in developing zebrafish","volume":"53","author":"Tu","year":"2019","journal-title":"Environ. Sci. Tech."},{"issue":"2","key":"10.1016\/j.envint.2023.107951_b0605","doi-asserted-by":"crossref","first-page":"E390","DOI":"10.1152\/ajpendo.00257.2002","article-title":"Characterization and identification of steroid sulfatetransporters of human placenta","volume":"284","author":"Ugele","year":"2003","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.envint.2023.107951_b0735","unstructured":"UNEP, 2009. Decision SC-4\/17: Listing of Perfluorooctane Sulfonic Acid (PFOS), its Salts and Perfluorooctane Sulfonyl Fluoride in Annex B."},{"key":"10.1016\/j.envint.2023.107951_b0610","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.envint.2013.08.021","article-title":"Fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their potential precursors","volume":"60","author":"Wang","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107951_b0615","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.chemosphere.2019.01.061","article-title":"PFOS, PFOA, estrogen homeostasis, and birth size in Chinese infants","volume":"221","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0620","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1021\/es401525n","article-title":"First report of a Chinese PFOS alternative overlooked for 30 years: its toxicity, persistence, and presence in the environment","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0625","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.envpol.2017.04.086","article-title":"Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative \/nitrosative stress in humans","volume":"229","author":"Wang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107951_b0630","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/toxsci\/kfp275","article-title":"Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths","volume":"113","author":"Weaver","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0635","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfp055","article-title":"Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin","volume":"109","author":"Weiss","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0640","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1210\/en.2014-1439","article-title":"Unliganded thyroid hormone receptor alpha controls developmental timing in Xenopus tropicalis","volume":"156","author":"Wen","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.envint.2023.107951_b0645","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/toxsci\/kfn166","article-title":"Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths","volume":"106","author":"Wolf","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0650","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chemosphere.2016.09.161","article-title":"Analysis of perfluorinated compounds in human serum from the general population in Shanghai by liquid chromatography-tandem mass spectrometry (LC-MS\/MS)","volume":"168","author":"Wu","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.133853","article-title":"Global performance and trends of research on per- and polyfluoroalkyl substances (PFASs) between 2001 and 2018 using bibliometric analysis","volume":"295","author":"Wu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0665","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.clinre.2017.02.001","article-title":"An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2\/ASBT)","volume":"41","author":"Xiao","year":"2017","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.envint.2023.107951_b0670","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1021\/acs.est.9b01579","article-title":"Comparative in vitro and in vivo evaluation of the estrogenic effect of hexafluoropropylene oxide homologues","volume":"53","author":"Xin","year":"2019","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0675","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.chemosphere.2007.07.079","article-title":"Perfluorinated acids as novel chemical tracers of global circulation of ocean waters","volume":"70","author":"Yamashita","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.envint.2023.107951_b0680","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/toxsci\/kfq219","article-title":"Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates","volume":"117","author":"Yang","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.envint.2023.107951_b0685","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1021\/acs.est.0c00049","article-title":"Nontarget screening of per-and polyfluoroalkyl substances binding to human liver fatty acid binding protein","volume":"54","author":"Yang","year":"2020","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0690","doi-asserted-by":"crossref","first-page":"37003","DOI":"10.1289\/EHP11403","article-title":"Emerging and Legacy Perfluoroalkyl Substances in Breastfed Chinese Infants: Renal Clearance, Body Burden, and Implications","volume":"131","author":"Yao","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0695","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1124\/dmd.121.000702","article-title":"Emerging Roles of the Human Solute Carrier 22 Family","volume":"50","author":"Yee","year":"2021","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.envint.2023.107951_b0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105262","article-title":"Probing the hepatotoxicity mechanisms of novel chlorinated polyfluoroalkyl sulfonates to zebrafish larvae: Implication of structural specificity","volume":"133","author":"Yi","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107951_b0705","doi-asserted-by":"crossref","first-page":"47010","DOI":"10.1289\/EHP8054","article-title":"Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays","volume":"129","author":"Young","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.envint.2023.107951_b0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106745","article-title":"Varied thyroid disrupting effects of perfluorooctanoic acid (PFOA) and its novel alternatives hexafluoropropylene-oxide-dimer-acid (GenX) and ammonium 4,8-dioxa-3H-perfluorononanoate (ADONA) in vitro","volume":"156","author":"Zhang","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.envint.2023.107951_b0715","doi-asserted-by":"crossref","first-page":"11293","DOI":"10.1021\/es4026722","article-title":"Structure-based investigation on the interaction of perfluorinated compounds with human liver fatty acid binding protein","volume":"47","author":"Zhang","year":"2013","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.envint.2023.107951_b0720","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1038\/srep03888","article-title":"Concentration-dependent polyparameter linear free energy relationships to predict organic compound sorption on carbon nanotubes","volume":"4","author":"Zhao","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.envint.2023.107951_b0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113714","article-title":"Indoor exposure to per- and polyfluoroalkyl substances (PFAS) in the childcare environment","volume":"258","author":"Zheng","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.envint.2023.107951_b0730","first-page":"915","article-title":"Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of","volume":"1771","author":"Zoete","year":"2007","journal-title":"Lipids"}],"container-title":["Environment International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023002246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0160412023002246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T12:28:04Z","timestamp":1758976084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0160412023002246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":147,"alternative-id":["S0160412023002246"],"URL":"https:\/\/doi.org\/10.1016\/j.envint.2023.107951","relation":{},"ISSN":["0160-4120"],"issn-type":[{"value":"0160-4120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insight into the binding model of per- and polyfluoroalkyl substances to proteins and membranes","name":"articletitle","label":"Article Title"},{"value":"Environment International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.envint.2023.107951","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107951"}}